JANUARY 1990 VOL 43 NO 1

CLINICAL

PATHOLOGYThe Journal of the Association of Clinical Pathologists

1

3

Occasionals

Papers

Techniques

Letters

Miscellanea

Editorial Plus ca change J S Lilleyman

Review: Increased albumin excretion in diabetes J C Townsend

9 Immunocytochemical examination ofbone marrow in disseminated neuroblastoma P J Carey,L T7hom, G Buckle,MM Reid

13 Paragangial cells ofurinary bladder and prostate: potential diagnostic problem J Rode,A Bentley, C Parkinson

17 Observer variability in histopathological reporting of transitional cell carcinoma andepithelial dysplasia in bladders A J Robertson, J Swanson Beck, R A Burnett, S R Howatson, FD Lee,AM Lessells, et al

22 Ultrastructural analysis offine needle aspirates from benign breast lesions D JP Ferguson,CA Wells, V Crucioli

27 Lamina propria eosinophils and mast cells in ulcerative colitis: comparison between Asiansand Caucasians G FA Benfield, R Bryan, J Crocker

32 Thin basement membranes in minimally abnormal glomeruli S Saxena, D J Davies,R L G Kirsner

39 Chronic carotid glomitis and the glomus pulmonale Q Khan, D Heath43 Changes in alveolar macrophage, monocyte, and neutrophil cell profiles after smoke

inhalation injury B M S Riyami, R Tree, J Kinsella, C J Clark, WM Reid, D Campbell, et al46 Assessment ofoestrogen receptor content of breast carcinoma by immunohistochemical

techniques on fixed and frozen tissue and by biochemical ligand binding assay D A Paterson,C P Reid, TJ Anderson, R A Hawkins

52 Demonstration of multiple HPV types in normal cervix and in cervical squamous cellcarcinoma using the polymerase chain reaction on paraffin wax embedded materialNR Griffin, I S Bevan, F A Lewis,M Wells, L S Young

57 Small intestinal bacterial overgrowth in patients with chronic lymphocytic leukaemiaGM Smith, I M Chesner, P Asquith,M J Leyland

60 Campylobacter pylori in the upper gastrointestinal tract of patients with HIV-l infectionND Francis, R PH Logan,MM Walker, R J Polson, A W Boylston, A J Pinching, et al

63 Viral and Toxoplasma gondii infections in children after liver transplantationA Salt, G Sutehall,M Sargaison, C Woodward, ND Barnes, R Y Calne, et al

68 ACP Broadsheet 123- Examination oflung specimens A R Gibbs, R ME Seal73 Detection of lupus like anticoagulant: current laboratory practice in the United Kingdom The

Lupus Anticoagulant Working Party76 Simple technique for detecting Kl antigen of Escherichia coli D A Devine, A P Roberts, B Rowe79 Serological diagnosis of neurobrucellosis A Sanchez-Sousa, C Torres,M G Campello, C Garcia,

F Parras, E Cercenado, et al

82 Distribution ofCampylobacter pylori in the upper and lower gastrointestinal tract: amicrobiological and histological studyMM Walker, Q N Karim, A Payne, JH Baron

82 Primary malignant melanoma of the oesophagus N S Simpson, R A J Spence, JD Biggart,CH S Cameron

83 Secondary tumour deposits in needle biopsy tracks: an underestimated risk? K J Denton,D WK Cotton, R A Nakielny, JR Goepel

83 Simplified method ofpreparing neutrophil slides to examine antibodies to cytoplasmicantigens D E Roberts, R Daggett, C Peebles

84 Matters arismng - Book reviews * Notices

BRITISH MEDICAL ASSOCIATION TAVISTOCK SQUARE LONDON WC1H 9JR

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VOLUME 43 CONTENTS

No 1 JANUARY 1990 Page Occasionals1 Editorial: Plus ca change J S Lilleyman3 Review: Increased albumin excretion in diabetes J C Townsend

Papers9 Immunocytochemical examination of bone marrow in disseminated neuroblastoma P J Carey, L Thomas, G Buckle,MM Reid

13 Paraganglial cells of urinary bladder and prostate: potential diagnostic problem J Rode, A Bentley, C Parkinson17 Observer variability in histopathological reporting of transitional cell carcinoma and epithelial dysplasia in bladders

A J Robertson, J Swanson Beck, R A Burnett, S R Howatson, FD Lee, A M Lessells, et al22 Ultrastructural analysis of fine needle aspirates from benign breast lesions D JP Ferguson, C A Wells, V Crucioli27 Lamina propria eosinophils and mast cells in ulcerative colitis: comparison between Asians and Caucasians

G F A Benfield, R Bryan, J Crocker32 Thin basement membranes in minimally abnormal glomeruli S Saxena, D J Davies, R L G Kirsner39 Chronic carotid glomitis and the glomus pulmonale Q Khan, D Heath43 Changes in alveolar macrophage, monocyte, and neutrophil cell profiles after smoke inhalation injury

B M S Riyami, R Tree, J Kinsella, C J Clark, WM Reid, D Campbell, et al46 Assessment of oestrogen receptor content of breast carcinoma by immunohistochemical techniques on fixed and

frozen tissue and by biochemical ligand binding assay D A Paterson, C P Reid, T J Anderson, R A Hawkins52 Demonstration of multiple HPV types in normal cervix and in cervical squamous cell carcinoma using the

polymerase chain reaction on paraffin wax embedded material NR Griffin, I S Bevan, FA Lewis, M Wells,L S Young

57 Small intestinal bacterial overgrowth in patients with chronic lymphocytic leukaemia GM Smith, I M Chesner,P Asquith,M J Leyland

60 Campylobacter pylori in the upper gastrointestinal tract of patients with HIV-1 infectionND Francis,R PH Logan, MM Walker, R J Poison, A W Boylston, A J Pinching, et al

63 Viral and Toxoplasma gondii infections in children after liver transplantation A Salt, G Sutehall, M Sargaison, CWoodward,N D Barnes, R Y Calne, et al

Techniques68 ACP Broadsheet 123: Examination of lung specimens A R Gibbs, R ME Seal73 Detection of lupus like anticoagulant: current laboratory practice in the United Kingdom The Lupus Anticoagulant

Working Party76 Simple technique for detecting KI antigen of Escherichia coli D A Devine, A P Roberts, B Rowe79 Serological diagnosis of neurobrucellosis A Sanchez-Sousa, C Torres, M G Campello, C Garcia, F Parras,

E Cercenado, et al

Letters82 Distribution of Campylobacter pylori in the upper and lower gastrointestinal tract: a microbiological and

histological studyMM Walker, Q N Karim, A Payne, JH Baron82 Primary malignant melanoma of the oesophagus N S Simpson, R A J Spence, J D Biggart, C H S Cameron83 Secondary tumour deposits in needle biopsy tracks: an underestimated risk? K J Denton, D WK Cotton,

R A Nakielny, J R Goepel83 Simplified method of preparing neutrophil slides to examine antibodies to cytoplasmic antigens D E Roberts,

R Daggett, C Peebles

Miscellanea84 Matters arising * Book reviews * Notices

No 2 FEBRUARY 1990 Occasionals89 Royal College of Pathologists' United Kingdom pilot study of laboratory accreditation The College Accreditation

Steering Committee92 Laboratory costing system based on number and type of test: its association with the Welcan workload

measurement system I F Tarbit

Papers98 Aplastic anaemia associated with organochlorine pesticide: case reports and review of evidence F P Rugman,

R Cosstick102 Circulating high molecular weight IgG fibronectin complexes in myeloproliferative disorders TP Baglin,

SM Price, B J Boughton106 Rheumatoid lymphadenopathy: a morphological and immunohistochemical study GM Kondratowicz,

D P M Symmons, PA Bacon, R A K Mageed, E L Jones114 Cerebral aspergillosis in liver transplantation A P Boon, DH Adams, J Buckels, P McMaster119 Hepatic iron in dialysed patients given intravenous iron dextran L W Fleming, D Hopwood, A N Shepherd,

W K Stewart125 Familial increased serum intestinal alkaline phosphatase: a new variant associated with Gilbert's syndrome

A G Lieverse, G G van Essen, G J J Beukeveld, J Gazendam, E C Dompeling, L P ten Kate, et al129 Combined non-isotopic in situ hybridisation and immunohistochemistry on routine paraffin wax embedded tissue:

identification of cell type infected by human parvovirus and demonstration of cytomegalovirus DNA and antigen inrenal infection H J Porter, A Heryet, A M Quantrill, KA Fleming

133 DNA hybridisation of routinely processed tissue for detecting HPV DNA in anal squamous cell carcinomas over 40years JH Scholefield, P McIntyre, J G Palmer, P J Coates,NA Shepherd, JMA Northover

137 Monitoring rejection after heart transplantation: cytoimmunological monitoring on blood cells and quantitativebirefringence measurements on endomyocardial biopsy specimens P J L Wijngaard, JA Gimpel, H-J Schuurman,A van der Meulen, FH J Gmelig Meyling, G Jambroes

143 Mucin depletion in inflammatory bowel disease D A McCormick, L WL Horton, A S Mee147 Nucleolar organiser regions in kidney tumours and xanthogranulomatous pyelonephritis R L Bryan, J Crocker,

A Farr149 Oestrogen receptors in colorectal carcinoma PM Dawson, S Shousha, S D Blair, G D Carter, J Jones,

J Alaghband-Zadeh, et al152 Radiation and other pathological changes in breast tissue after conservation treatment for carcinoma A C Girling,

A M Hanby, R R Millis157 Prognostic value of nucleolar morphometric variables in cytological breast cancer specimens P J van Diest,

J Mouriquand, NW Schipper, JPA Baak

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Techniques160 Effect of haemolysate preparation on measurement of red cell folate by a radioisotopic method C R Gilois, J Stone,

A P Lai, A S Wierzbicki163 Evaluation of Serodia Myco II particle agglutination test for detecting Mycoplasma pneumoniae antibody:

comparison with p-capture ELISA and indirect immunofluorescence CE Barker,M Sillis, T G Wreghitt166 Evaluation of the equivocal test results of Treponema pallidum haemagglutination assay S J Su, S Huang,

C Y Chung, HM Yang, Y 0 Chow168 Computer assisted diagnosis of fine needle aspirate of the breast HA Heathfield,N Kirkham, IO Ellis,

G WinstanleyLetters

171 Staphylococcus lugdenensis and endocarditis B Walsh, JP Mounsey171 Lack of in vitro activity of omeprazole against Campylobacter pylori A M Ghelani, S Hale,H Coleman,

H Radziwonik, C Robertson,M Atkinson172 Elective surgery in a haemophilic patient with high titre inhibitors: use of extracorporeal protein A

inimunoabsorption B J Boughton, A Payne, A Serman, C Owen172 Spiral shaped bacteria in gastric mucosaN Figura, P Guglielmetti, S Quaranta

Miscellanea173 Matters arising * Book reviews* Notices

No 3 MARCH 1990 Occasionals177 Guidelines on oral anticoagulation: second edition British Societyfor Haematology184 Review: Assessment of cell proliferation in histological material P A Hall, D A Levison

Papers193 Value of the necropsy in perioperative deaths JH Shanks, G McCluggage,NH Anderson, P G Toner196 Mast cells in leprosy skin lesions I A Cree, G Coghill, J Swanson Beck201 Histopathology of acute human immunodeficiency virus exanthema E Balslev,HK Thomsen,K Weismann203 Histological and immunohistochemical study of hepatitis B virus in human immunodeficiency virus infection

R D Goldin, D E Fish, A Hay, J A Waters,M J McGarvey, J Main, et al206 Idiopathic portal hypertension associated with cytotoxic drugs P Shepherd, D J Harrison211 Methylation ofDNA in megaloblastic anaemia J Perry, I Chanarin, R Deacon,M Lumb213 Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelia U Latza, G Niedobitek,

R Schwarting,H Nekarda,H Stein220 Demonstration of Epstein-Barr virus in primary brain lymphoma by in situ DNA hybridisation in paraffin wax

embedded tissue JK Murphy, L S Young, I S Bevan, F A Lewis, D Dockey, J W Ironside, et al224 Immunohistochemical and electron microscopic findings in benign fibroepithelial vaginal polyps T P Rollason,

P Byrne, A Williams230 Immunoreactive a interferon in cervical flat koilocytic lesions and intraepithelial neoplasia C J R Stewart,

MA Farquharson, A M McNicol, A K Foulis235 Role of nucleolar organiser regions in differentiating malignant from benign tumours of the colon P Yang,

G S Huang, X S Zhu239 Immunohistological study of oestrogen receptors in breast carcinomas that are biochemically receptor negative

S Shousha, T Stamp, KR James, J Alaghband-ZadehTechniques

243 Rate nephelometric determination of rheumatoid factor: comparison between Kallestad QM-300 and BeckmanICS-II (RF) methods R J Collins, J C Neil, R J Wilson

246 Coagulase testing compared with commercial kits for routinely identifying Staphylococcus aureus A S Rossney,L F English, C T Keane

253 Comparison of solid media for cultivation of anaerobesM Heginbothom, T C Fitzgerald, W G Wade257 Technical improvements in the immunoperoxidase study of renal biopsy specimens A J Howie, J Gregory,

R A Thompson,M A Adkins, A J NiblettLetters

260 Rapid identification of Chlamydia psittaci and TWAR (C pneumoniae) in sputum samples using an amplifiedenzyme immunoassay M Sillis, P White

260 Diagnosis of toxoplasmosis using DNA probes D Savva, R E Holliman261 Evaluation of 3-fucosyl N-acetyllactosamine antibody staining in histological assessment of CIN A J Robertson,

J Swanson Beck, R A Burnett, et al262 Serum IgE concentrations in complete Behqet's diseaseK Cengiz

Miscellanea262 Matters arising. Notices

No 4 APRIL 1990 Occasionals265 Why have Pneumocystis carinii trophozoites been ignored? JM W Chatterton, A WL Joss,MM Davidson,

D 0 Ho-Yen269 Role of papillomaviruses F Chang

Papers277 Lead poisoning: clinical, biochemical, and haematological aspects of a recent outbreak A Pagliuca, G J Mufti,

D Baldwin, A N Lestas, R M Wallis, A J Bellingham282 Monocyte esterase deficiency in malignant neoplasia GM Markey, JA McCormick, T CM Morris,

H D Alexander, L Nolan, L M Morgan, et al287 Histogenesis of ovarian malignant mixed mesodermal tumours T J Clarke291 Severe granulomatous arthritis due to spinous injury by a "sea mouse" annelid worm G E Wilson, A Curry,

JH Kennaugh, L J McWilliam, J S Watson295 Enhancement of c-sis proto-oncogene transcription in bronchoalveolar mononuclear cells from patients with

pulmonary sarcoidosis Y Deguchi, S Kishimoto298 Immunohistochemical studies of intrahepatic tumour necrosis factor a in chronic liver disease K Yoshioka,

S Kakumu, M Arao, Y Tsutsumi,M Inoue, T Wakita, et al303 Reflux gastritis in the intact stomach GM Sobala, R F G King, A T R Axon,M F Dixon307 Brush border enzymes in coeliac disease: histochemical evaluation JMercer,M E Eagles, I C Talbot313 Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine

T T MacDonald,M A Horton,M Y Choy, P I Richman316 Serum bactericidal resistance of faecal Escherichia coli and bactericidal competence of serum from patients with

ulcerative colitis D A Burke, S A Clayden, A T R Axon

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320 Observer reproducibility in grading dysplasia in colorectal adenomas: comparison between two different gradingsystems C Fenger, M Bak, 0 Kronborg,H Svanholm

325 Proliferation in non-Hodgkin's lymphoma: a comparison of Ki-67 staining on fine needle aspiration and cryostatsections D C Brown, K C Gatter, D Y Mason

Techniques329 Use of immunocytochemistry and biotinylated in situ hybridisation for detecting measles virus in central nervous

system tissue S McQuaid, S Isserte, G M Allan, M J Taylor, I V Allen, S L Cosby334 Immunohistochemistry detection of neuroblastoma in frozen sections of bone marrow trephine biopsy specimens

MM Reid, A J Malcolm, A G McGuckin337 Evaluation of semiautomated procedure for lymphocyte subset analysis G J Bryson, R P Keegan, C P Quinn,

R J Collins342 Evaluation and comparison of neutrophil bipolar shape formation with a migration assay R A Lord, S Roath

Letters346 Tipp-ex fluid: a convenient marker for surgical resection marginsM D Harris346 Giant inflammatory polyposis in ulcerative colitis presenting with protein losing enteropathy R L Bryan,

J Newman, J Alexander-Williams347 Folicular mucinosis, mycosis fungoides, and acute myeloid leukaemia H W Habboush, N P Lucie, R M Mackie,

J Ashworth, M Turbitt347 Faecal leucocytes in Escherichia coli 0157:H7 enteritis N Cimolai

Miscellanea348 Matters arising * Book reviews * Notices

No 5 MAY 1990 Occasionals353 Helicobacter pylori (formerly Campylobacter pyloridis/pylori) 1986-1989: a review A C Maddocks

Papers357 Chronic myeloproliferative disorders: prognostic importance of new working classification R Burkhardt, K Jaeger,

G Kettner, G Helmer365 Early reconstitution of haemoatopoiesis after allogeneic bone marrow transplantation: a prospective

histopathological study of bone marrow biopsy specimens H van den Berg, Ph M Kluin, J M Vossen370 Measurement of glomerular filtration rate in homozygous sickle cell disease: a comparison of 5'Cr-EDTA clearance,

creatinine clearance, serum creatinine and 32 microglobulin S A J R Aparicio, S Mojimimiyi, J D S Kay,B J Shepstone, K de Ceulaer, G R Serjeant

373 Management of cytomegalovirus antibody negative patients undergoing heart transplantation R Freeman,F K Gould, A McMaster

377 Chromosome 11 allele loss in sporadic insulinoma P Patel, S O'Rahilly, V Buckle, Y Nakamura, R C Turner,J S Wainscoat

379 Detection of a mucin marker for the adenoma-carcinoma sequence in human colonic mucosa by monoclonalantibody AM-3 C Hanski, G Bornhoeft, N Topf, U Hermann, H Stein, E 0 Riecken

385 Expression of epidermal growth factor receptor in breast carcinoma S Lewis, A Locker, J H Todd, J A Bell,R Nicholson, C W Elston, et al

390 Nucleolar organiser regions: new prognostic variable in breast carcinomas E Sivridis, B Sims393 Contribution of the cytobrush to determining cellular composition of cervical smears H Doornewaard,

Y van der Graaf397 Antral Helicobacter pylori in patients with chronic renal failure S Shousha, A H Arnaout, S H Abbas, R A Parkins400 Prevalence of chlamydial antibody in Malaysians Y F Ngeow, S P Rachagan, S Ramachandran403 Oxygen derived free radicals in patients with chronic pancreatic and other digestive diseases D Basso,

M P Panozzo, C Fabris, G del Favero, T Meggiato, P Fogar, et al406 Combined assessment of intestinal disaccharidases in congenital asucrasia by differential urinary disaccharide

excretion D G Maxton, S D Catt, I S MenziesTechniques

410 ACP Broadsheet 124: Examination of faeces for bacterial pathogens S J Pedler, K E Orr416 In situ hybridisation in herpetic lesions using a biotinylated DNA probeM Dictor, E Renfiard, A Brun420 Blind comparison of Abbott and Dupont HIV antigen ELISA tests for detecting antigenaemia in asymptomatic

human immunodeficiency virus antibody positive homosexual men D C Shanson, K E Brown, S Goonesekera,B Gazzard, A R M Coates

424 Detection of messenger RNA using a digoxigenin end labelled oligodeoxynucleotide probe M Farquharson,R Harvie, A M McNicol

429 Rapid method for distinguishing clonal from polyclonal B cell populations in surgical biopsy specimensK P McCarthy, J P Sloane, L M Wiedemann

433 Factor VIII inhibitor assay using skin puncture blood samples R F Hinchliffe, G J Bellamy, J S LilleymanLetters

435 Histomorphometry and immunohistochemistry of beef sausages A P Boon435 DNA ploidy in adenocarcinoma in situ of the uterine cervix R C Jaworski, A Jones436 Lymphocytic gastritis and coeliac disease T Karttunen, S Niemeld437 Treatment of Waldenstrom's macroglobulinaemia with a interferon M Bhavnani, J Marples, J A Liu Yin437 Apoptotic cell death during renal transplant rejection D R Gouldesbrough, D J Harrison

Miscellanea438 Matters arising * Book reviews* Errata* Notices

No 6 JUNE 1990 Occasionals441 Consequences of the provision of laboratory services for the National Health Service by commercial firms: a view

from the University sector L G Whitby, C C Bird, J G Collee, et al445 Hepatitis C virus and transfusion transniitted liver disease: Review J C E Underwood

Papers448 Epithelial markers in pancreatic carcinoma: immunoperoxidase localisation ofDD9, CEA, EMA and CAM 5-2

E Heyderman, SE Larkin, PJ O'Donnell, et al453 Proliferation rate of colonic mucosa in normal subjects and patients with colonic neoplasms: a refined

immunohistochemical methodJ W M Welberg, EG E de Vries, MJ Hardonk, et al457 Incidence of thin membrane neophropathy: morphometric investigation of a population sample F E Dische,

V E R Anderson, SJ Keane, et al461 Preferential localisation of human lymphocytes bearing y5T cell receptors to the red pulp of the spleen

D Bourdessoule, P Gaullard, D Y Mason465 Ploidy of smooth muscle tumours: retrospective image analysis study of formalin fixed, paraffin wax embedded

tissue A Dorman, D Graham, B Curran, et al

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469 Bone marrow biopsy in monoclonal gammopathies: correlations between pathological findings and clinical dataA Riccardi, G Ucci, R Luoni, et al

476 Fibrinolysis and the bleeding tendency in patients with hepatosplenic schistosomiasis S A Omran, N A Hussein,A A Mohamed, et al

479 Microbiological investigations into an outbreak of Pontiac fever due to Legionella micdadei associated with use of awhirlpool R J Fallon, T J Rowbotham

484 Bacteriostatic and bactericidal actions of boric acid against bacteria and fungi commonly found in urine P D Meers,C K Chow

488 Production and characterisation of a monoclonal antibody to human papillomavirus type 16 using recombinantvaccinia virus C S McLean,M J Churcher, J Meinke, et al

493 Assessment of the one hour adrenocorticotrophic hormone test in the diagnosis of attentuated21-hydroxylase deficiency V T Innanen, JM Vale

496 Spontaneous mutation rate in retinoblastoma J A MorrisTechniques

499 Tissue extraction ofDNA and RNA and analysis by the polymerase chain reaction D P Jackson, F A Lewis,G R Taylor, et al

505 Rapid assessment of haemophilia A carrier state by non-invasive techniques using the polymerase chain reactionJ Ball, L J Warnock, F E Preston

508 Comparison of an immunochemical assay for plasma fibrinogen and a turbidimetric thrombin clotting technique todiscriminate hyperlipidaemic patients from healthy controls M L Knapp,MD Feher,H Carey, et al

511 Comparison of ELISA antigen preparations alone or in combination for serodiagnosing Helicobacter pyloriinfections A M Hirschl, B J Rathbone, J I Wyatt, et al

514 Enzyme linked immunosorbent assay for detecting adenoviruses in stool specimens: comparison with electronmicroscopy and isolation A L Martin, G Kudesia

516 Technique for identifying cutting artefacts in sections of undecalcified bone biopsy specimens D J Wood,WH B Mawhinney, A J Malcolm, et al

Letters518 Immunocytochemical detection of Helicobacter pylori in formalin fixed tissue biopsy specimens R W Cartun,

C A Pederson, G A Krzymowski, et al518 AgNOR counts in intraendometrial neoplasia A Hansen, B Ostergdrd519 Reproducible test for detecting Helicobacter pylori in frozen samples S Abdalla, F Marco, R M Perez, et al519 Acute phase response and deep lower limb venous thrombosis H Syrijdld, K Haukipuro,H Kiviniemi520 Light and electron microscopic demonstration ofimmune deposits in renal tissue A D McKinnon, J G Simpson

Miscellanea520 Book reviews * Notices

No 7 JULY 1990 Occasionals525 Consequences of the provision of laboratory services for the National Health Service by commercial firms: a view

from the private sector JM ShanksPapers

527 Sialic acid histochemistry and the adenoma-carcinoma sequence in colorectum S Agawa, J R Jass533 Primary adenocarcinoma of the jejunum and ileum: clinicopathological review of 25 cases T F Lioe, J D Biggart537 Activity of duodenal disaccharidases in relation to normal and abnormal mucosal morphology JM Langman,

R Rowland541 Expression of CD15 antigen in urinary bladder transitional cell carcinoma D M Parham, K Morton, G Coghill,

A J Robertson, M A Kerr544 Cerebral lymphomas: review of 70 cases J Hume Adams, A G Howatson548 Clonality ofT cell and phenotypically undefincd lymphoid neoplasms: the value of genotypic analyses E Hodges,

G N Stacey, WM Howell, D B Jones, J L Smith554 Adenoacanthoma of the endometrium: morphological changes induced by human papillomavirus W F Kealy,

P G Annis, J A Barry, JM Hogan560 Plasma fibronectin concentrations in patients with human immunodeficiency virus infection D Torre,M Issi,

C Sampietro, G P Fiori, G Chelazzi, G Ferraro563 Multiple drug resistance in salmonellae in England and Wales: a comparison between 1981 and 1988 L R Ward,

E J Threlfall, B Rowe567 Antibody response of fibrocystic patients to homologous 0-typable and 0-defective isolates of Pseudomonas

aeruginosa J MacDougall,M E Hodson, T L Pitt572 Cholesterol absorption by the gall bladder P E Ross, A N Butt, C Gallacher

Techniques576 ACP Broadsheet 125: Bacteriological diagnosis of diphtheria R Brooks, D HM Joynson581 Evaluation of two rapid methods for identifying and biotyping Haemophilus influenzae P G Murphy, I Craig,

A C Lafong, E TM Smyth584 Application of immunoblotting to detect soluble Pneumocystis carinii antigen(s) in bronchoalveolar lavage of

patients with Pneumocystis pneumonia and AIDS KK Sethi587 Evaluation of Cathra system for identifying Gram negative aerobic bacteria JM Ling, L-C Zhang, Y-W Hui,

G L French591 Automated immunochemistry WH B MaWhinney, A Warford,M J L Rae, I Lauder597 Does delay in fixation affect the number of mitotic figures in processed tissue? S S Cross, R D Start, JH F Smith600 Use of benzidine for histological demonstration ofhaemoglobin in human bite marks R T Allison, D K Whittaker604 Differential marking of excision planes in screened breast lesions by organically coloured gelatins J S Armstrong,

I P Weinzwieg, J D DaviesLetters

608 Salivary duct adenocarcinoma J I Lopez, M Nevado, B Eizaguirre608 Alcian blue: reliable rapid method for marking resection margins P J Birch, M J Jeffrey, M I J Andrews609 Congenital malaria in one identical twin D Cummins, C Brain, S C Davies609 Survival of Helicobacter pylori in water and saline A P West, M R Millar, D S Tompkins610 Selective medium for isolating Arcanobacterium haemolyticum N P Brenwald, E L Teare, L K Mountfort,

R E Tettmar610 Colorimetric determination ofhuman albumin R J Hinton, B S Mallon, K D Morris, J Miller, et al

Miscellanea610 Matters arising * Book reviews - Notices

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No 8 AUGUST 1990

No 9 SEPTEMBER 1990

Occasionals613 Pathology across Europe: differences and sinilarities. 1 HaematologyNK Shinton616 Early clinical pathologists 2 Thomas Hodgkin: pathologist, physician, and philanthropist B W Hancock

Papers619 Monocytoid B cell lymphoma: clinical and prognostic features of 21 patients S B Cogliatti, K Lennert,

M-L Hansmann, et al626 Prognostic value of cytophotometric analysis ofDNA in lymph node aspirates from patients with non-Hodgkin's

lymphoma J Vuckovic,M Dubravcic', J M Matthews, et al630 Value of bilateral bone marrow biopsy specimens in non-Hodgkin's lymphoma S K Juneja,MM Wolf, I A Cooper633 Virus infections in bone marrow transplant recipients: a three year prospective study C E Taylor, L Sviland,

A D J Pearson, et al638 Antibody to hepatitis C virus in multiply transfused patients with thalassaemia major B Wonke, A V Hoffbrand,

D Brown, et al641 Giardiasis: analysis of histological changes in biopsy specimens of 80 patients G Oberhuber,M Stolte644 Is candidiasis the true cause of vulvovaginal irritation in women with diabetes mellitus? B R Rowe,MN Logan,

I Farrell, et al646 Signature patterns ofDNA restriction fragments of Helicobacter pylori before and after treatment R J Owen,

J Fraser, M Costas, et al650 Calcium overload in human giant cell myocarditis H G Olbrich, G Herrmann, G Vandeplassche, et al654 Localisation of CD10 to biliary canaliculi by immunoelectron microscopical examination S L Loke, C Y Leung,

K Y Chiu, et al657 Nucleolar organiser regions in adenocarcinoma in situ and invasive adenocarcinoma of the cervix J F Darne,

S V Polacarz, E Sheridan, et al661 Epidemiological study of complete and partial hydatidiform mole in Abu Dhabi I H Graham, A M Fajardo,

R L Richards

Techniques665 Immunoalkaline phosphatase technique applied to paraffin wax embedded tissues in diagnostic renal pathology

R Jackson, E R Holme, G M Phimister, et al671 Demonstration of progesteron receptors in paraffin wax sections of breast carcinoma S Soomro, S Shousha675 Reticulocyte counting using flow cytometry P R Nobes, A B Carter679 Automation and the prothrombin time: a United Kingdom field study of two widely used coagulometers

JM Thomson, D A Taberner, L Poller685 Evaluation of a urinary antigen ELISA for diagnosing Legionella pneumophila serogroup 1 infection R J Birtles,

T G Harrison, D Samuel, et al691 Assessment of rapid ELISA test for Epstein-Barr virus infection B A Matheson, SM CIisholm, D 0 Ho-Yen

Letters694 Are calculated globulin measurements useful in screening for paraproteinaemia? L N Sandle, D M Alderson694 T cell non-Hodgkin's lymphoma with uveitis, pancreatitis, digital gangrene and multiple chromosomal

abnormalities P 0 Mansour, R D Adams, J C Ridway, et al695 Intraepithelial stage of signet-ring cell carcinoma of the stomach R A Caruso696 Rapid diagnosis of Candida mediastinitis by coagglutination G Koshi, V Anandi,M V Jesudason, et al696 Intraepithelial malakoplakia F I Young696 Expression of epithelial membrane antigen by carcinoid tumours A Gledhill, C Sparham,M F Dixon

Miscellanea697 Matters arising * Book reviews * Foreword to Instructions to authors * Notices

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OccasionalsPathology across Europe: differences and similarities 2 Microbiology J E BanatavalaGuidelines on the investigation and management of thrombophilia The British Committeefor Standards inHaematologyInstructions to Authors

PapersSpecimen transport audit P Garner, R G MastertonTartrate resistant acid phosphatase positive splenic lymphoma: a relatively benign condition occurring in a time-space cluster? P Kettle, T C M Morris, G M Markey, et alUse of monoclonal antibody KP1 for identifying normal and neoplastic human mast cells H-P Horny,G Schaumburg-Lever, S Bolz,M L Geerts, E KaiserlingArgyrophilic nucleolar organiser region (AgNOR) staining in normal bone marrow cells E P Nikicicz, D H NorbackAssessment of fetal-maternal haemorrhage in mothers with hereditary persistence of fetal haemoglobinWN Patton, G S Nicholson, A H Sawers, I M Franklin, F A Ala, A W SimpsonTesticular sex cord stromal tumour with granulosa cell differentiation: detection of steroid hormone receptors as apossible basis for tumour development and therapeutic management W Dfie, K-P Dieckmann, G Niedobitek,G Bornhoft, V Loy, H SteinUpper gastrointestinal pathology in familial adenomatous polyposis: results from a prospective study of 102patients P Domizio, I C Talbot, A D Spigelman, C B Williams, R K S PhillipsImmunohistochemical detection of abnormal cell proliferation in colonic mucosa of subjects with polypsR G Wilson, A N Smith, C C BirdFundamental study on the mechanism ofDNA degradation in tissues fixed in formaldehyde Y Tokuda,T Nakamura, K Satonaka, et alJC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processedtissue sections D V Parums, J L Cordell, K Micklem, A R Heryet, K C Gatter, D Y MasonAntigen specific serum antibody response to Chlamydia trachomatis in patients with acute pelvic inflammatorydisease A Miettinen, P K Heinonen, K Teisala, R Punnonen, J PaavonenSerum pepsinogen I and gastrin concentrations in children positive for Helicobacter pylori G Oderda, D Vaira,D Dell'olio, et alLatex enzyme immunoassay for measuring IgG antibodies to rubella virus G Duverlie, C Roussel,M Driencourt,J OrfilaUse of urea filter paper disc to detect urease activity in Enterobacteriaceae by multipoint replication techniquesD B Winter, S N McDermottMultiple breakpoint method for measuring effect of antibiotics on endocarditis strains of streptococci J Marks,A PaullEffect of sample volume on yield of positive blood cultures from adult patients with haematological malignancyD F J Brown, R E Warren

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No 10 OCTOBER 1990

No 11 NOVEMBER 1990

Letters780 True lipoma of Glisson's capsule P Sossai, R Barbazza780 Benign lymphoepithelial lesion of salivary gland in a patient with AIDS W FKnox, L J McWilliam, S S Banerjee781 Acinetobacter spp L-form infection of a cemented Charnley total hip replacement S Haley, J Paul, D W Crook,

S H White782 Necrotising lymphadenitis without granulocytic infiltration: case from WesternSamoa N Paksoy782 Fibrinogen standards P Hogg, D Prangnell782 ANTI-HBc IgM assays and diagnosis of acute hepatitis B D J Morris783 Pulmonary aspergillosis in patients with leukaemia S M Kelsey, A C Newland, J van der Walt, H Doran783 Potential benefit of 1 a cholecalciferol in hypomagnesaemia induced by cyclosporin C J Pearce, JM Davies784 Parathyroid hormone related peptide in ovarian carcinoma PB J Burton, D E Knight, P Quirke, R Smith, C Moniz784 Prorenin in ovarian cyst fluid CM Bessant, PA Charlton,MJPrice-Jones, J Kay, WA Reid

Miscellanea785 Book reviews Notices

Occasionals789 Current concerns in haematology: 1 Is the painful crisis of sickle cell disease a "steal" syndrome? G R Serjeant,

R M Chalmers792 ACP Broadsheet No 126: Examination of specimens of the larynx L Michaels796 Pathology across Europe: differences and similarities 3 Histopathology CL Berry

Papers800 Sensitivity of digoxigenin and biotin labelled probes for detection of human papillomavirus by in situ hybridisation

R G Morris,MJ Arends, P E Bishop, K Sizer, EDuvall, C C Bird806 In situ hybridisation with digoxigenin labelled DNA probes for detection of viral genomes Y Furuta, T Shinohara,

K Sano, M Meguro, K Nagahsima810 Application of 1 nm gold probes on paraffin wax sections for in situ hybridisation histochemistry P Jackson,

D A Dockey, F A Lewis, M Wells813 Use of immunoelectron microscopy to show Ebola virus during the 1989 United States epizootic T W Geisbert,

P B Jahrling817 Adenomyosis in Pakistani women: four year experience at the Aga Khan University Medical Centre, Karachi

H Shaikh, K S Khan820 Importance of sampling method in DNA analysis of lung cancer F A Carey, D Lamb, C C Bird824 Crypt cell proliferation and HLA-DR expression in pelvic ileal pouches H J de Silva, K C Gatter, P R Millard,

M Kettlewell,NJ Mortensen, D P Jewell829 Cells immunoreactive for neuropeptide in human thymomas L Lauriola, N Maggiano, L M Larocca, et al

833 Tissue preparation for simultaneous flow cytometric quantitation of tumour associated antigens and DNA in solidtumours P A Van Dam, J V Watson, D G Lowe, H Cox,M Curling, J H Shepherd

840 Computer assisted selection and assessment of antibodies in the diagnosis of lymphomas P J R Harkin, S A Kelly,A S Jack

844 Immunocytochemical analysis of lymph node aspirates in patients with human immunodeficiency virus infectionJ Oertel, B Oertel, H Lobeck, D Huhn

847 Value of monoclonal anti-myeloperoxidase (MPO7) for diagnosing acute leukaemia J Storr, G Dolan, E Coustan-Smith, D Burnett, J T Reilly

850 Observations on the haemopoietic response to critical illness R J Amos, M Deane, C Ferguson, G Jeifries,C J Hinds, J A L Amess

857 Transient erythroblastopenia of childhood with CD1O, TdT, and cytoplasmic p lymphocyte positivity in bonemarrow A B M Foot,MN Potter, J E Ropner, TB Wallington, A Oakhill

860 Use of latex agglutination technique for detecting Legionella pneumophila (serogroup 1) antibodies M G Holliday863 Comparison of methods for the diagnosis of typhoid fever R Duthie, G L French866 Production of extra-cellular slime by Staphylococcus epidermidis during stationary phase of growth: its association

with adherence to implantable devices R Bayston, J Rodgers871 Immunoblot technique to visualise serum pepsinogen A isozymogen patterns A Zwiers, C Toonstra, G Pals,

A J M Donker, G M Meuwissen, R W ten Kate

Letters875 Screening of urines with dipstrips: does it reduce workload and consumable costs? A P MacGowan, P Cowling,

R J Marshall, D S Reeves875 Rapid identification of Klebsiella L Baillie875 Successful treatment of chronic immune thrombocytopenia using fresh frozen plasma H G Watson, T A J Phaure876 Leukemic phase of mantle zone lymphoma J Soler, R Bordes, F Ortunio, E Rubiol877 Hypercalcaemia and osteolytic lesions associated with chronic lymphatic leukaemia T J Littlewood, A PM Lydon,

C J Barton877 Thoracic aortitis due to salmonellaM J Steiger

Miscellanea878 Matters arising * Book reviews - Notices * Corrections

Occasionals881 Pathology across Europe 4: Chemical pathologyMG Rinsler882 Current concerns in haematology 2: Classification of acute leukaemia B Bain, D Catovsky

Papers888 Monoclonality in B cell lymphoma detected in paraffin wax embedded sections using the polymerase chain reaction

JH Wan, K J Trainor, M J Brisco, A A Morley891 Use of cytoplasmic 5'nucleotidase for differentiating malignant from benign monoclonal gammopathies

G Majumdar, SE Heard, A K Singh893 Cellular expression of lymphocyte function associated antigens and the intercellular adhesion molecule-I in normal

tissueME F Smith, J A Thomas901 Immunohistochemical demonstration of pancreatic secretory trypsin inhibitor in normal and neoplastic colonic

mucosa H Bohe, M Bohe, C Lindstrom, K Ohlsson905 Spherical connective tissue inclusions in epithelial hyperplasia of the breast ("collagenous spherulosis") C A Wells,

C W Wells, P Yeomans, M Vinia, S Jordan, A J d'Ardenne909 Human papillomavirus in oesophageal squamous cell carcinoma S L Loke, L Ma, M Wong, G Srivastava, I Lo,

C C Bird913 Detection and typing of human papillomavirus using the Vira Type "in situ" kit: comparison with a conventional

dot blot technique B E Faulkner-Jones, VM Bellomarino, A J Borg, K Orzeszko, SM Garland

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918 Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil G Niedobitek, S Pitteroff,H Herbst, et al

922 Measurement techniques for melanoma: a statistical comparison C J Calder, A P Campbell, S R Plastow924 New technique for analysing conjugated bile acids in gastric juiceD C Gotley, A P Morgan, M J Cooper929 Serum alanine transaminase (ALT) reference ranges estimated from blood donors D J Goldie, A A McConnell932 Evaluation of a prototype for a reference platelet counter S M Lewis, R M Rowan, F Kubota937 Erythroid colony growth from peripheral blood and bone marrow in polycythaemia G S Masters, P Baines,

A Jacobs942 Bone marrow stromal cell changes in haematological malignancies S A Dilly, C J Jagger947 Comparison of three-compartment Petri dishes and individual plates for routine culture of vaginal swabs

J C Reeder, A P Shakespeare, C Bryan, MG L Keaney, LA Ganguli950 Non-specific reactions in enzyme linked immunosorbent assays for serum antibody to Entamoeba histolytica and

Giardia lamblia in non-endemic areas NP Shetty, IS Raj, R S Macaden953 Antibody coated bacteria in urine of patients with recent spinal injury A Galloway, H T Green, K K Menon,

B P Gardner, S Pemberton, KR Krishnan957 Lectin typing of Campylobacter isolates N O'Sullivan,J Benjamin, MB Skirrow

Letters961 Campylobacter-like organisms in heterotopic gastric mucosa of the upper oesophagus J-F Flejou, F Potet,

G Molas, et al961 Superior stain for Helicobacter pylori using toluidine 0 B Slater961 Thrombotic thrombocytopenic purpura (TTP) complicating leptospirosis: a previously undescribed association

R W Laing, C Teh, C H Toh962 Implications of delay in culturing for Campylobacter C J Butt, M C J Wale963 Flow cytometric DNA in ectopic pregnancy R Aine, R Karikoski-Leo, P K Heinonen

Miscellanea963 Matters arising - Book reviews Notices

No 12 DECEMBER 1990 Occasionals969 Medical students' views on necropsies E W Benbow977 The negative coroner's necropsy: a personal approach and consideration of difficulties W Lawler

Papers981 Gastric epithelium in the duodenum; its association with Helicobacter pylori and inflammation J I Wyatt,

B J Rathbone, GM Sobala, et al987 Helicobacter pylori in dyspeptic patients in Kuwait D P Britt, MHBarakat, M F Tungekar, et al992 Labelling of cells of the mononuclear phagocyte system in routinely processed archival biopsy specimens with

monoclonal antibody EBM/11 G IN Greywoode, S P McCarthy,J O'D McGee997 Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistological distinction

and implications for osteoclast ontogeny and function N A Athanasou, J Quinn1004 Type II oestrogen binding sites in human colorectal carcinoma M Piantelli, R Ricci, L M Larocca, et al1007 Primary lymphoma of the liver: clinical and pathological features of 10 patients PP Anthony, P Sarsfield, T Clarke1014 Abnormal fucosylation of ilial mucus in cystic fibrosis: IA histochemical study using peroxidase labelled lectins

S Thiru, G Devereux, A King1019 Abnormal fucosylation of ileal mucus in cystic fibrosis: II A histochemical study using monoclonal antibodies to

fucosyl oligosaccharides A King, M McLeish, S Thiru1023 Comparative in situ hybridisation study of juvenile laryngeal papillomatosis in Papua New Guinea and Australia

R G Wright, D P Murthy, A C Gupta, N Cox, R A Cooke1026 Monoclonal antibody B72.3 in benign breast lesions S Soomro, S Shousha1029 Improved silver staining of nucleolar organiser regions in paraffin wax sections using an inverted incubation

technique G Coghill, A Grant, JM Orrell, J Jankowski, A TEvans1032 Potential role of IgG avidity for diagnosing toxoplasmosis D HM Joynson, R A Payne, B K Rawal1034 Comparison of two preparatory techniques for urine cytology J Dhundee, H S Rigby

Letters1036 Primary hepatic vascular leiomyosarcoma of probable portal vein origin M Sundaresan, SB Kelly, I S Betnamin,

A B Akosa1036 Peliosis hepatis after liver transplantation P J Scheuer, S Mathur, A K Burroughs, K Rolles1037 Postoperative necrotising granulomata in the cervix and ovary GE Wilson, N Y Haboubi, L J McWilliam,

P J Hirsch1038 Traumatic aneurysm of the left common carotid artery F G Johnston, A Waters, G A Gresham1039 Cross-linked fibrin degradation products as a predictor of pulmonary embolism F Hogg, C Copping, P Grffiths,

M I Adelman, DR PrangnellMiscellanea

1039 Book reviews* Notices1041 List of assessors1042 Annual author index to Vol 431042 Annual subject index to Vol 43

Annual contents index to Vol 43

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