A 3DTouchTM printer can be employed to produce reactionware devices with controlled dimensions, area and shape. The use of polypropylene, easily and quickly allow to fabricate cheap and robust reactors.

Introduction The realisation of rapidly configurable and scalable reactor devices for the exploration of complex chemical systems is a highly sought after target. [1] Three dimentional (3D) printing technique can be used to make milli- and micro- scale ‘reactionware’ devices, which can be designed to realize bespoke and low-cost lab-on-a-chip devices and easily connected to in-line analytical instruments. [2] The utility of this reactionware is demostrated by organic, inorganic and materials synthesis.

Configurable 3D-Printed

Millifluidic and Microfluidic ‘Lab on a Chip’

Reactionware Devices Vincenza Dragone, Philip J. Kitson, Mali H. Rosnes, Victor Sans, Leroy Cronin*

WestCHEM, School of Chemistry, The University of Glasgow, Glasgow, G12 8QQ, UK •Email: L.Cronin@chem.gla.ac.uk

References [1] G. J. T. Cooper, P. J. Kitson, R. S. Winter, M. Zagnoni, D.-L. Long, L. Cronin, Angew. Chem., Int. Ed., 2011, 50, 10373. [2] P. J. Kitson, M. H. Rosnes, V. Sans, V. Dragone, L. Cronin, Lab Chip, 2012, 12, 3267-3271.

Conclusion It is demonstrated the versatility and configurability of completely reusable and bespoke millifluidic and microfluidic reactionware. Within the timespan of one day a geometry tailored to a specific reaction can be designed and printed with a extremely low-cost fabrication technique. As an added benefit it is very simple to alter the design of the devices in terms of geometry, inlets, outlets and sizes of channels that is very rare with traditional fluidic devices, where redesign and refabrication of devices can be time consuming. Further work aim to increase the versatility of the miniaturised devices, especially for applications in complex chemical systems and integrated bio-and-chemo-reactionware.

Organic synthesis

Bla bla bla

Organic synthesis

Flow synthesis of an imine derived from benzaldehyde and benzylamine. The reaction was followed in-line with an ATR-IR and the effect of the flow rate on the yield of the reaction was determined.

Materials synthesis

Bla bla bla

Organic synthesis

The synthesis of gold nanoparticles is followed by UV-Vis spectroscopy then confimed by DLS. The device inlets are connected to pumps that flow acqueous solutions of: (A) HAuCl4/citrate and (B) NaBH4 .

Inorganic synthesis

Bla bla bla

M POM synthesis monitored by in-line UV-Vis spectroscopy and then confirmed by DLS. In the 1-inlet device only HCl is flowed through silos filled with Na2MoO4

.H2O and reducing agent.

These reactionware devices can be connected with analytical intruments to follow in-line the reaction progress. Once printed, the devices are fitted with standard PTFE 1/16” OD tubing attached to the inlet and outlet openings of each device.

The devices are connected to a flow set-up employing standard connectors, i.e. the inlets to pumps and the outlets to the in-line ATR-IR and/or UV-Vis flow-cells.