CURRICULUM VITAE

Joya Chandra, Ph.D.

PRESENT TITLE AND AFFILIATION Primary Appointment

Associate Professor, Department of Pediatrics - Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment Adjunct, Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX

CITIZENSHIP United States

HOME ADDRESS 10822 Burdine Houston, TX 77096

OFFICE ADDRESS The University of Texas MD Anderson Cancer Center 1515 Holcombe Blvd. Unit Number: 853 Houston, TX 77030 Room Number: MOD2.017 Phone: 713-563-5405 Fax: 713-563-9607

EDUCATION Degree-Granting Education

Louisiana State University, Baton Rouge, LA, BS, 1993, Major: Microbiology, Minors: English and Spanish

University of Texas Graduate School of Biomedical Sciences and M.D. Anderson Cancer Center, Houston, TX, PhD, 1998, Cancer Biology and Immunology

Postgraduate Training Postdoctoral Fellowship, Apoptosis, Oxidative stress, Division of Toxicology, Institute for Environmental Medicine, Karolinska Institute, Stockholm, Sweden, Sten Orrenius, MD, 1998-2000

Postdoctoral Fellowship, Drug development, Apoptosis, Leukemia Therapy, Division of Oncology Research, Mayo Clinic, Rochester, MN, Scott Kaufmann, MD, PhD, 2000-2002

EXPERIENCE/SERVICE Academic Appointments

Research Technician, Department of Cell Biology, Baylor Medical School, Houston, TX, 1993-1994

Graduate Research Assistant, Cell Biology, University of Texas MD Anderson Cancer Center, Houston, TX, 1994-1998

Postdoctoral Research Assistant, Institute for Environmental Medicine, Karolinska Institute, Stockholm, Sweden, 1999-2000

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Assistant Professor, Department of Pediatrics - Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2002-8/2008

Associate Professor, Department of Pediatrics - Research, Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2008-present

Adjunct, Associate Professor, Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX, 3/2013-present

Administrative Appointments/Responsibilities Member, Faculty Senate, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009-2013

Director, ON (Optimizing Nutrition) to Life Program, The University of Texas MD Anderson Cancer Center, Houston, TX, 11/2009-present

Member, Knudson Award Committee for Outstanding Dissertation, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010-2012

Member, Executive Committee of the Faculty Senate, The University of Texas MD Anderson Cancer Center, Houston, TX, 2010-2013

Member, Margaret L. Kripke Legend Award Selection Committee, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2010-2013

Member, Executive Committee of the Science Faculty, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011-2012

Member, Committee on Faculty Awards, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011-2012

Member, Research Council, The University of Texas MD Anderson Cancer Center, Houston, TX, 2011-2013

Member, Knudson Award Committee for Outstanding Dissertation, The University of Texas MD Anderson Cancer Center, Houston, TX, 2014

Co Director, Center for Energy Balance, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016-present

Other Appointments/Responsibilities Research Trainee, Summer Research Program for College Students, The University of Texas MD Anderson Cancer Center, Houston, TX, 1991

Member, Graduate Faculty, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2002-present

Member, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences Alumni Association, Houston, TX, 1/2003-8/2008

Vice President, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences Alumni Association, Houston, TX, 9/2004-9/2005

Member, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences Student Affairs Committee, Houston, TX, 10/2004-9/2007

President, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences Alumni Association, Houston, TX, 9/2005-10/2006

Chair, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences Student Affairs Committee, Houston, TX, 10/2006-9/2007

Member, Subcommittee on Faculty/Student Contracts, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, 2/2007-8/2007

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Retreat Organizer, The University of Texas MD Anderson Cancer Center, Center for Cancer Epigenetics, Houston, TX, 2009-2010

Member, Executive Committee for Experimental Therapeutics Program, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 11/2010-present

Chair, Awards Committee for Experimental Therapeutics Program, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 11/2010-present

Member, Admissions Committee for Cancer Biology Program, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 11/2011-12/2011

Member, Medical Advisory Board, TeamConnor Cancer Foundation, Dallas, 2012-present

Member, GSBS Recruiting Council, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 9/2012-2015

Member, Clinical and Translational Sciences Graduate Program, University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2013-present

Judge and Chair, Graduate Student Basic Science Category, Trainee Research Day, Houston, TX, 6/2013

Member, Patient-Reported Outcomes, Survey and Population Research (PROSPR) Shared Resource Advisory Committee, University of Texas MD Anderson Cancer Center, Houston, TX, 10/2013-2015

Research Mentorship Committee, UT System-Wide, Houston, TX, 2015-2016

Instructor, Mentoring Works Mini Course for Faculty, Graduate School of Biomedical Sciences, Houston, TX, 2015-2016

Member, Executive Committee, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015-present

Member, Program Metamorphosis Committee, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2015-2016

Co-Director, Center for Energy Balance, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016-present

Director of Research Training for Pediatric Hematology Oncology Fellows 2017-present

Team Leader, Leukemia & Lymphoma Team, Division of Pediatrics 2017-present

Team Member, Energy Balance Team, Division of Pediatrics 2017-present

Team Member, AYA Team, Division of Pediatrics 2017-present

Team Member, Survivorship Team, Division of Pediatrics 2017-present

Member, Medical Advisory Board, Bear Necessities Pediatric Cancer Research Foundation, 2018-present

Institutional Committee Activities The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, Member, Trainee Excellence Awards Subcommittee, 3/2003-3/2006

The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, Chair, Receptions Subcommittee, 3/2003-10/2006

The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, Regular Member, 3/2003-2009

New Agents Working Group, Member, 12/2003-2008

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Joint Student Affairs Council, University of Texas MD Anderson Cancer Center, Regular Member, 1/2005-2009

SACS Site Visit, Participant, 7/2005

The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, Chair elect, 10/2005-10/2006

The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, Chair, International Affairs Subcommittee, 1/2006-2010

The University of Texas MD Anderson Alumni and Faculty Association Steering Committee, Chair, 10/2006-10/2007

Odyssey Fellowship Committee, Member, 8/2008-2011

SACS Site Visit, Participant, 3/2010

The University of Texas MD Anderson Graduate Education Committee, Member, 10/2012-9/2015

The University of Texas MD Anderson Graduate Education Committee Academic Standards Subcommittee, Chair, 2013-2014

Faculty Search, Committee Member, Department of Epigenetics and Molecular Carcinogenesis, 2014-5/2015

Faculty Search, Committee Member, Center for Energy Balance, 2014-2016

Faculty Search, Committee Member, Department of Epigenetics and Molecular Carcinogenesis, 9/2015-2016

Faculty Search, Committee Member, Division of Pediatrics Health Outcomes Researcher, 9/2015-2017

Faculty Search, Chair, Department of Epigenetics and Molecular Carcinogenesis, 2017-2018

Faculty Search, Committee Member, Center for Energy Balance, 2017-present

Reviewer, Start-up package Proposals, Dept of Lymphoma/Myeloma 2017

Chair Search, Committee Member, Department of Symptom Research, 2016-2018

Cancer Metabolism Symposium on Basic Cancer Research, Organizer, 2016-2017

Cancer Survivorship and Energy Balance Research Symposium, Planning Committee, 2017-2018

HONORS AND AWARDS John P. McGovern Award, University of Texas Graduate School of Biomedical Sciences, 1996

Rhone-Poulenc Rorer Travel Award from American Association for Cancer Research (AACR), 1996

AACR-AFLAC Young Investigator Award, 1997

American Legion Auxiliary Fellowship, 1997-1998

Andrew Sowell-Wade Huggins Endowed Scholarship, 1997-1998

M.D. Anderson Associates Travel Award, 1997

Special Commendation Award, University of Texas Graduate School of Biomedical Sciences, 1997

Texas Regional Immunology Conference James W. McLaughlin Oral Award, 1997

Karolinska Institute Fellowship for Visiting Scientists, 1999-2000

Travel Scholarship for Seventh European Conference on Apoptosis, 1999

NIH NRSA Institutional (T32) Training Grant, 2000-2001

Wenner-Gren Foundation Fellowship for Visiting Scientists, 2000

AACR-AFLAC Scholar-in-Training Award, 2001

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NIH NRSA Individual (F32) Training Grant, 2001-2003

Children's Oncology Group Young Investigator Award, 2003-2004

The University of Texas MD Anderson Cancer Center Institutional Research Grant, 2003-2005

Leukemia SPORE Career Development Award, 2004-2007

Texas Federation of Business and Professional Women's Club Award, 2004

Faculty Educator of the Month (May), The University of Texas MD Anderson Cancer Center, 2009

John P. McGovern Outstanding Teacher Award, GSBS Graduate Student Association, 2012

Faculty Educator of the Month (April), The University of Texas MD Anderson Cancer Center, 2013

Faculty Leadership Academy, 2014-2015

Texas Business Women's Award, 2014

President’s Recognition for Faculty Excellence, 2015

Experimental Therapeutics Academic Program Students’ Faculty Choice Award, 2016

Highest Commendation for Service to the UTHSC Graduate School of Biomedical Sciences (GSBS), 2016

University of Texas System Regents' Outstanding Teaching Award, 2016

President’s Recognition for Faculty Excellence in Education and Mentorship Advancement, 2017

RESEARCH Grants and Contracts

Funded Principal Investigator, 10%, Targeting PLK1 as a Common Mechanism in Ph-like ALL, Reach Grant, Alex’s Lemonade Stand

Principal Investigator, 20%, Preclinical evaluation of a novel combinatory epigenetics based therapy for glioblastoma, R21 NS093387, NIH/NINDS

Principal Investigator, 5% HDAC6 expression, upregulation and immunomodulatory effects in myeloma and lymphoma models. Sponsored Research Agreement, Karus Pharmaceuticals,

Collaborator, 5%, Epigenetics in Medulloblastoma Development and Therapeutics, RP150301, Cancer Prevention & Research Institute of Texas (CPRIT), PI - Vidya Gopalakrishnan

Completed in Past Five Years

Developmental Research Project PI, 10%, Manipulating metabolic pathways to enhance HDAC inhibitor efficacy in refractory multiple myeloma, NIH/NCI P50 CA142509, SPORE in Multiple Myeloma, PI – Robert Orlowski

Principal Investigator, 30%, Role of redox dependent signaling in leukemia, R01 CA115811, NIH/NCI

Co-Investigator, 5%, Role of IGF-IR tyrosine kinase in NPM-ALK-expressing T-cell lymphoma, 1 R01 CA151533, NIH/NCI, PI – Hesham Amin

Principal Investigator, ON to Life Program, Farrah Fawcett Foundation

Mentor, Dual LSD1 and HDAC Inhibition for Cancer Therapy, F32 CA150610, NIH/NCI, PI - Melissa Singh

Developmental Research Project PI, 10%, Targeting Epigenetic Alterations in Acute Leukemias, NIH/NCI, P50 CA100632, Leukemia SPORE. PI – Hagop Kantarjian

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Mentor, The role of HO-1 in FLT3-ITD positive AML proliferation and drug resistance, F32 CA171905, NIH/NCI, PI - Mary Irwin

Principal Investigator, A Community Based Nutrition and Physical Activity Intervention, Luci Baines Johnson Foundation

Principal Investigator, A Community Based Cancer Prevention Study in Obese Children and Families, Racing for Cancer Foundation

Co-Investigator, 1%, Biomarkers for Clinical Trials in Multiple Myeloma Evaluating Carfilzomib and Panobinostat, Novartis Pharmaceuticals

Grant Reviewer/Service on Study Sections The University of Texas MD Anderson Cancer Center Institutional Research Grant Basic Science Study Section, The University of Texas MD Anderson Cancer Center, Grant Reviewer, 2004-2007

MDACC Institutional Bridge Funding Reviewer, MDACC, Reviewer, 2007

Life Sciences Review Committee, Texas Emerging Technology Fund, Reviewer, 2007-present

Center for Targeted Therapeutics, The University of Texas MD Anderson Cancer Center, Ad Hoc Reviewer, 2008

MDACC Odyssey Postdoctoral Fellowship Program, MDACC, Reviewer, 2008-2011

American Cancer Society IRG Review Committee, MD Anderson Cancer Center, Reviewer, 2008-2011

2RG1OBIA Challenge Grant Reviewer (RCI), NIH, Member, 2009

Peer Reviewed Medical Research Program Blood Cancer Panel, DOD, Member, 2009

Health and Technologies Young Investigator Study Section, Italian Ministry of Health, Reviewer, 2009-2015

LRP (Loan Repayment) OD09-109 Pediatric L40 A2 Study Section, NIH, Member, 2009-present

NIH COBRE Center of Biomedical Research Excellence Pilot Project Grant, NIH, Reviewer, 2010

Bankhead-Coley Cancer Research Program, Florida Department of Health, Grant Reviewer, 2010-2015

Grant Review Study Section, TeamConnor Foundation, Reviewer, 2011-present

Portuguese Foundation for Science and Technology, Portuguese Foundation, Grant Reviewer, 2012

Office of Science and Technology Grant Reviewer, Portuguese Ministry of Education and Science, Member, 2012-2013

ZRG1 F05-D Fellowship Cell biology, Development Biology and Bioengineering Special Emphasis Panel, NIH, Member, 2014-present

Genetic Research Cancer, DOD, Reviewer, FY15 Peer Review Cancer Research Program, 2015-2016

Ohio Cancer Research Associates, Reviewer, 2015-presen

Peer Reviewed Medical Research Program Pediatric Brain Tumor Panel, DOD, Reviewer 2016-2017

Special Emphasis Panel for UO1 applications on “Biological Comparisons in Patient-Derived Models of Cancer,” NIH, Reviewer 2017

Peer Reviewed Medical Research Program Blood Cancer Panel, DOD, Reviewer 2018

PUBLICATIONS

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Peer-Reviewed Original Research Articles 1. McConkey DJ, Chandra J, Wright S, Plunkett W, McDonnell TJ, Reed JC, Keating M.

Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. J Immunol 156:2624-2630, 1996. PMID: 8786328.

2. Balasubramanian K, Chandra J, Schroit AJ. Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition. J Biol Chem 272:3113-3117, 1997. PMID: 9388264.

3. Chandra J, Gilbreath J, Freireich EJ, Kliche KO, Andreeff M, Keating M, McConkey DJ. Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes. Blood 90:3673-3681, 1997. PMID: 9345052.

4. Bouvet M, Bold RJ, Lee J, Evans DB, Abbruzzese JL, Chiao PJ, McConkey DJ, Chandra J, Chada S, Fang B, Roth JA. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer. Ann Surg Oncol 5:681-688, 1998. PMID: 9869513.

5. Chandra J, Niemer I, Gilbreath J, Kliche KO, Andreeff M, Freireich EJ, Keating M, McConkey DJ. Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes. Blood 92:4220-4429, 1998. PMID: 9834227.

6. Multani AS, Chandra J, McConkey J, Sen S, Cabral TF, Pathak S. Cell death in paclitaxel-dependent Chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats. Oncol Res 11:455-460, 1999. PMID: 10850886.

7. Bold RJ, Chandra J, McConkey DJ. Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann Surg Oncol 6:279-285, 1999. PMID: 10340887.

8. Fadeel B, Gleiss B, Hogstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A. Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression. Biochem Biophys Res Commun 266:504-511, 1999. PMID: 10600532.

9. Multani AS, Ozen M, Narayan S, Kumar V, Chandra J, McConkey DJ, Newman RA, Pathak S. Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia 2:339-345, 2000. PMCID: PMC1550291.

10. Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 29:323-333, 2000. PMID: 11035261.

11. Lundberg M, Johansson C, Chandra J, Enoksson M, Jacobsson G, Ljung J, Johansson M, Holmgren A. Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. J Biol Chem 276:26269-26275, 2001. PMID: 11297543.

12. Chandra J, Yang SN, Kohler M, Zaitsev S, Juntti-Berggren L, Berggren PO, Zhivotovsky B, Orrenius S. Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells. Diabetes 50 Suppl 1:S77-S81, 2001. PMID: 11272207.

13. Lotfi K, Mansson E, Chandra J, Wang Y, Xu D, Knaust E, Spasokoukotskaja T, Liliemark E, Eriksson S, Albertioni F. Pharmacological basis for cladribine resistance in a human acute T lymphoblastic leukaemia cell line selected for resistance to etoposide. Br J Haematol 113:339-346, 2001. PMID: 11380397.

14. Chandra J, Zhivotovsky B, Zaitsev S, Juntti-Berggren L, Berggren PO, Orrenius S. Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes 50 Suppl 1:S44-S47, 2001. PMID: 11272200.

15. Kagan VE, Gleiss B, Tyurina YY, Tyurin VA, Elenstrom-Magnusson C, Liu SX, Serinkan FB, Arroyo A, Chandra J, Orrenius S, Fadeel B. A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J Immunol 169:487-499, 2002. PMID: 12077280.

16. Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ. Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis. J Biol Chem 277:20301-8, 2002. PMID: 11909872.

17. Mow BM, Chandra J, Svingen PA, Hallgren CG, Weisberg E, Kottke TJ, Narayanan VL, Litzow MR, Griffin JD, Sausville EA, Tefferi A, Kaufmann SH. Effects of the Bcr/abl kinase

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inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood 99:664-671, 2002. PMID: 11781252.

18. Chandra J, Mansson E, Gogvadze V, Kaufmann SH, Albertioni F, Orrenius S. Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release. Blood 99:655-663, 2002. PMID: 11781251.

19. Meng XW, Chandra J, Loegering D, Van Becelaere K, Kottke TJ, Gore SD, Karp JE, Sebolt-Leopold J, Kaufmann SH. Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro. J Biol Chem 278:47326-47339, 2003. PMID: 12963734.

20. Chandra J, Hackbarth J, Le S, Loegering D, Bone N, Bruzek LM, Narayanan VL, Adjei AA, Kay NE, Tefferi A, Karp JE, Sausville EA, Kaufmann SH. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood 102:4512-4519, 2003. PMID: 12920036.

21. Ruiz S, Krupnik Y, Keating M, Chandra J, Palladino M, McConkey D. The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia. Molecular Cancer Therapeutics 5(7):1836-1843, 2006. PMID: 16891470.

22. Orsolic N, Golemovic M, Quintas-Cardama A, Scappini B, Manshouri T, Chandra J, Basic I, Giles F, Kantarjian H, Verstovsek S. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer Science 97(9):952-960, 2006. PMID: 16822295.

23. Chandra J, Tracy J, Loegering D, Flatten K, Verstovsek S, Beran M, Gorre M, Estrov Z, Donato N, Talpaz M, Sawyers C, Bhalla K, Karp J, Sausville E, Kaufmann SH. Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance. Blood 107:2501-2506, 2006. PMCID: PMC1895739.

24. Long J, Manchandia T, Ban K, Gao S, Miller C, Chandra J. Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1. Cancer Chemother & Pharmaco 59(4):527-535, 2007. PMID: 16924499.

25. Miller CP, Ban K, Dujka ME, McConkey DJ, Munsell M, Palladino M, Chandra J. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS -dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood 110(1):267-277, 2007. PMCID: PMC1896116.

26. Ban K, Gao Y, Amin HM, Howard A, Miller C, Lin Q, Leng X, Munsell M, Bar-Eli M, Arlinghaus RB, Chandra J. BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood 111(5):2904-8, 2008. PMCID: PMC2254539.

27. Gao S, Mobley A, Miller C, Boklan J, Chandra J. Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells. Leuk Res 32(5):771-80, 2008. PMCID: PMC2320596.

28. Gao Y, Howard A, Ban K, Chandra J. Oxidative stress promotes transcriptional upregulation of Fyn in BCR-ABL1 expressing cells. J Biol Chem 284(11):7114-25, 2009. PMCID: PMC2652262.

29. Miller CP, Rudra S, Keating MJ, Wierda WG, Palladino M, Chandra J. Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells. Blood 113(18):4289-99, 2009. PMCID: PMC2676087.

30. Kopetz S, Lesslie DP, Dallas NA, Park SI, Johnson M, Parikh NU, Kim MP, Abbruzzese JL, Ellis LM, Chandra J, Gallick GE. Synergistic Activity of the Src Family Kinase Inhibitor Dasatinib and Oxaliplatin in Colon Carcinoma Cells is Mediated by Oxidative Stress. Cancer Res 69(9):3842-9, 2009. PMCID: PMC2709758.

31. Merritt WM, Danes CG, Shahzad MM, Lin YG, Kamat AA, Han LY, Spannuth WA, Nick AM, Mangala LS, Stone RL, Kim HS, Gershenson DM, Jaffe RB, Coleman RL, Chandra J, Sood AK. Anti-angiogenic Properties of Metronomic Topotecan in Ovarian Carcinoma. Cancer Biol Ther 8(16):1596-1603, 2009. PMCID: PMC3916970.

32. Howard AN, Bridges KA, Meyn RE, Chandra J. ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress. Cancer Chemother Pharmacol 65(1):41-54, 2009. PMID: 19404643.

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33. Rivera-Del Valle N, Gao S, Miller CP, Fulbright J, Gonzales C, Sirisawad M, Steggerda S, Wheler J, Balasubramanian S, Chandra J. PCI-24781, a novel hydroxamic acid HDAC inhibitor, exerts cytotoxicity and histone alterations via caspase-8 and FADD in leukemia cells. Int J Cell Biol. 2010. PMCID: PMC2817379.

34. Shi P, Chandra J, Sun X, Gergely M, Cortes JE, Garcia-Manero G, Arlinghaus RB, Lai R, Amin HM. Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid leukemia cells. J Cell Mol Med 14(6B):1777-92, 6/2010. PMCID: PMC3444523.

35. Hu J, Liu X, Hughes D, Esteva FJ, Liu B, Chandra J, and Li S. Herceptin conjugates linked by EDC boost direct tumor cell death via programmed tumor cell necrosis. PLoS ONE(8):e23270, 6/2011. PMCID: PMC3154407.

36. Singh M, Manton C, Bhat K, Tsai W-W, Aldape K, Barton M, Chandra J. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro-Oncology 13(8):894-903, 8/2011. PMCID: PMC3145466.

37. Miller CP, Manton C, Hale R, DeBose L, Macherla VR, Potts BC, Palladino MA, and Chandra J. Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs. Chemico-Biological Interactions 194(2011):58-68, 10/2011. PMCID: PMC3186881.

38. Singh MM, Howard A, Irwin ME, Gao Y, Lu X, Multani A, Chandra J. Expression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia. PLoS ONE. 7(12):e51611, 7/2012. PMCID: PMC3524192.

39. Singh MM, Irwin ME, Gao Y, Ban K, Shi P, Arlinghaus RB, Amin HM, Chandra J. Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia. Cancer 118(13):3433-45, 7/2012. PMCID: PMC3297684.

40. Badr H, Chandra J, Paxton RJ, Ater JL, Urbauer D, Cruz CS, Demark-Wahnefried W. Health-related quality of life, lifestyle behaviors, and intervention preferences of survivors of childhood cancer. Journal of Cancer Survivorship 7(4):523-34. e-Pub 6/2013. PMCID: PMC3825822.

41. Dent SY, Chandra J. The lasting influence of LSD1 in the blood. Elife 2(963), 6/2013. PMCID: PMC3687340.

42. Beltran A, Li R, Ater J, Baranowski J, Buday R, Thompson D, Chandra J, Baranowski T. Adapting A Videogame to the Needs to Pediatric Cancer Patients and Survivors. Games for Health Journal 2(4):213-221, 8/2013. PMID: 26192225.

43. Irwin ME, Nelson LD, Santiago-O'Farrill JM, Knouse PD, Miller CP, Palla SL, Siwak DR, Mills GB, Estrov Z, Li S, Hughes DP, Chandra J. Small Molecule ErbB Inhibitors Decrease Proliferative Signaling and Promote Apoptosis in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia. Plos One 8(8):e70608, 2013. e-Pub . PMCID: PMC3731286.

44. Papke CL, Cao J, Kwartler CS, Villamizar C, Byanova KL, Lim SM, Sreenivasappa H, Fischer G, Pham J, Rees M, Wang M, Chaponnier C, Gabbiani G, Khakoo AY, Chandra J, Trache A, Zimmer W, Milewicz DM. Smooth muscle hyperplasia due to loss of smooth muscle a-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-B. Hum Mol Genet 22(15):3123-31, 2013. PMCID: PMC3699068.

45. Santa Maria D, Swartz M, Markham C, Chandra J, McCurdy S, Basen-Engquist K. Exploring Parental Factors Related to Weight Management in Survivors of Childhood CNS Tumors. Journal of Pediatric Oncology Nursing 31(2):89-84, 2014. PMID: 24608701.

46. Li R, Raber M, Chandra J. Developing a healthy web-based cookbook for pediatric cancer patients and survivors: rational and methods. JMIR Research Protocols 4(1), 2015. PMCID: PMC4397390.

47. Corrales-Medina FF, Manton CA, Orlowski RZ, Chandra J. Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models. Leukemia Research 39(3):371-9, 2015. PMCID: PMC4420632.

48. Braun FK, Mathur R, Sehgal L, Wilkie-Grantham R, Chandra J, Berkova Z, Samaniego F. Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLoS ONE.10(3), 2015. PMCID: PMC4349737.

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49. Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro-Oncology, 2015. PMID: 25795306.

50. Li R, Raber M, Mejia L, Domenech M, Brewster A, Swartz MC, Strong L, Chandra J. Development and Feasibility of a Culturally Sensitive Cooking and Physical Activity Program Designed for Obese Hispanic Families. Infant, Child, & Adolescent Nutrition 20(10):1-8, 2015.

51. Irwin M, Johnson B, Manshouri R, Amin H, Chandra J. A NOX2/Egr-1/Fyn pathway delineates new targets for TKI resistant malignancies. Oncotarget 6(27):23631-46, 2015. PMID: 26136341.

52. Fulbright JM, Egas-Bejar DE, Huh WW, Chandra J. Analysis of redox and apoptotic effects of anthracyclines to delineate a cardioprotective strategy. Cancer Chemother Pharmacol 76(6):1297-307, 2015. PMCID: PMC4651800.

53. Luan J, Chu Z, Chandra J, Zhang P. Small Molecular Inhibitors Targeting Chromatin Regulating Proteins for Cancer. Curr Protein Pept Sci. 2016. PMID: 26796303.

54. Raber M, Swartz MC, Maria DS, O'Connor T, Baranowski T, Li R, Chandra J. Parental involvement in exercise and diet interventions for childhood cancer survivors: A systematic review. Pediatric Research. 2016. PMID: 27064243.

55. Swartz MC, Basen-Engquist KM, Markham C, Lyons EJ, Cox M, Chandra J, Ater JL, Askins MA, Scheurer ME, Lupo PJ, Hill R, Murray J, Chan W, Swank PR. Psychometric Analysis of the Three-Factor Eating Questionnaire-R18V2 in Adolescent and Young Adult-Aged Central Nervous System Tumor Survivors. Journal of Adolescent and Young Adult Oncology. 2016. PMID: 27042872.

56. Li R, Donnella H, Knouse P, Raber M, Crawford K, Swartz MC, Wu J, Liu D, Chandra J. A randomized nutrition counseling intervention in pediatric leukemia patients receiving steroids results in reduced caloric intake. Pediatric Blood & Cancer. 2016. PMID: 27615542.

57. Raber M, Chandra J, Upadhyaya M, Schick V, Strong LL, Durand C, Sharma S. An evidence-based conceptual framework of healthy cooking. Preventive Medicine Reports 4:23-8, 2016. PMCID: PMC4929050.

58. Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Scientific Reports 6:18953, 2016. PMCID: PMC4726202.

59. Raber M, Crawford K, Chandra J. Healthy cooking classes at a children's cancer hospital and patient/survivor summer camps: initial reactions and feasibility. Public Health & Nutrition:1-7. 2017. PMID: 28463101.

60. Zaky W, Manton C, Miller C, Khatua S, Gopalakrishnan V, Chandra J. The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities. Cancer and Metastasis Reviews. 2017. PMID: 29071526

61. Schadler K, Kleinerman E, Chandra J. Diet and exercise interventions for pediatric cancer patients during therapy: tipping the scales for better outcomes. Pediatric Research. 83:50-56. 2017 PMID: 29068433

62. Rivera-Del Valle N, Cheng T, Irwin M, Donnella H, Singh M, Chandra J. Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations. Cancer Chemotherapy & Pharmacology. 81(3):483-495. 2018 PMID: 29313067/

63. Raber M, Huynh TN, Crawford K, Kim S, Chandra J. Development and feasibility of a community based, culturally flexible colorectal cancer prevention program. Journal of Community Health. 43(5):882-885. 2018. PMID: 29532214

64. Wang F, Iskra B, Kleinerman E, Alvarez-Florez C, Andrews T, Shaw A, Chandra J, Schadler K, Aune GJ. Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity. Journal of Pediatric Hematology and Oncology. 40(3):208-215. 2018. PMID:29557918

65. Eterovic AK, Maher OM, Chandra J, Chen K, Huse J, Zaky W. Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing. J Natl Compr Canc Netw. 16(6):683-691. 2018. PMID:29891519

Joya Chandra, Ph.D.

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66. Herbrich SM, Kannan S, Nolo RM, Hornbaker M, Chandra J, Zweidler-McKay PA. Characterization of TRKA signaling in acute myeloid leukemia. Oncotarget. 10;9(53): 2018. PMID:30046390

Invited Articles 1. McConkey DJ, Chandra J. Protease activation and glucocorticoid-induced apoptosis in

chronic lymphocytic leukemia. Leuk Lymphoma 33:421-431, 1999. PMID: 10342570. 2. Mow BM, Blajeski AL, Chandra J, Kaufmann SH. Apoptosis and the response to anticancer

therapy. Curr Opin Oncol 13:453-462, 2001. PMID: 11673685. 3. Robertson JD, Chandra J, Gogvadze V, Orrenius S. Biological reactive intermediates and

mechanisms of cell death. Adv Exp Med Biol 500:1-10, 2001. PMID: 11764918. 4. Chandra J. Oxidative stress by targeted agents promotes cytotoxicity in hematological

malignancies. Antioxid Redox Signal 11(5):1123-1127, 5/2009. PMCID: PMC2842131. 5. Fulbright JM, Huh W, Anderson P, Chandra J. Can anthracycline therapy for pediatric

malignancies be less cardiotoxic? Current Oncology Reports 12(6):411-9, 11/2010. PMID: 20820959.

6. Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan, D, Cusack Jr JC, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, McBride W, McConkey DJ, Miller C, Neuteboom STC, Ovaa H, Pajonk F, Roccaro AM, Sloss CM, Spear MA, Valash E, Younes A and Palladine MA. Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials. Current Cancer Drug Targets 11(3):254-284, 2011.

7. Miller CP, Singh MM, Rivera-Del Valle N, Manton CA, Chandra J. Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inibitors. Journal of Biomedicine and Biotechnology, 2011. PMCID: PMC3134392.

8. Co-Reyes E, Li R, Huh W, Chandra J. Malnutrition and Obesity in Pediatric Cancer Patients: Causes, Consequences, and Interventions. Pediatric Blood & Cancer 59(7):1160-1167, 2012. PMCID: PMC3468697.

9. Irwin ME, Rivera-Del Valle N, Chandra J. Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities. Antioxidants & Redox Signaling 18(11):1349-83, 2013. PMCID: PMC3584825.

10. Cheng T, Grasse L, Shah J, Chandra J. Panobinostat, a pan-histone deacetylase inhibitor: rationale for and application to treatment of multiple myeloma. Drugs of Today--Prous Thomson Reuters 51(8):491-504, 2015. PMID: 26380387.

Book Chapters 1. Chandra J, Orrenius S. Apoptosis and oxidative stress: Promotion, modulation and

abrogation. In: Free Radicals in Chemistry, Biology and Medicine. OICA International UK Limited, 2000.

2. Chandra J, Orrenius S. Mitochondria, oxygen metabolism and the regulation of cell death. In: Proceedings from the Third International Conference on Oxygen and Life. Elsevier Sciences, 2002.

3. Chandra J, Kaufmann SH. Apoptotic pathways in cancer progression and treatment. In: Signal Transduction and Human Health. John Wiley & Sons, Inc., 2003.

4. Chandra J, Miller C. Therapeutic Utility of Proteasome Inhibitors for Acute Leukemia. In: New Agents for the Treatment of Acute Lympoblastic Leukemia, Chapter 13. Ed(s) Saha V. Kearns P. Springer, 273-298, 2011. PMID: 1-4419-8458-6.

5. Manton C, Chandra J. Oxidative stress and the proteasome: Mechanisms and therapeutic relevance. In: Resistance to Proteasome Inhibitors in Cancer. Ed(s) Q. Ping Dou. Springer International Publishing: Switzerland, 249-274, 2014. PMID: 978-3-319-06752-0.

EDITORIAL AND REVIEW ACTIVITIES Editor/Service on Editorial Board(s)

Joya Chandra, Ph.D.

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Editorial Board Member, Scientific Reports, 2014-present

Editorial Board Member, Leukemia & Lymphoma, 2017-present

Journal Reviewer Reviewer, Biochemical and Biophysical Research Communications, 2000-present

Reviewer, Cell Death and Differentiation, 2000-present

Reviewer, Leukemia, 2002-present

Reviewer, Anti-Cancer Drugs, 2003-present

Reviewer, Leukemia Research, 2003-present

Reviewer, Journal of Pediatric Hematology and Oncology, 2004-present

Reviewer, Molecular Cancer Research, 2004-present

Reviewer, Cancer Research, 2005-present

Reviewer, Clinical Cancer Research, 2005-present

Reviewer, Molecular Cancer Therapeutics, 2005-present

Reviewer, Blood, 2007-present

Reviewer, Journal of Cellular and Molecular Medicine, 2007-present

Reviewer, Journal of Molecular Medicine, 2007-present

Reviewer, Journal of the National Cancer Institute (JNCI), 2007-present

Reviewer, Antioxidant and Redox Signaling, 2008-present

Reviewer, Journal of Clinical Investigation, 2008-present

Reviewer, Medical Science Monitor, 2008-present

Reviewer, Oncogene, 2008-present

Reviewer, Pediatric Blood and Cancer, 2008-present

Reviewer, Apoptosis, 2009-present

Reviewer, Cancer Epidemiology, Biomarkers & Prevention, 2009-present

Reviewer, FABEB Journal, 2009-present

Reviewer, Leukemia & Lymphoma, 2009-present

Reviewer, Cancer Chemotherapy & Pharmacology, 2010-present

Reviewer, Chemico-Biological Interactions, 2010-present

Reviewer, Journal of Biomedicine and Biotechnology, 2010-present

Reviewer, Cancers, 2011-present

TEACHING Teaching Within Current Institution - The University of Texas MD Anderson Cancer Center

Formal Teaching Courses Taught

Lecturer, "Molecular Basis of Programmed Cell Death", Course Number: GS040181 1996-1997

Lectured, "Cancer Cell Signaling", Course Number: GS040133 2002-2009

Lectured, "Mechanisms in Cancer Therapeutics", Course Number: GS040213 4/2005-present

Lecturer, "Cancer Cell Signaling", Course Number: GS040133

Joya Chandra, Ph.D.

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2011-2014

Lecturer, "Cell Biology", Course Number: GS040013 2011-2014

Lecturer, Topics in Molecular Medicine, The University of Texas Graduate School of Biomedical Sciences, Course Number: GS211611

2012-2014

Translational Sciences: From Bedside to Bench and Back, The University of Texas Graduate School of Biomedical Science, Course Number: GS211232

2012-present

Lecturer, Fundamental Mechanisms in Cancer Development, The University of Texas Graduate School of Biomedical Sciences

9/2013-present

Lecturer and Week 10 Leader, GSBS Core Course 2015-present

Supervisory Teaching Committees

Advisory Committees Sanaz Khanbolooki, 1/2003-5/2006

Jack Bevers, 6/2003-7/2004

Rina Bhagat, 7/2003-2/2005

Banafshah Mirkinjoo, 8/2004-4/2005

Chair, Claudia Miller, 10/2004-4/2005

Lei Guo, 10/2004-6/2005

Brett Ewald, 10/2004-12/2005

Stacey Ruiz, 5/2005-4/2006

Kathleen Jensen, 5/2005-8/2007

Scott Teakell, 6/2005-11/2007

Cornel Philip, 10/2005-5/2007

Rina Bhagat, 1/2006-5/2009

Marlene Artime, 3/2006-7/2006

Chair, Adrienne Howard, 5/2006-12/2008

Brett Ewald, 6/2006-5/2008

Banafshah Mirkinjoo, 6/2006-2/2009

Claudia Miller, 3/2007-5/2009

Lei Guo, 5/2007-5/2008

Cornell Philip, 2/2008-6/2009

Jessica Deorbeta, 5/2008-12/2012

Deeksha Vishwamitra, 8/2008-8/2009

Hillary Gibbons, 8/2008-8/2009

Krithi Rao Bindal, 8/2008-5/2012

Chair, Nilsa Rivera, 8/2008-5/2013

Scott Kopetz, 9/2008-5/2009

Joya Chandra, Ph.D.

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Matthew White, 9/2008-5/2013

Hillary Caruso, 11/2008-5/2010

Jennifer Cultrera, 2/2009-5/2011

Wells Brown, 5/2009-8/2012

Stephanie Erzinger, 10/2009-5/2011

Lakiesha DeBose, 11/2009-12/2012

Lenka Hurton, 1/2010-10/2014

Chair, Christa Manton, 3/2010-1/2015

Jen-Te Tseng, 5/2010-8/2010

Jillian Wise, 9/2010-5/2012

Limin Zhu, 10/2010-5/2014

Chair, Blake Johnson, 2/2011-10/2011

Viralkumar Patel, 2/2011-10/2011

Jiemiao Hu, 3/2011-12/2012

Camille Graham, 5/2011-6/2014

Nat Greeley, 7/2011-2/2012

Alessandra DiLorenzo, 10/2011-5/2013

Qingshan Yang, 10/2011-5/2013

Monica Reyes, 12/2011-12/2014

Nat Greeley, 2/2012-8/2012

Geraldine Raja, 2/2012-2017

Madonna McManus, 2/2012-2016

Blake Johnson, 4/2012-12/2014

Nupur Lala, 4/2012-2017

Simin Kiany, 4/2012-2017

Sarah Klein, 5/2012-12/2013

Andrea Ochoa, 7/2012-2017

Felix Nwajui, 7/2012-2017

Janice Santiago-O'Farrill, 8/2012-5/2015

Lindsey Minter, 9/2012-8/2014

David Rushworth, 3/2013-4/2015

Fnu Preetypriya, 10/2013-5/2015

Todd Bartkowiak, 11/2014-2017

Anitha Somanchi, 1/2015-2017

Selena Hernandez, 6/2015-2017

Gloria Galvan, 8/2015-present

Bryan Wehrenberg, 9/2015-present

Jena Tavormina 10/2015-present

Devin Plote 10/2015-present

Joya Chandra, Ph.D.

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SuetYan Kwan 10/2015-12/2015

Shelley Herbrich 10/2015-present

Farah Hasan 8/2016-present

Andrea Garcia 8/2016-5/2017

Rosa Santana Carrerro 9/2016-present

Teresa Nguyen 10/2016-present

Pavitra Viswanath 11/2016-2018

Shradha Wali 12/2016-present

Hieu Van 9/2017-present

Ashabari Mukherjee 9/2017-present

Anchit Bhagat 10/2017-present

Jiseong Kim 10/2017-present

Mitra Nair 3/2018-present

Examining Committees Jennifer Carew, 6/2003-1/2004

Stephen Nawrocki, 6/2003-1/2004

Sanaz Khanbolooki, 5/2004-5/2005

Pangela Papageorgeou, 6/2004-5/2005

Stacey Ruiz, 8/2004-12/2004

Keyi Zhu, 1/2005-7/2005

Jennifer Frey, 2005-2006

Banafshah Mirkinjoo, 5/2005-6/2006

Marlene Artime, 5/2005-12/2006

Lei Guo, 7/2005-2006

Brett Ewald, 1/2006-12/2006

Rina Bhagat, 1/2006-12/2006

Cornel Philip, 5/2007-10/2007

JenTe Tseng, 6/2007-5/2008

Scott Kopetz, MD, 11/2007-6/2008

Lenka Hurton, 2/2009-8/2009

Chair, Matthew White, 11/2009-5/2010

Mai Ngoc-Anh Tran, 1/2010-7/2010

Jillian Wise, 6/2010-2/2011

Katrina Salazar, 8/2010-10/2010

Chair, Jiemiao Hu, 9/2010-12/2010

Chair, Carly Yang, 2/2011-7/2011

Chair, GSBS, Monica Reyes, 2/2011-10/2011

Chair, GSBS, Quingshan Yang, 4/2011-10/2011

Noc Bui, 8/2011-10/2014

Joya Chandra, Ph.D.

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Blake Johnson, 10/2011-12/2011

Chair, Viralkumar Patel, 10/2011-1/2012

Avinashnarayan Venkatnarayan, 10/2011-3/2012

Lindsey Ann Cauthen, 10/2011-3/2012

Member, Lindsey Minter, 11/2011

Daniel Smith, 1/2012-9/2012

Limin Zhu, 3/2012-8/2012

Justin Wong, 4/2012-3/2015

Amanda Hanks, 7/2012-10/2012

Deeksha Vishwamitra, 7/2012

Jing Li, 8/2012-11/2012

Madonna McManus, 8/2012-11/2012

Dennis Ruder, 9/2013-12/2013

Andrea Ochoa, 9/2013

Felix Nwajei, 10/2013

Jeanette Tucker, 1/2014

Jolie Schafer, 7/2015-8/2015

Todd Bartkowjak, 8/2015

Ruoji Zhou, 9/2015

Marissa Hornbaker, 12/2015

Chair - Devin Plote, 9/2016

Gloria Galvan, 9/2016

Marimar de la Cruz Bonilla, 9/2016

Chair- Shelley Herbrich 4/2017

Jiseong Kim 9/2017

Shradha Wali 10.2017

Direct Supervision Undergraduate and Allied Health Students

Bradley Eisemann, 6/2004-7/2004

Jason Long, 8/2004-4/2006

Tejas Manchandia, 5/2006-8/2006

Shan Gao, 5/2006-5/2008

Sharmistha Rudra, 5/2007-8/2008

Randal Hale, 5/2008-8/2008

Carolina Gonzales, 6/2009-7/2009

Michael Ting, 5/2010-12/2010

Michelle Suh, 6/2010-7/2010

Jalissa Furr, 6/2011-7/2011

Lotanna Ikeotuonye, 6/2011-7/2011

Mary Blake, 6/2012-8/2012

Joya Chandra, Ph.D.

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Muhammad Jalal, 6/2012-8/2012

Ashley Garza, 6/2013-8/2013

Kathleen Wilson, 6/2013-8/2013

Vivian Hu, 6/2013-8/2013

Rachel Robinson, 6/2014-8/2014

Srikar Ranga, 6/2014-8/2014

LaNisha Patterson, 6/2015-8/2015; 6/2016-8/2016

Megan Mandile, 6/2015-8/2015

Amanda Pacheco, 6/2016-8/2016

Yusha Sun, 6/2017-8/2017; 6/2018-8/2018

Trever Carter, 6/2017-8/2017

Lawrence Garvin, 6/2018-8/2018

Emily Steinman, 6/2018-8/2018

Medical Students Erica Co-Reyes, 2011-2012

Philip Knouse, 6/2013-8/2013

Patrick Ruggles, 6/2015-8/2015

Kendal Kiser, 6/2016-8/2016

Graduate Students Graduate School of Biomedical Sciences, Jennifer Carew, Predoctoral Fellow, 11/2002-7/2003

Graduate School of Biomedical Sciences, Melanie Dujka, Predoctoral Tutorial Student, 1/2003-3/2003

Graduate School of Biomedical Sciences, Claudia Miller, Predoctoral Fellow, 3/2003-6/2010

Graduate School of Biomedical Sciences, Stacey Ruiz, Predoctoral Fellow, 3/2005-4/2006

Graduate School of Biomedical Sciences, Johanna James, Predoctoral Tutorial Student, 9/2005-12/2005

Graduate School of Biomedical Sciences, Aaron Mobley, Predoctoral Tutorial Student, 2006

Graduate School of Biomedical Sciences, Adrienne Howard, Predoctoral Fellow, 1/2006-12/2008

Graduate School of Biomedical Sciences, Elizabeth Barba, Predoctoral Tutorial Student, 3/2006-6/2006

Graduate School of Biomedical Sciences, Nilsa Rivera, Predoctoral Fellow, 6/2008-3/2013

Graduate School of Biomedical Sciences, Michael Wetzel, Predoctoral Tutorial Student, 9/2008-11/2008

Graduate School of Biomedical Sciences, LaKeisha DeBose, Predoctoral Tutorial Student, 3/2009-6/2009

Graduate School of Biomedical Sciences, Christa Manton, Predoctoral Tutorial Student, 5/2009-8/2009

Joya Chandra, Ph.D.

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Graduate School of Biomedical Sciences, Tanushree Chatterjee, Predoctoral Tutorial Student, 11/2009-11/2010

Graduate School of Biomedical Sciences, Deeksha Vishwamitra, Predoctoral Tutorial Student, 3/2010-5/2010

Graduate School of Biomedical Sciences, Thuy Vu, Predoctoral Tutorial Student, 3/2010-5/2010

Graduate School of Biomedical Sciences, Christa Manton, Predoctoral Fellow, 3/2010-5/2010

Graduate School of Biomedical Sciences, Blake Johnson, Predoctoral Tutorial Student, 9/2010-11/2010

Graduate School of Biomedical Sciences, Michelle Martinez, Predoctoral Tutorial Student, 9/2010-11/2010

Graduate School of Biomedical Sciences, Janice Santiago-O'Farrill, Predoctoral Tutorial Student, 1/2011-3/2011

Graduate School of Biomedical Sciences, Phillip Knouse, Predoctoral Tutorial Student, 3/2011-5/2011

Graduate School of Biomedical Sciences, Denisse Meza, Predoctoral Tutorial Student, 9/2011-11/2011

Graduate School of Biomedical Sciences, Daisy Martinez, Predoctoral Tutorial Student, 3/2012-6/2012

Graduate School of Biomedical Sciences, Maryann Shariati, Predoctoral Tutorial Student, 9/2013-12/2013

Graduate School of Biomedical Sciences, Selena Hernandez, Predoctoral Tutorial Student, 9/2014-12/2014

Graduate School of Biomedical Sciences, Cavan Bailey, Predoctoral Tutorial Student, 3/2015-6/2015

Graduate School of Biomedical Sciences, Luisa Coronel, Predoctoral Tutorial Student, 3/2016-6/2016

Graduate School of Biomedical Sciences, Ashabari Mukherjee, Predoctoral Tutorial Student, 8/2016-12/2016

Graduate School of Biomedical Sciences, Mary Figueroa, Predoctoral Tutorial Student, 3/2016-6/2016

Graduate School of Biomedical Sciences, Alexandria Blackburn, Predoctoral Tutorial Student, 3/2016-6/2016

GSBS Students Completing Degrees Claudia Miller 10/2004-5/2009 Adrienne Howard 9/2006-12/2008 Nilsa Rivera Del Valle 8/2008-5/2013 Christa Manton 9/2010-5/2015 Blake Johnson 4/2012-12/2014 Cavan Bailey 5/2015-present Nupur Lala 7/2015-12/2015 Luisa Coronel 5/2016-present Mary Figueroa 5/2017-present

Postdoctoral Research Fellows

Susan Stephenson, Ph.D., 11/2004-6/2005

Joya Chandra, Ph.D.

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Kechen Ban, Ph.D., 1/2005-1/2006

Yin Gao, Ph.D., 8/2006-11/2007

Melissa M. Singh, Ph.D., 3/2009-8/2014

Claudia Miller, Ph.D., 6/2009-6/2010

Mary Irwin, Ph.D., 8/2010-8/2016

Tiewei Cheng, PhD, 3/2015-present

Alexsandra Espejo, PhD, 11/2016-11/2017

Clinical Residents and Fellows Joy Fulbright, M.D., 2008-2010

Lorimar Ramirez, M.D., 11/2010-5/2012

Daniella Egas-Bejar, M.D., 9/2012-6/2014

Fernando Corrales-Medina, M.D., 9/2012-6/2014

Brianna Murphy, D.O., 8/2017-present

Other Supervisory Teaching Margaret Raber, MPH, 5/2012-8/2018

Teaching Outside Current Institution Formal Teaching

Courses Taught Lectured and led laboratory practical portion in, "Apoptosis: Theory and Methods", Karolinska Institute

1999-2000

Lectured, "Drug resistance in cancer chemotherapy", Karolinska Institute, Karolinska Hospital Course

1999

Lecturer, Emerging Agents for the Treatment of Cancer and AIDS, Mayo Graduate School 2001

Lectured, Mayo Graduate School Course "Emerging Agents for the Treatment of Cancer and AIDS", Mayo Clinic

2001

Supervisory Teaching Committees

Advisory Committees Member, Dissertation Committee, UT School of Nursing, Laura Santibanez, PhD, 9/2015-present

Supervisory Committees N/A

Examining Committees Baylor College of Medicine, Melanie Anne Heney, 9/2008

Direct Supervision Graduate Students

Biochemistry and Molecular Biology, Mayo Clinic, Jennifer Hackbarth, Predoctoral fellow

Division of Toxicology, Karolinska Institute, Lena Goldschmidt, Predoctoral fellow

Division of Toxicology and Medical Nobel Institute, Karolinska Institute, Mari Enoksson, Predoctoral fellow

Joya Chandra, Ph.D.

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The University of Texas-Houston School of Public Health, Mayurika Pise, Predoctoral Student, 2010-2011

The University of Texas-Houston School of Public Health, Maria Chang, Predoctoral Student, 2010-2015

The University of Texas-Houston School of Public Health, Margaret Raber, Predoctoral Student, 2013-2018

University of Houston, UHand Program, Sahar Eshtehardi, Predoctoral Student, 2018-present

CONFERENCES AND SYMPOSIA Organization of Conferences/Symposia (Include chairing session)

2nd International Conference on Drug Discovery & Therapy, Dubai, United Arab Emirates, Organizing Secretary/Track Chair, 2/2010

MDACC / Baylor College of Medicine Joint Symposia on Pediatric Oncology, Houston, TX, Organizer and Session Chair, 2/2013

MDACC Pediatric Neuro-oncology Symposium in Memory of Dr. Marnie Rose, Houston, TX, Chair, 2/2014

University of Texas MD Anderson Cancer Center, Symposia on Cancer Research 2015, Houston, TX, Moderator, 10/2015

Neuro Oncology and Brain Tumor Conference Organizer, Brisbane, Australia, 7/19/2016

MDACC Second Pediatric Neuro-oncology Symposium in Memory of Dr. Marnie Rose, Houston, TX, Organizer and Session Chair, 2/2017

University of Texas MD Anderson Cancer Center, Symposia on Cancer Research, Cancer Metabolism, Houston, TX, Organizer and Session Chair, 10/2017

Presentations at National or International Conferences Invited

Effects of adaphostin, a novel tyrphostin inhibitor, in diverse models of imatinib mesylate resistance, 12th SPORE Investigator's Workshop, Baltimore, MD, 7/1/2004

Preclinical evaluation of NPI-0052, an irreversible proteasome inhibitor, in hematological malignancies, Winter SPORE Meeting for Hematological Malignancies, City of Hope, Duarte, CA, 7/2005

The novel, orally active proteasome inhibitor, NPI-0052, induces apoptosis in leukemia cell lines and patient specimens, 47th Annual Meeting of American Society of Hematology, Atlanta, GA, 12/2005

The novel proteasome inhibitor, NPI-0052, synergizes with HDAC inhibitors to trigger apoptosis in leukemia cells, 97th Annual Meeting of the American Association for Cancer Research, Los Angeles, CA, 4/2007

Incorporating measurements of oxidative stress into correlative studies for targeted therapies, POETIC Conference, POETIC Semi-Annual Meeting, Aspen, CO, 8/2007

Novel clinically relevant proteasome inhibitors and HDAC inhibitors, Ehrlich II, 2nd World Conference on Magic Bullets, Nurenberg, Germany, 10/3/2008

Oncogene-induced oxidative stress: implications for cancer progression and drug resistance in leukemia, Life Sciences 2nd Annual Cancer Congress-2009, Beijing, China, 6/1/2009

Joya Chandra, Ph.D.

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Translational Cancer Research Using Novel Clinically Relevant Proteasome Inhibitors and Histone Deacetylase Inhibitors, 2nd International Conference on Drug Discovery and Therapy, Dubai, United Arab Emirates, 2/4/2010

Augmenting the Efficacy of HDAC Inhibitors, Cambridge Healthtech Institute's 8th International Discovery on Target, Boston, MA, 11/2010

Targeting of Fyn induction by oxidative stress is an effective strategy for overcoming kinase inhibitor resistance in chronic myeloid leukemia and treating blast crisis, AACR International Conference on New Horizons in Cancer Research, Gurgaon, Delhi, India, 12/16/2011

Targeting histone methylation and acetylation in acute lymphocytic leukemia, NCI, Hematological Malignancy SPORE Workshop, Rockville, MD, 3/9/2015

The epigenetics of pediatric cancers, 11th Annual Life Sciences and Society Symposium, University of Missouri, Columbia, MO, 3/15/2015

Overcoming TKI resistance in chronic myeloid leukemia and EGFR mutant glioblastoma by targeting a Nox2-Egr1-Fyn pathway, Special Conference on Anticancer Drug Action and Drug Resistance: from Cancer Biology to the Clinic, EACR-AACR-SIC 2015, Florence, Italy, 6/22/2015

Seminar Invitations from Other Institutions Oxidatively stress-ing out leukemia cells, Stanford University, Palo Alto, CA, 5/2006

Leukemia cells thrive on oxidative stress: a mechanistic role for the Src family member, Fyn, University of Maryland, Greenebaum Cancer Center, Baltimore, MD, 9/2007

A role for oxidative stress in the mechanism of action of novel biologically targeted therapies, AC Camergo Hospital, Pediatric Department, Sao Paulo, Brazil, 4/4/2008

Exploiting redox environments in leukemia cells for therapeutic value. DKFZ, German Cancer Research Center, Heidelberg, Germany, 10/8/2008

Exploiting the Oxidative Environment of Leukemia Cells for Therapeutic Gain, The University of Puerto Rico, San Juan, Puerto Rico, 12/5/2008

Proteasome inhibitors in glioblastoma, Emory School of Medicine, Atlanta, GA, 6/2013

Being a postdoc in the land of Nobel, Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital, Columbus, OH, 11/22/2013

Leveraging the cellular redox environment to optimize cancer therapies and minimize late effects, Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital, Columbus, OH, 11/22/2013

Understanding the redox environment of cancer cells to design and improve therapeutics, University of Texas Health Science Center at Houston, Pathology and Lab Medicine, Houston, TX, 3/14/2014

Cellular life and death decisions mediated by oxidative stress, Loyola University, Signal Transduction Research Institute, Chicago, IL, 5/16/2014

Modulating Oxidative Stress in Cancer Cells, Baylor/Texas Children's, Center for Cell & Gene Therapy, Houston, TX, 1/20/2015

Targeting Oxidative Stress Emanating from Oncogenic Kinases, Molecular Physiology Seminar Series, Baylor College of Medicine, Molecular Physiology and Biophysics, Houston, TX, 2/24/2015

Promoting healthy lifestyles in pediatric cancer patients and survivors, University of Queensland School of Public Health, Brisbane, Australia, 7/25/2016

Promoting healthy lifestyles in pediatric cancer patients and survivors, Department of Health and Human Performance, University of Houston, Houston, TX 10/26/2016

Joya Chandra, Ph.D.

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PROFESSIONAL MEMBERSHIPS/ACTIVITIES Professional Society Activities, with Offices Held

National and International American Association for Cancer Research

Member, 1996-present

American Association for the Advancement of Science Member, 1997-1999

Women in Cancer Research Member, 1997-present

American Society of Hematology Member, 2003-present

Children's Oncology Group Member, 2003-present

Society for Neurooncology

Member, 2017-present

UNIQUE ACTIVITIES NIH Awards Trainees Mentored

1. F31 CA123645, Ruth L. Kirchstein National Research Service Award, Claudia P. Miller, 2006-

2009 2. F32 CA150610, Ruth L. Kirchstein National Research Service Award, Melissa Singh, 2011-

2014 3. F32 CA171905, Ruth L. Kirchstein National Research Service Award, Mary E. Irwin, 2012-

2015 4. NCI R25 Fellowship for Cancer Prevention Research Training Program, Maria Chang, 2012-

2013 5. NCI R25 Fellowship for Cancer Prevention Research Training Program, Margaret Raber,

2014-2018