conversant bio biospecimen sourcing capabilities

Biospecimen Sourcing Capabilities

Conversant Bio © 2014. All rights reserved.

Approved for Use Via Slideshare| 2

A Few Things to Know About Conversant Bio

1. We are glad to be here!

2. We believe in open and honest communication in order to

build strong, lasting relationships

3. We believe in failing forward to embrace innovation and

continuous improvement

4. Everything we do is because patients are waiting . . .

http://www.conversantbio.com/


What makes Conversant Bio unique?



Our unique business model

Feature Benefit to you

We know complex projects

We handle regulatory details

80% on-demand

IRB approved

Embedded coordinators

Access to patient records

Rapid Processing

Custom tubes, custom kits

Deep clinical data

We process samples



The only Premier Support in the

industry

Your dedicated Project Manager will:

• Confirm Order details immediately

• Provide regular updates

• Answer any questions at any time

Our Clinical Data Analysts will:

• Target patients according to your criteria

• Provide patient annotation

age, race, sex, smoking history, alcohol history, and primary

diagnosis, path reports, cyto reports, mutation data

(866) [email protected]

A growing U.S. site network

U.S. site procurement

• Hospitals and physician clinics

• Full regulatory/IRB compliance

• Consent and waiver of consent studies

• Dedicated Site Development professionals focused on growing

our capacity and capabilities

• Many new sites added to the collection network

– Fixed Formalin Paraffin Embedded Tissue and Fresh Frozen Tissue

– Fresh Bone Marrow

– Matched Cord Blood & Placenta



Why do people work with us?

Oncology

• Lung

• Breast

• CRC

• Prostate

• other tumors

• Leukemia

• Myeloma

• Lymphoma

• MGUS

• other hem/onc

Autoimmune

• Lupus

• Rheumatoid Arthritis

• Sarcoidosis

• Scleroderma

• Crohn’s Disease

• Psoriasis

• Idiopathic Pulmonary Fibrosis

Other

• Normal Controls

• Multiple Sclerosis

• Pregnancy

• Specialized cells (CAF, CD34+, CD138+, etc.)

We have access to many diseases



We have access to many diseases

Across many tissue types

Ascites Fluid

Peripheral Blood

Bone Marrow

Leukopak

Skin

Sputum

Tissue

UrineCord Blood

leu



Fresh, frozen, and custom processed tissues from…

Including a wide array of FFPE

Which block has the highest tumor load?


Approved for Use Via Slideshare

Tumor Load 100% Tumor Load 75% Tumor Load 40%

Which block has the most utility?

• OK for <10 4um sections

• OK for 1 10um curl

• OK for whole block sale

• 1 x 13mm tumor

• OK for >100 4um sections

• OK for >20 10um curl


• Not ideal for arrays (shallow)

• 38 x 5mm tumor

• OK for >100 4um sections

• OK for >20 10um curl


• OK for TMAs (thick)

• 15 x 11mm tumor

| 10

Cu

sto

me

rs r

ely

on

us t

o…



Provide data about the samples

| 11

• Customer needed 90 unique RA patients

• Inclusion/exclusion criteria included current and

past treatments, plus comorbidities

• Previous and current lab data (e.g. ESR, CRP,

Anti-CCP, RF, CBC, etc.) were provided to the

researcher

Cu

sto

me

rs r

ely

on

us t

o…



Obtain samples quickly for pilot studies

| 12

• SLE pilot study required HIV and HBV testing

before being shipped to customer’s lab

• Patients had to have active SLE and an anti-DNA

antibodies test within the last three months

• Samples were targeted, tested, and shipped within

1 week of receiving the purchase order

Cu

sto

me

rs r

ely

on

us t

o…



Provide age-matched bone marrow samples

• Age-matched normal BMMCs to compare to

diseased samples

• Short lead time between order and deliveries

• Isolation of CD138+ and CD34+

• High cell viability

• Cryopreserved inventory of wide variety of

donors

Our Model

Co

nve

rsan

t B

io Prospective Collections

Banked Inventory

Lab

PBMCs Dissociated Tumor CellsPlasma Xenograft CellsSerum Ascites FluidBMMCs Buffy CoatFFPE Fresh Frozen Tissue

Oncology HematologyAuto-Immune MetabolismPulmonology NormalsNeurology

Custom ProtocolsCell isolationFlow CytometryViral/antibacterial testingMutation Testing



Researchers enjoy our resources



eBooks focused on helpful topics

How do we work with you?



Step 1Project discussion, Quote, and PO approval

Step 2Project setup

Step 3Patient targetingand kits built

Step 4Samples collectedand processed

Step 5Samples shipped and data delivered

1 2 3 4 5

Inventory Orders take 2 days (average)

Prospective Orders take 7 days (average)

Ordering is simple and quick

Please consider us a resource

Phone (866) 838-2798

Email [email protected]

Web www.conversantbio.com

Visit 601 Genome Way, Huntsville, AL 35806

Contact us for any project needs

mailto:[email protected]


Predictive biomarker discovery Renal Cell Carcinoma Tissue (Published AACR ‘13)

Companion diagnostic to Phase 2 drugNon-Small Cell Lung Cancer (Presented AACR ‘13)

Circulating tumor cell characterizationNon-Small Cell Lung Cancer, Breast Cancer (Presented Molecular Medicine Tri-Con ’13)

Customers succeed with us



conversant bio biospecimen sourcing capabilities

Technology