CLINICAL RESULTS 2016

In Vitro Fertilisation (IVF-ICSI) 12,876 cycles

Ovum Donation (OVODON) 6,989 cycles

Frozen Embryo Transfer 12,068 cycles

Preimplantation Genetic Diagnosis (PGD) 5,101

RESULTS OF ASSISTED REPRODUCTIVE TREATMENTS CARRIED OUT

AT THE IVI GROUP DURING 2016

Preimplantation Genetic Diagnosis (PGD) 5,101 cycles

Vitrification of ova 4,117 cycles

Artificial Insemination (AI) 3,971 cycles

________________________________________________________________

Total 45,122 cycles

NB: Number of procedures from our clinics in Spain+ Lisbon+ Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu

Dhabi.

2016 RESULTS FOR IVF-ICSI AND OVUM DONATION (OVODON)

IVF- ICSIOVUM

DONATION

Cycles performed

(embryo transfers)12,876 (5,173) 6,989 (5,692)

No. of pregnancies 2,847 3,888No. of pregnancies 2,847 3,888

% Pregnancy per Transfer 55.0 68.3

% Pregnancy per embryo

transferred38.3 52.6

% Twin pregnancy 22.4 21.6

NB: Number of procedures from our clinics in Spain+ Lisbon+ Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu Dhabi

PREGNANCY AND IMPLANTATION RATES WITH IVF AND ICSI BY AGE GROUPS 2016

488

2,206

4,849

3,525

239

3.000

4.000

5.000

6.000

40.00%

50.00%

60.00%

70.00%

80.00%

Pregnancy rate

NB: These rates include fresh cycles and its deferred transfers (transfers of cryopreserved embryos from the fresh cycles).

They apply to our clinics Spain+ Lisbon+ Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu Dhabi.

71.03%64.30%

56.27%

47.54%

29.41%

50.07% 48.70%

39.16%34.41%

20.00%

239

0

1.000

2.000

0.00%

10.00%

20.00%

30.00%

<= 29 30 - 34 35 - 39 40 - 44 >= 45

Implantation rate

PREGNANCY RATES FOR A FIRST IVF-ICSI ATTEMPT AT IVI CLINICS COMPARED

TO PREVIOUS ATTEMPTS IN OTHER CLINICS.

40.0%

45.0%

50.0%

55.0%

60.0%

4,168 2,807 2,211 1,498 1,448

NB: The chart shows treatment data for patients who have undergone previous cycles, including frozen cycles,

between 2007 and 2016 at our clinics in Spain+Lisbon+Rome.

52.2% 52.0% 51.2% 51.5% 50.8%

20.0%

25.0%

30.0%

35.0%

1 2 3 4 5 or more

2016 RESULTS FOR FROZEN EMBRYO TRANSFERS

TOTAL

Embryos thawed

(Frozen Embryo Transfers)12,068(11,340)

Rate of Embryo Transfer % 94.0

No. of pregnancies 6,059

% Pregnancy per Transfer 53.4

% Embryo Implantation 39.6

NB: Number of procedures from our clinics in Spain + Lisbon + Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu Dhabi

CUMULATIVE CLINICAL PREGNANCY RATE AFTER THREE ATTEMPTS (including

Frozen Embryo Transfers)

N= 94,846 N= 53,103

53.48%

70.02%

75.61%

90.97%86.97%

97.23%

60.00%

70.00%

80.00%

90.00%

100.00%

NB: The chart shows data for patients who were discharged from our clinics in Spain and Lisbon

between 2005 and 2016.

53.48%

0.00%

10.00%

20.00%

30.00%

40.00%

50.00%

OWN EGGS OVUM DONATION

1st attempt 2nd attempt 3rd attempt

2016 PGD RESULTS. Study of chromosomal abnormalities: FISH and CGH Arrays

methods combined

TOTAL

Cycles performed

(Embryo Transfers)3,210 (1,901)

% Abnormal Embryos 67.6% Abnormal Embryos 67.6

No. of Pregnancies 1,232

% Pregnancy per transfer 64.8

% Implantation 53.1

NB: The chart shows data for patients who undergone cycles with biopsy of embryos in our clinics in Spain+ Lisbon in 2016. The chart also

includes the number of transfers involving frozen embryos that were previously biopsied in 2016.

2016 PGD RESULTS. Study of monogenic disorders: PCR method.

Myotonic dystrophy, Fragile X Syndrome,

Cystic Fibrosis, Spinal Muscular Atrophy...

Cycles performed

(Embryo Transfers)121(106)

No. of Pregnancies 61No. of Pregnancies 61

% Pregnancy per Transfer 57.5

% Implantation 46.4

NB: The chart shows data for patients who undergone cycles with biopsy of embryos in our clinics in Spain+ Lisbon in 2016. The chart also

includes the number of transfers involving frozen embryos that were previously biopsied in 2016.

RESULTS FOR ARTIFICIAL INSEMINATION 2016

TreatmentArtificial Insemination

(using donor sperm)

Artificial

Insemination

No. of Cycles 1,909 2,062

Pregnancies 459 363Pregnancies 459 363

% Pregnancy/Cycle 24.0 17.6

% Twin Pregnancy 10.1 12.2

NB: Number of procedures from our clinics in Spain+ Lisbon+ Latin America (Chile, Buenos Aires, Panama, Salvador, Mexico)+ Rome + Abu Dhabi

LIVE BIRTH RATES (LB)

OWN EGGS

AGE OWN EGGS FRESH OWN EGGS FROZEN

OWN EGGS (FRESH+

FROZEN)

LIVE BIRTH PER CYCLE <35 43.7% 65.5% 49.4%

35-37 32.6% 30.5% 32.0%

38-39 22.3% 26.2% 23.3%

40-42 11.4% 19.1% 24.0%

43-44 2.8% 16.4% 5.1%

>44 1.6% 13.5% 3.1%

LIVE BIRTH PER EMBRYO

TRANSFERRED

<35 28.3% 45.0% 32.5%

35-37 22.7% 21.8% 22.5%

38-39 17.4% 19.4% 18.0%

40-42 13.7% 15.8% 22.8%

NB: The information shows the live birth rates from treatments at our clinics in Spain+ Lisbon between 2003 and 2015.

DONOR EGGS

FRESH OVUM

DONATION FROZEN OVUM DONATION

OVUM DONATION (FRESH+

FROZEN )

LIVE BIRTH PER CYCLE 46.8% 31.0% 41.5%

LIVE BIRTH PER EMBRYO TRANSFERRED 28.4% 21.7% 26.4%

PROPORTION OF SINGLE BIRTHS 71.8% 81.6% 74.4%

40-42 13.7% 15.8% 22.8%

43-44 7.3% 16.2% 10.3%

>44 6.6% 15.2% 9.7%

PROPORTION OF SINGLE BIRTHS <35 70.6% 79.2% 72.7%

35-37 76.8% 83.7% 78.8%

38-39 84.4% 85.9% 84.9%

40-42 88.6% 89.8% 89.0%

43-44 92.9% 88.7% 90.7%

>44 87.5% 90.5% 89.2%

GLOSSARY OF TERMS

•Pregnancy rate: the percentage of positive results from biochemical pregnancy tests in relation to

the number of embryo transfers.

•Clinical pregnancy rate: the percentage of pregnancies with a gestational sac observed by

ultrasound scan in relation to the number of embryo transfers.

•Implantation rate: the percentage of gestational sacs observed by ultrasound scan in relation to

the number of embryos transferred.

•Twin pregnancy rate: the percentage of pregnancies with 2 gestational sacs in relation to the total

number of pregnancies.

•Deferred Embryo Transfer: embryo transfers that are not performed during the same stimulation •Deferred Embryo Transfer: embryo transfers that are not performed during the same stimulation

cycle, where it is necessary to defer the transfer to a subsequent cycle using cryopreserved

embryos.

•Rate of abnormal embryos: the percentage of abnormal embryos among the biopsied embryos.

•Live birth per cycle: the percentage of procedures with LB in regards to the total number of

procedures.

•Live birth per embryo transferred: the percentage of LB in regards to the total number of

transferred embryos.

•Proportion of singleton LB: the percentage of births with a singleton LB in regards to the total

number of births.

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