congenital defects from maternal rubella

1
1034 thrombin is low and relatively flat, whereas that from antithrombin in defibrinated plasma rises in relation to the time of incubation of the mixture. Thus it is diffi- cult for us to reconcile the finding of low antithrombin titres obtained from serum with unequivocal diagnosis of cystic fibrosis of the pancreas regardless of the extent of involvement. In our data only extreme cases of cystic fibrosis of the pancreas, with minimal or absent external pancreatic secretions, show very low antithrombin titres. Further, in our experience there is no constant relation between absent pancreatic secretions in the duodenum and the antithrombin level in the blood. Since it is apparent that serum-antithrombin deter- minations result in low flat curves, the stage of pancrea- titis characterised by markedly increased antithrombin and trypsin levels in the blood would necessarily be missed in serum determinations. It would indeed be most helpful in clarifying the differences in results obtained if plasma-antithrombin determinations could be made on the 67 cases so well presented and discussed by Dr. MacFarlane. IRVING INNERFIELD ALFRED ANGRIST JAMES W. BENJAMIN. Department of Physiology and Pharmacology, New York Medical College, New York. CONGENITAL DEFECTS FROM MATERNAL RUBELLA IAN G. ROBIN. SiR,-As an otologist and a member of the committee of the Deaf Children’s Society, I have been very per- turbed to learn that some general practitioners are questioning the diagnosis of rubella in the first three months of pregnancy when associated with fcetal abnor- malities. In 1940 and subsequently, Gregg, Swan, and others in Australia pointed out the very definite danger of rubella early in pregnancy leading to congenital deafness, blindness, and sometimes a cardiac lesion. It is thought by some that the infection was not true rubella and that other cases have not occurred since. This is a very dangerous, as well as an erroneous, supposition. There is no doubt whatever that children are still being seen with these tragic defects as the result of infection in their mothers by a simple " illness indistinguishable from typical rubella often this has been very mild. Pregnant women should still be extremely careful to avoid contact with rubella : in fact there seems every justification to recommend that all girls should be exposed to rubella before leaving school. London, W.I. IAN G. ROBIN. DENTAL TREATMENT FOR CHILDREN T. H. LIPTROT Hon. Secretary, Public Dental Officers’ Group, British Dental Association. SiR,-Your leading article of Oct. 25 contains the following statement concerning children’s dentistry : "The work is mainly routine and holds little interest for the highly trained dental surgeon." May I encroach on your space to challenge as briefly as possible the correctness of this statement. The public dental officer in treating the priority classes performs the same range of operations as is performed in the general dental service. In the case of school-children, who form the bulk of his patients, he must perform these same operations in a much smaller oral cavity and on a patient who is emotionally less stable than an adult, requiring from the operator a greater skill and more tact and patience than is necessary in other spheres of dentistry. As the school dentist is dealing with patients in their developmental stage, his knowledge and understanding of developmental irregu- larities, and their prevention and treatment, must be of a high order. By contrast the treatment of mature mouths, subject only to the processes of decay, is flat and insipid. The more frequent use of general anaes- thetics, with increased dimculties of administration, is a further feature of children’s dentistry. I trust that this letter will go some way towards removing your implied slur on those dental surgeons who for vocational reasons remained faithful to the children, and resisted the financial attractions of the easier, though less satisfying, work of general service. THE CORRECT SPELLING OF MEDICAL TERMS KENNETH MARSH. Sm,ňDr. L. E. Napier (Nov. 1) is fighting a battle for many of us in defence of etymologically correct spelling. Nowadays, editors refuse to accept emp’yemata, and one journal recently removed sinus into the second declension. Camberwell, London, S.E.5. KENNETH MARSH. SKIING ACCIDENTS SiR,-In 1950 a committee was set up by the Ski Club of Great Britain to inquire into ways of reducing the number of skiing accidents. A simple safety device was introduced consisting of a strap passing from the heel-spring of the ski binding to a ring attached to the ski 2 in. behind the heel. The object of this device was to cause the foot to come adrift from the ski in the event of a severe forward fall. Other and more elaborate safety bindings prevent rotation strains, but they have not yet been widely used in the Alps. In order to obtain information on (a) the incidence of skiing injuries, and (b) the effectiveness of this simple safety device, a card was circulated in 1951 to 12,750 members of the Ski Club of Great Britain, asking for the following information : Age ; sex number of seasons’ experience ; safety device used, if any ; description of injury from any accident in previous season ; causes of accident (fall, collision, snow conditions) ; days on ski before accident ; feet downhill per day (average). 254 replies were received ; the results of analysis were as follows : The injuries were as follows sprairas 46 (ankle 22, knee 20, shoulder 4) ; fractures 7 (ankle 3, patella 1, thumb 1, ribs 2) ; muscle lesions 2 (calf 1, thigh 1) ; lacerations 2 (thigh 1, wrist 1) ; unspecified 1. Under causes of the accident the replies were as follows: snow conditions 40 (powder snow 15 ; wet soft snow 9 ; ice 7 ; icy ruts 5 breakable crust 4) ; obstructions 4 (tree, rock, or ice block) collisions nil. Snow conditions were not reported in 3 cases ; 11 accidents happened in good snow conditions on the piste. There are obvious statistical objections to this type of inquiry. The findings would not necessarily be the same in a random sample of the members of the Ski Club of Great Britain ; they may apply only to the type of person who takes the trouble to reply, and people who have had accidents may be more likely to reply than those who have not. On the other hand, those who have worn a safety device and escaped injury may be more likely to reply than those who have had no injury and worn no safety device. Despite these objections, the results confirm the impression gained from empirical observation that injuries to skiers are extremely common, though most of them are not serious. The evidence also suggests that the Ski Club of Great Britain safety device significantly reduces the incidence of accidents. This device clearly cannot influence the incidence of injuries to parts of the body other than the lower limbs. The number of such

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Page 1: CONGENITAL DEFECTS FROM MATERNAL RUBELLA

1034

thrombin is low and relatively flat, whereas that fromantithrombin in defibrinated plasma rises in relationto the time of incubation of the mixture. Thus it is diffi-cult for us to reconcile the finding of low antithrombintitres obtained from serum with unequivocal diagnosisof cystic fibrosis of the pancreas regardless of the extentof involvement.

In our data only extreme cases of cystic fibrosis of thepancreas, with minimal or absent external pancreaticsecretions, show very low antithrombin titres. Further,in our experience there is no constant relation betweenabsent pancreatic secretions in the duodenum and theantithrombin level in the blood.

Since it is apparent that serum-antithrombin deter-minations result in low flat curves, the stage of pancrea-titis characterised by markedly increased antithrombinand trypsin levels in the blood would necessarily be missedin serum determinations.

It would indeed be most helpful in clarifying thedifferences in results obtained if plasma-antithrombindeterminations could be made on the 67 cases so wellpresented and discussed by Dr. MacFarlane.

IRVING INNERFIELDALFRED ANGRISTJAMES W. BENJAMIN.

Department of Physiologyand Pharmacology,

New York Medical College,New York.

CONGENITAL DEFECTS FROM MATERNALRUBELLA

IAN G. ROBIN.

SiR,-As an otologist and a member of the committeeof the Deaf Children’s Society, I have been very per-turbed to learn that some general practitioners are

questioning the diagnosis of rubella in the first threemonths of pregnancy when associated with fcetal abnor-malities. In 1940 and subsequently, Gregg, Swan, andothers in Australia pointed out the very definite danger ofrubella early in pregnancy leading to congenital deafness,blindness, and sometimes a cardiac lesion. It is thoughtby some that the infection was not true rubella and thatother cases have not occurred since.

This is a very dangerous, as well as an erroneous,supposition. There is no doubt whatever that childrenare still being seen with these tragic defects as the resultof infection in their mothers by a simple " illness

indistinguishable from typical rubella often this hasbeen very mild. Pregnant women should still be extremelycareful to avoid contact with rubella : in fact there seemsevery justification to recommend that all girls shouldbe exposed to rubella before leaving school.London, W.I. IAN G. ROBIN.

DENTAL TREATMENT FOR CHILDREN

T. H. LIPTROTHon. Secretary, Public Dental Officers’ Group,

British Dental Association.

SiR,-Your leading article of Oct. 25 contains the

following statement concerning children’s dentistry :"The work is mainly routine and holds little interestfor the highly trained dental surgeon." May I encroachon your space to challenge as briefly as possible thecorrectness of this statement.The public dental officer in treating the priority

classes performs the same range of operations as is

performed in the general dental service. In the case ofschool-children, who form the bulk of his patients, hemust perform these same operations in a much smalleroral cavity and on a patient who is emotionally lessstable than an adult, requiring from the operator a

greater skill and more tact and patience than is necessaryin other spheres of dentistry. As the school dentistis dealing with patients in their developmental stage, hisknowledge and understanding of developmental irregu-larities, and their prevention and treatment, must beof a high order. By contrast the treatment of maturemouths, subject only to the processes of decay, is flatand insipid. The more frequent use of general anaes-thetics, with increased dimculties of administration,is a further feature of children’s dentistry.

I trust that this letter will go some way towardsremoving your implied slur on those dental surgeonswho for vocational reasons remained faithful to thechildren, and resisted the financial attractions of theeasier, though less satisfying, work of general service.

THE CORRECT SPELLING OF MEDICAL TERMS

KENNETH MARSH.

Sm,ňDr. L. E. Napier (Nov. 1) is fighting a battlefor many of us in defence of etymologically correct

spelling. Nowadays, editors refuse to accept emp’yemata,and one journal recently removed sinus into the seconddeclension.

Camberwell, London, S.E.5. KENNETH MARSH.

SKIING ACCIDENTS

SiR,-In 1950 a committee was set up by the SkiClub of Great Britain to inquire into ways of reducingthe number of skiing accidents. A simple safety devicewas introduced consisting of a strap passing from theheel-spring of the ski binding to a ring attached to theski 2 in. behind the heel. The object of this device wasto cause the foot to come adrift from the ski in the eventof a severe forward fall. Other and more elaboratesafety bindings prevent rotation strains, but they havenot yet been widely used in the Alps.

In order to obtain information on (a) the incidence ofskiing injuries, and (b) the effectiveness of this simplesafety device, a card was circulated in 1951 to 12,750members of the Ski Club of Great Britain, asking for thefollowing information :

Age ; sex number of seasons’ experience ; safety deviceused, if any ; description of injury from any accident inprevious season ; causes of accident (fall, collision, snow

conditions) ; days on ski before accident ; feet downhill perday (average).

254 replies were received ; the results of analysis wereas follows :

The injuries were as follows sprairas 46 (ankle 22, knee 20,shoulder 4) ; fractures 7 (ankle 3, patella 1, thumb 1, ribs 2) ;muscle lesions 2 (calf 1, thigh 1) ; lacerations 2 (thigh 1,wrist 1) ; unspecified 1.Under causes of the accident the replies were as follows:

snow conditions 40 (powder snow 15 ; wet soft snow 9 ; ice 7 ;icy ruts 5 breakable crust 4) ; obstructions 4 (tree, rock, orice block) collisions nil. Snow conditions were not reportedin 3 cases ; 11 accidents happened in good snow conditionson the piste.

There are obvious statistical objections to this type ofinquiry. The findings would not necessarily be the samein a random sample of the members of the Ski Club ofGreat Britain ; they may apply only to the type of personwho takes the trouble to reply, and people who have hadaccidents may be more likely to reply than those whohave not. On the other hand, those who have worn asafety device and escaped injury may be more likely toreply than those who have had no injury and worn nosafety device.

Despite these objections, the results confirm theimpression gained from empirical observation thatinjuries to skiers are extremely common, though mostof them are not serious. The evidence also suggests thatthe Ski Club of Great Britain safety device significantlyreduces the incidence of accidents. This device clearlycannot influence the incidence of injuries to parts of thebody other than the lower limbs. The number of such