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GEORGE  V.Z  DEDOUSSIS,  PHD  

DATE  AND  PLACE  OF  BIRTH:  25TH  OF  MAY  1966  IN  ATHENS  

PROFESSOR  OF  HUMAN  MOLECULAR  GENETICS  

NATIONALITY:  GREEK  

DEPARTMENT  OF  NUTRITION  AND  DIETETICS,  HAROKOPIO  UNIVERSITY,  70  EL.  VENIZELOU  

STR,  17671  KALLITHEA  –ATHENS,  TEL:  0030-‐210-‐9549304,  CELL:  0030-‐6973536730,  EMAIL:  DEDOUSI@HUA.GR  

 

Diplomas  and  Awards  

1988   Bachelor  of  Biology,  University  of  Patras  

1989   Erasmus  fellowship  for  post-‐graduate  studies  in  Compiegne,  France.  

1990   D.E.A  of  Biotechnology,  Microbiology  et  Bioconversion,  University  of  Compiegne,  France.  Title  of  

research  project:  “Production  of  human  monoclonal  antibodies  against  tumor  antigens  in  breast  

cancer”,  Compiegne,  France  

1990-‐1994   Participation  in  the  EEC  program  “Production  of  Monoclonal  Antibodies  against  cancer”  Saint  Savas  

Anticancer  Hospital  of  Athens  

1995   PhD  Thesis.  “Phenotypic  and  functional  characterization  of  tumor  infiltrating  lymphocytes  in  breast  

cancer”.  Medical  School  of  Athens.  

1996-‐1998   Post-‐Doctoral  research  in  the  laboratory  of  Molecular  Biology  in  the  Center  of  Thalassaemia  in  

Athens.  Participation  in  the  EEC  program  EPET  I  “Development  of  new  biotechnological  approaches  

for  the  diagnosis  and  therapy  of  genetic  disorders.  

2004  

2010-‐today  

2009-‐today  

 

 

 

2000-‐today  

 

2018  

Fulbright  Fellow  for  three  months  at  Harvard  Medical  School,  Department  of  Genetics,  Boston  

Guest  Editor  in  Genetics:  Current  Nutrition  Reports  

Grant  reviewer  for  the  Greek  General  Secretary  of  Research  and  Technology  GREECE,  Institute  

National  de  la  santé  et  de  la  recherché  medicale,  101.  Rue  de  Tolbiac,  75654  Paris  Cedex  13,  

FRANCE,  Romanian  National  Council  for  Scientific  Research,  Schitu  Magureanu  Blvd,  3rd  floor,  5th  

sector,  050025  Bucharest,  Romania.  

Grants  awarded  from  National  funding,  private  sector  and  European  Union,  in  total  >4.000.000  

Euros.  

Among  the  higly  cited  scientists  for  the  last  decade  

Professional  situation  

1990-‐1994   Participation  in  the  EEC  program  “Production  of  Monoclonal  Antibodies  against  cancer”  Saint  Savas  

Anticancer  Hospital  of  Athens  

1991=2000   Lecturer  at  the  Department  of  Psychology,  University  of  Rouen,  and  the  Department  of  Sociology,  

University  of  Strasburg,  France  in  collaboration  with  the  Francophone  college  (CFES)  

2000-‐2004   Lecturer  of  Molecular  Biology  

2004-‐2008   Assistant  Professor  of  Human  Cellular  and  Molecular  Biology  

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2009-‐2013   Associate  Professor  of  Human  Cellular  and  Molecular  Biology  

2013-‐today   Full  Professor  

Administration  assignements  

Institutional  coordinator  of  the  Erasmus  program  (2011-‐2018)  

Board  Member  of  the  University  Council  (2012-‐2016)  

Member  of  the  National  Research  and  Innovation  Council  (2016-‐2020)  

Director  of  the  Laboratory  of  Biology/Biochemistry/Microbiology/Physiology  (2017-‐2020)  

 

Invited  speaker  in  international  meetings    

 

1. 8th   International   Seminar   of   the   Greek   Institute   of   Osteoporosis,   Athens,   November   2003.   Speaker   in  

roundtable  on  "The  role  of  genetics  in  the  pathogenesis  of  osteoporosis."    

2. Biologie  Prospective   -‐   Santorini  Conference  2004  From  Human  Genetic  Variations   to  Prediction  of  Risks  

and  Responses  to  the  Environment.    

3. ESPT   (European   Society   of   Pharmacogenetics   and   Theranostics)   Summer   School,   Lyublyana   2012.   Two  

lectures:  Introduction  to  Human  Genetics,  Nutrigenetics/Nutrigenomics.  

4. 6th   Santorini   Conference   Biology   Prospective   “Systems   Biology   and   Personalised   Health   Science   and  

Translation”  Title  of  Lecture:  Gene  Environment  Interactions,  Santorini,  30/09-‐02/10/2012.  

5. 3rd   congress  of   the  European  Society  of  Preventive  Medicine   (EUSPM),  Riolo  Terme,   Italy,   9-‐10  March,  

2013.  Title  of  Lecture:  Genetic  predisposition  of  childhood  obesity.  The  impact  of  nutrition.  

6. EASD   NAFLD   Study   Group   Meeting   NewCastle,   11th-‐12th   May   2015.   The   Hellenique   NAFLD   study.  

Genetics  and  Lifestyle  determinants.  Nutritional  intervention  with  Corinthian  raisins.  

7. 7th   Santorini   Conference   Biology   Prospective   “Systems   Biology   and   Personalised   Health   Science   and  

Translation”   Title   of   Lecture:   Non-‐alcoholic   fatty   liver   disease.   Genetic   etiology   and   nutritional  

intervention,  Santorini,  25-‐27/9/2014.  

8. 8th   Santorini   Conference:   Systems   Medicine   and   Personalized   Health   and   Therapy,   Title   of   Lecture:  

Nutritional   interventions   in   Non-‐alcoholic   fatty   liver   disease.   The   MAST4HEALTH   program.   Santorini,  

Greece,  3-‐5  October  2016.    

 

Visiting  Professor  abroad    

 

[1]  Visiting  Professor,  (2004,  2007,  2009,  2010,  2018),  at  INSERM  U525  Equipe  4,  Faculté  de  Pharmacie  -‐  

UHP  Nancy  1  (Director:  Professor  Gérard  SIEST),  30  rue  Lionnois  -‐  54000  NANCY  –  France.  

[2]  Visiting   Professor   at   the   University   of   Tartu,   Estonia,   under   the   auspices   of   bilateral   collaborations  

Greece-‐Estonia,  6/2006.  

 

Academic  duties  

 

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Supervisor  of  the  following  PhD  thesis  

1) Mutation   analysis   in   Familial   Hypercholesterolemia   patients   of   Greek   and   German   origin.   (Status:  completed).  

2) Mutation  analysis  of  SLC3A1  and  SLC7A9  genes  in  Greek  patients  with  cystinuria.  (Status:  completed).  3) Interactions  of  genes,  nutrition  and  lifestyle  determinants  in  ageing  people.  (Status:  completed).  4) Interactions  of  genetic  and  nutrition  determinants  in  childhood  obesity.  (Status:  completed).  5) Dietary  patterns  and  genetic  predisposition  on  phenotypes  associated  with  cardiovascular  disease.    

(Status:  completed).  6) Cardiometabolic  indices  in  isolated  cohorts:  Genetic  predisposition  and  environmental  modifiers.  

(Status:  completed).  7) Genomics  in  extreme  obesity.  (Status:  in  progress,  expected  to  defend  soon).  8) Interactions  of  genetic  variants  with  lifestyle  determinants  in  bone  metabolism  indices.  (Status:  

expected  to  defend  soon).  9) Non  alcoholic  fatty  liver  disease.  Genetic  aetiology  and  interactions  with  dietary  factots.  (Status:  

completed).  10) Functional  Biology  in  cardiovascular  disease.  (Status:  in  progress).  11) Design  of  prognostic  computational  tools  in  Non-‐Alcoholic  Fatty  Liver  Disease.  (Status:  in  progress).    

Research  Grants  awarded  (>4,000,000  Euros)  

 

Project  acronym   Title   Funding  Agency     Duration  (years)  

Budget  (Euros)  

PAVET  2000  (coordinator)  

Methods   for   the   analysis  recording   and   saving   of   genetic  data   in   Familial  Hypercholesterolemia  (FH)  

Secretary  of  research  and  innovation  of  

Greek  ministry  (GSRT)  

2   255.320  

IKYDA  2001  (coordinator)  

Mutation  analysis  of  LDL-‐R  gene  in  Greek   and   German   patients   with  FH.  

IKY   2   15.000  

Private  (coordinator)  

Association  of  CTR  genotype  with  responsiveness   to   therapy   with  calcitonin   in   meta-‐menopausal  females  with  osteoporosis.    

Novartis   1   5.000  

PENED  2003  (coordinator)  

Study   of   polymorphisms   in  endothelium   inflammation.  Dietary  determinatns  as  modifiers  in   gene   expression   in  cardiovascular  disease.    

GSRT   3   67.500  

ZINCAGE  (partner)  

Nutritional   zinc,   oxidative   stress  and   immunosenescence:  biochemical,   genetic   and   lifestyle  implications  for  healthy  ageing    

FP6-‐FOOD  European  Community  

3   115.000  

EUGINDAT  (partner)  

European   Genomics   Initiative   on  Disorders   of   Plasma   membrane  Amino  acid  Transporters  

FP6-‐2002-‐LIFESCIHEALTH  

3   25.000  

GENDAI  (coordinator)  

Gene  nutrient  interactions  in  childhood  obesity  

Coca  Cola   2   100.000  

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WilsonIndia  (partner)  

Novel  opportunities  for  diagnosis  and  therapy  of  Wilson’s  disease  in  India  

FP7-‐PEOPLE-‐2009-‐IRSES.  Marie  Curie    

3   7.500  

Androgenetic  Alopecia  (coordinator)  

Genetic  predisposition  of  androgenetic  alopecia  

DHI  Global  Medical  Group  

1   11.800  

HELIC  (co-‐coordinator)  

Study  of  cardiometabolic  indices  in  Hellenic  Isolated  Cohorts  

Wellcome  Trust  Sanger  Institute  

2   147.000  

HRAKLEITOS  ΙΙ  (coordinator)  

Gene-‐dietary  patterns  interactions  in  childhood  obesity  

Ministry  of  Education  and  religion  affairs  

3   38.750  

Cooperation  2011  (partner)  

Obesity  and  metabolic  syndrom:  Nutritional  intervention  with  Corinthian  raisins  in  NAFLD/  NASH  patients.  Exploration  of  molecular  mechanisms.  

GSRT   3   245.000  

Erasmus  2011-‐16  (coordinator)  

Placements  of  Harokopio  University  students  and  staff  members  

ΙΚΥ   4   350.000  

THALIS    (coordinator)  

Genomic  study  in  morbid  obesity.  Genetic  risk  varinats,  the  role  of  nutrition  and  the  lifgestyle.  

Ministry  of  Education  and  religion  affairs  

3   585.000  

Marie-‐Curie  RISE    (coordinator)  

Mastiha  treatment  for  healthy  obese  with  NAFLD  diagnosis  (MAST4HEALTH).  

EU   4   2.124.000  

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Publications (15 out of 275)

 

1. Giri  A,  Hellwege  JN,  Keaton  JM,  ...Dedoussis  G,...  Edwards  TL.  Trans-‐ethnic  association  study  of  blood  pressure   determinants   in   over   750,000   individuals.   Nat   Genet.   2019   Jan;51(1):51-‐62.   doi:  10.1038/s41588-‐018-‐0303-‐9.      

2. Gilly  A,  Southam  L,  Suveges  D,  Kuchenbaecker  K,  Moore  R,  Melloni  GEM,  Hatzikotoulas  K,  Farmaki  AE,  Ritchie  G,   Schwartzentruber   J,   Danecek   P,   Kilian   B,     Pollard  MO,  Ge   X,   Tsafantakis   E,  Dedoussis  G,  Zeggini   E.   Very   low   depth   whole   genome   sequencing   in   complex   trait   association   studies.  Bioinformatics.  2018  Dec    21.  doi:  10.1093/bioinformatics/bty1032.      

ACADEMIC SCORING Citations h-factor Total impact factor Mean impact factor Publications

>45000 70 >6000 21 275

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3. Hackinger   S,   Prins   B,   Mamakou   V,   Zengini   E,   Marouli   E,   Brčić   L,   Serafetinidis     I,   Lamnissou   K,  Kontaxakis  V,  Dedoussis  G,  Gonidakis  F,  Thanopoulou  A,  Tentolouris  N,  Tsezou  A,  Zeggini  E.  Evidence  for  genetic  contribution  to  the  increased  risk  of  type  2  diabetes  in  schizophrenia.  Transl  Psychiatry.  2018  Nov  23;8(1):252.  doi:  10.1038/s41398-‐018-‐0304-‐6.      

4. Gilly  A,  Suveges  D,  Kuchenbaecker  K,  Pollard  M,  Southam  L,  Hatzikotoulas  K,  Farmaki  AE,  Bjornland  T,  Waples  R,  Appel  EVR,  Casalone  E,  Melloni  G,  Kilian  B,  Rayner  NW,  Ntalla  I,  Kundu  K,  Walter  K,  Danesh  J,  Butterworth  A,  Barroso  I,  Tsafantakis  E,  Dedoussis  G,  Moltke  I,  Zeggini  E.  Cohort-‐wide  deep  whole  genome   sequencing   and   the   allelic   architecture   of   complex   traits.   Nat   Commun.   2018   Nov  7;9(1):4674.  doi:  10.1038/s41467-‐018-‐07070-‐8.      

5. Mahajan  A,  Taliun  D,  Thurner  M,  Dedoussis  G,..McCarthy  MI.   Fine-‐mapping   type  2  diabetes   loci   to  single-‐variant   resolution   using   high-‐density   imputation   and   islet-‐specific   epigenome   maps.   Nat  Genet.  2018  Nov;50(11):1505-‐1513.  doi:  10.1038/s41588-‐018-‐0241-‐6.    

 6. Turcot  V,  Lu  Y,  Highland  HM,…Dedoussis  G…Loos  RJF.Protein-‐altering  variants  associated  with  body  

mass   index   implicate   pathways   that   control   energy   intake   and   expenditure   in   obesity.   Nat   Genet.  2018  Jan;50(1):26-‐41.  doi:  10.1038/s41588-‐017-‐0011-‐x.  

 7. Kraja   A,   Cook   JP,   Warren   HR,...Dedoussis   G,….   Howson   J.   New   Blood   Pressure   Associated   Loci  

Identified   in   Meta-‐Analysis   of   475.000   individuals.   Circ   Cardiovasc   Genet.   2017   Oct.   doi:  10.1161/CIRCGENETICS.117.001.778.  

 8. Mozaffarian   D,   Dashti   HS,   Wojczynski   MK,…   Dedoussis   G,   Chasman   DI,   Raitakari   O,   Tanaka   T.  

Genome-‐wide  association  meta-‐analysis  of   fish  and  EPA+DHA  consumption   in  17  US  and  European  cohorts.  PLoS  One.  2017  Dec  13;12(12):e0186456.  doi:  10.1371/journal.pone.0186456.  

 9. Marouli  E,  Kanoni  S,  Mamakou  V,  Hackinger  S,  Southam  L,  Prins  B,  Rentari  A,  Dimitriou  M,  Zengini  E,  

Gonidakis   F,   Kolovou   G,   Kontaxakis   V,   Rallidis   L,   Tentolouris   N,   Thanopoulou   A,   Lamnissou   K,  Dedoussis   G,   Zeggini   E,   Deloukas   P.   Evaluating   the   glucose   raising   effect   of   established   loci   via   a  genetic  risk  score.  PLoS  One.  2017  Nov  10;12(11):e0186669.  doi:  10.1371/journal.pone.0186669.  

 10. Stathopoulou   M,   Xie   T,   Ruggiero   D,…,Dedoussis   G,..,Visvikis-‐Siest   S.   -‐   The   VEGF   ConsortiumA  

transnational   collaborative   network   dedicated   to   the   study   and   applications   of   the   Vascular  Endothelial  Growth  Factor–A  in  medical  practice:  The  VEGF  Consortium".  Clin  Chem  Lab  Med.  2017  Oct   31.   pii:   /j/cclm.ahead-‐of-‐print/cclm-‐2017-‐0838/cclm-‐2017-‐0838.xml.   doi:   10.1515/cclm-‐2017-‐0838.  

 11. Liu  DJ,  Peloso  GM,  Yu  H…Dedoussis  G,…,Kathiresan  S.  Exome-‐wide  association  study  of  plasma  lipids  

in  >300,000  individuals.  Nat  Genet.  2017  Dec;49(12):1758-‐1766.  doi:  10.1038/ng.3977.    

12. Tachmazidou  I,  Süveges  D,  Min  JL,  …Dedoussis  G,…,Zeggini  E.  Whole-‐Genome  Sequencing  Coupled  to  Imputation   Discovers   Genetic   Signals   for   Anthropometric   Traits.   Am   J   Hum   Genet.   2017   Jun  1;100(6):865-‐884.  doi:  10.1016/j.ajhg.2017.04.014.  

 13. Nelson  CP,  Goel  A,  Butterworth  AS,…Dedoussis  G,…,Deloukas  P.  Association  analyses  based  on  false  

discovery  rate  implicate  new  loci  for  coronary  artery  disease.  Nat  Genet.  2017  Sep;49(9):1385-‐1391.  doi:  10.1038/ng.3913.  

 14. Kaliora   AC,   Kalafati   IP,   Gioxari   A,   Diolintzi   A,   Kokkinos   A,   Dedoussis   GV.   A   modified   response   of  

NAFLD  patients  with  non-‐significant  fibrosis   in  nutritional  counseling  according  to  GCKR  rs1260326.  Eur  J  Nutr.  2017  Jul  10.  doi:  10.1007/s00394-‐017-‐1499-‐7.  

 15. Xue   Y,   Mezzavilla   M,   Haber   M,   McCarthy   S,   Chen   Y,   Narasimhan   V,   Gilly   A,   Ayub   Q,   Colonna   V,  

Southam   L,   Finan   C,  Massaia   A,   Chheda   H,   Palta   P,   Ritchie   G,   Asimit   J,   Dedoussis   G,   Gasparini   P,  Palotie  A,  Ripatti  S,  Soranzo  N,  Toniolo  D,  Wilson  JF,  Durbin  R,  Tyler-‐Smith  C,  Zeggini  E.  Enrichment  of  low-‐frequency   functional   variants   revealed   by   whole-‐genome   sequencing   of   multiple   isolated  European  populations.  Nat  Commun.  2017  Jun  23;8:15927.  doi:  10.1038/ncomms15927.