comparative effectiveness of radiofrequency uvuloplasty … · 2016. 10. 12. · 23. bassioun y a.,...

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COMPARATIVE EFFECTIVENESS OF RADIOFREQUENCY UVULOPLASTY VERSUS RADIOFREQUENCY REDUCTION OF SOFT PALATE IN TREATING SNORING AND MILD AND MODERATE OBSTRUCTIVE SLEEP APNEA SYNDROME G.L.Khandanyan, G.I. Petrosyants, I.K. Morsikyan, A.K. Shukuryan Radiofrequency surgery of the so palate presents a promising alternative for the treatment of sleep-disor- dered breathing (SDB). A clinical trial using either ra- diofrequency (RF) uvuloplasty or simultaneous RF of the so palate and the inferior nasal turbinates was inves- tigated to determine comparative efficacy of these two methods in the treatment of snoring and mild to moder- ate Obstructive Sleep Apnea Syndrome (OSAS). A prospective study of 56 snorers and/or OSAS patients were investigated concerning before and, at minimum, 2 months aer the RF surgery against SDB. Among them, 24 patients underwent RF reduction of the inferior nasal turbinates and RF reduction of so palate (Group 1), and the remaining 32 underwent RF reduction of the inferior nasal turbinates, medial regions of the so palate as well as RF uvuloplasty. We made between-group comparison of post-surgical changes of practice param- eters: Body Mass Index (BMI), nasal breathing (airflow), snoring, apnea hypopnea index (AHI), daytime sleepiness measured by Epworth Sleepiness Scale (ESS) and severi- ty of post-surgery pain (VAS). We observed no post-surgery significant changes of patients’ BMI in either of group. Post-surgery nasal turbinate airflow was completely restored in 79% of pa- tients in Group 1 vs. 84.5% of those in Group 2. Aer surgery, nasal mild breathing impairment was found in 12.5% of patients both in Group 1 and 2. In addition, aer nasal surgery, loudness of snoring dropped from 8.1±1.3 to 5.2±2.4 in Group 1 and from 8.4±2.2 to 2.7±2.3 in Group 2 (P<0.05 for both). AHI decreased from 18.2±4.2 to 10.4±3.7 in Group 1 and from 19.4±5.5 to 5.9±1.73 in Group 2 (P<0.05 for both). ESS also de- creased from 9.5±3.5 to 5.2±2.2 in Group 1 and from 9.3±3.6 to 2.3±1.81 in Group 2 (P<0.05 for both). How- ever, post-surgery pain index was greater in Group 2 than in Group 1 (7.2±2.6 vs. 3.8±3.2, P<0.05). Both nasal surgery approaches are acceptable for the treatment of snoring. Though the 2 nd approach seems a bit more effective, it may cause more intensive post-sur- gery pain. References 1. lemons W.W. Clinical practice. Obstructive sleep apnea. N Engl. J. Med., 2002; 347(7): 498–504. 2. Гапанович В.Я., Глинник С.В. Патогенетические факторы храпа. Здравоохранение Белоруссии, 1989, 2, с.31-33. 3. Osborne J.E., Osman E.Z., Hill P.D., Lee B.V., Sparkes C. A new acoustic method of differentiating palatal from non-palatal snoring. Clin. Otolaryngol. Allied Sci., 1999;24(2):130–133. 4. eorgalas C. The role of the nose in snoring and obstructive sleep apnoea: an update. Eur. Arch. Oto- rhinolaryngol., 2011;268(9):1365-73. 5. Hsia J.C., Camacho M., Capasso R. Snoring exclu- sively during nasal breathing: a newly described re- spiratory pattern during sleep. Sleep Breath, 2013; 18: 159-164. 6. Koskenvuo M., Partinen M., Sarnas S. Snoring as a risk factor for hypertension and angina pectoris. Lancet, 1985;13:393–396. 7. ematsu T. Study of snoring, 4th report: therapy. J. Jpn. Otorhinolaryngol., 1964; 64:434–435. 8. S adling J. Obstructive sleep apnoea: defini- tions, epidemiology, and natural history. Thorax, 1995;50:683-9. 9. Meen E.K., Chandra R.K. The role of the nose in sleep-disordered breathing. Am. J. Rhinol. Allergy, 2013; 27: 213-20. 10. 0 eorgalas C. The role of the nose in snoring and obstructive sleep apnoea: an update. Eur. Arch. Oto- rhinolaryngol., 2011;268:1365-73. 11. 1 oung T, Palta M., Dempsey J., Skatrud J., We- ber S., Badr S. The occurence of sleep-disordered breathing among middle-aged adults. N. Engl. J. Med., 1993;328:1230–1235. 12. Kripke D.F., Ancoli-Israel S., Klauber M.R., Wing- ard D.L., Mason W.J., Mullaney D.J. Prevalence of sleep-disordered breathing in ages 40–64 years: A population-based survey. Sleep, 1997; 20:65–76. 13. Fujita S., Conway W., Zorick F., Roth T. Surgical correction of anatomic abnormalities in obstructive sleep apnea syndrome: uvulopalatopharyngoplasty. Otolaryngol., Head Neck Surg., 1981; 89(6):923-34. 14. 4. Kama Y.V. Laser CO2 for snoring. Preliminary re- sults. Acta Otorhinolaryngol., 1990; 44:451–456. 15. Stuck B.A., Starzak K., Hein G., Verse T., Hörmann K., Maurer J.T. Combined radiofrequency surgery of the tongue base and so palate in obstructive sleep apnoea. Acta Otolaryngol., 2004 Sep;124(7):827-32. Abstract

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Page 1: COMPARATIVE EFFECTIVENESS OF RADIOFREQUENCY UVULOPLASTY … · 2016. 10. 12. · 23. Bassioun y A., El Salamawy A., Abd El-Tawab M., Atef A. Bipolar radiofrequency treatment f or

COMPARATIVE EFFECTIVENESS OF RADIOFREQUENCY UVULOPLASTY VERSUS

RADIOFREQUENCY REDUCTION OF SOFT PALATE IN TREATING SNORING AND

MILD AND MODERATE OBSTRUCTIVE SLEEP APNEA SYNDROME

G.L.Khandanyan, G.I. Petrosyants, I.K. Morsikyan, A.K. Shukuryan

Radiofrequency surgery of the so� palate presents a promising alternative for the treatment of sleep-disor-dered breathing (SDB). A clinical trial using either ra-diofrequency (RF) uvuloplasty or simultaneous RF of the so� palate and the inferior nasal turbinates was inves-tigated to determine comparative effi cacy of these two methods in the treatment of snoring and mild to moder-ate Obstructive Sleep Apnea Syndrome (OSAS).

A prospective study of 56 snorers and/or OSAS patients were investigated concerning before and, at minimum, 2 months a� er the RF surgery against SDB. Among them, 24 patients underwent RF reduction of the inferior nasal turbinates and RF reduction of so� palate (Group 1), and the remaining 32 underwent RF reduction of the inferior nasal turbinates, medial regions of the so� palate as well as RF uvuloplasty. We made between-group comparison of post-surgical changes of practice param-eters: Body Mass Index (BMI), nasal breathing (airfl ow), snoring, apnea hypopnea index (AHI), daytime sleepiness measured by Epworth Sleepiness Scale (ESS) and severi-

ty of post-surgery pain (VAS).

We observed no post-surgery signifi cant changes of patients’ BMI in either of group. Post-surgery nasal turbinate airfl ow was completely restored in 79% of pa-tients in Group 1 vs. 84.5% of those in Group 2. A� er surgery, nasal mild breathing impairment was found in 12.5% of patients both in Group 1 and 2. In addition, a� er nasal surgery, loudness of snoring dropped from 8.1±1.3 to 5.2±2.4 in Group 1 and from 8.4±2.2 to 2.7±2.3 in Group 2 (P<0.05 for both). AHI decreased from 18.2±4.2 to 10.4±3.7 in Group 1 and from 19.4±5.5 to 5.9±1.73 in Group 2 (P<0.05 for both). ESS also de-creased from 9.5±3.5 to 5.2±2.2 in Group 1 and from 9.3±3.6 to 2.3±1.81 in Group 2 (P<0.05 for both). How-ever, post-surgery pain index was greater in Group 2 than in Group 1 (7.2±2.6 vs. 3.8±3.2, P<0.05).

Both nasal surgery approaches are acceptable for the treatment of snoring. Though the 2nd approach seems a bit more eff ective, it may cause more intensive post-sur-gery pain.

References

1.. lemons W.W. Clinical practice. Obstructive sleepapnea. N Engl. J. Med., 2002; 347(7): 498–504.

2. Гапанович В.Я., Глинник С.В. Патогенетическиефакторы храпа. Здравоохранение Белоруссии,1989, 2, с.31-33.

3. Osborne J.E., Osman E.Z., Hill P.D., Lee B.V.,

Sparkes C. A new acoustic method of diff erentiatingpalatal from non-palatal snoring. Clin. Otolaryngol.Allied Sci., 1999;24(2):130–133.

4.. eorgalas C. The role of the nose in snoring andobstructive sleep apnoea: an update. Eur. Arch. Oto-rhinolaryngol., 2011;268(9):1365-73.

5. Hsia J.C., Camacho M., Capasso R. Snoring exclu-sively during nasal breathing: a newly described re-spiratory pattern during sleep. Sleep Breath, 2013;18: 159-164.

6. Koskenvuo M., Partinen M., Sarnas S. Snoring asa risk factor for hypertension and angina pectoris.Lancet, 1985;13:393–396.

7.. ematsu T. Study of snoring, 4th report: therapy. J.Jpn. Otorhinolaryngol., 1964; 64:434–435.

8.. S adling J. Obstructive sleep apnoea: defi ni-tions, epidemiology, and natural history. Thorax,1995;50:683-9.

9. Meen E.K., Chandra R.K. The role of the nose insleep-disordered breathing. Am. J. Rhinol. Allergy,2013; 27: 213-20.

10.0 eorgalas C. The role of the nose in snoring andobstructive sleep apnoea: an update. Eur. Arch. Oto-rhinolaryngol., 2011;268:1365-73.

11.1 oung T, Palta M., Dempsey J., Skatrud J., We-

ber S., Badr S. The occurence of sleep-disorderedbreathing among middle-aged adults. N. Engl. J.Med., 1993;328:1230–1235.

12. Kripke D.F., Ancoli-Israel S., Klauber M.R., Wing-

ard D.L., Mason W.J., Mullaney D.J. Prevalence ofsleep-disordered breathing in ages 40–64 years: Apopulation-based survey. Sleep, 1997; 20:65–76.

13. Fujita S., Conway W., Zorick F., Roth T. Surgicalcorrection of anatomic abnormalities in obstructivesleep apnea syndrome: uvulopalatopharyngoplasty.Otolaryngol., Head Neck Surg., 1981; 89(6):923-34.

14.4. Kama Y.V. Laser CO2 for snoring. Preliminary re-sults. Acta Otorhinolaryngol., 1990; 44:451–456.

15. Stuck B.A., Starzak K., Hein G., Verse T., Hörmann

K., Maurer J.T. Combined radiofrequency surgeryof the tongue base and so� palate in obstructive sleepapnoea. Acta Otolaryngol., 2004 Sep;124(7):827-32.

Abstract

Page 2: COMPARATIVE EFFECTIVENESS OF RADIOFREQUENCY UVULOPLASTY … · 2016. 10. 12. · 23. Bassioun y A., El Salamawy A., Abd El-Tawab M., Atef A. Bipolar radiofrequency treatment f or

16. Rombaux P., Bertrand B., Boudewyns A. et al.

Royal Belgian Society for Ear, Nose, Throat, Headand Neck Surgery. Acta Otorhinolaryngol Belg. Stan-dard ENT clinical evaluation of the sleep-disorderedbreathing patient; a consensus report, Acta Otorhi-nolaryngol., Belg., 2002;56:2:127-37.

17. Stuck B.A. Radiofrequency-assisted uvulopalatoplas-ty for snoring: long-term follow-up. Laryngoscope,2009;119(8):1617-20.

18. Bäck L.J., Hytönen M.L., Roine R.P., Malmivaara

A.O. Radiofrequency ablation treatment of so� pal-ate for patients with snoring: a systematic reviewof eff ectiveness and adverse eff ects. Laryngoscope,2009;119(6):1241-50.

19. Baisch A., Maurer J.T., Hörmann K., Stuck B.A.

Combined radiofrequency assisted uvulopalatoplastyin the treatment of snoring. Eur. Arch. Otorhinolar-yngol., 2009;266(1):125-30.

20. Hytönen M.L., Bäck L.J., Malmivaara A.V., Roine

R.P. Radiofrequency thermal ablation for patientswith nasal symptoms: a systematic review of eff ec-tiveness and complications. Eur. Arch. Otorhinolar-yngol., 2009 Aug;266(8):1257-66.

21. Olsen K.D., Kern E.B., Westbrook P.R. Sleep andbreathing disturbance secondary to nasal obstruc-tion. Otolaryngol. Head Neck Surg., 1981;89(5):804-10.

22. Meen E.K., Chandra R.K. The role of the nose insleep-disordered breathing. Am. J. Rhinol. Allergy.,2013;27:213-20.

23. Bassiouny A., El Salamawy A., Abd El-Tawab M.,

Atef A. Bipolar radiofrequency treatment for snoringwith mild to moderate sleep apnea: a comparativestudy between the radiofrequency assisted uvulopal-atoplasty technique and the channeling technique.Eur. Arch. Otorhinolaryngol., 2007, 264(6):659-67.