CURRICULUM VITAE October, 2014

Professional address: Service de Chirurgie Générale, Hépatique Endocrinienne et Transplantation Hopital Universitaire de HAUTEPIERRE Avenue Molière 67098 STRASBOURG – France Secretary +33 3 88 12 72 58

Birth Date: June 07, 1960

Birth Place: Lons-le-Saunier , France

Education:

1978 Graduated from High School

1991 M.D. University Louis Pasteur. School of Medicine - Strasbourg - France

2001 Master’s degree (Diplôme d’Etudes Approfondies DEA) Molecular Biology Department University Louis Pasteur - School of Medicine - Strasbourg - France

2005 Accreditation to Supervise Research Division of Research and Medical Study University Louis Pasteur - School of Medicine - Strasbourg - France

Philippe BACHELLIER

Professor of Surgery and Chairman HPB Surgery Department of HPB Surgery & Transplantation University Hospital of Hautepierre Strasbourg, - France

Training and Diplomas:

1986-1991 Resident in Surgery : University Hospital - Strasbourg, - France (One year duty as Doctor in French Army in 1998)

1991-1994 Registrar in Digestive Surgery : University Hospital - Strasbourg, - France

1991-1994 Chief Resident: University Louis Pasteur - School of Medicine - Strasbourg

1994 - 2006 Consultant in Digestive and HPB Surgery University Hospital - Strasbourg - France

Since 2006, Apr. 1st Professor of Surgery HPB Surgery Department of HPB Surgery & Transplantation University Hospital of Hautepierre- Strasbourg - France

Since 2008, Sept. 1st Professor of Surgery and Chairman HPB Surgery Department of HPB Surgery & Transplantation

University Hospital of Hautepierre- Strasbourg - France

Since 2011, Feb. 1st Head of « Pôle des Pathologies Digestives, Hépatiques et de la Transplantation » which gathers three Departments in University Hospital of Hautepierre- Strasbourg - France - Department of Digestive Surgery (Upper GI and Colo-Rectal Surgery).

Chairman : Prof. Serge Rohr - Department of Gastroenterolgy.

Chairman : Prof. Bernanrd Duclos - Department of HPB Surgery & Transplantation.

Chairman Prof. Philippe Bachellier

Surgical associations Member of AFC (Association Française de Chirurgie) Member of ACHBT (Association de Chirurgie Hépatobiliaire et Transplantation) Membre de la FFCD (Fédération Francophone de Cancérologie Digestive) Member of IASGO (International Association of Surgeons, Gastroenterologists and Oncologists) Member of IHPBA (International Hepato-Pancreato-Biliary Association) Member of A-EHPBA (African and European Hepato-Pancreato-Biliary Association) Associate member of Académie Nationale de Chirurgie (Paris-France)

Main Publications (Impact Factor >1) among 134 referenced in Pub Med 1. PARIS F., ARNAUD J.P., SCHAAL J.C., PIAT J.M., BACHELLIER P., JAECK D.

Résection des métastases hépatiques des cancers colo-rectaux. Gastroentérol. Clin. Biol. 1992, 16, 879-889.

2. JAECK D., BACHELLIER P., GUIGUET M., BOUDJEMA K., VAILLANT J.C., BALLADUR P., NORDLINGER B., and the Association Française de Chirurgie

Long-term survival following resection of colorectal hepatic metastases. Br. J. Surg. 1997, 84, 977-980.

3. JAECK D., BACHELLIER P.

Conférence de Consensus – Textes des experts Sixième question : Quel traitement proposer dans les cancers coliques localement avancés et/ou métastatiques ? Quel traitement chirurgical proposer dans les cancers du côlon avec métastases viscérales (synchrones et métachrones) ? Gastroenterol. Clin. Biol. 1998, 22, S168-S176

4. BACHELLIER P., NAKANO H., OUSSOULTZOGLOU E., WEBER J.C., BOUDJEMA K., WOLF Ph., JAECK D.

Is pancreaticoduodenectomy with mesentericoportal venous resection safe and worthwhile ? Am. J. Surg. 2001, 182(2), 120-129

5. JAECK D., OUSSOULTZOGLOU E., BACHELLIER P., LEMARQUE P., WEBER J.C., NAKANO H., WOLF Ph.

Hepatic metastases of gastroenteropancreatic neuroendocrine tumors : Safe hepatic surgery. World J. Surg. 2001, 25(6), 689-692

6. WEBER J.C., NAKANO H., BACHELLIER P., OUSSOULTZOGLOU E., INOUE K, SHIMURA H., WOLF Ph., CHENARD-NEU M.P., JAECK D.

Is a proliferation index of cancer cells a reliable prognostic factor after hepatectomy in patients with colorectal liver metastases ? Am. J. Surg. 2001, 182(1), 81-88

7. BACHELLIER P., NAKANO H., WEBER J.C., LEMARQUE P., OUSSOULTZOGLOU E., CANDAU C., WOLF Ph., JAECK D.

Surgical repair after bile duct and vascular injuries during laparoscopic cholescystectomy: When and how? World J. Surg. 2001, 25(10), 1335-1345

8. JAECK D., NAKANO H., BACHELLIER P., INOUE K., WEBER J.C., OUSSOULTZOGLOU E., WOLF Ph., CHENARD-NEU M.P.

Significance of hepatic pedicle lymph node involvement in patients with colorectal liver metastases: a prospective study. Ann. Surg. Oncol. 2002, 9(5), 430-438

9. BOUDJEMA K., BACHELLIER P., WOLF Ph., TEMPE J.D., JAECK D.

Auxiliary liver transplantation and bioartificial bridging procedures in treatment of acute liver failure. World J. Surg. 2002, 26(2), 264-274

10. JAECK D., BACHELLIER P., NAKANO H., OUSSOULTZOGLOU E., WEBER J.C., WOLF Ph., GREGET M.

One or two-stage hepatectomy combined with portal vein embolization for initially nonresectable colorectal liver metastases. Am. J. Surg. 2003, 185(3), 221-229

11. WEBER J.C., BACHELLIER P., OUSSOULTZOGLOU E., JAECK D.

Simultaneous resection of colorectal primary tumour and synchronous liver metastases Br. J. Surg. 2003, 90, 956-962

12. OUSSOULTZOGLOU E., BACHELLIER P., BIGOURDAN J.M., WEBER J.C., NAKANO H., JAECK D.

Pancreaticogastrostomy decreased relaparotomy caused by pancreatic fistula after pancreaticoduodenectomy compared with pancreaticojejunostomy Arch. Surg. 2004, 139, 327-335

13. JAECK D., BACHELLIER P., OUSSOULTZOGLOU E., WEBER J.C., WOLF Ph

Surgical resection of hepatocellular carcinoma. Post-operative outcome and long-term results in Europe : an overview Liver Transplant., 2004, 10, (2)Suppl 1,S58-S63

14. BACHELLIER P., HABIB N.A., WEBER J.C., JIAO L.R.

Bloodless liver resection using the monopolar floating-ball plus Ligasure diathermy World J. Surg. 2005, 29(1), 116

15. LUCESCU I., BACHELLIER P., ROSSO E., SCURTU R., OUSSOULTZOGLOU E., CIMPEANU I., JAECK D.

Preservation of the middle hepatic vein during left hepatectomy. J. Am. Coll. Surg. 2005, 201(3), 482-485

16. ROSSO E., BACHELLIER P., OUSSOULTZOGLOU E., SCURTU R., MEYER N, NAKANO H., VERASAY G., JAECK D.

Toward zero pancreatic fistula after pancreaticoduodenectomy with pancreaticogastrostomy Am.J.Surg. 2006, 191(6), 726-732

17. OUSSOULTZOGLOU E., BACHELLIER P., ROSSO E., SCURTU R., LUCESCU I., GREGET M., JAECK D.

Right portal vein embolization before right hepatectomy for unilobar colorectal liver metastases reduces the intra-hepatic recurrence rate. Ann. Surg. 2006, 244(1), 71-79

18. SCURTU R., BACHELLIER P., OUSSOULTZOGLOU E., ROSSO E., MARONI R., JAECK D.

Outcome after pancreaticoduodenectomy for cancer in elderly patients. J. Gastroint. Surg. 2006, 10(6), 813-822

19. FUKUDA S., OUSSOULTZOGLOU E., BACHELLIER P., ROSSO E., NAKANO H., AUDET M., JAECK D.

Significance of the depth of portal vein wall invasion after curative resection for pancreatic adenocarcinoma. Arch. Surg. 2007, 142(2), 172-179; discussion 180

20. ZACHARIAS T, JAECK D., OUSSOULTZOGLOU E., NEUVILLE A., BACHELLIER P.

Impact of lymph node involvement on long-term survival after R0 pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas J. Gastrointest. Surg. 2007, 11(3), 350-356

21. AYAV A., BACHELLIER P., HABIB N.A., PELLICCI R., TIERRIS J., MILICEVIC M.

Impact of radiofrequency assisted hepatectomy for reduction of transfusion requirements Am . J. Surg. 2007, 193(2), 143-148

22. BACHELLIER P., AYAV A., PAI M., WEBER J.C., ROSSO E., JAECK D., HABIB N.A., JIAO L.R.

Laparoscopic liver resection assisted with radiofrequency Am. J. Surg. 2007, 193(4), 427-430

23. BACHELLIER P., OUSSOULTZOGLOU E., ROSSO E., SCURTU R., LUCESCU I., OSHITA A., JAECK D.

Pancreatogastrostomy as a salvage procedure to treat severe postoperative pancreatic fistula after pancreatoduodenectomy Arch Surg 2008;143(10):966-70; discussion 971.

24. OUSSOULTZOGLOU E., PANARO F., ROSSO E., ZECA I., BACHELLIER P., PESSAUX P., JAECK D.

Use of Biclamp decreased the severity of hypocalcemia after total thyroidectomy compared with Ligasure: a prospective study World J Surg 2008;32(9):1968-73.

25. AYAV A., JIAO L., DICKINSON R., NICHOLLS J., MILICEVIC M., PELLICCI R., BACHELLIER P., HABIB N.

Liver resection with a multiprobe bipolar radiofrequency device Arch Surg 2008;143(4):396-401; discussion 401.

26. GIRAUDO G., GREGET M., OUSSOULTZOGLOU E., ROSSO E.; BACHELLIER P., JAECK D. Preoperative contralateral portal vein embolization before major hepatic resection is a safe and efficient procedure: a large single institution experience

Surgery 2008;143(4):476-82.

27. NAKANO H., OUSSOULTZOGLOU E., ROSSO E., CASNEDI S., CHENARD-NEU M.P., DUFOUR P., BACHELLIER P., JAECK D. Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy. Ann Surg 2008;247(1):118-24. 28. KHORSANDI S.E., BACHELLIER P., WEBER J.C., GREGET M., JAECK D., ZACHAROULIS D., ROUNTAS C., HELMY S., HELMY A., AL-WARACKY M., SALAMA H., JIAO L., NICHOLLS J., DAVIES A.J., LEVICAR N., JENSEN S., HABIB N.

Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human. Cancer Gene Ther. 2008; 15(4): 225-230. Epub 2008 Feb 8

29. VIDAL I., BLANCHARD N., ALEXANDRE E., GANDILLET A., CHENARD-NEU M.P., STAEDLER F., SCHUMACHER M., BACHELLIER P., JAECK D., FIRAT H., HEYD B., RICHERT L Improved xenogenic hepatocyte implantation into nude mouse liver parenchyma with acute liver failure when followed by repeated anti-Fas antibody (Jo2) treatment Cell Transplant 2008;17(5):507-24. 30. ILL0UZ S., ALEXANDRE E., PATTENDEN C., MARK L., BACHELLIER P., WEBB M., BERRY D., DENNISON A., RICHERT L.

Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes Phytother Res 2008; 22(12): 1688-91.

31. PESSAUX P., ROSSO E., PANARO F., OUSSOULTZOGLOU E., BACHELIER P.,

JAECK D. Preliminary experience with the hanging maneuvre for pancreaticoduodenectomy Eur J Surg Oncol 2009; 35(9): 1006-1010

32. ZACHARIAS T., OUSSOULTZOGLOU E., JAECK D. PESSAUX P., BACHELLIER P.

Surgery for recurrence of periampullary malignancies J Gastrointest Surg 2009;13(4):760-7

33. OUSSOULTZOGLOU E., ROSSO E., FUCHSHUBER P., STEFANESCU V., DIOP B.,

GIRAUDO G., PESSAUX P., BACHELLIER P., JAECK D. Perioperative carcinoembryonic antigen measurements to predict curability after liver resection for colorectal metastases : a prospective study Arch Surg 2008 ; 143(12) :1150-8 ; discussion 1158-9

34. OUSSOULTZOGLOU E., ROMAIN B., PANARO F., ROSSO E., PESSAUX P., BACHELLIER P., JAECK D.

Long-term survival after liver resection for colorectal liver metastases in patients with hepatic pedicle lymph nodes involvement in the era of new chemotherapy regimens Ann Surg 2009 ; 249(6) : 879-86

35. ROSSO E., CASNEDI S., PESSAUX P., OUSSOULTZOGLOU E., PANARO F., MAHFUD M., JAECK D., BACHELLIER P.

The role of « fatty pancreas » and of BMI in the occurrence of pancreatic fistula after pancreaticoduodenectomy. J Gastrointest Surg 2009 ; 13(10) : 1845-51

36. MARZANO E., LERMITE E., NOBILI C., TESSEYDOU C., BACHELLIER P., ARNAUD J.P., PESSAUX P.

Malignant rhabdoid tumour of the liver in the young adult : report of first two cases HPB Surg 2009 ; 2009 :628206.

37. OSHITA A., BACHELLIER P., ROSSO E., OUSSOULTZOGLOU E., LUCESCU I., AAHARA T., JAECK D.

A new technique for reconstruction of the middle hepatic vein without graft interposition “ the digging technique “. Hepatogastroenterology 2009 ; 56(94-95) : 1507-10

38. ABADIE-VIOLLON C, MARTIN H., BLANCHARD N., PEKTHONG D., BACHELLIER P ., MANTION G., HEYD B., SCHULER F., COASSOLO P., ALEXANDRE E., RICHERT L.

Follow-up to the pre-validation of a harmonised protocol for asessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation condition. Toxicol In Vitro 2010 ; 24(1) : 346-56. Epub 2009 Jun 2

39. RICHERT L., ABADIE C., BONET A., HEYD B., MANTION G., ALEXANDRE E., BACHELLIER P., KINGSTON S., PATTENDE C., ILLOUZ S., DENNISON A., HOFFMANN S, COECKE S.

Inter-laboratory evaluation of the response of primary human hepatocyte culture s to model CYP inducers - a European Centre for Validationof Alternative Methods (ECVAM) - funded re-validation study. Toxicol In Vitro 2010 ; 24(1) : 335-45. Epub 2009 Jun 2

40. NOBILI C., LECEVIC V., MARZANO E., CASNEDI S., GREGET M., BACHELLIER P., PESSAUX P.

Primary pancreatic sarcoma with livermetastases : is there a place for radical surgery ? Gastroenterol. Clin. Biol. 2010 ; 34(3) : 227-30. Epub 2010 Feb 4

41. PESSAUX P., PANARO F., CASNEDI S., ZECA I., MARZANO E., BACHELLIER P., JAECK D., CHENARD MP.

Targeted molecular therapies (cetuximab and bevacizumab) do not induce additional hepatotoxicity : preliminary results of a case-control study. Eur. J. Surg. Oncol. 2010 ; 36(6) : 575-82. Epub 2010 May 7

42. NTOURAKIS D., MARZANO E., LOPEZ PENZA P., BACHELLIER P., JAECK D., PESSAUX P.

Robotic distal splenopancreatectomy : bridging the gap between pancreatic and minimal access surgery. J. Gastrointest. Surg. 2010 ; 14(8) : 1326-30. Epub 2010 May 11

43. PESSAUX P., MARZANO E., CASNEDI S., BACHELLIER P., JAECK D., CHENARD MP.

Histological and immediate postoperative outcome after preoperative cetuximab : case-matched control study. World J. Surg. 2010 ; 34(11) : 2765-72.

44. PESSAUX P., CHENARD MP., BACHELLIER P., JAECK D.

Consequences of chemotherapy on resection of colorectal liver metastases. J. Visc. Surg. 2010 ; 147(4) :e193-201. Epub 2010 Jul 23

45. MARZANO E., ROSSO E., OUSSOULTZOGLOU E., COLLANGE O., BACHELLIER P., PESSAUX P.

Laparoscopic treatment of biliary peritonitis following nonoperative management of blunt liver trauma. World J. Emerg. Surg. 2010 ; 5 : 26.

46. OUSSOULTZOGLOU E., JAECK D., ADDEO P., FUCHSHUBER P, MARZANO E., ROSSO E., PESSAUX P., BACHELLIER P.

Prediction of mortality rate after major hepatectomy in patients without cirrhosis. Arch. Surg. 2010 ; 145(11) : 1075-81.

47. BACHELLIER P., ROSSO E., LUSCESCU I., OUSSOULTZOGLOU E., TRACEY J., PESSAUX P., FERREIRA N., JAECK D.

Is the need for an arterial resection a contraindication to pancreatic resection for locally advanced pancreatic adenocarcinoma ? A case-matched controlled study. J. Surg. Oncol. 2011 ;103(1) : 75-84.

48. FARGES O., FUKS D., LE TREUT YP., AZOULAY D., LAURENT A., BACHELLIER P., NUZZO G., BELGHITI J., PRUVOT FR., REGIMBEAU JM.

AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma : by the AFC-IHCC-2009 study group. Cancer 2011 ; 117(10):2170-7

49. NARITA M., OUSSOULTZOGLOU E., CHENARD MP., ROSSO E., CASNEDI S., PESSAUX P., BACHELLIER P., JAECK D.

Sinusoidal obstruction syndrome compromises liver regeneration in patients undergoing two-stage hepatectomy with portal vein embolization. Surg. Today 2011 ; 41(1) : 7-17

50. BACHELLIER P., ROSSO E, PESSAUX P, OUSSOULTZOGLOU E., NOBILI C., PANARO F., JAECK D.

Risk factors for liver failure and mortality after hepatectomy associated with portal vein resection. Ann. Surg. 2011 ; 253(1) : 173-9.

51. NEUVILLE A., NICOLET C., MEYER N., SCHNEIDER A., LEGRAIN M., BRIGAND C., DUCLOS B., BACHELLIER P., OUDET P., BELLOCQ JP., KEDINGER M., GAUB MP., GUENOT D.

Histologic characteristics of non-microsatellite-instable colon adenomas correlate with distinct molecular patterns. Hum. Pathol. 2011 ; 42(2) : 244-53.

52. REGIMBEAU JM., FUKS D., LE TREUT YP., BACHELLIER P., BELGHITI J., BOUDJEMA K., BAULIEUX J., PRUVOT FR., CHERQUI D., FARGES O.

Surgery for hilar cholangiocarcinoma : A multi-institutional update on practice and outcome by the AFC-HC study group. J. Gastrointest. Surg. 2011 ; 15(3) : 480-8

53. REGIMBEAU JM., FUKS D., BACHELLIER P., LE TREUT YP., PRUVOT FR., NAVARRO F., CHICHE L., FARGES O.

Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group. Eur. J. Surg Oncol. 2011, 37(6) : 505-12.

54. FARGES O., FUKS D., LE TREUT YP., AZOULAY D., LAURENT A., BACHELLIER P., NUZZO G., BELGHITI J., PRUVOT FR., REGIMBEAU JM.

AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma : By the AFC-IHCC-2009 study group. Cancer 2011, 117(10) : 2170-7.

55. NARITA M., OUSSOULTZOGLOU E., BACHELLIER P., ROSSO E., PESAUX P., JAECK D. Two-stage hepatectomy procedure to treat initially unresectable multiple bilobar colorectal liver metastases : technical aspects. Dig. Surg. 2011, 28(é) : 121-6.

56. FUKS D., REGIMBEAU JM., LE TREUT YP., BACHELLIER P., RAVENTOS A., PRUVOT FR., CHICHE L., FARGES O.

Incidental gallbladder cancer by the AFC-GBC-2009 Study Group. World J. Surg. 2011, 35(8) : 1887-97.

57. NARITA M., OUSSOULTZOGLOU E., JAECK D., FUCHSHUBER P., ROSSO E., PESSAUX P., MARZANO E., BACHELLIER P.

Two stage hepatectomy for multiple bilobar colorectal liver metastases Br. J. Surg. 2011, 98(10) : 1463-75.

58. HEINRICH S., PESTALOZZI B., LESURTEL M., BERREVOET F., LAURENT S, DELPERO JR., RAOUL JL., BACHELLIER P., DUFOUR P., MOEHLER M ., WEBER A., LANG H., ROGIERS X., CLAVIEN PA.

Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer : a randomized multicenter phase III study (NEOPAC study). BMC Cancer 2011 ; 11 : 346.

59. GUERIN E., RAFFELSBERGER W., PENCREACH E., MAIER A., NEUVILLE A., SCHNEIDER A., BACHELLIER P., ROHR S., PETITPREZ A., POCH O., MORAS D., OUDET P., LARSEN AK., GAUB MP., GUENOT D.

In vivo topoisomerase I inhibition attenuates the expression of Hypoxia Inducible Factor 1 alpha target genes and decreases tumor angiogenesis. Mol. Med. 2011 ; 18 : 83-94

60. FARGES O., FUKS D., BOLESLAWSKI E., LE TREUT YP., CASTAING D., LAURENT A., DUCERF C., RIVOIRE M., BACHELLIER P., CHICHE L., NUZZO G., REGIMBEAU JM.

Influence of surgical margins on outcome in patients with intrahepatic cholangiocarcinoma : a multicenter study by the AFC-IHCC-2009 Study Group. Ann. Surg. 2011, 254(5) : 824-30.

61. NARITA M., OUSSOULTZOGLOU E., CHENARD MP., FUCHSHUBER P., ROSSO E., PESSAUX P., JAECK D., BACHELLIER P.

Impact of biomarkers expression before and after portal vein embolization on recurrence after two-stage hepatectomy for colorectal liver metastases. J. Gastrointest. Surg. 2011 ; 16(3) : 554-61

62. FERREIRA N., OUSSOULTZOGLOU E., FUCHSUBER P., NTOURAKIS D., NARITA M., RATHER M., ROSSO E., ADDEO P., PESSAUX P., JAECK D., BACHELIER P.

Splenic vein-inferior mesenteric vein anastomosis to lessen left-sided portal hypertension after pancreaticoduodenectomy with concomitant vascular resection. Arch Surg. 2011 ;146(12):1375-81.

63. NOBILI C., MARZANO E., OUSSOULTZOGLOU E., ROSSO E., ADDEO P., BACHELLIER P., JAECK D., PESSAUX P.

Multivariate analysis of risk factors for pulmonary complications after hepatic resection. Ann Surg. 2012 ; 255(3):540-50

64. NARITA M., OUSSOULTZOGLOU E., FUCHSHUBER P., PESSAUX P., CHENARD M.P., ROSSO E., NOBILI C., JAECK D., BACHELLIER P.

What Is a Safe Future Liver Remnant Size in Patients Undergoing Major Hepatectomy for Colorectal Liver Metastases and Treated by Intensive Preoperative Chemotherapy? Ann Surg Oncol. 2012 ;19(8):2526-38

65. NARITA M., OUSSOULTZOGLOU E., CHENARD M.P., FUCHSHUBER P., RATHER M., ROSSO E., ADDEO P., JAECK D., BACHELLIER P.

Liver Injury Due to Chemotherapy-induced Sinusoidal Obstruction Syndrome Is Associated with Sinusoidal Capillarization. Ann Surg Oncol. 2012 ; 19(7) : 2230-7

66. ROSSO E., LOPEZ P., ROEDLISCH M.N., NARITA M., OUSSOULTZOGLOU E., BACHELLIER P. Double Omental Flap Reduced Perianastomotic Collections and Relaparotomy Rates after Pancreaticoduodenectomy with Pancreaticogastrostomy. World J Surg. 2012 ; 36(7) : 1672-8

67. NARITA M., OUSSOULTZOGLOU E., FUCHSHUBER P., CHENARD M.P., ROSSO E., YAMAMOTO K., JAECK D., BACHELLIER P. Prolonged Portal Triad Clamping Increases Postoperative Sepsis after Major Hepatectomy in Patients with Sinusoidal Obstruction Syndrome and/or Steatohepatitis.

World J Surg. 2012 ; 36(8) : 1848-57

68. ALEXANDRE E., BAZE A., PARMENTIER C., DESBANS C., PEKTHONG D., GERIN B., WACK C., BACHELLIER P., HEYD B., WEBER J.C., RICHERT L. Plateable cryopreserved human hepatocytes for the assessment of cytochrome P450 inducibility: experimental condition-related variables affecting their response to inducers. Xenobiotica. 2012 ; 42(10):968-79 69. NARITA M., OUSSOULTZOGLOU E., IKAI I., BACHELLIER P., JAECK D. Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg. 2012 Sep;256(3):e7-8; author reply e16-7 70. TURRINI O., PAYE F., BACHELIER P., SAUVANET A., Sa CUNHA A., Le TREUT Y.P., ADHAM M., MABRUT J.Y., CHICHE L., DELPERO J.R.; French Surgical Association (AFC). Pancreatectomy for adenocarcinoma in elderly patients: postoperative outcomes and long term results: a study of the French Surgical Association. Eur J Surg Oncol. 2013 Feb;39(2):171-8 71. ZAHID M.N., TUREK M., XIAO F., THI V.L., GUERIN M., FOFANA I., BACHELLIER P., THOMPSON J., DELANG L., NEYTS J., BANKWITZ D., PIETSCHMANN T., DREUX M., COSSET F.L., GRUNERT F., BAUMERT T.F., ZEISEL M.B. The postbinding activity of scavenger receptor class B type I mediates initiation of hepatitis C virus infection and viral dissemination. Hepatology. 2013 Feb;57(2):492-504 72. FARGES O., GOUTTE N., BENDERSKY N., FALISSARD B.; ACHBT-French Hepatectomy Study Group. Incidence and risks of liver resection: an all-inclusive French nationwide study. Ann Surg. 2012 Nov;256(5):697-704 73. FARGES O., REGIMBEAU J.M., FUKS D., LeTREUT Y.P., CHERQUI D., BACHELLIER P., MABRUT J.Y., ADHAM M., PRUVOT F.R., GIGOT J.F. Multicentre European study of preoperative biliary drainage for hilar cholangiocarcinoma. Br J Surg. 2013 ; 100(2):274-83 74. ADDEO P., OUSSOULTZOGLOU E., FUCHSHUBER P., ROSSO E., NOBILI C., SOUCHE R., JAECK D., BACHELLIER P. Reoperative surgery after repair of postcholecystectomy bile duct injuries: is it worthwhile? World J Surg. 2013 Mar;37(3):573-81 75. AUPET S., SIMONE G., HEYD B., BACHELLIER P., VIDAL I., RICHERT L., MARTIN H. Isolation of viable human hepatic progenitors from adult livers is possible even after 48 hours of cold ischemia. Tissue Eng Part C Methods. 2013 ; 19(7):497-506

76. ADDEO P., ROSSO E., FUCHSHUBER P., OUSSOULTZOGLOU E., SOUCHE R., NOBILI C., JAECK D., BACHELLIER P. Double purse-string telescoped pancreaticogastrostomy: an expedient, safe, and easy technique. J Am Coll Surg. 2013 Mar;216(3):e27-33 77. ADDEO P., DELPERO J.R., PAYE F., OUSSOULTZOGLOU E., FUCHSHUBER P., SAUVANET A., Sa CUNHA A., Le TREUT Y.P., ADHM M., MABRUT J.Y., CHICHE L., BACHELLIER P.; French Surgical Association (AFC). Pancreatic fistula after a pancreaticoduodenectomy for ductal adenocarcinoma and its association with morbidity : a multicentre study of the French Surgical Association. HPB (Oxford). 2014 ; 16(1):46-55 78. DELPERO J.R., BACHELLIER P., REGENET N., Le TREUT Y.P., PAYE F., CARRERE N., SAUVANET A., AUTRET A., TURRINI O., MONGES-RANCHIN G., BOHER J.M. Pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: a French multicentre prospective evaluation of resection margins in 150 evaluable s pecimens. HPB (Oxford). 2014 ; 16(1):20-33 79. VIDAL I., BLANCHARD N., CHENARD-NEU M.P., BACHELLIER P., HEYD B., STAEDTLER F., SCHUMACHER M., ALEXANDRE E., RICHERT L. Increased survival despite failure of transplanted human hepatocyte implantation into liver parenchyma of Nude mice with repeated lethal Jo2 induced-liver deficiency. Cell Transplant. 2013 Apr 29. [Epub ahead of print] 80. TURCANU M., ADDEO P., ROSSO E., BACHELLIER P. Pancreaticoduodenectomy after coronary artery bypass grafting with use of an in situ right gastroepiploic artery graft. Eur J Cardiothorac Surg. 2013 Aug;44(2):382-3 81. ADDEO P.,TUDOR G.,OUSSOULTZOGLOU E., AVEROUS G., BACHELLIER P. Pancreatic hamartoma. Surgery. 2013 May 4. pii: S0039-6060(13)00073-1 82. FUKS D., REGIMBEAU J.M., PESSAUX P., BACHELLIER P., RAVENTOS A., MANTION G., GIGOT J.F., CHICHE L., PASCAL G., AZOULAY D., LAURENT A., LETOUBLON C., BOLESLAWSKI E., RIVOIRE M., MABRUT J.Y., ADHAM M., Le TREUT Y.P., DELPERO J.R., NAVARRO F., AYAV A., BOUDJEMA K., NUZZO G., SCOTTE M., FARGES O. Is port-site resection necessary in the surgical management of gallbladder cancer? J Visc Surg. 2013 Sep;150(4):277-84 83. IMPERIALE A., ADDEO P., AVEROUS G., NAMER I.J., BACHELLIER P. Solid pseudopapillary pancreatic tumor mimicking a neuroendocrine neoplasm on "8F-FDOPA PET/CT. J Clin Endocrinol Metab. 2013 ; 98(7):2643-4 84. DESBANS C., HILGENDORF C., LUTZ M., BACHELLIER P., ZACHARIAS T., WEBER J.C., DOLGOS H., RICHERT L., UNGELL A.L. Prediction of fraction metabolized via CYP3A in humans utilizing cryopreserved human hepatocytes from a set of 12 single donors. Xenobiotica. 2014 ; 44(1):17-27 85. IMPERIALE A., ELBAYED K., MOUSSALLIEH F.M., REIX N., PIOTTO M., BELLOCQ J.P., GOICHOT B., BACHELLIER P., NAMER I.J. Metabolomic profile of the adrenal gland: from physiology to pathological conditions. Endocr Relat Cancer. 2013 28;20(5):705-16

86. ROSSO E., LANGELLA S., ADDEO P., NOBILI C., OUSSOULTZOGLOU E., JAECK D., BACHELLIER P. A safe technique for radical antegrade modular pancreatosplenectomy with venous resection for pancreatic cancer. J Am Coll Surg. 2013 ; 217(5):e35-9] 87. IMPERIALE A., MOUSSALLIEH F.M., SEBAG F., BRUNAUD L., BARLIER A., ELBAYED K., BACHELLIER P., GOICHOT B., PACAK K., NAMER I.J., TAIEB D. A new specific succinate-glutamate metabolomic hallmark in SDHx-related paragangliomas. PLoS One. 2013 ; 8(11):e80539 88. IMPERIALE A., RUST E., GABRIEL S., DETOUR J., GOICHOT B., DUCLOS B., KURTZ J.E., BACHELLIER P., NAMER I.J., TAIEB D. 18F-fluorodihydroxyphenylalanine PET/CT in patients with neuroendocrine tumors of unknown origin: relation to tumor origin and differentiation. J Nucl Med. 2014 ; 55(3):367-72 89. BACHELLIER P., ROSSO E., FUCHSHUBER P., ADDEO P., DAVID P., OUSSOULTZOGLOU E., LUCESCU I.. Use of a temporary intraoperative mesentericoportal shunt for pancreatic resection for locally advanced pancreatic cancer with portal vein occlusion and portal hypertension. Surgery. 2014 ; 155(3):449-56 90. ADDEO P., SAOULI A.C., WOEHL-JAEGLE M.L., ELLERO B., OUSSOULTZOGLOU E., MARCELLIN L., BACHELLIER P. Candida albicans arteritis transmitted by preservation fluid after liver transplantation. Ann Transplant. 2014 ; 19:64-7 91. ADDEO P., OUSSOULTZOGLOU E., FUCHSHUBER P., ROSSO E., NOBILI C., LANGELA S., JAECK D., BACHELLIER P. Safety and outcome of combined liver and pancreatic resections. Br J Surg. 2014 ; 101(6):693-700 92. REGIMBEAU J.M., FUKS D., PESSAUX P., BACHELLIER P., CHATELAIN D., DIOUF M., RAVENTOS A., MANTION G., GIGOT J.F., CHICHE L., PASCAL G., AZOULAY D., LAURENT A., LETOUBLON C., BOLESLAWSKI E., RIVOIRE M., MABRUT J.Y., ADHAM M., Le TREUT Y.P., DELPERO J.R., NAVARRO F., AYAV A., BOUDJEMA K., NUZZO G., SCOTTE M., FARGES O. Tumour size over 3!cm predicts poor short-term outcomes after major liver resection for hilar cholangiocarcinoma. By the HC-AFC-2009 group. HPB (Oxford). 2014 [Epub ahead of print] 93. MONTAUT S., MALLARET M., LAGUNA A.E., LAGHA-BOUKBIZA O., ENTZ WERLE N., MARCELLIN L., BACHELLIER P., IMPERIALE A., NAMER I.J., THOMAS L., ANHEIM M., TRANCHANT C. Anti-Hu-associated brainstem encephalitis with ganglioneuroblastoma in a young adult. J Neurol. 2014 ; 261(9):1822-4

Invited speaker (lectures)

1. Hepatectomy and adjuvant chemotherapy for colorectal liver metastases The 114th Annual Congress of Japan Surgical Society April 3-5, 2014 : Kyoto Japan BACHELLIER P 2. Extended pancreatectomy in the era of neoadjuvant chemotherapy The 112th Annual Congress of Japan Surgical Society April 12-14, 2012 : Chiba Japan BACHELLIER P 3. Advances in radical pancreatic surgery Annual HPB meeting : Hammersmith Hospital October 15h, 2012 : London UK 4. Safe and reliable procedure of hepatectomy The 23rd Meeting of the Japanese Society of Hepato-Biliary-Pancreatic Surgery June 8-10th, 2011 : Tokyo-Japan BACHELLIER P. 5. Multidisciplinary approach for treatment of colorectal liver metastases June 14th, 2011 University Medical School, Kyoto – Japan BACHELLIER P. 6. Pancreas surgery for pancreatic cancer Chiba University Graduate School of Medicine March 10th : Chiba – Japan BACHELLIER P. 7. Limits of pancreatic surgery and vascular reconstructions (in French) Multidisciplinary Symposium June 30th, 2011 University Hospital, Lausanne - Switzerland BACHELLIER P. 8. The pancreatogastric anastomosis (20 min) International meeting-Centro Congressi Humnitas Pancreatic resection : an update March 26-27th, 2010, Milano – Italy BACHELLIER P. 9. To drain or not to drain after pancreatic resection (20 min) International meeting-Centro Congressi Humnitas Pancreatic resection : an update March 26-27th, 2010, Milano – Italy BACHELLIER P. 10. Radical pancreatic resection Annual Course of HPB Surgery Hammersmith Hospital Conference Center September 28-29th, 2009, London - UK BACHELLIER P.

11. What’s new in pancreatic surgery Latest in radical surgery 31st National Congress SICO June 19-20th, 2008, Forli – Italy BACHELLIER P. 12. Controversies in the treatment of colorectal liver metastases and future perspectives May 16th, 2008 Luxembourg Hospital Center, Luxembourg BACHELLIER P.

French multicentric study (Book):

Rapport de l’Association Française de Chirurgie (AFC) 2010: Cancer du Pancréas. DELPERO JR., PAYE F., BACHELLIER P. 112ème Congrès Français de Chirurgie – PARIS – Oct 2010 A french multicentric retrospective and prospective study which collected 1670 resected patients for pancreatic adenocarcinoma in 37 institutions.

Book chapters: 1- WOLF Ph., BOUDJEMA K., ELLERO B., ODEH M., PARIS F., SCHAAL J.C.,

PIAT J.M., BACHELLIER P., JAECK D., CINQUALBRE J. Technique chirurgicale des multi-prélèvements. In "Le prélèvement d'organes". Ph. Lang et D. Houssin Edit. Masson, 1992 2- JAECK D., BALLADUR P., BACHELLIER P., PARIS F., VAILLANT J.C.,

SCHAAL J.C., BOUDJEMA K., NORDLINGER B. La résection chirurgicale des métastases hépatiques est-elle justifiée? In "Pratiques actuelles en hépatologie. Stratégies diagnostiques et thérapeutiques". M. Doffoël et D. Jaeck, Edit. Arnette, Paris, 1994, 39-51. 3- JAECK D., VEILLON F., BACHELLIER P., BOUDJEMA K., DOFFOEL M. Syndrome de Budd-Chiari: questions-réponses à propos du diagnostic et du traitement du bloc suprahépatique. In "Pratiques actuelles en hépatologie. Stratégies diagnostiques et thérapeutiques". M. Doffoël et D. Jaeck, Edit. Arnette, Paris, 1994, 99-102. 4- VETTER D., KARSENTY L., BACHELLIER P., ANANNA A., DOFFOEL M. Approche actuelle du traitement de la lithiase biliaire: cholécystectomie par voie coelioscopique et sphinctérotomie endoscopique. In "Pratiques actuelles en hépatologie. Stratégies diagnostiques et thérapeutiques". M. Doffoël et D. Jaeck, Edit. Arnette, Paris, 1994, 125-131. 5- BACHELLIER P., JAECK D. Plaie, contusion de l'abdomen. Orientation diagnostique et traitement d'urgence. La Revue du Praticien 1995, 45, 2205-2213.

6- JAECK D., BOUDJEMA K., BACHELLIER P., WEBER JC., ASENSIO T., WOLF Ph. Pancréatectomies Encycl. Méd. Chir. (Elsevier, Paris), Techniques Chirurgicales-Appareil digestif, 40-880-A, 1998, 2p.

7- JAECK D., BOUDJEMA K., BACHELLIER P., WEBER JC., ASENSIO T.,

WOLF Ph. Exérèses pancréatiques céphaliques : duodénopancréatectomies céphaliques (DPC) Encycl. Méd. Chir. (Elsevier, Paris), Techniques Chirurgicales-Appareil digestif, 40-880-B, 1998, 17p

8- JAECK D., BOUDJEMA K., BACHELLIER P., WEBER JC., ASENSIO T.,

WOLF Ph. Exérèse des tumeurs périampullaires Encycl. Méd. Chir. (Elsevier, Paris), Techniques Chirurgicales-Appareil digestif, 40-880-C, 1998, 5p

9- JAECK D., BOUDJEMA K., BACHELLIER P., WEBER JC., ASENSIO T.,

WOLF Ph. Pancréatectomies gauches ou distales. Encycl. Méd. Chir. (Elsevier, Paris), Techniques Chirurgicales-Appareil digestif, 40-880-D, 1998, 6p

10- JAECK D., BOUDJEMA K., BACHELLIER P., WEBER JC., ASENSIO T., WOLF Ph. Duodénopancréatectomies totales. Encycl. Méd. Chir. (Elsevier, Paris), Techniques Chirurgicales-Appareil digestif, 40-880-E, 1998, 5p

11- JAECK D., BOUDJEMA K., BACHELLIER P., WEBER JC., ASENSIO T.,

WOLF Ph. Pancréatectomies avec conservation duodénale. Encycl. Méd. Chir. (Elsevier, Paris), Techniques Chirurgicales-Appareil digestif, 40-880-F, 1998, 10p

12- JAECK D., BOUDJEMA K., BACHELLIER P., WOLF Ph.

Indications validées de la transplantation hépatique et autres indications. In « Progrès en hépato-gastroentérologie 3 (Nouvelle Série 1998) Transplantation hépatique : avant et après » Farges O., Miguet J.P., Doin Edit., Paris, 1998, Chapitre 2, 19-30

13- BACHELLIER P., JAECK D.

Résection hépatique segmentaire : technique de la segmentectomie IV J. Chir. 1999, 136(5), 257-263.

14- BACHELLIER P., JAECK D.

Métastases hépatiques des cancers colo-rectaux. Indications chirurgicales actuelles. Le Concours Médical 2000, 122 (29), 1999-2006

15- WEBER J.C., GONZALES N., BACHELLIER P., WOLF Ph., JAECK D.

Traitement chirurgical palliatif des cancers du pancréas. Encycl. Méd. Chir. (Elsevier, Paris), Techniques Chirurgicales-Appareil digestif, 40-894, 2000, 8p

16- STEIB A., SCHMITT-MUTTER C., BACHELLIER P., DUPEYRON J.P. Anesthésie pour chirurgie hépatique (en dehors de la transplantation) Conférences d’actualisation 2001. 43ème Congrès national d’anesthésie et de réanimation In ‘’ Editions scientifiques et médicales Elsevier SAS, et Sfar ‘’ 2001, 369-383

17- WEBER J.C., ARORA A., BACHELLIER P., JAECK D. Surgery in colorectal metastatic cancer.

In « Multi-treatment modalities of liver tumours » Nagy A. Habib Editor, Kluwer Academic/Plenum Publisher, New York, 2002, 43-54

18- JAECK D., MONEK O., OUSSOULTZOGLOU E., BACHELLIER P.

Bilobar metastatic colon cancer In « Surgical Management of Hepatobiliary and Pancreatic Disorders » Poston G.J. and Blumgart L.H., Martin Dunitz: Taylor & Francis Group, London and New York, 2003, 93-121

19- WEBER J.C., BACHELLIER P., OUSSOULTZOGLOU E., JAECK D.

Traitements chirurgicaux des métastases hépatiques. Encycl. Méd. Chir. (Elsevier, Paris) Techniques Chirurgicales- Appareil digestif 40-784, 2002, 7 p

20- BACHELLIER P., TIERRIS J., J.C. WEBER Current practice in pancreatic surgery In « Liver and Pancreatic Diseases Management » Series : Advances in Experimental Medicine and Biology, vol. 574, 2006, 111-143 Habib N. and Canelo R. Editors Springer Publisher

21- LEVICAR N., JIAO L., BACHELLIER P., ZAHAROULIS D., JAECK D., HELMY S.,

SALAMA H., NICHOLLS J., JENSEN S., HABIB N.A. Liver gene therapy : will gene therapy deliver to the liver patient ? In « Liver and biliary tract surgery. Embryological anatomy to 3D-imaging and transplant

innovations » Karaliotas, Broelsch, Habib, Springer Wien New-York, 2007, chapter 35, 441-449 22- BACHELLIER P., HOUSSEAU E., JAECK D.

A Whipple Pancreaticoduodenectomy Associated with « en monobloc »Mesenterico-Portal Vein Resection ACS Multimedia Atlas of Surgery : Pancreatic Surgery Volume. Chapter 30, 269-279 (2011)

23- BACHELLIER P, ROSSO E, JAECK D. Surgery of the Pancreatic Carcinoma : Commentary In « International Practices in Pancreatic Surgery » Mantke R, Lippert H, Büchler MW, Sarr MG Editors Springer-Verlag Berlin Heidelberg, 2013, Part I, 35-41 24- BACHELLIER P, ADDEO P. Extended Left Hepatectomy for Klatskin Tumor

ACS Multimedia Atlas of Surgery : Liver Surgery Volume. (Ahead of print)

Videos : 1) D. JAECK, Ph. BACHELLIER

Résection hépatique : Techniques chirurgicales. Vidéo, 1996

2) D. JAECK, Ph. BACHELLIER

La duodénopancréatectomie céphalique. Vidéo, 1997

3) D. JAECK, Ph. BACHELLIER Leberresektion in Strasbourg.

Vidéo, 2000 4) Ph. BACHELLIER, D. JAECK, J.C. WEBER, G. BRAUER et les Hôpitaux Universitaires de Strasbourg

Cholangiocarcinome du hile du foie : traitement chirurgical. 7e Festival International du Film Médical d’Amiens, (2e Prix) Amiens,

20-21 Septembre 2000 5) Ph. BACHELLIER, D.JAECK Pancreaticoduodenectomy with mesenterico-portal venous resection. Vidéo, 2001 6) D. JAECK, Ph. BACHELLIER, J.C. WEBER

Two stage hepatectomy combined with portal vein embolization for bilobar colorectal metastases. 50e Anniversaire de la première hépatectomie droite, Paris, 14-15 Décembre 2001 7) Ph. BACHELLIER, D. JAECK DPC avec curage ganglionnaire et résection veineuse. Vidéo, 2002 8) Ph. BACHELLIER, D. JAECK Laparoscopic resection of liver adenoma. Vidéo, 2002 9) Ph. BACHELLIER, D. JAECK Pancreatogastrostomy Vidéo, 2003 10) Ph. BACHELLIER, D. JAECK Treatment of bile duct injuries. Vidéo, 2004 11) Ph. BACHELLIER, D. JAECK Resection of Klatskin III-A tumor Vidéo, 2006 12) Ph. BACHELLIER, D. JAECK Resection of Klatskin III-B tumor Vidéo, 2008 13) Ph. BACHELLIER

Extended Duodenopancreatectomy with Vascular Resection and a Special “ Hanging Manoeuver “ to perform the Left splanchnicectomie Video, 2009

14) Ph. BACHELLIER

Pancreas adenocarcinoma of the uncinate process : duodenopancreatectomy with superior mesenteric vessels resection (arterial and venous resection) Video, 2010 Philippe Bachellier