“codon distribution in dna”
TRANSCRIPT
8/3/2019 “Codon Distribution In DNA”
http://slidepdf.com/reader/full/codon-distribution-in-dna 1/16
[pjysigs/?4?5?54\ Gbmbn Mistrieutibns in MND
drZiv.brc > pjysigs > drZiv1pjysigs/?4?5?54
Mbwn`bdm1◂ _MF
◂ _bstWgript
◂ Btjhr fbrldts
Gurrhnt erbwsh gbnthxt1
pjysigs
0 prhv | nhxt >
nhw | rhghnt |?4?5
Uhfhrhnghs & Gitdtibns
◂ NDWD DMW
Ebbkldrk (wjdt is tjis2)
_jysigs > Eib`bcigd` _jysigs
Gbmbn Mistrieutibns in MND
D. Wbl, W. Gjdttbpdmjydy, A. Gjdkrdedrti, M. Ednmybpdmjydy
(Wuelitthm bn 9 Fhe 5??4)
]jh gbmbns, sixtyfbur in nulehr, drh mistrieuthm bvhr tjh gbminc pdrts bf MND shquhnghs. ]jh mistrieutibn
fungtibn is tjh pbt bf frhquhngy-vhrsus-rdnk bf tjh gbmbns. ]jhsh mistrieutibns drh gjdrdgthrishm eypdrdlhthrs tjdt drh dlbst univhrsd, i.h., chnh inmhphnmhnt. ]jhrh is eut d sld pdrt tjdt mhphnms bn tjh
chnh. Sh prhshnt tjh tjhbry tb gdgudth tjh univhrsd (chnh-inmhphnmhnt) pdrt. ]jh pdrt tjdt is chnh-
sphgifig, jbwhvhr, jds unmhthrlinhm bvhrdps dnm fugtudtibns.
Gbllhnts1 74 pdchs, 8 ficurhs
Wueahgts1 Eib`bcigd` _jysigs (pjysigs.eib-pj); Mdtd Dndysis, Wtdtistigs dnm
_rbedeiity (pjysigs.mdtd-dn); Tudntitdtivh Eibbcy (q-eib)
MBI1 4?.44?7/_jysUhvH.67.?849?:
Gith ds1 drZiv1pjysigs/?4?5?54v4 [pjysigs.eib-pj\
Wuelissibn jistbry
Frbl1 Wuady Gjdttbpdmjydy [vihw hldi\
[v4\ Fri, 9 Fhe 5??4 ?31?5186 CL] (5=ke)
Sjigj dutjbrs bf tjis pdphr drh hnmbrshrs2
Sh crdthfu``y
dgknbw`hmch
suppbrtinc
institutibns
Whdrgj br Drtigh-im (Jhp | Dmvdnghm shdrgj)
Gbrnh`` Xnivhrsity
@ierdry
fi`h1///G|/Mbgulhnts%5?dnm%5?Whttincs/MHEX/Mhsktbp/?4?5?54.jtl (4 bf 5) [45/=/5?44 451791=3 DL\
D`` pdphrs Cb!
8/3/2019 “Codon Distribution In DNA”
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[pjysigs/?4?5?54\ Gbmbn Mistrieutibns in MND
@ink edgk tb1 drZiv, fbrl inthrfdgh, gbntdgt.
fi`h1///G|/Mbgulhnts%5?dnm%5?Whttincs/MHEX/Mhsktbp/?4?5?54.jtl (5 bf 5) [45/=/5?44 451791=3 DL\
8/3/2019 “Codon Distribution In DNA”
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Jblh Erbwsh Whdrgj Wuesgriptibns Jhp
Gitdtibn
Whdrgj1
Vb. _dch/
Drtigh
D_W »Aburnds »_jys. Uhv. H »
Vbulh 67 »Issuh 8
0 _rhvibus Drtigh |Nhxt Drtigh >
_jys. Uhv. H 67, ?849?: (5??4) [:
pdchs\
Gbmbn mistrieutibns in
MND
Destrdgt Uhfhrhnghs
_jys. Uhv. H 67, ?849?: (5??4)1 Gbmbn mistrieutibns in MND
GitincDrtig`hs(=)
Dlhrigdn _jysigd` Wbgihty
@bc in | Grhdth Dggbunt (wjdt's
tjis2)
UWW Fhhms | Hldi Dhrts
_jys. Uhv. @htt.
8/3/2019 “Codon Distribution In DNA”
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_jys. Uhv. H 67, ?849?: (5??4)1 Gbmbn mistrieutibns in MND
Dpri 5??4
]jh gbmbns, 6= in nulehr, drh mistrieuthm bvhr tjh gbminc pdrts bf
MND shquhnghs. ]jh mistrieutibn fungtibn is tjh pbt bf frhquhngy
vhrsus rdnk bf tjh gbmbns. ]jhsh mistrieutibns drh gjdrdgthrizhm ey
pdrdlhthrs tjdt drh d`lbst univhrsd, i.h., chnh inmhphnmhnt. ]jhrh
is eut d sld` pdrt tjdt mhphnms bn tjh chnh. Sh prhshnt tjh tjhbry
tb gdgudth tjh univhrsd (chnh-inmhphnmhnt) pdrt. ]jh pdrt tjdt is
chnh-sphgifig, jbwhvhr, jds unmhthrlinhm bvhrdps dnm fugtudtibns.
© 5??4 ]jh Dlhrigdn _jysigd Wbgihty
XU@1
jttp1//ink.dps.brc/mbi/4?.44?7/_jysUhvH.67.?849?:MBI1
4?.44?7/_jysUhvH.67.?849?:
_DGW1
:3.4?.+h, :3.48.-v, ?8.=?.-d, 35.3?.+l
*Hldi dmmrhss1 tpdsOldjhnmrd.idgs.rhs.in†Hldi dmmrhss1 tpsgOldjhnmrd.idgs.rhs.in
‡Hldi dmmrhss1 tpagOldjhnmrd.idgs.rhs.in§Hldi dmmrhss1 ednmybOisigd.dg.in
0 _rhvibus Drtigh |Nhxt Drtigh >
Fbgus1 Dnbtjhr Wthp Edgk fbr Sdvh-_drtig`h
Mud`ity
8/3/2019 “Codon Distribution In DNA”
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_jys. Uhv. H 67, ?849?: (5??4)1 Gbmbn mistrieutibns in MND
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8/3/2019 “Codon Distribution In DNA”
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8/3/2019 “Codon Distribution In DNA”
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8/3/2019 “Codon Distribution In DNA”
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8/3/2019 “Codon Distribution In DNA”
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8/3/2019 “Codon Distribution In DNA”
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8/3/2019 “Codon Distribution In DNA”
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8/3/2019 “Codon Distribution In DNA”
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@INCXIW] @ist - _dphr Mhtdi`s
8/3/2019 “Codon Distribution In DNA”
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@INCXIW] @ist - _dphr Mhtdi`s
◂ Wuelit ◂ With Ldp ◂ Dmvdnghm Whdrgj ◂ Uhdm @INCXIW] ◂
◂ Uhvihwhr @bcin ◂
◂
@INCXIW] @ist > _ue`igdtibns > Dgdmhlig _dphrs > _dphr Mhtdi`s
❌ Debut Xs
❌ @INCXIW] Wtdff
❌ @INCXIW] @ist
❌ @INCXIW] _rbahgts
❌ Abes
❌ Gbnfhrhnghs
❌ _ue`igdtibns
❌ Dmvdnghm Whdrgj
❌ _hbp`h & _rbcrdls
❌ She @inks
❌ Ldi`inc @ists
❌ Dsk d Tuhstibn
❌ Dumib dnm Vimhb
◂ MBND]H
_ue`isjinc _drtnhr1
_ue`isjhr @bcin
fi`h1///G|/Mbgulhnts%5?dnm%5?Whttincs/MHEX/Mhsktbp/erbwsh-pdphrs-dgtibn.gfl.jtl (4 bf 7) [45/=/5?44 4518?146 DL\
Cb
@INCXIW] @ist - _dphr Mhtdi`s
8/3/2019 “Codon Distribution In DNA”
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@INCXIW] @ist _dphr Mhtdi`s
Dgdmhlig _dphr
]it`h1 Gbmbn Mistrieutibns in MND
_dphr XU@1 jttp1//drxiv.brc/des/pjysigs/?4?5?54 Dutjbr1 W. Gjdttbpdmjydy
Hldi`1 g`igk jhrh tb dgghss hldi`
Dutjbr1 A. Gjdkrdedrti
Hldi`1 g`igk jhrh tb dgghss hldi`
Dutjbr1 Mhedprdsdm Ednmybpdmjydy
Hldi`1 g`igk jhrh tb dgghss hldi`
Jblhpdch1 jttp1//isim.dgdmhlid.hmu/MhedprdsdmEdnmybpdmjydy
Institutibn1 Inmidn Wtdtistigd` Instituth
@incuistig Fih`m1 Misgip`inh bf @incuistigs
Destrdgt1 ]jh syleb`ig shquhnghs bf tjh hxbns tjdt ldkh juldn prbthins drh sueahgthm tb lhtjbms bf stdtistigd`
`incuistigs. ]jh imhds mhvh`bphm fbr tjh ndturd` `dncudchs ey C.K. Qipf, wjhn dpp`ihm tb tjhsh shquhnghs,
sjbw d sicnifigdnt prblish. In _drtigu`dr, wh drcuh, ]jh Qipf's hxpbnhnt miffhrhntidth, dnm jhngh, imhntifihs
mispdrdth juldn shquhnghs. ]jh gbmbns, 6= in nulehr, drh mistrieuthm bvhr tjh gbminc pdrt bf MND
shquhnghs. Lhtdpjbrigd``y sphdkinc, tjh shquhnghs d`lbst rhshle`hs `incuistig strugturh. ]jh mistrieutibn
fungtibn is tjh p`bt bf frhquhngy vhrsus rdnk bf tjh gbmbns. ]jhsh mistrieutibns drh gjdrdgthrizhm ey
pdrdlhthrs tjdt drh d`lbst univhrsd`, i.h., chnh inmhphnmhnt. Dutjbrs (D, Wbl, W.Gjdttbpdmjydy, A.
Gjdkrbedrti dnm Mhedprdsdm Ednmybdpmjydy) prhshnt tjh tjhbry tb gd`gu`dth tjh univhrsd` (chnh
inmhphnmhnt) witj tjh jh`p bf `incuistig tjhbry. ]jh pdrt tjdt is chnh sphgifig, jbwhvhr jds unmhthrlinhm
bvhr`dps dnm f`ugtudtibns.
]yph1 Gb``hgtibn
Wtdtus1 Gblp`hthm
Vhnuh1 Inmidn Dssbgidtibn fbr Gu`tivdtibn bf Wgihngh, Kb`kdtd
_ue`igdtibn Infb1 _jysigd` Uhvihw H, Vb`. 67, issuh 8, ?849?:(pp.?849?:-4- ?849?:-:). X.W.D.
XU@1 jttp1//drxiv.brc/des/pjysigs/?4?5?54
Edgk
Dmm d nhw pdphr
Uhturn tb Dgdmhlig _dphrs ldin pdch
Uhturn tb Mirhgtbry bf @incuists ldin pdch
fi`h1///G|/Mbgulhnts%5?dnm%5?Whttincs/MHEX/Mhsktbp/erbwsh-pdphrs-dgtibn.gfl.jtl (5 bf 7) [45/=/5?44 4518?146 DL\
@INCXIW] @ist - _dphr Mhtdi`s
8/3/2019 “Codon Distribution In DNA”
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@INCXIW] @ist _dphr Mhtdi`s
Debut @INCXIW] | Gbntdgt Xs | Uhpbrt Erbkhn @ink
Sji`h tjh @INCXIW] @ist ldkhs hvhry hffbrt tb hnsurh tjh incuistig rh`hvdngh bf siths isthm bn its
pdchs, it gdnnbt vbugj fbr tjhir gbnthnts.
fi` ///G|/M t %5? m%5?W tti /MHEX/M kt /e ti f jt (7 f 7) [45/=/5?44 45 8? 46 DL\