curriculum vitae david paul lunn - nc state university · lunn/cv-2/18/17 1 curriculum vitae david...

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Lunn/CV-2/18/17 1 Curriculum vitae David Paul Lunn BVSc, MS, PhD, MRCVS, Diplomate ACVIM Date of birth February 26, 1959 Nationality British, US Landed Immigrant. Degrees BVSc, Honours Degree, 1982, University of Liverpool, Great Britain. MS, 1988, University of Wisconsin-Madison, USA. Ph.D, 1991, University of Cambridge, Great Britain Board Certification Diplomate, 1992, American College of Veterinary Internal Medicine Societies Member of the Royal College of Veterinary Surgeons. Professional and educational background February 2012 to present: Dean, College of Veterinary Medicine, North Carolina State University, Raleigh. August 2003 to February 2012: Professor and Head of the Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins. A 75% administrative, 25% for teaching & research appointment. October 2000 to August 2003: Associate Dean for Clinical Affairs and Director of the Veterinary Medical Teaching Hospital, July 2000. A 60% administrative, 40% research appointment. October 1991 to 2000: Assistant Professor, Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. A 45% research, 50% teaching and clinical work, and 5% service appointment. Promoted to Associate Professor with tenure 1998. October 1988 to October 1991: PhD. studies, University of Cambridge, Great Britain. Thesis: Monoclonal antibodies recognizing equine leucocyte surface antigens and immunoglobulins July 1985 to June 1988: Resident, Large Animal Internal Medicine, School of Veterinary Medicine, University of Wisconsin-Madison, USA. Master of Science Degree studies, University of Wisconsin- Madison. Thesis: Renal Electrolyte and Net Acid Excretion in Metabolic Alkalosis in Sheep. September 1983 – June 1985: General practice, Pennard Veterinary Group, Sevenoaks, Kent, Great Britain. July 1982 - July 1983: Intern, Large Animal Medicine and Surgery, Ontario Veterinary College, Guelph, Ontario. September 1977 - June 1982: Bachelor of Veterinary Science (Honors) degree studies, Faculty of Veterinary Science, University of Liverpool, Great Britain.

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Page 1: Curriculum vitae David Paul Lunn - Nc State University · Lunn/CV-2/18/17 1 Curriculum vitae David Paul Lunn BVSc, MS, PhD, MRCVS, Diplomate ACVIM Date of birth February 26, 1959

Lunn/CV-2/18/17 1

Curriculum vitae David Paul Lunn BVSc, MS, PhD, MRCVS, Diplomate ACVIM Date of birth February 26, 1959 Nationality British, US Landed Immigrant. Degrees BVSc, Honours Degree, 1982, University of Liverpool, Great Britain. MS, 1988, University of Wisconsin-Madison, USA. Ph.D, 1991, University of Cambridge, Great Britain Board Certification Diplomate, 1992, American College of Veterinary Internal Medicine Societies Member of the Royal College of Veterinary Surgeons.

Professional and educational background February 2012 to present:

Dean, College of Veterinary Medicine, North Carolina State University, Raleigh. August 2003 to February 2012:

Professor and Head of the Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins. A 75% administrative, 25% for teaching & research appointment.

October 2000 to August 2003: Associate Dean for Clinical Affairs and Director of the Veterinary Medical Teaching Hospital, July 2000. A 60% administrative, 40% research appointment.

October 1991 to 2000: Assistant Professor, Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. A 45% research, 50% teaching and clinical work, and 5% service appointment. Promoted to Associate Professor with tenure 1998.

October 1988 to October 1991: PhD. studies, University of Cambridge, Great Britain. Thesis: Monoclonal antibodies recognizing equine leucocyte surface antigens and immunoglobulins

July 1985 to June 1988: Resident, Large Animal Internal Medicine, School of Veterinary Medicine, University of Wisconsin-Madison, USA. Master of Science Degree studies, University of Wisconsin-Madison. Thesis: Renal Electrolyte and Net Acid Excretion in Metabolic Alkalosis in Sheep.

September 1983 – June 1985: General practice, Pennard Veterinary Group, Sevenoaks, Kent, Great Britain.

July 1982 - July 1983: Intern, Large Animal Medicine and Surgery, Ontario Veterinary College, Guelph, Ontario.

September 1977 - June 1982: Bachelor of Veterinary Science (Honors) degree studies, Faculty of Veterinary Science, University of Liverpool, Great Britain.

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Publications: Publications in refereed journals 1. Goehring LS, Brandes K, Ashton LV, Wittenburg LA, Olea-Popelka FJ, Lunn DP, Soboll

Hussey G: Anti-inflammatory drugs decrease infection of endothelial cells with EHV-1 in vitro. Equine Veterinary Journal, DOI 10.1111/evj.12656, 2016.

2. Stringer AS, Lunn DP, Reid S: Report on the First Havemeyer Workshop on Infectious Diseases in Working Equids, Addis Ababa, Ethiopia. Equine Veterinary Journal, 47: 6-9, 2015.

3. Hackett ES, Lunn DP, Ferris RA, Horohov DW, Lappin MR, McCue PM: Detection of bacteraemia and host response in healthy neonatal foals. Equine Veterinary Journal, 47: 405-9, 2015.

4. Lunn DP, Antczak DF, McCue P, Richardson D, Scollay M: ‘Equine research – our only business’: The Grayson-Jockey Club Research Foundation. Equine Veterinary Journal, 46 (4): 515-516, 2014.

5. Soboll Hussey G, Ashton LV, Quintana A, Van de Walle GR, Osterrieder N, Lunn DP: Equine herpesvirus type 1 pUL56 modulates innate responses of airway epithelial cells, Virology, 464-465(1): 76-86, 2014.

6. Soboll Hussey G, Ashton LV, Quintana AM, Lunn DP, Goehring L, Annis K, Landolt G: Innate immune responses of airway epithelial cells to infection with Equine Herpesvirus-1. Veterinary Microbiology. 170(1-2): 28-38, 2014.

7. Broccardo CJ, Soboll Hussey G, Goehring L, Lunn DP, Prenni JE: Proteomic Profiling of Equine Cerebrospinal Fluid. J. Eq.Vet.Sci, 4 (3): 451-458, 2014.

8. Soboll Hussey G, Goehring L, Lunn DP, Hussey SB, Osterrieder N, Powell C, Hand J, Slater J: EHV-1 experimental infection induces chorioretinal lesions. Veterinary Research. 44: 118, 2013.

9. Goerhing L, Soboll-Hussey G, Gomez-Diez M, Benedict K, Maxwell L, Morley P, Sloet van Oldruitenborgh-Oosterbaan M, Lunn DP: Plasma D-dimer concentrations during experimental EHV-1 infections” J Vet Int Med, 27: 1535-1542, 2013.

10. Carlson JK, Traub-Dargatz J, Lunn DP, Morley P, Kohler A, Kasper K, Landolt GA, Barnett C, Lunn KF: Equine Viral respiratory pathogen surveillance at horse shows and sales. J. Eq.Vet.Sci, 33: 229-237, 2013.

11. Gardiner DW, Lunn DP, Goehring LS, Chiang Y-W, Cook C, Osterrieder N, McCue P, Del Piero F, Hussey SB, Hussey GS: Strain impact on equine herpesvirus type 1 (EHV-1) abortion models: viral loads in fetal and placental tissues and foals. Vaccine, 30: 6564-6572, 2012.

12. Kydd JH, Slater J, Osterrieder N, Lunn DP, Antczak DF, Azab W, Balasuriya U, Barnett C, Brosnahan M, Cook C Damiani A, D Elton D, Frampton A, Gilkerson J, Goehring LS, Horohov DW, Maxwell L, Minke J, Morley P, Nauwynck H, Newton R, Perkins G, Pusterla N, Soboll-Hussey G, Traub-Dargatz J, Townsend HGG, Van de Walle GR, Wagner B: Third International Havemeyer Workshop on Equine Herpesvirus Type 1 (EHV-1), Home Ranch, Steam Boat Springs, Colorado, USA, 19th-22nd September 2011. Equine Veterinary Journal, 44: 513-517, 2012.

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13. Burgess B, Tokateloff N, Manning S, Lohmann KL. Lunn DP, Hussey SB, Morley PS: Nasal shedding of Equine Herpesvirus-1 from horses in an outbreak of Equine Herpes Myeloencephalopathy in Western Canada. J Vet Int Med, 26: 384-392, 2012.

14. Dauvillier J, Flaminio MJ, Lunn DP, Lavoie-Lamoureux A, Leclere M, Beachamp G, Lavoie J-P: Effect of long-term fluticasone treatment on immune function in horses with heaves. J Vet Int Med, 25; 549-557, 2011.

15. Hussey GS, Hussey SB, Wagner B, Horohov DW, Van de Walle GR, Osterrieder N, Goehring LS, Rao S, Lunn DP: Evaluation of immune responses following infection of ponies with an EHV-1 ORF1/2 deletion mutant. Veterinary Research, 42; 23-29, 2011.

16. Durando M, Birks EK, Hussey SB, Lunn DP: Cardiac troponin I concentrations in ponies challenged with equine influenza virus. J Vet Int Med, 25, 339-344, 2011.

17. Wilsterman S, Soboll G, Lunn DP, Ashton LV, Callan RJ, Hussey SB, Rao S, Goerhing LS: Equine herpesvirus-1 infected peripheral blood mononuclear cell subpopulations during viremia. Vet. Micro. 149, 40-47, 2011.

18. Goerhing LS, Soboll G, Ashton LV, Schenkel A, Lunn DP: Infection of central nervous system endothelial cells by cell-associated EHV-1. Vet. Micro. 148, 389-39, 2011.

19. Pusterla N, Hussey SB, Mapes S, Johnson C, Collier JR, Hill J, Lunn DP, Wilson WD: Molecular Investigation of the Viral Kinetics of Equine Herpesvirus-1 in Blood and Nasal Secretions of Horses after Corticosteroid-Induced Recrudescence of Latent Infection. J Vet Intern Med, 24: 1153-1157, 2010.

20. Kydd JH, Slater J, Osterrieder N, Lunn DP: Report of the Second Havemeyer EHV-1 Workshop, Steamboat Springs, Colorado, September 2008. Equine Veterinary Journal, 42: 572-5, 2010.

21. Landolt GA, Hussey SB, Kreutzer K, Quintana A, Lunn DP: Intra lymph node low-dose DNA vaccination in ponies. Vet. Rec., 167: 302-4, 2010.

22. Goehring LS, Wagner B, Bigbie R, Hussey SB, Rao S, Morley PS, Lunn DP: Control of EHV-1 viremia and nasal shedding by commercial vaccines. Vaccine, 28: 5203-5211, 2010.

23. Muirhead T, McClure J, Wichtel J, Stryhn H, Markham F, McFarlane D, Lunn DP: The Effect of Age on Systemic Antibody Response Following Rabies and Influenza Vaccination in Healthy Horses. J. Comp. Path. 142: S85-S90, 2010.

24. Lindsay WA, Wiedner E, Isaza R, Townsend HGG, Boleslawski M, Lunn DP: Immune responses of Asian elephants (Elephas maximus) to commercial tetanus toxoid vaccine. Vet Immunol Immunopathol. 133; 287-289, 2010.

25. Soboll G, Breathnach CC, Kydd, Hussey SB, Mealey R, Lunn DP: Vaccination of ponies with the IE gene of EHV-1 in a recombinant modified live vaccinia vector protects against clinical and virological disease. Vet Immunol Immunopathol, 135: 108-117, 2010.

26. Soboll G, Hussey SB, Minke JM, Hunter JS, Jagannatha S, Lunn DP: Onset and duration of immunity to equine influenza virus resulting from canarypox-vectored (ALVAC) vaccination. Vet Immunol Immunopathol, 135: 100-107, 2010.

27. Wagner B, Miller WH, Erb HN, Lunn DP, Antczak DF: Sensitization of skin mast cells with IgE antibodies to Culicoides allergens occurs frequently in clinically healthy horses. Vet Immunol Immunopathol, 132, 53–61, 2009.

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28. Pusterla N, Hussey SB, Mapes S, Leutenegger CM, Madigan JE, MacLachlan NJ, Ferraro GL, WilsonWD, Lunn DP: Comparison of different methods to quantitate equine herpesvirus-1 load by real-time PCR in nasal secretions of experimentally and naturally infected horses. J Vet Diag Invest, 21: 836–840, 2009.

29. Lunn DP, Davis-Poynter N, Flaminio MJBF, Horohov DW, Osterrieder K, Pusterla N, Townsend HGG: ACVIM EHV-1 consensus statement. J. Vet. Intern. Med. 23:450–461, 2009.

30. Lunn DP, Hurley DJ: The role of leukocyte biology in laminitis. Vet Immunol Immunopathol. 129;158–160, 2009.

31. Marti, E., Gerber, V., Wilson, A. D., Lavoie, J. P., Horohov, D., Crameri, R., Lunn, DP, Antczak, D., Bjornsdottir, S., Bjornsdottir, T. S., Cunningham, F., Derer, M., Frey, R., Hamza, E., Horin, P., Heimann, M., Kolm-Stark, G., Olafsdottir, G., Ramery, E., Russell, C., Schaffartzik, A., Svansson, V., Torsteinsdottir, S., and Wagner, B.: Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Holar, Iceland, June 2007 Vet Immunol Immunopathol. 126; 651-361, 2008.

32. Muirhead T, McClure J, Wichtel J, Stryhn H, Markham F, McFarlane D, Lunn DP: The Effect of Age on Systemic Antibody Response Following Rabies and Influenza Vaccination in Healthy Horses. J. Vet. Intern. Med. 22; 654-661, 2008.

33. Flaminio MJ, Ibrahim S, Lunn DP, Stark R, Steinbach F. Further analysis of anti-human leukocyte mAbs with reactivity to equine leukocytes by two-colour flow cytometry and immunohistochemistry. Vet Immunol Immunopathol 119:92-9, 2007.

34. Ibrahim S, Saunders K, Kydd JH, Lunn DP, Steinbach F. Screening of anti-human leukocyte monoclonal antibodies for reactivity with equine leukocytes. Vet Immunol Immunopathol 119: 63-80, 2007.

35. Breathnach CC, Sturgill-Wright T, Stiltner JL, Adams AA, Lunn DP, Horohov DW. Foals are interferon gamma-deficient at birth. Vet Immunol Immunopathol 112:199-209, 2006.

36. Hussey SB, Clark R, Lunn KF, Breathnach CC, Soboll G, Whalley JM, Lunn DP: Detection and quantification of EHV-1 viremia and nasal shedding by real-time PCR. J Vet Diag Invest, 18: 335-342, 2006.

37. Breathnach CC, Clark HJ, Clark RC, Olsen CW, Townsend HGG, Lunn DP: Immunization with recombinant modified vaccinia virus Ankara (rMVA) constructs encoding the HA or NP gene protects ponies from equine influenza virus challenge. Vaccine, 24: 1180-1190, 2006.

38. Holmes MA, Townsend HGG, Kohler AK, Hussey S, Breathnach CC, Barnett C, Holland R, Lunn DP: Immune responses to commmercial equine vaccines against equine herpesvirus-1, equine influenza virus, eastern equine encephalomyletitis, and tetanus. Vet Immunol Immunopathol, 111: 67-80, 2006.

39. Slater JS, Lunn DP, Horohov DW, Antczak DF, Babiuk L, Breathnach CC, Chang Y-W, Davis-Poynter N, Edington N, Ellis S, Foote C, Goehring L, Kohn CW, Kydd J, Matsumura T, Minke J, Morley P, Mumford J, Neubauer T, O’Callaghan D, Osterrieder K, Reed S, Smith K, Townsend HGG, van der Meulen K, Whalley M, Wilson WD: Report of the Equine Herpesvirus-1 Havermeyer Workshop, San Gimignano, Tuscany, June 2004. Vet Immunol Immunopathol, 111: 3-13, 2006.

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40. Soboll G, Hussey SB, Whalley JM, Allen GP, Koen GT, Santucci N, Fraser DG, Macklin MD, Swain WF, Lunn DP: Antibody and cellular immune responses following DNA vaccination and EHV-1 infection in horses. Vet Immunol Immunopathol, 111: 81-95, 2006.

41. Coombs DK, Patton T, Kohler AK, Soboll G, Breathnach CC, Townsend HGG, Lunn DP: Cytokine responses to EHV-1 infection in immune and non-immune ponies. Vet Immunol Immunopathol, 111: 109-116, 2006.

42. Black SJ, Lunn DP, Yin C, Hwang M, Lenz SD, Belknap JK: Leukocyte emigration in the early stages of laminitis. Vet Immunol Immunopathol, 109: 161-166, 2006.

43. Breathnach CC, Soboll G, Suresh M, Lunn DP: Equine herpesvirus-1 infection induces IFN-g production by equine T lymphocyte subsets. Vet Immunol Immunopathol, 103; 207-215, 2005

44. Breathnach CC, Rudersdorf R, Lunn DP: Use of recombinant modified vaccinia Ankara viral vectors for equine influenza vaccination. Vet Immunol Immunopathol, 98: 127-136, 2004.

45. Holznagel DL, Hussey S, Mihalyi JE, Wilson WD, Lunn DP: Onset of immunoglobulin production in foals. Equine Veterinary Journal, 35: 620-622, 2003.

46. Soboll G, Whalley JM, Koen GT, Allen GP, Fraser DG, Macklin MD, Swain WF, Lunn DP: Identification of equine herpesvirus-1 antigens recognized by cytotoxic T-lymphocytes. J Gen Virol, 84:2625–2634, 2003.

47. Soboll G, Horohov DW, Aldridge BM, Olsen CW, McGregor MW, Drape R, Macklin MD, Swain WF, Lunn DP: Regional antibody and cellular immune responses to equine influenza virus infection and DNA vaccination. Vet Immunol Immunopathol, 94: 47–62, 2003.

48. Soboll G, Nelson KM, Leuthner ES, Clark RJ, Drape R, Macklin MD, Swain WF, Olsen CW, Lunn DP: Mucosal co-administration of cholera toxin and influenza virus hemagglutinin-DNA in ponies generates a local IgA response. Vaccine 21: 3081–3092, 2003.

49. Marti E, Horohov DW, Antzak DF, Lazary S, Lunn DP: Advances in equine immunology: Havemeyer workshop reports from Santa Fe, New Mexico, and Hortobagy, Hungary. Vet Immunol Immunopathol, 91: 233-243, 2003.

50. Lalko CC, Deppe E, Ulatowski D, Lugen A, Hart AP, Patton EA, Lunn DP, Suresh M, Darien BJ: Equine platelet P-selecting expression: a phenotypic and morphologic study. Vet Immunol Immunopathol, 91: 119-134, 2003.

51. McClure JT, DeLuca JL, Lunn DP, Miller J: Evaluation of IgG Concentration and Function in Foals with Complete or Partial Failure of Passive Transfer after Administration of Intravenous Serum of Plasma. Equine Veterinary Journal, 7:681-686, 2001.

52. Chambers TM, Holland RE, Tudor LR, Townsend HGG, Cook A, Bogdan J, Lunn DP, Hussey S, Whitaker-Dowling P, Youngner JS, Sebring RW, Penner SJ, Stiegler GL: A new

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modified-live equine influenza virus vaccine: Stability, restricted spread, and efficacy against heterologous virus challenge. Equine Veterinary Journal, 7: 630-636, 2001.

53. Wilson WD, Mihalyi JE, Hussey S, Lunn DP: Passive transfer of specific immunoglobulin isotype antibodies against tetanus and influenza and their effect on the response of foals to vaccination. Equine Veterinary Journal, 7:644-650, 2001.

54. Lunn DP, Hussey S, Sebring R, Rushlow KE, Radecki SV, Whitaker-Dowling P, Youngner JS, Chambers TM, Holland RE, Horohov DW: Safety, efficacy, and immunogenicity of a modified-live equine influenza virus vaccine in horses after induction of exercise-induced immunosuppression. J Am Vet Med Assoc, 218: 900-906, 2001.

55. McClure JT, Young KM, Fiste M, Sharkey LC, Lunn DP: Immunphenotypic classification of leukemia in three horses. J.Vet.Intern.Med, 15: 144-152, 2001.

56. Lunn DP: Pharyngeal lymphoid tissue: gatekeeper or showstopper? Equine Veterinary Journal, 33: 218-220, 2001.

57. Horohov DW, Lunn DP, Townsend HGG, Wilson D: Equine Vaccination: an ACVIM Consensus Statement. J.Vet.Intern.Med.: 14; 221-222, 2000.

58. Swiderski CE, Soboll G, Lunn DP, Horohov DW: Molecular Cloning, Sequencing, and Expression of Equine Interleukin 6. Vet Immunol Immunopathol 77: 213-220, 2000.

59. Slack JA, Risdahl JM, Valberg S, Murphy MJ, Schram BR, Lunn DP: Effects of corticosteroids on equine IgG sub-isotype responses to vaccination. Am J Vet Res, 61: 1530-1533, 2000.

60. Slukvin II, Lunn DP, Watkins DI, Golos TG: Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey. Proceedings of the National Academy of Sciences, 97: 9104-9109, 2000.

61. Lunn DP, Townsend HGG: Equine Vaccination. Vet Clinics of North America: Equine Practice: Immunology 16: 199-226, 2000.

62. Young K, Lunn DP: Immunodiagnostics. Vet Clinics of North America: Equine Practice: Immunology 16: 79-103, 2000.

63. Lunn DP, Soboll G, Schram BR, Quass J, McGregor MW, Macklin MD, McCabe DE, Swain WF, Olsen CW: Antibody responses to DNA Vaccination of Horses using the influenza virus hemagglutinin gene. Vaccine, 17: 2245-2258, 1999.

64. Kim CA, Parrish JJ, Momont HW, Lunn DP: Characterization of antisperm antibodies in bulls and their effect on In Vitro Fertilization. Biology of Reproduction, 60: 1285-1291, 1999.

65. Aldridge BM, McGuirk SM, Clark RJ, Knapp LA, Watkins DI, Lunn DP: Denaturing Gradient Gel Electrophoresis: a rapid method for differentiating BoLA DRB3 alleles. Animal Genetics, 29: 389-394, 1998.

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66. Nelson KM, Schram BR, McGregor MW, Olsen CW, Lunn DP: Local and Systemic Isotype-Specific Antibody Responses to Equine Influenza Virus Infection versus Conventional Vaccination. Vaccine, 16: 1306-1313, 1998.

67. Kalsow CM, Albrecht TR, Steinberg NP, Lunn DP: Antibody selection for immunohistochemical survey of equine tissues. J Comp Path, 119: 467-472, 1998.

68. Aldridge BM, McGuirk SM, Lunn DP: Effect of Colostral Ingestion on Immunoglobulin-positive Cells in Calves. Vet Immunol Immunopathol, 62, 51-64 1998.

69. Lunn DP, Holmes MA, Antczak DF, N. Agerwal, Baker J, Bendali-Ahcene S, Blanchard-Channell M,. Byrne KM, Cannizzo K, Davis W, Hamilton MJ, Hannant D, Kondo T, Kydd JH, Monier MC, Moore PF, O’Neil T, Schram BR, Sheoran A, Stott JL, Sugiura T, Vagnoni KE: Report of the Second Equine Leucocyte Antigen Workshop, Squaw Valley, California, July 1995. Vet Immunol Immunopathol, 62: 101-143, 1998.

70. Sheoran AS, Lunn DP, Holmes MA :Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization. Vet Immunol Immunopathol, 62: 153-165, 1998.

71. Larsen DL, Dybdahl-Sissoko N, McGregor MW, Drape R, Neumann V, Swain WF, Lunn DP, Olsen CW: Co-administration of DNA encoding interleukin-6 and hemagglutinin confers protection from influenza virus challenge in mice. J Virol, 72: 1704-1708, 1998.

72. Konkle D, Nelson, KM, Lunn DP: Nosocomial transmission of cryptosporidium in a veterinary hospital. J Vet Intern Med 11: 340-343, 1997.

73. Lunn DP, Vagnoni KE, Ginther OJ: The equine immune response to endometrial cups. J Repro Immunol 34: 203-216, 1997.

74. Olsen CW, McGregor MW, Dybdahl-Sissoko N, Schram BR, Nelson KM, Lunn DP, Macklin MD, Swain WF, Hinshaw VS: Immunogenicity and efficacy of baculovirus-expressed and DNA-based equine influenza virus hemagglutinin vaccines in mice. Vaccine 15: 1149-1156, 1997.

75. Vagnoni K, Lunn DP, Ginther OJ: Equine chorionic girdle cells: molecular aspects. ARTA, 9:223-235, 1997.

76. Lunn DP, Schram BR, Vagnoni KE, Schobert CS, Horohov DW, Ginther OJ: Positive selection of EqCD8+ precursors increases equine lymphokine-activated killing. Vet Immunol Immunopathol, 53:1-13 1996.

77. Vagnoni K, Ginther OJ, Lunn DP: Expression of major histocompatibility complex antigen and timing of invasion by equine chorionic girdle cells cultured on Matrigel. Biology of Reproduction, 54:219-223, 1996.

78. Vagnoni KE, Schram BR, Ginther OJ, Lunn DP: Equine chorionic girdle cells are susceptible to lymphokine activated killer cells. Am J Repro Immunol, 36:184-190, 1996.

79. Lunn DP, Holmes MA, Antczak DF: Summary Report of the Second Equine Leucocyte Antigen Workshop. Vet Immunol Immunopathol 54:159-161, 1996.

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80. Lunn DP, McClure JT, Schobert CS, Holmes MA: Abnormal patterns of equine leucocyte differentiation antigen expression in SCID foals suggests the phenotype of normal equine NK cells Immunology 84: 495-499, 1995.

81. Lunn DP, Holmes MA, Schram B, Duffus WPH: Monoclonal antibodies specific for equine IgG sub-isotypes including an antibody which recognizes B lymphocytes. Vet Immunol Immunopathol 47:239-251, 1995.

82. Vagnoni K, Ginther OJ, Lunn DP: The role of metalloproteinase activity in equine chorionic girdle cell invasion. Biology of Reproduction, 53: 800-805, 1995.

83. Lunn DP, Holmes MA, Duffus WPH: Polymorphic expression of an equine T lymphocyte and neutrophil subset marker. Vet Immunol Immunopathol, 42: 83-89, 1994.

84. Holmes MA, Lunn DP: Variation of MHC II expression on canine lymphocytes with age. Tissue Antigens, 43: 179-183, 1994.

85. Kydd J, Antczak DF, Allen WR, Barbis D, Butcher G, Davis W, Duffus WPH, Edington N, Grunig G, Holmes MA, Lunn DP, McCulloch J, O’Brien A, Perryman, LE, Tavernor A, Williamson S, Zhang C: Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, U.K., July 1991. Vet Immunol Immunopathol, 42: 1-60, 1994

86. Grunig G, Barbis DH, Zhang CH, Davis WC, Lunn DP, Antczak DF: Correlation between monoclonal antibody reactivity and expression of CD4 and CD8a genes in the horse Vet Immunol Immunopathol, 42: 61-69, 1994

87. Lunn DP, Holmes MA, Duffus WPH: Equine T lymphocyte MHC II expression: variation with age and subset. Vet Immunol Immunopathol 35: 225-238, 1993.

88. Lunn DP: A comparative review of human and equine leucocyte differentiation antigens. British Veterinary Journal 149: 31-49, 1993.

89. Lunn DP, Cuddon PA, Shaftoe S, Archer RA: Familial occurrence of narcolepsy in Miniature Horses. Equine Veterinary Journal 25: 483-487, 1993.

90. McClure JT, Lunn DP, McGuirk SMM: Combined Immunodeficiency In Three Foals. Equine Veterinary Education 5: 14-18, 1993.

91. Lunn DP, McClure JT: Assessing equine immune function. Equine Veterinary Education 5: 30-32, 1993.

92. Tavernor AS, Deverson EV, Coadwell WJ, Lunn DP, Zhang C, Davis W, Butcher,GW: Molecular cloning of equine CD44 cDNA by a COS cell expression system. Immunogenetics 37:474-477, 1993.

93. Lunn DP, Holmes MA, Duffus WPH: Three monoclonal antibodies identifying antigens on all equine T-lymphocytes, and two mutually exclusive T-lymphocyte subsets. Immunology 74: 251-257, 1991.

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94. Lunn, DP, Holmes MA, Gibson J, Field HJ, Kydd JH, Duffus WPH: Haematological changes and equine lymphocyte subpopulation kinetics during primary infection and attempted re-infection of specific pathogen free foals with EHV-1. Equine Veterinary Journal: Supplement 12, 35-41, 1991.

95. Lunn DP, Butler DG: Idiopathic thrombocytopaenia in a Holstein bull. Canadian Veterinary Journal 32:559-561, 1991.

96. Holmes MA, Lunn DP: A study of bovine and equine immunoglobulin levels in foals fed bovine colostrum. Equine Veterinary Journal 23: 116-119, 1991.

97. O'Brien MA, Holmes MA, Lunn DP, Duffus WPH: Evidence for MHC class-I restricted cytotoxicity in the one-way, primary mixed lymphocyte reaction. Equine Veterinary Journal: Supplement 12, 30-35, 1991.

98. Chong YC, Duffus WPH, Field HJ, Gray D, Awan AR, O'Brien MA, Lunn DP: The raising of colostrum deprived foals; maintenance and assessment of specific pathogen (EHV 1) free status. Equine Veterinary Journal 23:111-116, 1991.

99. Lunn DP, McGuirk SM, Smith DF, MacWilliams PS: Renal net acid and electrolyte excretion in an experimental model of hypochloraemic metabolic alkalosis in sheep. Am J Vet Res 51: 1723-1731, 1990.

100. Smith DF, Lunn DP, Robinson GM, McGuirk SM, Nordheim EV, MacWilliams PS: An experimental model of hypochloraemic metabolic alkalosis caused by diversion of abomasal outflow in sheep. Am J Vet Res 51: 1715-1722, 1990.

101. Hovda LR, McGuirk SM, Lunn DP: Total parenteral nutrition in a neonatal llama. J Am Vet Med Assoc 196: 319-322, 1990.

102. Lunn DP, McGuirk SM: Renal regulation of electrolyte and acid-base balance in ruminants. Vet Clinics of North America: Food Animal Practice 6: 1-28, 1990.

103. Lunn DP, Mayhew IG: Neurological examination of the horse. Equine Veterinary Education 1: 94-101, 1989.

104. Lunn DP: Ataxia in a horse. Equine Veterinary Education 1: 85-88, 1989.

105. Lunn DP, Hinchcliff K: Cerebrospinal fluid eosinophilia and ataxia in five llamas. Vet Rec. 124: 302-305, 1989.

106. Lunn DP, Peel JE: Successful treatment of traumatic oesophageal rupture with severe accompanying cellulitis in a mare. Vet Rec. 116: 544-545, 1985.

Book chapters 1. Lunn DP, McIlwraith W: Equine Health and Disease. In: Equine Welfare, Editors,

McIlwraith W, Rollin B, Blackwell Publishing, Chichester, pages 59-70, 2011.

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2. Goehring L, Lunn DP: Viral respiratory diseases of the older foal. In: Equine Reproduction, 2nd Edition, Editors, McKinnon A, Squires EL, Vaala W, Voss J, Wiley-Blackwell, Chichester, pages 720-727, 2011.

3. Lunn DP, Horohov DW: The Equine Immune System. In: Equine Internal Medicine, 3rd edition, Editors: Reed S, Bayly W, Sellon D; WB Saunders, Philadelphia, pages 2-56, 2009.

4. Landolt G, Lunn DP: Equine respiratory viruses. In: Large Animal Medicine, 6th edition, Editors, Smith B; Elsevier, St. Louis, pages 542-550, 2008.

5. Goehring LS, Lunn DP: Equine herpesvirus myeloencephalopathy. In: Current Therapy in Equine Medicine, 6th edition, Editor Robinson NE; Saunders, St. Louis, pages 177-181, 2008.

6. Landolt G, Townsend HGG, Lunn DP: Equine Influenza Virus. In: Equine Infectious Diseases, 1st edition, Editors, Sellon D, Long M; Elsevier, Philadelphia, page 124-133, 2007.

7. Lunn DP, Soboll G, Breathnach CC: Immunology and Immunopathology. In: Equine Respiratory Disorders, 1st edition, Editors, McGorum B, Robinson E, Dixon P, Schumacher J; Elsevier, Philadelphia, pages 71-82, 2006.

8. Lunn DP, Horohov DW: Editors of Vet Clinics of North America: Equine Practice: Immunology Volume16, 2000.

9. Lunn DP, McClure JT: Immunological principles of equine vaccination. In: Equine Medicine and Surgery, 5th edition, Editor: Moore J, Mayhew I, Mosby Inc., St. Louis, pp 183-190, 1999.

10. McClure JT, Lunn DP: Practical applications of equine vaccination. In: Equine Medicine and Surgery, 5th edition, Editor: Moore J, Mayhew I, Mosby Inc., St. Louis, pp 191-195, 1999.

11. Lunn DP, Horohov DW, Hannant, D: Immunology of Horses and Donkeys. In: A Handbook of Vertebrate Immunology. Editors: P.-P. Pastoret, H Bazin, P Griebel, A Govaerts. Academic Press, London. pp. 343-372, 1998.

12. Lunn DP, Olsen CW, Soboll G, McGregor MW, Macklin MD, McCabe DE, Swain WF,: Development of practical DNA vaccination strategies for use in horses. In: Equine Infectious Diseases VIII. Wernery U, Wade JA, Mumford JA, Kaaden O-R eds. R&W Publications, Newmarket. 1999; 38-43.

13. Lunn DP: Preventative immunology. Proceedings of the 1997 Dubai International Equine Symposium: The diagnosis and treatment of respiratory disease. Editors: NW Rantanen, ML Hauser. Neyenesch Printers Inc. pp. 89-106 1997.

14. Lunn DP, Schram B, Vagnoni K, Schobert CS, Truax R, Horohov DW: Receptor interactions in equine lymphokine-activated killing. Equine Infectious Diseases VII;

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Proceedings. Eds H. Nakajima, W. Plowright. R & W Publications, Newmarket. pp.133-138, 1995.

15. Lunn DP, Duffus WPH: Equine T lymphocytes. Sixth International Equine Infectious Disease Conference Proceedings, Eds W. Plowright, P.D. Rossdale, JF Wade. R & W Publications, Newmarket. pp.113 - 120, 1992.

16. McGuirk SM, Shaftoe S, Lunn DP: Cardiovascular Diseases. In: Smith BP (Ed), Large Animal Internal Medicine. 1st edition. Pennsylvania: CV Mosby Co. pp. 454-488, 1990.

Abstract presentations and publications Oral presentations 1. Aklilu N, Stringer, A, Lunn DP: Infectious Diseases of Working Equids: Havemeyer

Workshop Report. Annual Medical Forum ACVIM, Nashville, June, 2014. 2. G Soboll Hussey, SB Hussey, DW Gardiner, DP Lunn, K Osterrieder, Y-W Chiang, P

McCue, F Del Piero. Development of an in vivo Equine herpesvirus-1 abortion model. Invited Platform Presentation at the 34’th ASRI meeting, Long Island, NY June 2014.

3. G Soboll Hussey, DP Lunn, LK Maxwell, EJ Ehrhart. Choroidal vasculitis during experimental and naturally occurring EHV-1 infection in horses. LS Goehring, ACVIM Forum, Nashville, TN June 2014.

4. Soboll Hussey G, Ashton LV, Hussey SB, Horohov, DW, Lunn DP, Kiupel M, Kydd JH. Determination of in vivo cell-mediated immune responses to Equine herpesvirus 1 ORF64 (IE) peptides in MHC class I A3.1-positive ponies for generation of tetramers. Conference of Research Workers in Animal Diseases, Chicago, December 2013.

5. Soboll Hussey G, Ashton LV, Quintana AM, Landolt GM , Lunn DP, Van de Walle G, Osterrieder N, Annis K. Equine herpesvirus-1 ORF1 modulates airway epithelial responses. Veterinary satellite workshop of the 83th annual International Herpesvirus Workshop, Grand Rapids, MI, July 2013.

6. Soboll Hussey G, Goehring L, Lunn DP, Hussey S, Osterrieder N, Powell C, Hand J, Slater J. Development of an equine ocular endothelial cell model to study equine herpesvirus myelitis (EHM). Conference of Research Workers in Animal Diseases, Chicago, December 2012.

7. Goehring LS, Brandes K, Wittenburg L, Olea-Popelka F, Lunn DP, Soboll Hussey G: Anti-inflammatory drugs will decrease infection of endothelial cells with EHV-1. 9th International Conference on Equine Infectious Diseases, Lexington, October, 2012.

8. Soboll Hussey G, Lunn DP, Hussey SB, Broccardo C, Broeckling C, Prenni J, Ashton LV, Goehring LS: Use of CSF biomarkers as a model to study EHM. 9th International Conference on Equine Infectious Diseases, Lexington, October, 2012

9. Soboll Hussey G, Van de Walle G, Ashton LV, Quintana AM, Osterrieder N, Lunn DP: Modulation of MHC I & II and cytokine expression by EHV-1 ORF 1/2 at the respiratory epithelium. Conference of Research Workers in Animal Diseases, Chicago, December 2011.

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10. Lunn DP, Sellers AD, Goehring LS, Townsend HGG, Hussey SB, Tuttle J, Stenbom RM: Protection against EHV-1 challenge by inactivated vaccines. Annual Meeting of the American Association of Equine Practitioners, San Antonio, November 2011.

11. Sellers, A, Landolt G, Townsend HGG, Tuttle J, Stenbom RM, Lunn DP: Protection from contemporary equine influenza virus by commercial vaccines. Annual Medical Forum ACVIM, Denver, 2011

12. McConnico RS, Lunn DP: Review of controversial issues (nomenclature, case definition, diagnostic testing, and management practices) in equine herpes myelitis (EHM). Annual Meeting of the American Association of Equine Practitioners, Baltimore, December 2010.

13. Quintana AM, Landolt GA, Lunn DP, Annis KM, Soboll Hussey G. Immune responses of equine respiratory epithelial cells to equine herpesvirus-1. Conference of Research Workers in Animal Diseases, Chicago, December 2010

14. Burgess BA, Tokateloff N, Poirier K, Manning S, Lohmann K, Lunn DP, Hussey S, Morley PS. Nasal Shedding of Equine Herpesvirus-1 from Horses in an Outbreak of Equine Herpes Myeloencephalopathy in Western Canada. Proceedings of the 91st Annual Meeting of the Conference of Research Workers in Animal Disease, Chicago, 2010.

15. Lunn DP, Osterrieder K, Goehring LS, Gardiner D, Chiang Y-W: EHV-1 abortion models: quantitation of virus loads in fetal and placental tissues and foals, and strain impact on model. Annual Medical Forum ACVIM, Montreal, June, 2009.

16. Wilsterman S, Ashton L, Callan RC, Lunn DP, Rao S, Goehring LS: EHV-1 positive PBMC fractions during cell-associated viremia following experimental infection. Annual Medical Forum ACVIM, Montreal, June, 2009.

17. Soboll G, Wager B, Horohov DW, Van der Walle G, Osterrieder N, Lunn DP: Evaluation of early cytokine responses following infection of ponies with EHV-1. Conference of Research Workers on Animal Disease, Chicago, Il, December 2008.

18. Lunn DP, ChiangY-W: Experiences with an EHV-1 abortion/neurological disease model. 2nd Havemeyer Foundation Workshop on EHV-1. Steamboat, Co, September, 2008.

19. Soboll G, Case R, MacRae S, Lunn DP, Kydd JH: Identifying CTL epitopes of EHV-1 ORF64 (IE gene) for generation of tetramers with the MHC class I B2 allele: a progress report. 2nd Havemeyer Foundation Workshop on EHV-1. Steamboat, Co, September, 2008.

20. Goehring LS, Hussey SB, Rao S, Bigbie R, Lunn DP: Control of EHV-1 viremia and nasal shedding by current commercial vaccines. Annual Medical Forum ACVIM, San Antonio, June, 2008.

21. Durando MM, Birks EK, Reef VB, Hussey SB, Lunn DP: Cardiac Troponin I Concentrations in Ponies Challenged with Influenza Virus. Annual Medical Forum ACVIM, San Antonio, June, 2008.

22. Soboll G, Breathnach CC, Kydd J, Hussey SB, Mealey R, Lunn DP: Vaccination of ponies with a recombinant modified live vaccinia ancara vector containing the IE gene of EHV-1 (rMVA-IE) protects from viremia. Conference of Research Workers on Animal Disease, Chicago, Il, December 2007.

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23. Gregg A, Schenkel A, Lunn DP: The role of immunological receptors in endothelial cell interactions with haematopoietic cells. 1st International Laminitis Workshop convened by the Dorothy Russell Havemeyer Foundation, Myrtle Beach, South Carolina, May, 2007.

24. Lunn DP, Hussey S, Horohov DW: Immunoregulatory responses to corticosteroids and immune stimulants in ponies. 3rd International Workshop on Allergic Diseases of the Horse, convened by the Dorothy Russell Havemeyer Foundation, Holar, Iceland, June, 2007.

25. Yactor-Carlson JK, Lunn DP, Chiang Y-W, Kramer RJ, Dillion S, Landolt GA: Development of a real-time PCR assay for detection and quantification of equine influenza virus. Conference of Research Workers on Animal Disease, Chicago, Il, December 2006.

26. Yactor-Carlson JK, Lunn KF, Traub-Dargatz J, Morley PS, Barnett DC, Lunn DP: Development of a duplex real time PCR assay for equine herpesvirus-1 and 4 and its application to a surveillance study. Conference of Research Workers in Animal Disease. Chicago, Il. December 2006.

27. Yactor JK, Lunn KF, Traub-Dargatz JL, Morley PS, Barnett CD, Kohler AK, Kasper KS, Kivi AJ, Lunn DP. Detection of Nasal Shedding of EHV-1 & 4 at Equine Show Events and Sales by Multiplex Real-Time PCR. 52nd Annual American Association of Equine Practitioners Convention. San Antonio, Texas. December 2-6, 2006.

28. Lunn DP, Landolt G, Lunn KF, Hussey SB: Real-time PCR diagnosis of equine viral respiratory disease. 3rd World Equine Airway Symposium, Cornell University, July, 2005.

29. Lunn DP, Coombs D, Soboll G, Breathnach CC: Immunoregulatory basis of immunity to EHV-1 respiratory disease. 3rd World Equine Airway Symposiuim, Cornell University, July, 2005.

30. Soboll G, Hussey SB, Whalley JM, Allen GP, Fraser DG, Swain WF, Lunn DP: Antibody and cellular immune responses to DNA vaccination and EHV-1 infection of horses. Conference of Research Workers in Animal Diseases, Chicago, November, 2004.

31. Bielec P, Breathnach CC, Soboll G, Frasier DG, Lunn DP. Isoelectric focusing of equine MHC I proteins. MHC Workshop, International Veterinary Immunology Symposium, Quebec City, Canada, August, 2004.

32. Soboll G, Whalley JM, Koen MMT, Allen GP, Fraser DG, MacKlin MD, Swain WF, Lunn DP: EHV-1 antigen specificity of cytotoxic T-lymphocytes. Dorothy L. Havemeyer Foundation Workshop on EHV-1. San Gimignano, Tuscany, Italy, June, 2004.

33. Soboll G, Hussey SB, Whalley JM, Allen GP, Koen MMT, Santucci N, Fraser DG, MacKlin MD, Swain WF, Lunn DP: Cytotoxic T-lymphocyte responses to DNA vaccination. Dorothy L. Havemeyer Foundation Workshop on EHV-1. San Gimignano, Tuscany, Italy, June, 2004.

34. Holmes MA, Townsend HGG, Hussey S, Breathnach C, Barnett C, Holland R, Lunn DP: Immune responses to commercial equine vaccines. American Association of Equine Practitioners, New Orleans, November, 2003.

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35. Coombs DK, Patton T, Soboll G, Breathnach C, Horohov DW, Lunn DP: Quantification of IL-4 and IFNg mRNA production by peripheral blood mononuclear cells from ponies infected with EHV-1. Conference of Research Workers in Animal Diseases, Chicago, November, 2003.

36. Breathnach CC, Clark HJ, Clark R, Olsen CW, Macklin M, Swain WF, Lunn DP. Immunization with recombinant modified vaccinia Ankara (rMVA) constructs protects ponies from equine influenza virus challenge. Conference of Research Workers in Animal Diseases, Chicago, November, 2003.

37. Breathnach CC, Lunn DP: Equine herpesvirus-1 infection induces production of IFN-g by circulating T lymphocyte subsets in ponies. Conference of Research Workers in Animal Diseases, Chicago, November, 2003.

38. Lunn DP, Soboll G, Breathnach C: Immunization against equine herpesvirus-1. Third International Veterinary Vaccines and Diagnostics Conference,University of Guelph, Ontario, July, 2003.

39. Soboll G, Whalley JM, Allen GP, Lunn DP: Identification of Equine herpesvirus-1 antigens that induce cytotoxic T-cell responses. Conference of Research Workers in Animal Diseases, St. Louis, November, 2002. (1st place prize winner in American Association of Veterinary Immunologists graduate student competition).

40. Lunn DP: Pediatric immunity. Symposium on Orthopaedic Infection in the Horse - Dorothy L. Havemeyer Foundation Workshop. County Kildare, Ireland, August, 2002.

41. DeLuca JL, McClure JT, Lunn DP, Miller J: Evaluation of IgG Concentration and Function in Foals with Complete or Partial Failure of Passive Transfer after Administration of Intravenous Serum of Plasma. American Association of Equine Practitioners, San Diego, November, 2001.

42. Patton EA, Soboll G, Coombs D, Lunn DP: Evaluation of T cell proliferatifve responses following EHV-1 infection. Conference of Research Workers in Animal Diseases, St. Louis, November, 2001.

43. Lunn DP: Equine-specific monoclonal antibodies. Second International Symposium on Allergic Diseases of the Horse - Dorothy L. Havemeyer Foundation Workshop. Hortobagy-Mata, Hungary, April 2001.

44. Lunn DP: Therapeutic potential of genetic vaccination in equine hypersensitivity. Second International Symposium on Allergic Diseases of the Horse - Dorothy L. Havemeyer Foundation Workshop. Hortobagy-Mata, Hungary, April 2001.

45. Lunn DP: Monoclonal antibodies: what’s next?. Equine immunology in 2001 - Dorothy L. Havemeyer Foundation Workshop. Santa Fe, New Mexico, January 2001.

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46. Soboll G, Lunn DP: Regualtion of mucosal immune responses. Equine immunology in 2001 - Dorothy L. Havemeyer Foundation Workshop. Santa Fe, New Mexico, January 2001.

47. Soboll G, Leuthner ES, Clark RJ, Drape R, Macklin MD, Swain WF, Olsen CW, Lunn DP: Mucosal co-administration of cholera toxin and DNA vaccination in horses generates a local IgA response. Conference of Research Workers in Animal Diseases, Chicago, November, 2000. (2nd place prize winner in American Association of Veterinary Immunologists graduate student competition).

48. Soboll G, Swiderski CE, Larsen D, McGregor MW, Drape RJ, Macklin MD, Swain WF, Horohov DW, Olsen CW, Lunn DP: Mechanisms of protective immunity against equine influenza virus infection following DNA vaccination or infection in the horse. 17th Annual Medical Forum ACVIM, Chicago 1999.

49. Leuthner ES, Soboll G, Horohov DW, Lunn DP: Characterization of DNA vaccine-generated monoclonal antibodies recognizing equine interleukin 2. 17th Annual Medical Forum ACVIM, Chicago 1999.

50. Lunn DP, Hussey S, Sebring R, Rushlow KE, Radecki SV, Whitaker-Dowling P, Youngner JS, Chambers TM, Holland RE, Horohov DW: A potent modified-live equine influenza vaccine: safe even after exercise-induced immunosuppression" American Association of Equine Practitioners, Aluburquerque, December 1999.

51. Aldridge BM, Lunn DP, Clark RC, Watkins DI, McGuirk SM: Maternal immune cells are transferred to the newborn calf. 17th Annual Medical Forum ACVIM, Chicago 1999.

52. Soboll G., Swiderski CE, Larsen D, McGregor M, Drape RJ, Macklin M, Swain W, Horohov DW, Olsen CW, Lunn DP: Use of an equine IL6 plasmid as an adjuvant in DNA Influenza vaccination of Horses. 5th International Veterinary Immunology Symposium, Ludhiana, India, November, 1998.

53. Aldridge BM, Lunn DP, Clark RC, Watkins DI, McGuirk SM: Transfer of maternal immune cells to the newborn calf. Conference of Research Workers in Animal Diseases, Chicago, November, 1998. (1st place prize winner in American Association of Veterinary Immunologists graduate student competition).

54. Clark R, McGuirk SM, Lunn DP, Crabb J, Widmer G, Drape R, Swain W, Olsen CW: DNA vaccination against Cryptosporidium parvum in mice and cattle. Conference of Research Workers in Animal Diseases, Chicago, November, 1998.

55. Soboll G, Swiderski CE, Horohov DW, McGregor M, Larsen D, Olsen CW, Lunn DP: Development of an equine IL-6 Plasmid for use as an adjuvant in DNA vaccination. 16th Annual Medical Forum American College of Internal Medicine, San Diego, California, May, 1998.

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56. Lunn DP: Available monoclonal antibodies to equine immunoglobulins: Equine allergic disease - Dorothy L. Havemeyer Foundation Workshop. Lippica, Slovenia, March 1998.

57. Lunn DP, Olsen CW, Soboll G, McGregor MW, Macklin MD, McCabe DE, Swain WF: Development of Practical DNA Vaccination Strategies for use in Horses. Equine Infectious Diseases VIII, Dubai, United Arab Emirates, March 1998.

58. Lunn DP, Soboll G, Swiderski C, Horohov DW, Olsen CW: Equine cytokine expressing plamids: applications as DNA vaccine adjuvants and for generation of anti-cytokine monoclonal antibodies Equine Infectious Diseases VIII, Dubai, United Arab Emirates, March 1998.

59. Slack JA, Risdahl J, Valberg S, Murphy M, Schram BR, Lunn DP: Effects of corticosteroids on equine immune responses to vaccination. Conference of Research Workers in Animal Diseases, Chicago, November, 1997. (2nd place prize winner in American Association of Veterinary Immunologists graduate student competition).

60. Soboll G, Schram BR, McGregor MW, Macklin MD, McCabe DE, Swain WF, Olsen CW, Lunn DP: Equine antibody isotype responses resulting from Accel™ Gene Gun immunization with the influenza virus hemagglutinin gene. Conference of Research Workers in Animal Diseases, Chicago, November, 1997.

61. Aldridge BM, Lunn DP, Clark RJ, Crabb JH, McGuirk SM: Clinical and immunologic responses to C.parvum challenge in calves receiving colostrum from C. Parvum vaccinated cows. Conference of Research Workers in Animal Diseases, Chicago, November, 1997.

62. Lunn DP, Olsen CW, Quass J, Schram BR, McGregor MW, Macklin MD, McCabe DE, Swain WF, Hinshaw VS: Accell® Gene Gun Administration of the Influenza Virus Hemagglutinin Gene Protects Horses from Challenge Infection. Conference of Research Workers in Animal Diseases, Chicago, November, 1996.

63. Kim CA, Parrish JJ, Momont HW, Lunn DP: Effect of bovine antisperm antibodies on in vitro fertilization. Conference of Research Workers in Animal Diseases, Chicago, November, 1996.

64. Aldridge BM, Knapp LA, McGuirk SM, Clark RJ, Watkins DI, Lunn DP: Denaturing gradient gel electrophoresis: a rapid method for differentiating bovine class II MHC alleles. Conference of Research Workers in Animal Diseases, Chicago, November, 1996. (2nd place prize winner in American Association of Veterinary Immunologists graduate student competition)

65. Larsen DL, Dybdahl-Sissoko N, McGregor MW, Lunn DP, Drape B, Neumann V, Swain WF, Olsen CW: Accell® Gene Gun Administration of the Hemagglutinin Gene of Influenza Virus with Interleukin 6 as a Cytokine Adjuvant. Conference of Research Workers in Animal Diseases, Chicago, November, 1996.

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66. Schram BR, Holmes MA, Lunn DP: Characterization of an Equine Homologue of the Myeloid Differentiation Antigen CD13. Conference of Research Workers in Animal Diseases, Chicago, November, 1996.

67. Aboellail TA, Hegazy AA, Fahmy LS, Hurley DJ, Lunn D, Sellon DC, Chase CCL: Characterization Of Leukocytes Of Dromedary Camel. Conference of Research Workers in Animal Diseases, Chicago, November, 1996.

68. Olsen CW, Dybdahl-Sissoko N, McGregor MW, Hinshaw VS, Schram BR, Lunn DP, Drape B, Neumann V, Macklin MD, Swain WF,: Accell® Gene Gun Administration of the Hemagglutinin Gene of A/Equine/Kentucky/1/81 protects mice against Homologous Influenza Virus Challenge Infection. American Society for Virology, Western Ontario, July, 1996.

69. Nelson K, Olsen CW, Schram BR, McGregor MW, Hinshaw VS, Lunn DP: Antibody isotype responses to cholera toxin or cholera toxin B subunit as mucosal adjuvants in horses. Conference of Research Workers in Animal Diseases, Chicago, November, 1995.

70. Aldridge BA, McGuirk SM, Lunn DP: Comparison of immunoglobulin positive cells in the mesenteric lymph nodes of colostrum fed and colostrum deprived calves. Conference of Research Workers in Animal Diseases, Chicago, November, 1995.

71. Nelson K, Olsen CW, Schram BR, McGregor MW, Hinshaw VS, Lunn DP: Local and circulating antibody isotype responses to equine influenza virus infection or vaccination. Second Equine Leucocyte Antigen Workshop, Davis, July, 1995.

72. Lunn DP, Holmes MA, Antczak DF: Summary of the second equine leucocyte antigen workshop. Fourth International Veterinary Immunology Symposium, Davis, July, 1995.

73. Lunn DP, Schram B, Vagnoni K, Schobert CS, Truax R, Horohov DW: Receptor interactions in equine lymphokine-activated killing. Seventh International Equine Infectious Disease Conference Tokyo, July, 1994.

74. Lunn DP: Quantitation of functional immunity in the equine respiratory tract. Seventh International Equine Infectious Disease Conference Tokyo, July, 1994.

75. Vagnoni KE, Ginther OJ, Lunn DP: Role of proteinases in equine chorionic girdle cell migration. Proceedings: Conference of Research Workers in Animal Diseases, Chicago, November, 1994.

76. Vagnoni KE, Schram BR, Ginther OJ, Lunn DP: Equine cultured endometrial cup cells are susceptible to Lymphokine Activated Killer cells. American Society of Animal Science Conference, Minneapolis, July, 1994.

77. Lunn DP, Schobert CS, Truax R, Horohov DW:Equine lymphokine-activated killing is restricted to EqCD8+ lymphocytes. Proceedings: Conference of Research Workers in Animal Diseases, Chicago, November, 1993.

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78. Lunn DP, McClure JT, Schobert CS, Holmes MA: Equine lymphocyte differentation antigen expression in SCID foals. Wellcome Trust Meeting: Immunological reagents for the study of disease in companion animals. London, November, 1993.

79. Lunn DP, Holmes MA: The ontogeny of lymphocyte differentiation antigens in foals: putative identification of naive and memory lymphocytes. Disturbances in equine foetal maturation: comparative aspects - Havemeyer Foundation Workshop. Naples, Florida, January 1992.

80. Lunn DP, Holmes MA, Duffus, WPH: Monoclonal antibodies recognising equine homologues of CD5, CD4 and CD8. 8th Annual Medical Forum ACVIM, New Orleans1991.

81. Allen WR, Kydd JH, Mathias S, Lunn DP, Holmes MA, Zhang C, Grunig G, Antczak DF: The maternal cell mediated response to equine endometrial cups: temporal changes in the expression of EqCD4, EqCD5 and EqCD8 markers on the invading lymphocytes during early gestation. 4th Meeting of the European Placentation Society/Rochester Trophoblast Conference, Guatt, Switzerland. December 1991.

82. Lunn DP, McGuirk SM, Smith DF: Renal electrolyte and net acid excretion in metabolic alkalosis in sheep. 5th Annual Medical Forum ACVIM Proceedings, 1987.

Poster presentations

1. Goehring LS, Soboll Hussey G, Hussey SB, Lunn DP: D-dimer concentrations and (experimental) EHV-1 infection. Annual Medical Forum ACVIM, Denver, 2011.

2. Pusterla N, Hussey SB, Mapes SM, Johnson C, Collier J, Hill J, Lunn DP, Wilson WD: Molecular investigation of the viral kinetics of equine Herpesvirus-1 in blood and nasal secretions of horses following corticosteroid induced recrudescence of latent infection. Annual Medical Forum ACVIM, Anaheim, 2010.

3. Burgess BA, Tokateloff N, Poirier K, Manning S, Lohmann K, Lunn DP, Hussey SB, Morley PS: Nasal shedding of equine herpesvirus-1 from horses in an outbreak of equine herpes myeloencephalopathy in Western Canada. Annual Medical Forum ACVIM, Anaheim, 2010.

4. Little MG, Townsend HGG, Little JP, Stenbom RM, Hussey SB, Lunn DP: Equine serological responses to commercial vaccines. Annual Medical Forum ACVIM, Anaheim, 2010.

5. Soboll G, Case R, MacRae R, Lunn DP, Kydd JH: Identifying CTL epitopes of EHV-1 ORF64 (IE gene) for generation of tetramers with the MHC class I A3/B2 allele: a progress report. USDA Progress report at: Conference of Research Workers in Animal Diseases, Chicago, December, 2008.

6. Hussey SB, Clark R, Lunn KF, Breathnach CC, Soboll G, Whalley JM, Lunn DP. EHV-1 viremia and nasal shedding detection and quantification by real-time PCR. Conference of Research Workers in Animal Diseases, Chicago, November, 2004.

7. Slack JA, Hussey S, Soboll G, Breathnach C, Hartmann FA, Tinge SA, Timoney JF, Lunn DP: Equine influenza virus DNA vaccination using attenuated Salmonella typhimurium for

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delivery. Third International Veterinary Vaccines and Diagnostics Conference,University of Guelph, Ontario, July, 2003.

8. Holmes MA, Townsend HGG, Hussey S, Barnett C, Holland R, Lunn DP: Serological and cellular responses to commercial inactivated equine vaccines . Third International Veterinary Vaccines and Diagnostics Conference,University of Guelph, Ontario, July, 2003.

9. Breathnach CC, Rudersdorf R, Macklin M, Moss B, Lunn DP: Preliminary investigation of a DNA prime – modified vaccinia Ankara (MVA) boost influenza vaccination regimen in horses Third International Veterinary Vaccines and Diagnostics Conference, University of Guelph, Ontario, July, 2003.

10. Lunn DP, Hussey S, Holznagel D, Mihalyi JE, Wilson WD: The onset of antibody proeduction in foals. Third Workshop on Rhodococcus equi and equine rhodococcal pneumonia - Dorothy L. Havemeyer Foundation Workshop. Washington State University, Pullman, Washington, July, 2002.

11. Lindsay W, Boleslawski M, Hussey S, Lunn DP: Elephant antibody response to tetanus vaccination. Conference of Research Workers in Animal Diseases, St. Louis, November, 2001.

12. Soboll G, Horohov DW, Folsom R, Macklin M, Swain W, Olsen CW, Lunn DP: Regulation of the equine immune response to influenza virus infection and vaccination. 6th International Veterinary Immunology Symposium, Uppsala, Sweden, 2001.

13. McClure JT, Fiste M, Sharkey L, Young KM, Lunn DP: Immunophenotype of leukemia in 3 horses. 17th Annual Medical Forum ACVIM, Chicago 1999.

14. Leuthner ES, Soboll G, Horohov DW, Lunn DP: DNA vaccination for production of monoclonal antibodies recognizing equine cytokines, Nucleic Acid Mediated Vaccines in Veterinary Medicine, Ames, Iowa, September, 1998.

15. Leuthner ES, Soboll G, Horohov DW, Lunn DP: DNA vaccination for production of monoclonal antibodies to equine IL-2, Conference of Research Workers in Animal Disease, Chicago, November, 1998.

16. Aldridge BM, Lunn DP, Clark RC, Watkins DI, McGuirk SM: Are maternal cells a component of the newborn calf immune system? 5th International Veterinary Immunology Symposium, Ludhiana, India, November, 1998.

17. Vagnoni KE, Ginther OJ, Lunn DP: Characteristics of equine chorionic girdle cell invasion. Society for Studies in Reproduction, Davis, July 1995.

18. Nelson K, Olsen CW, Schram BR, McGregor MW, Hinshaw VS, Lunn DP: Antibody isotypes and protection induced by equine influenza virus infection versus vaccination. Fourth International Veterinary Immunology Symposium, Davis, July, 1995.

19. Lunn DP, McClure JT, Schobert CS, Holmes MA: Abnormal equine leucocyte differentation antigen expression in SCID foals. British Equine Veterinary Association Congress Proceedings, September, 1993.

20. Lunn DP, Duffus WPH, Holmes MA: Production and characterisation of a panel of monoclonal antibodies recognising equine lymphocyte subsets. Sixth International Equine

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Infectious Disease Conference Proceedings, Eds W. Plowright, P.D. Rossdale, JF Wade. R & W Publications, Newmarket. pp.322, 1992.

21. Lunn DP, Holmes MA, Kydd JH, Gibson JS, Field HJ: Haematological and lymphocyte subset changes during primary EHV-1 infection in specific pathogen free foals. Sixth International Equine Infectious Disease Conference Proceedings, Eds W. Plowright, P.D. Rossdale, JF Wade. R & W Publications, Newmarket. pp.321, 1992.

22. Holmes MA, Lunn DP: A survey of equine umbilical cord blood lymphocyte cell surfaqce phenotypes. Disturbances in equine foetal maturation: comparative aspects - Dorothy L. Havemeyer Foundation Workshop. Naples, Florida, January 1992.

23. Lunn DP, Duffus WPH, Holmes, MA. Monoclonal antibodies specific for equine immunoglobulin (a, b & c). Second International Society of Veterinary Perinatology conference Proceedings, July 1990.

24. Lunn DP, Holmes MA, Y-Chung C, Duffus WPH. Measurement of equine immunoglobulin G in foals fed only bovine colostrum. British Equine Veterinary Association Congress Proceedings, September 1990.

25. Holmes, MA, Lunn DP, Y.-Chung, C and Duffus, WPH. Absorption of bovine colostral immunoglobulin G1 in newborn foals. Second International Society of Veterinary Perinatology Conference Proceedings, July 1990

26. Hovda LR, McGuirk SM, Lunn DP: Total parentral nutrition in a neonatal llama. First International Veterinary Perinatology Conference Proceedings, December 1987.

Invited Presentations 1. “ Havemeyer Highlights: Focus on EHV-1 Workshop” Annual Medical Forum ACVIM,

New Orleans, 2012. 2. “Equine influenza virus: an evolving pathogen and evolving immunity”. Visiting Professor

Presentation, Faculty of Veterinary Science, Debre Zeit, University of Addis Ababa, Ethiopia, December, 2011.

3. “Herpes vaccines, lessons from the horse's mouth”. Invited presentation to Pfizer Animal Health at inaugaration of their new equine infectious disease facility, Kalamazoo, MI, October, 2011.

4. “New Models for studying EHV-1 and lessons learnt” Visiting Professor Presentation, Department of Veterinary Science (Maxwell E. Gluck Equine Research Center), University of Kentucky, Lexington, also produced as a webinar, June, 2011

5. “Faculty Evaluation Using an Electronic Reporting System and a Senior Faculty Committee.” Program presentation to the Annual Dept. Head, VTH Director meeting of the American Association of Veterinary Clinicians. Atlanta, March, 2011.

6. “Immunity to Histoplasma capsulatum farciminosum and vaccination”, A one hour presentation at the Epizootic Lymphangitis Workshop, Faculty of Veterinary Science, Debre Zeit, University of Addis Ababa, Ethiopia, February, 2010.

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7. “Equine Immunology: critical clinical applications”, The one hour Sir Frederick Smith Lecture at the British Equine Veterinary Association Annual Meeting, Birmingham, UK, September 2009. Plenary address.

8. “New diseases, new vaccines, old challenges” A 30 minute presentation at the International Veterinary Vaccines and Diagnostics Conference, Madison, Wisconsin, July 2009.

9. “International movement of horses and the risk of emerging disease.” At the European meeting on New Developments in Equine Viral Disease. Hosted by Merial, Lyon, France, September, 2008.

10. “Molecular innovations in equine vaccination.” Visiting Scientist lecture, Free University, Berlin, July, 2008.

11. “EHV-1 CTL detection and viremia” Visiting Scientist lecture, College of Veterinary Medicine, University of Califoria, Davis, January, 2008.

12. “ACVIM Consensus Statement: EHV-1” 25th Annual Veterinary Medical Forum of the American College of Veterinary Internal Medicine, Seatle, June 2007.

13. “State of the art: Pathogenesis and control of EHV-1 infections” Annual meeting of the British Equine Veterinary Association, Edinburgh, Scotland, September, 2007.

14. “Future Vaccination Technologies” Annual meeting of the British Equine Veterinary Association, Edinburgh, Scotland, September, 2007.

15. “Prospects for EHV-1 prophylaxis” 23rd Annual Veterinary Medical Forum of the American College of Veterinary Internal Medicine, Louisville, June 2006.

16. “EHV-1 update”. Annual meeting of the British Equine Veterinary Association, Harrogate, Great Britain, September, 2005.

17. “Practical assessment of equine immunity”. Annual meeting of the British Equine Veterinary Association, Harrogate, Great Britain, September, 2005.

18. “Immunomodulation: principles and mechanisms.” One hour lecture, 50th Annual Convention, American Association of Equine Practitioners, Denver, Colorado, December, 2004.

19. “Equine influenza virus: pathogenesis, epidemiology and immunity” 21st Annual Veterinary Medical Forum of the American College of Veterinary Internal Medicine, Minneapolois, June 2004.

20. “Equine Immunity to Influenza Virus” One hour lecture, visiting professor, University of California-Davis, May, 2003.

21. “Influenza in horses and humans” Visiting professor lecture, Comparative Biosciences Lecture Series, College of Veterinary Medicine, University of Minnessota, Minneapolis, December, 2003.

22. “Equine Influenza and Rhinopneumonitis, what Protects?” D.L.T. Smith lecture: University of Saskatoon, Canada, October, 2001.

23. “Genetic vaccines for equine respiratory viruses: results and prospects” Visiting Scientist presentation at the Veterinary Infectious Disease Organization, Saskatoon, Canada, October, 2001.

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24. “Inducing an appropriate immune response: prospects for respiratory vaccines” at the Annual meeting of the British Equine Veterinary Association, Birmingham, Great Britain, September, 2001.

25. “Immunomodulators: prospects and realities for therapy” at the Annual meeting of the British Equine Veterinary Association, Birmingham, Great Britain, September, 2001.

26. “Viral infections: pulmonary immune responses and therapeutic modulation” 19th Annual Veterinary Medical Forum of the American College of Veterinary Internal Medicine, Denver, May 2001.

27. “Equine immunity to influenza virus” Visiting Professor Presentation, School of Veterinary Medicine, University of Purdue, March, 2001.

28. “Respiratory viral infection, what does protect?” Visiting Professor Presentation, Department of Veterinary Science (Maxwell E. Gluck Equine Research Center), University of Kentucky, Lexington, February, 2001.

29. “Immunity to Viral Respiratory Disease” and “Viruses and cytokines” at the Annual meeting of the British Equine Veterinary Association, Birmingham, Great Britain, September, 2000.

30. “Development of DNA Vaccines for Equine Respiratory Pathogens” Phi Zeta Day Keynote Presentation, Kansas State University College of Veterinary Medicine, Manhattan, Kansas, March, 2000.

31. "Comparative aspects of regional immunity to influenza virus infection and DNA vaccination" 17th Symposium of the Comparative Respiratory Society, Harrison Hot Springs, British Columbia, October 1999.

32. "Novel Vaccines" 4th International Meeting of OIE and WHO experts on control of equine influenza, Miami, August 1999.

33. “Equine immunology: so far, so what?”. 17th Annual Veterinary Medical Forum of the American College of Veterinary Internal Medicine, Chicago, June 1999.

34. “Equine vaccination: practical strategies and future possibilities”. 17th Annual Veterinary Medical Forum of the American College of Veterinary Internal Medicine, Chicago, June 1999.

35. “Manipulating equine immune responses to respiratory viruses with DNA vaccination.” International Business Communications’ 4rd International Symposium on Veterinary Vaccines, Lake Buena Vista, Florida, March 1999.

36. "Influenza virus; infection and immunity". Visiting Professor - Louisiana State University, January 1999

37. “Local and systemic immune responses to influenza virus infection and DNA vaccination in horses.” Visiting Professor seminar, College of Veterinary Medicine, University of Florida, Gainesville, August 1998.

38. “DNA Vaccination in Horses”. 16th Annual Veterinary Medical Forum of the American College of Veterinary Internal Medicine, San Diego, California, May 1998.

39. “Systemic and mucosal equine immune responses to influenza virus induced by natural infection, conventional and unconventional vaccines.” International Business

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Communications’ 3rd International Symposium on Veterinary Vaccines, Tampa, Florida, February 1998.

40. Developing DNA vaccination in horses. Visiting Professor seminar, Department of Veterinary Science (Maxwell E. Gluck Equine Research Center), University of Kentucky, Lexington, August 1997.

41. Preventative Immunology. Dubai International Equine Symposium: The diagnosis and treatment of respiratory disease, Dubai, United Arab Emirates, March 1997.

42. Neonatal cellular immunity: comparative studies in a bovine model. Havemeyer Foundation Workshop on R.equi and equine neonatal immunity, Guelph, Ontario, July 1996.

43. New strategies for equine vaccination. 14th Annual Veterinary Medical Forum of the American College of Veterinary Internal Medicine, San Antonio, Texas, May 1996.

44. Manipulating Equine Mucosal Immunity. Veterinary Science Seminar Series, UW-Madison, December 1995.

45. Mucosal Vaccination. Visiting Professor - Louisiana State University, March 1995 46. Maternal-Placental immune interactions in the horse. Primate Research Center Seminar,

University of Wisconsin 1994 47. Equine T-lymphocytes. Keynote address: Sixth International Equine Infectious Disease

Conference, Cambridge, Great Britain, July 1991. 48. Equine Lymphocyte Differentiation Antigens. Departmental "Tea-Club" seminar series,

University of Cambridge, May 1991.

Funded Research Projects

Title

Granting Agency

Amount Role

Dates

EHV-1 modulation of airway epithelial responses determines induction of immunity and protection

USDA: Agriculture and Food Research Initiative (AFRI) Animal Health Program

$499,852 Co-I 12/11 – 11/15

Use of CSF biomarkers for development of an EHM model

Infectious Disease Supercluster, CSU

$24,034 Co-I 7/11-6/12

Proteomic and metabolomic CSF changes in EHM

College Research Council

$15,800 Co-I 7/11-6/12

Duration of immunity of Calvenza™ EHV vs. Intervet Prodigy™.

Boehringer Ingelheim Vetmedica, Inc

$124,000

PI 7/10 – 6/12

Proof of concept: EHV-1 gG deletion mutant MLV vaccine

Novartis Animal Health

$120,000

PI 2/10 – 6/12

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Develoment of a model of EHV-1 myeloencephalopathy

Biotechnology Research and Development Corporation

$401,867 PI 12/09 – 11/11

The effect of EHV-1 immunosuppressive genes on the respiratory epithelium

Morris Animal Foundation

$100,328

Co-I 7/10 – 6/11

Duration of immunity of Calvenza™ Influenza Ohio’03 vs. FDAH Innovator.

Boehringer Ingelheim Vetmedica, Inc

$168,000

PI 11/08 – 6/10

Generation of Tetramers to Study Immune Modulation Via Equine MHC-1 Antigen presentation by EHV-1 Gene Products.

USDA-NRI $384,000 Co-PI

9/07 – 8/11

Pneumabort-K™ vs. Rhinomune™ protection against EHV-1 challenge study: protection against viremia, nasal shedding and clinical disease

Fort Dodge Animal Health

$124,313 PI 5/07 – 12/08

Neuropathogenesis of EHV-1 in horses

Grayson-Jockey Club Research Foundation

$93,481 Co-I 4/08 – 3/10

Protection against influenza virus challenge by novel killed vaccines

Fort Dodge Animal Health

$65,743

PI 5/07 – 4/08

Can Zylexis improve antibody responses to vaccination in normal or in immunosuppressed ponies?

Pfizer $41,872

PI 2/07-12/07

Onset of immunity to equine influenza by a recombinant canary pox vector vaccine

Merial, France $86,648

PI 11/06 – 12/07

Molecular basis for influenza virus transmission to dogs

Morris Animal Foundation

$97,139 Co-I 10/06 – 12/08

Tetramers for precise measurement of immunity to EHV-1

Grayson-Jockey Club Research Foundation

$116,641 PI 4/06 – 3/08

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Evaluation of long-term protection from equine influenza by a recombinant canary pox vector vaccine

Merial, France $66,684

PI 11/05 – 2/07

Evaluation of Duration of Immunity Induced by Duvaxyn IET/EHV1,4 Against Equine Influenza Virus in Horses

Fort Dodge Animal Health

$122,483

PI 10/05 – 9/07

Development of a model system for studying EHV-1 abortion

Fort Dodge Animal Health

$241,00 PI 10/05 – 9/09

Evaluation of the Efficacy of a Combination Vaccine Containing EHV-1 Whole Virus Antigen in Foals

Fort Dodge Animal Health

$183,066 PI 10/04 – 3/06

Frequency of contagious respiratory pathogen shedding at a major equine event.

College Research Council, CVMBS, Colorado State University

$22,000 PI 10/04 – 10/05

Multi-epitope EHV-1 vaccines for generation of cytotoxic T lymphocytes

Grayson-Jockey Club Research Foundation

$95,650 PI 4/04 – 3/06

Equine respiratory disease agent surveillance

Intervet $67,284

PI 1/04 – 3/06

Does equine influenza virus nucleoprotein induce antiviral cellular immunity in horses?

SVM – Basic Science Grant

$9,200 PI 7/02 – 6/03

Comparison of commercial killed equine vaccines

Intervet $83,000

PI 12/01 – 12/03

Cellular responses to conventional EHV-1 vaccines

Intervet $72,000

PI 12/01 – 12/03

Practical equine DNA vaccination: mucosal vectors and the "prime/ boost" strategy

Grayson-Jockey Club Research Foundation

$89,000 PI 4/01 – 3/03

Baypamune N Efficacy in Horses after Transport and Exposure to

Bayer $108,000

PI 11/00 – 11/02

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Influenza Virus Developent of attenuated salmonella and modified vaccinia Ankara as vectors for equine influenza DNA vaccination

Agricultural Experiment Station

$20,000 PI 1/00 – 8/02

Generation of cytotoxic lymphocytes and immunity to equine herpesvirus by DNA vaccination

USDA-NRI $273,000

PI 9/00 – 8/03

Regulation of equine immune responses to viral respiratory infection

Agricultural Experiment Station

$44,000 PI 9/99 – 8/01

Generation of protective immunity to equine herpesvirus infection using DNA vaccination

Grayson-Jockey Club Research Foundation

$79,000 PI 9/99 – 8/01

Generation of cytotoxic lymphocytes to equine herpes virus infection by DNA vaccination

Graduate School $12,000 - returned after matching external funding

PI 9/99-8/00

Regulation of mucosal and systemic immune responses to equine influenza virus

Agricultural Experiment Station

$40,000 PI 9/97 - 8/99

Immunity to influenza virus generated by DNA vaccination and cytokine-expressing plasmids

Grayson-Jockey Club Research Foundation

$73,000 PI 9/97-10/99

Regulation of equine mucosal immune responses induced by influenza virus and cytokine DNA vaccination

Graduate School $19,283 - returned after matching external funding

PI 9/97-8/98

Safety and efficacy testing of attenuated equine influenza virus vaccines in horses

Heska Corporation $345,949

PI 11/96 - 9/02

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Safety Testing of Influenza Vaccines

Heska Corporation $109,025

PI 1/96 - 12/96

Induction of immunity to Cryptosporidium parvum in pregnant dairy cattle by DNA vaccination

University-Industry Relations grant

$36,200 Co-PI

7/96-6/97

Transfer of maternal colostral cells to calves

Agricultural Experiment Station

$16,000 PI 9/96 - 8/98

Generation of protective immunity to equine influenza infection using DNA vaccination

Grayson-Jockey Club Research Foundation

$71,000 PI 9/95-10/97

Iso-immune responses and fertility in dairy bulls

SVM - Food Animal Research Grant

$11,500 PI 7/95 - 6/96

Maternal vaccination against cryptosporidiosis

Wisconsin Co-operative Grants

$42,000 Co-PI

7/95 - 6/96

Regulation of cellular invasion and migration in placentation as a model for metastasis

Graduate School $14,000 PI 7/95 - 6/96

Protection from equine influenza infection: the role of IgA versus IgG

Agricultural Experiment Station

$60,140 PI 9/93 - 8/96

Organization of the Second International Workshop on Equine Leucocyte Antigens

International Veterinary Immunological Society

$3,500 PI 9/93 - 8/95

The immune response of the mare to endometrial cups

American Quarter Horse Assoc.

$88,950 PI 10/92 - 9/95

Soluble CD44 levels in synovial fluid: a prognostic indicator in equine degenerative joint disease

Wisconsin State Horse Council

$2,500 PI 7/94 - 6/95

Absorption, longevity, and trafficking of maternal lymphocytes in the calf

SVM - Food Animal Research Grant

$10,260 Co-PI

7/94 - 6/95

The equine maternal immune response to endometrial cups:

SVM, Companion Animal

$16,000 PI 7/92 - 6/94

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modulation with heteroconjugate antibodies Protection from equine influenza infection: the role of IgA versus IgG

Wisconsin State Horse Council

$2,500 PI 7/93 - 6/94

Professional Student Teaching College of Veterinary Medicine, North Carolina State University Didactic Teaching

VMP 920, 2nd year Infection & Immunity, 2 hours of lectures annually, 2014-16 Small group facilitator

VMP 921, 2nd year Infection & Immunity course, 13 contact hours, 2014-17 VMC 944, 1st year communication course, 8 contact hours, 2017

College of Veterinary Medicine and Biomedical Sciences, Colorado State University Didactic Teaching

PVM 753 course, 3rd year medicine course, 4 hours of lectures annually, 2004-11 PVM763, 3rd year large animal medicine course, 1 hour annually 2006-2009 PVM 714, 2nd year epidemiology course, 2 hours annually 2009-10 PVM Perspective course, 1st year careers course, 1 hour annually, 2007-11 Post-Graduate Medicine Course, 2-3 hours, alternate years, 2004 – 11. VS 580 Physiological Basis of Medicine Post-Graduate course, 4 hours annually, 2007 – 11 Micro/Immuno/Path 682, 1 hour, 2009 - present.

Laboratory teaching Problem based learning seminar, 1 hour a week for the semester, three semesters from 2005-6. Veterinary Communications coach, 8 hours a week for four weeks, 2007.

University of Wisconsin-Madison, School of Veterinary Medicine Course Coordinator

Animal Health, History & Restraint - a one-credit second year course, 1991-2000. Veterinary Diagnostics and Therapeutics - a one-credit second year course, 1991-2000.

Didactic Teaching Veterinary Medicine I & II, 3rd year medicine course, 10 hours of lectures annually, 1991-present. Veterinary Physiology, 1st year course, 2 hours of lectures annually, 1991-present. Animal Health, History & Restraint - 2nd year lab. course, 8 hours annually, 1991-present.

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Veterinary Diagnostics & Therapeutics - 3rd year lab. course, 12 hours annually, 1991-present. Clinical Reasoning - 4th year elective didactic course, 12 - 36 hours annually, 1992-4, and 1997 Preventive Medicine - 3rd year didactic course, 6 hours annually, 1992-4.

Clinical Teaching Large Animal Medicine Clinical Rotation, 18 weeks annually of clinical service, with an average of 6 students per 2 week rotation, 1991-2000.

Graduate Student Committees Steven Friedenburg, PhD, Graduate Committee, 2013 – 2016 Brandy Burgess, PhD, Graduate Committee, 2010 – 2014. Carl Soffler, PhD, Graduate Committee, 2008 – 2012. Ryan Bragg, MS, Graduate Committee, 2008 – 2011. Jennifer Yactor, MS, Major Professor, 2005 – 2007. Studies on molecular diagnosis of

equine respiratory viruses. Gisela Soboll, PhD, Major Professor 1997-2002. MS awarded in 1999, thesis entitled:

Equine antibody isotype responses to DNA vaccination with the influenza virus hemagglutinin gene. PhD entitled: Equine immunity to respiratory viral infection.

Dane Coombs MS, Major Professor 1999- 2002. Thesis entitled: The quantification of interleukin-4 and gamma interferon mRNA production by peripheral blood mononuclear cells, from ponies experimentally infected with EHV-1.

Emily Sielman, MS, Major Professor 1997-99. Thesis entitled: Generation of monoclonal antibodies to equine IL-2 using DNA vaccination

Kay Nelson, Master of Science, Major Professor, 1993-6. Thesis entitled: Antibody isotypes responses and protective immunity resulting from equine influenza virus infection or conventional vaccination: evaluation of cholera toxin as a mucosal adjuvant

Carol Kim, Master of Science, Major Professor, 1994-7. Thesis entitled: Characterization of antisperm antibodies in bulls and their effect on In Vitro fertilization.

Jo Slack MS, Major Professor 2000-2003. Thesis entitled: Antibody responses to nasal vaccination with attenuated Salmonella typhimurium carrying equine influenza hemagluttinin DNA

Darlene Konkle, Master of Science, Graduate Committee, 1994-7. Brian Aldridge, Ph.D, Graduate Committee, 1993-98 Peter Evans, Ph.D, Graduate Committee, 1995-98 Eduardo Saban, Ph.D, Graduate Committee, 1995-9. Denise Acker, MS, Graduate Committee, 1998-2000

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Mark Sweat, PhD., Graduate Committee 1999-2001

Post-graduate training Dr. Karen Vagnoni, 2 year post doctoral fellowship, 1993-5. Dr. Cormac Breathnach, 2 year post doctoral fellowship, 2001 – 2004 Dr. Paul Bielec, 2 year post doctoral fellowship, 2002 – 2003

Large Animal Medicine Resident Training at the University of Wisconsin-Madison I have participated in the training of each of the following LAM residents since 1991 (year is time of programs completion). All of these individuals have subsequently become Diplomates of the ACVIM.

Dr. Terry Geros 1992 Dr. Kay Nelson 1995 - Resident supervisor Dr. Robert Callan 1993 Dr. Elizabeth Triplett 1995 Dr. J McClure 1994 Dr. Darlene Konkle 1997- Resident supervisor Dr. Christina Garcia-Cantu 1999 Dr. Gabrielle Landolt 2000 Dr. Dane Coombs (2002) Dr. Jo Slack 20003

Continuing Education Presentations

1. “Equine immunology and control of respiratory viruses” 2 hours in each of four Canadian cities (Vancouver, Calgary, Toronto & Montreal) sponsored by Pfizer, January, 2011.

2. “Equine Immunology and Vaccination” 5 hours to 65 attending veterinarians, Finnish Equine Veterinary Association, Helsinki, Finland, February, 2010.

3. “Influenza and EHV-1: infection & control”. 2 hours to 60 attendees, Melbourne Cup CPD meeting, University of Melbourne, November, 2009.

4. "Boarded, now what?" A talk to residents at the ACVIM Annual Forum in Montreal, June 2009.

5. “Departmental maintenance during financial meltdown downturn” Presentation at the AAVC Department Heads/Hospital Directors Annual Meeting in Atlanta, April, 2009.

6. “EHV-1 pathogenesis, diagnosis & control” One hour presentation Purina Veterinary CE conference, St. Louis, MS, October, 2009.

7. “ Influenza and EHV-1 control” Guest lecturer, two hours of presentations at the University of Melbourne, Faculty of Veterinary Medicine, Melbourne Cup Equine CE meeting, October, 2009.

8. “Update on equine respiratory disease and vaccination” 2 hours of continuing education to Boehringer Ingelheim. June 2008, Denver.

9. “Efficacy of EHV-1 vaccines & biosecurity strategies” One hour of continuing education. Western States, Las Vegas, February, 2008.

10. “Equine Immunology and Vaccination” 5 hours to 90 attending veterinarians, Tahoe Equine Meeting, Tahoe California, January, 2008.

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11. “Managing Infectious Disease Outbreaks at Events and Farms” 1 hour at the CVMBS Annual Conference, January, 2008.

12. “Respiratory Vaccines: the good, the bad, and the ugly.” Annual meeting of the British Equine Veterinary Association, Edinburgh, Scotland, September, 2007.

13. “Immunology of vaccination, and current vaccination strategies” 6 hours of continuing education for 50 participants. North Carolina Veterinary Association Annual Meeting, Raleigh, North Carolina, October, 2004.

14. “Equine immunology and vaccination” 5 hours of continuing education for 60 participants. Colorado Veterinary Association Annual Meeting, Steamboat, Colorado, September, 2004.

15. “Equine immunity and resistance to infection” 4 hours of continuing education for 100 participants. Alberta Veterinary Medical Association, Edmonton, January, 2003.

16. “Equine immunity to Rhodococcus equi” One hour lecture to 120 veterinarians and owners. Irish Thoroughbred Owners and Trainers, The Currragh, Ireland, March, 2003.

17. “Immunological basis of resistance to infectious disease”6 hours of continuing education for 80 participants. Indiana Equine Veterinary Association Annual Meeting, Indianapolis, Indiana, October, 2003.

18. “Immunology and infectious disease”6 hours of continuing education for 50 participants. Arizona Equine Veterinary Association Annual Meeting, Phoenix, Arizona, September, 2002.

19. Veterinary Professional Quest - Equine Internal Medicine Continuing Education Week (10 hours of lectures for 10 participants), Winter Park, Colorado, February 3 - February 9, 2002.

20. “Preventing infectious respiratory disease” University of Wisconsin, School of Veterinary Medicine – Equine Symposium, 1 hour of continuing education to 50 attendees, January, 2002.

21. “Equine Immunology and Vaccination” 3 hours of continuing education to 30 attendees at the Annual Fall Conference of the Atlantic Veterinary College, Prince Edward Island, Canada, October, 2001.

22. “Vaccination for equine infectious disease.” Ohio Veterinary Medical Association, Cleveland Ohio, 2 hours of continuing education for approximately 20 attendees, March, 2001

23. “Immunological Basis of Vaccination” Association of American Equine Practitioners: 1 hour talk to approximately 600 attendees, San Antonio, Texas, November, 2000.

24. “Immunological basis of resistance to infectious disease” Annual Equine Practitioner’s Conference, Cornell College of Veterinary Medicine, 3 hrs of continuing education for approximately 60 attendees, November, 2000.

25. “Equine immunity, infectious pathogens, and vaccination” Wild West Veterinary Conference: 5 hours of continuing education for 100 participants, Reno, Nevada, October, 2000.

26. “Vaccines and vaccine protocols of the future: an equine example” Annual convention of the American Veterinary Medical Association, Salt Lake City, Utah, August 2000.

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27. "Equine immunology and vaccinations" (6 hours of continuing education for 90 participants) British Columbia Veterinary Medical Association Equine Chapter, Delta, British Columbia, October 1999.

28. "Immunological basis of vaccination" (3 hours of continuing education for 50 participants) Kentucky Veterinary Medical Association Meeting, October 1999.

29. “Foal Immunology” and “Practical Vaccination Strategies in Foals” American Association of Equine Practitioners, Phoenix, Arizona, December 1997.

30. Vaccination update in horses - 3 hours of Continuing Education. Quebec Veterinary Association, October 1997.

31. Veterinary Professional Quest - Equine Internal Medicine Continuing Education Week (10 hours of lectures for 10 participants), Winter Park, Colorado, January 30 - February 3, 1997.

32. Control of Internal Parasites. Wisconsin Sheep Industry Conference, April 1997. 33. Only fools and horses..... Annual Campus Immunology Retreat, UW-Madison, February,

1996. 34. Metabolic diseases in growing lambs. University of Wisconsin Extension Service, Wisconsin

Public Radio Broadcast, March, 1996. 35. Epizootic diarrhoea in the SVM. Grand Rounds, School Vet. Med., October 1995 36. Veterinary Professional Quest - Equine Internal Medicine Continuing Education Week,

Winter Park, Colorado, January 29 - February 5, 1994, 12 hours of lectures for 8 participants 37. Dissecting equine immunity with monoclonal antibodies. Visiting professor, Ontario

Veterinary College, University of Guelph, 1993. 38. Chronic cough; a stable problem. University of Wisconsin Extension Service, Wisconsin

Public Radio Broadcast, 1993.

Committees and Service

Conferences organized and major editorial responsibilities First Havemeyer Workshop on Infectious Diseases of Working Equids. Chairman of organizing committee for a four day workshop held in Addis Ababa, Ethiopia, November 2013, and attended by 35 presenters. Personally raised $55,00 in sponsorship Report Third Havemeyer Workshop on EHV-1 – Chairman of organizing committee for a four day workshop held in Steamboat, Colorado, September 2001, and attended by 32 presenters. Personally raised $45,00 in sponsorship. Havemeyer Foundation 30th Anniversary Foundation Research Forum: Chaired the equine immunology section, invited five speakers. Saratoga, New York, August, 2011. Second Havemeyer Workshop on EHV-1 – Chairman of organizing committee for a four day workshop held in Steamboat, Colorado, September 2008, and attended by 45 presenters. Personally raised $50,00 in sponsorship.

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Guest editor (with Dr. David Horohov & Dr. Josh Slater) of the Veterinary Immunology and Immunopathology, EHV-1 Special Issue, Volume 111, issues 1-2, February 2006. First Havemeyer Workshop on EHV-1 – Chairman of organizing committee for a four day workshop held in San Gimignano, Tuscany, Italy in June, 2004, and attended by 32 presenters. Personally raised $45,00 in sponsorship. Guest editor (with Dr. David Horohov) of the Equine Veterinary Journal, Immunology Special Issue, Volume 7, 2001. Personally raised $7,500 from industry to support publication of this additional volume of the journal. Equine Immunology 2001 – Chairman of organizing committee for a three day workshop held in Santa Fe, New Mexico in January 2001, and attended by 32 presenters. Personally raised $39,500 in sponsorship. Guest editor (with Dr. David Horohov) of the Vet Clinics of North America: Equine Practice: Immunology Volume16, 2000. Guest editor (with Dr. Mark Holmes) of the Veterinary Immunology and Immunopathology, Equine Leukocyte Antigens II Special Issue, Volume 62, issues 2, 1998. Equine Leukocyte Antigen Workshop II – Chairman of organizing committee for a three day workshop held in Squaw Valley, California in July 1995, and attended by 28 presenters. Personally raised $17,000 in sponsorship.

International and National Committees President, American Association Veterinary Clinicians, 2009-2010 (President Elect, 2008-2010, Past-President 2010-11)). Chairman, Research Advisory Committee, Grayson-Jockey Club Research Foundation, 2009 – 2014. Grayson-Jockey Club Research Advisory Committee, 2003-2006, and 2008 – 2014. American Association of Equine Practitioners, Biological and Therapeutics Committee, 2010 – 2011. Editorial Advisory Board, Veterinary Immunology and Immunopathology, 2000 - 2010. Chairman of the International Veterinary Immunological Society Sub-Committee on Equine Immunology, 1993-2004 Editorial Advisory Board, The Veterinary Journal, Pubs. Bailliere Tindall, London. 1998 - 2004. Graduate Student Awards Committee, American Association of Veterinary Immunologists, 1997-2002. Appointments Committee, American Association of Veterinary Immunologists, 1997-2000. Board of the American Association of Veterinary Immunologists, 2000-2004 USDA review panel, Sustaining Animal Health and Well-being: Immunology and Parasitology, 2000-2002, 2004-2006

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Grayson-Jockey Club Research Foundation – Research Advisory Committee, 2003-2006, and 2008 – 2009. AAEP Ad Hoc committee on equine vaccination programs, 2000 American Association of Equine Practitioners, Infectious Disease Committee, 2005 – 2007 - Task Force on Outbreak Control - 2006 - Task Force on Equine Vaccination - 2007 American Horse Council, Health and Regulatory Committee, 2000-present

School Committees

College of Veterinary Medicine and Biomedical Sciences, Colorado State University As Department Head I served on numerous committees in the course of my duties, including the College Executive Committee.

School of Veterinary Medicine, University of Wisconsin-Madison Hospital and Instructional Resources Committee (Chairman - responsible for identifying long-term development goals for VMTH and school-wide teaching resources), 2001-2002 VMTH management committee (Chairman), 2000-present. Small Animal Hospital Building Design Committee (Chairman), 2000-present. Large Animal Hospital Building Design Committee (Chairman), 2002-present. Space Committee, (administers all research and teaching space in SVM), 1992-present Academic Advisory Council (principal management of the School of Veterinary Medicine), 2000-present Department of Medical Sciences Executive Committee, 1998-present Department of Medical Sciences Large Animal Medicine Search Committee (chairman), 2000. Research Committee, 1996-7. Large Animal Surgeon Search Committee, 1996. Department of Medical Sciences Chairman Search Committee, 1994-5. Department of Medical Sciences Large Animal Medicine Search committee, 1997. Department of Surgical Sciences Large Animal Surgeon Search Committee, 1997. Large Animal Research Facilities committee, 1997. Large Animal VMTH Facilities Planning Committee (Chairman), 1997.

Ad Hoc Reviewer Grants

USDA, “Sustaining Animal Health and Well-being” 1994-2004 USDA, “Animal Genetic Mechanisms and Gene Mapping” 1996-97 E.P. Taylor Equine Research Fund, Ontario Jockey Club, 1996- 1998

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Horserace Betting Levy Board, UK, 1997- present Home of Rest for Horses, UK, 1998- present

Journals

Vaccine Equine Veterinary Journal The Veterinary Journal Journal of the American Veterinary Medical Association American Journal of Veterinary Research Journal of Veterinary Internal Medicine Veterinary Immunology and Immunopathology Journal of Virology Journal of Immunology Journal of General Virology Veterinary Research

Professional organizations

British Equine Veterinary Association American College of Veterinary Internal Medicine Research Workers in Animal Disease American Veterinary Medical Association American Association of Equine Practitioners American Association of Veterinary Clinicians North Carolina Veterinary Medical Association

Awards

Faculty Achievement Award, American Association of Veterinary Clinicians, 2011.

Sir Frederick Smith Lecture, British Equine Veterinary Association Annual Meeting, Birmingham, UK, September 2009.

Publication Analytics Scopus Author ID: 35433024900 ORCID ID & QR CODE: orcid.org/0000-0002-7388-9766