Comparison Of IntrathecalFentanyl+Bupivacaine And Ketamine+BupivacaineFor Spinal Anesthesia Randomized Prospective Double Blind Study

ASHOK SHANKAR BHADE MD, MAHESH NAGAPPA MD Ashok Shankar Bhade MD, Professor and HODMahesh Nagappa MBBS, MD Senior ResidentDepartment of Anaesthesiology and Critical CareJawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India

Abstract

Background: This double blind study was designed to compare the cardiorespiratory stability and the incidence of side effects after intrathecal administration of ketamine-bupivacaine and fentanyl-bupivacaine for lower abdominal and lower limb surgeries.Method: Eighty ASA physical status 1 or 2 patients scheduled to undergo elective lower abdominal and lower limb surgeries under subarachnoid block were included in the study following approval from the institute ethics committee. Patients were randomly allocated to group K (ketamine, n=40) or group F (fentanyl, n=40) by the sealed envelope technique after taking an informed consent.Results: Intrathecal ketamine with bupivacaine as compared to fentanyl with bupivacaine produced faster onset of sensory block, longer duration of analgesia and longer duration of post-op analgesia (63.1sec vs 69sec, 108.2min vs 98.4min, 176.1min vs 141,3min, respectively) P