Commentary

Kinetics and Structures on the MolecularPath to the Quadruplex Form of theHuman Telomere

W. David Wilson and Ananya Paul 1625–1628

Featured Article

Folding and Unfolding Pathways of theHuman Telomeric G-Quadruplex

Robert D. Gray, John O. Trent andJonathan B. Chaires

1629–1650

Special Section: Emerging Concepts in Epigenetic SignalingGuest Editors: Sepideh Khorasanizadeh and Yang Shi

The Tudor Domain of the PHD FingerProtein 1 Is a Dual Reader of LysineTrimethylation at Lysine 36 of HistoneH3 and Lysine 27 of Histone Variant H3t

Ina Kycia, Srikanth Kudithipudi,Raluca Tamas, Goran Kungulovski,Arunkumar Dhayalan and Albert Jeltsch

1651–1660

Molecular Insights into the Recognitionof N-Terminal Histone Modifications bythe BRPF1 Bromodomain

Amanda Poplawski, Kaifeng Hu,Woonghee Lee, Senthil Natesan,Danni Peng, Samuel Carlson,Xiaobing Shi, Stefan Balaz,John L. Markley and Karen C. Glass

1661–1676

Constitutive Nuclear Localization of anAlternatively Spliced Sirtuin-2 Isoform

JohannesG.M. Rack, Magali R. VanLinden,Timo Lutter, Rein Aasland andMathias Ziegler

1677–1691

Articles

Determination of the Self-Association Residueswithin a Homomeric and a Heteromeric AAA+Enhancer Binding Protein

Edward Lawton, Milija Jovanovic,Nicolas Joly, Christopher Waite,Nan Zhang, Baojun Wang,Patricia Burrows and Martin Buck

1692–1710

Energetic Communication between FunctionalSites of the Gene-3-Protein during Infection byPhage fd

Stephanie Hoffmann-Thoms,Roman P. Jakob and Franz X. Schmid

1711–1722

Dimer–Dimer Interaction of the BacterialSelenocysteine Synthase SelA PromotesFunctional Active-Site Formation andCatalytic Specificity

Yuzuru Itoh, Markus J. Bröcker,Shun-ichi Sekine, Dieter Söll andShigeyuki Yokoyama

1723–1735

O-GlcNAc Modification of tau DirectlyInhibits Its Aggregation without Perturbingthe Conformational Properties of tauMonomers

Scott A. Yuzwa, Adrienne H. Cheung,Mark Okon, Lawrence P. McIntosh andDavid J. Vocadlo

1736–1752

journal home page :www.journals.elsevier.com/journal-of-molecular-biology

ContentsVolume 426, Issue 8

Abstracted/indexed in: BIOSIS, Biochemistry and Biophysics Citation Index, Biological Abstracts, Biological and Agricultural Index, Biostatistica,Biotechnology Citation Index, Chemical Abstracts, Current Contents (Life Sciences, Clinical Medicine), EMBASE, EMBiology, Excerpta Medica, Food

Science and Technology Abstracts, Genetics Abstracts, Immunology Abstracts, MEDLINE®, Reference Update, Research Alert, SCISEARCH, ScienceCitation Index, etc. Also covered in the abstract and citation database Scopus®. Full text available on ScienceDirect®

The C-Terminal Domain of SRA1p Has a FoldMore Similar to PRP18 than to an RRM andDoes Not Directly Bind to the SRA1 RNASTR7 Region

StephanieM.Bilinovich,CarolineM.Davis,Daniel L. Morris, Louis A. Ray,Jeremy W. Prokop, Gregory J. Buchanand Thomas C. Leeper

1753–1765

Structure and Function of Steroid Receptor RNAActivator Protein, the Proposed Partner of SRANoncoding RNA

David B. McKay, Linghe Xi,Kristen K.B. Barthel and Thomas R. Cech

1766–1785

A Novel C-Terminal Homologue of Aha1Co-Chaperone Binds to Heat Shock Protein 90and Stimulates Its ATPase Activity in Entamoebahistolytica

Meetali Singh, Varun Shah and Utpal Tatu 1786–1798

Immunoglobulin G1 Fc Domain Motions:Implications for Fc Engineering

Martin Frank, Ross C. Walker,WilliamN. Lanzilotta, JamesH. Prestegardand AdamW. Barb

1799–1811

Relative Domain Folding and Stability of aMembrane Transport Protein

Nicola J. Harris, Heather E. Findlay,John Simms, Xia Liu and Paula J. Booth

1812–1825

Determination of the Individual Roles of theLinker Residues in the Interdomain Motionsof Calmodulin Using NMR Chemical Shifts

Predrag Kukic, Carlo Camilloni,Andrea Cavalli and Michele Vendruscolo

1826–1838

Structural Analysis of a Fungal MethionineSynthase with Substrates and Inhibitors

Devinder Ubhi, Grace Kago,Arthur F. Monzingo and Jon D. Robertus

1839–1847

The Novel Microtubule-Destabilizing DrugBAL27862 Binds to the Colchicine Site ofTubulin with Distinct Effects on MicrotubuleOrganization

Andrea E. Prota, Franck Danel,Felix Bachmann, Katja Bargsten,Rubén M. Buey, Jens Pohlmann,Stefan Reinelt, Heidi Lane andMichel O. Steinmetz

1848–1860

Databases/Web Servers

NP-Sticky: A Web Server for Optimizing DNALigation with Non-Palindromic Sticky Ends

Daphne T.W. Ng and Casim A. Sarkar 1861–1869