c v i . s ta n fo rd .e d u | 1

QUARTERLY | SUMMER 2016AT THE FOREFRONT OF CARDIOVASCULAR MEDICINE

Welcoming New Faculty!Ioannis Karakikes, PhD, was appointed Assistant Professor of Car-diothoracic Surgery. Dr. Karakikes received his PhD from the Uni-versity of Essex (UK) and completed his postdoctoral training at the Cardiovascular Research Center at the Icahn School of Medicine at Mount Sinai, New York. His research focuses on delineating the mo-lecular mechanisms underling the pathogenesis of cardiomyopathies using patient-specific cardiomyocytes derived from human induced pluripotent stem cells (hiPSCs), and also the development of biologi-cal therapies for heart failure.

William Hiesinger, MD, has joined the Department of Cardiothoracic Surgery an Assistant Professor in Adult Cardiothoracic Surgery. He re-ceived his undergraduate degree from Dartmouth, and completed his medical degree at the University of Pennsylvania. He also conducted his general surgery and cardiothoracic surgery residency at Universi-ty of Pennsylvania. He has extensive surgical experience with thoracic transplantation, mechanical circulatory support, transcatheter aortic valve replacement, and endovascular thoracic aortic procedures. His lab at Stanford will focus on myocardial bioengineering, angiogenesis, and regeneration.

Elan Burton, MD, joins the Department of Cardiothoracic Surgery as a Clinical Assistant Professor, as its newest faculty member in Stanford’s Division of Adult Cardiothoracic Surgery. She will work at the divi-sion's Stanford program at the VA Hospital, and at the Santa Clara Val-ley Medical Center in San Jose. Dr. Bruton obtained her undergraduate degree from Duke University, and then went on to Morehouse School of Medicine to obtain her medical degree. She completed her residen-cy training in general surgery at the University of Pittsburgh Medical Center-Mercy. Dr. Burton then completed her cardiothoracic surgical training with Dr. Sarah Shumway at the University of Minnesota.

William Hiesinger, MD

Ioannis Karakikes, PhD

Elan Burton, MD

October 20th, 2016Stanford - Karolinska

Cardiovascular Research& MedicineSymposium

Li Ka Shing CenterBreakfast | Lunch | Wine & Cheese Reception

REGISTER HERE: http://tinyurl.com/cvik-2016

Cardiovascular Recruitment:• Two full-time academic

advanced heart failure andtransplant cardiologists in theMedical Center Line. Click fordetails.

• One full-time interventionalcardiologist to join the VA PaloAlto in the Medical Center Line.Click for details.

• One full-time faculty memberwith an interest in biobankingand the use of biobankedsamples in population researchin the University Tenure Line,Medical Center Line, or Non-Tenure Line (Research). Click fordetails.

• One full-time generalcardiologist in the ClinicianEducator line. Click for details.

• One full-time faculty memberin Pediatric Cardiology withan interest in cardiovasculargenetics in the University TenureLine or Medical Center Line.Click for details.

We are seeking highly qualified MD, PhD, or MD/PhD graduates. Applicants must be either a U.S. citizen or permanent resident to apply. Funding support includes postdoctoral salary, supplies, and travel for up to two years.

Application Deadline is August 15, 2016.

For information and to apply: http://med.stanford.edu/cvi/education/cvis-t32.html

Apply to CVI's T32 Imaging Fellowship

c v i . s ta n fo rd .e d u | 2

The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women

A recent study explored the relationship between adipokines leptin, adiponectin and resistin with incident of Atrial Fibrillation in women. The cohort included an ethnically diverse group of postmenopausal women aged 50–79 who were nationally recruited at 40 clinical centers as part of the Women's Health Initiative investigation. Of the 4,937 participants included, 892 developed AF over a follow-up of 11.1 years.

Those with AF had higher mean leptin, adiponectin and resistin levels. The study concluded that elevated levels of serum resistin are significantly associated with higher rates of incident AF and partially mediate the association between BMI and AF. Leptin and adiponectin levels were not significantly associated with AF.

Authors include Simon Ermakov, Farnaz Azarbal, Marcia L. Stefanick, Michael J. LaMonte, Wen-jun Li, Katie M. Tharp, Lisa W. Martin, Rami Nassir, Elena Salmoirago-Blotcher, Christine M. Al-bert, JoAnn E. Manson, Themistocles L. Assimes, Mark A. Hlatky, Joseph C. Larson, Marco V. Perez. This study was published in Heart, 2016 May 4.

The Institute currently consists of 124 faculty members representing engineers, physicians,

surgeons, basic and clinical researchers. The mission of the Institute is integrating fundamen-

tal research across disciplines and applying technology to prevent and treat cardiovascular

disease. To support cardiovascular research and education at CVI, please contact Cathy Hut-

ton, Senior Associate Director, Medical Center Development (cathy.hutton@stanford.edu) or

Dr. Joseph C. Wu, Director CVI ( joewu@stanford.edu), or Ingrid Ibarra, Assistant Director of

CVI, (iibarra@stanford.edu).

For more information: http://cvi.stanford.edu/waystogive.html and http://cvi.stanford.edu

About the Stanford Cardiovascular Institute

Cathy Hutton Ingrid Ibarra, PhD

Marcia Stefanick, PhD

ThemistoclesAssimes, MD PhD

Mark Hlatky, MD Marco Perez, MD

Study examines clinical outcomes of heart transplant

In a recent review Daniel Bernstein, MD, Alfred Woodley Salter and Mabel Smith Salter Endowed Professor in Pediatrics, highlights the contribution of the mitochondria- the energy hub of cells, in cardiovascular diseases.

The article entitled, ‘Mitochondrial remodeling: Rearranging, recy-cling, and reprogramming,’ was published in Cell Calcium Journal.

For more visit: http://www.ncbi.nlm.nih.gov/pubmed/27130902

Daniel Bernstein, MD

A recent study examined 102 heart transplant recipients to evaluate the relationship between periarterial neovascularization and the development of cardiac allograft vasculopathy (CAV) after heart transplantation. The group concluded that the presence of increasing periarterial small vessels (PSV) around the coronary arteries was associated with early CAV progression and reduced survival after heart transplantation. The article was published in J Heart Lung Transplant. 2016 and entitled ‘Association of periarterial neovas-cularization with progression of cardiac allograft vasculopathy and long-term clinical outcomes in heart transplant recipients.’ The authors include, Hideki Kitahara, Kozo Okada, Shigemitsu Tanaka, Kiran K. Khush, William F. Fearon and Yasuhiro Honda.

Mitochondrial remodeling: Rearranging, and reprogramming

Jin Qian, PhD

New T32 fellowJin Qian, PhD, was selected as a new trainee for the NIH fund-ed 'Mechanisms and Innova-tion in Vascular Disease' T32 training grant.

Her research is on "Develop-ment of PAH by progressive infiltration of ac-tivated macrophages that secrete LTB4 in the lung and mediate vascular remodeling".

c v i . s ta n fo rd .e d u | 3

By Sarah C. P. Williams

Stanford engineers and doctors collaborated with industry to design a possible new treatment for lymphedema, which often

affects cancer patients whose lymph nodes become blocked.

The lymphatic system drains fluids from the body’s tissues. When a lymphatic vessel is blocked, as is the case in lymphedema, fluid can get backed up into a limb, causing pain-ful swelling.

Researchers at the School of Medicine have developed a possible treatment for lymph-edema, the severe swelling of an arm or leg that can occur when the lymph system is blocked. Using scaffolding composed of specially patterned collagen nanofibers, the researchers coaxed lymph vessels to grow around lymph blockages.

The technique was effective at treating lymphedema in pigs, the scientists report in a study published online June 7 in Biomaterials.

“We were able to take a cue from nature about what molecules spur vessel growth, but also think outside the box and use this nanoscale scaffolding to bridge the blockages,” said Ngan Huang, PhD, assistant professor of cardiothoracic surgery and a co-senior author of the study. “I think combining the two was really key.”

The lymphatic system is responsible for draining fluids from the body’s tissues and filtering this lymph fluid. When a lymphatic ves-sel is blocked, as is the case in lymphedema, fluid can get backed up into a limb, causing painful swelling.

Huang’s lab, in collaboration with the Union City, California-based company Fibralign, has been studying how nanofibers of collagen can be used in medicine. Collagen, the most abundant protein in the human body, acts as a structural support in a variety of tissues. The scientists have designed nanofibers, dubbed “BioBridge,”

that mimic collagen’s different arrangements. “The unique feature about the BioBridge scaffolds is that they’re not just noodles on a nanoscale,” said Huang. “They have patterning that’s physiologi-cally relevant.”

Previously, Huang’s group has studied how the BioBridge nano-fibers can be used to guide new blood vessels. As new cells that make up the vessels grow, they align themselves along the nanofi-bers. But lymph vessels, at a molecular level, are similar to blood vessels. So Huang and her collaborators wondered whether the fibers could also be used to coax and direct new lymph vessel growth as well.

The scientists coated stretches of the BioBridge nanofibers with fragments of lymph nodes, since the nodes are known to produce molecules that stimulate new lymph vessel growth. Then, they surgically im-

Ngan Huang, PhD

Stanley Rockson, MD

planted the fibers around Photograph courtesy of Stanley Rockson

lymph blockages in pigs with lymphedema, building a stretch of fibers that bypassed each blockage like a bridge. After three months, the eight pigs that had received BioBridge scaffolding had 27 lymphatic collector vessels per square millimeter in the area around the implant, significantly more than the 1 lymphatic collector per square millimeter seen in control animals.

So far, the BioBridge approach has only been tested in pigs. But Fibralign has a small clinical trial planned in Latin America, and Rockson is putting together a Stanford-based study to test the treatment in breast cancer patients with lymphedema.

The study was funded by the U.S. Army Medical Research & Materiel Command and the National Science Foundation.

Read more: http://med.stanford.edu/news/all-news/2016/06/nanofi-

ber-scaffolds-could-treat-lymphedema.html

Nanofiber scaffolds could treat lymphedema by rerouting lymphatic system around blockages

Applications Due Aug. 1, 2016Each year the Cardiovascular Institute commits to support projects addressing major challenges in cardiovascular health and disease. To date the Institute has provided over $2,000,000 in awards to 70 projects since 2006. Projects aimed at establishing new areas of cardiovascular research and improve treatments are welcomed. Stanford faculty and Instructor members of the Cardiovascular Institute are eligible to apply. Visit http://tinyurl.com/cvisg2016 for details and previous seed award recipients.

2016 Stanford Cardiovascular Institute Seed AwardsResearch topics include:

• Diabetes and metabolism research• Pediatric and obstetric related

research• New methods and technologies• Vascular biology• Engineering• Genetics

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Stanford Biodesign New Arrhythmia TechnologiesIn May, the Stanford Biodesign New Arrhythmia Technologies Con-ference convened at Stanford to showcase updates on the latest in Sudden Cardiac Death (SCD) research. The conference presented the latest advances in state-of-the-art cardiac electrophysiology and provided opportunity for extensive discussion and interaction with the faculty and others interested in the field.

The audience included cardiac electrophysiologists, arrhythmia nurses and technologists, scientists, device experts, engineers, in-dustry and business leaders and scientists, investment leaders, and others with a special interest in arrhythmias. The Steven M. Gootter Foundation provided generous funding for this one- day conference organized by Paul Wang, MD and Sanjiv Narayan, MD.

Dorothy Dee & Marjorie Helene Boring Trust Research Award

As part of a $2M gift to the Cardiovascular Institute the Dorothy

Dee and Marjorie Helene Boring award supports medical students dedicated to cardiovascular research at Stanford

School of Medicine. Each recipient receives up to $15,000. Medical students

dedicate dto cardiovascular research should apply!

For details and to apply visit:

http://med.stanford.edu/cvi/research/i-heart-research-award.

html

A drug could be used to combat c a r d i o v a s c u l a r disease by targeting not mere risk factors such as high cholesterol or highblood pressure, but

the actual lesions bearing direct responsibility: atherosclerotic plaques.

Investigators at the Stanford University School of Medicine have learned the signal that tumor cells display on their surfaces to protect themselves from being devoured by the immune system also plays a role in enabling atherosclerosis, the process underlying heart attacks and strokes.

A biological drug capable of blocking this so-called “don’t eat me” signal is now being tested in clinical trials in cancer patients. The same agent, the investigators found, was able to prevent the buildup of atherosclerotic plaque in several mouse models of cardiovascular disease. If this success is borne out in human

studies, the drug could be used to combat cardiovascular disease — the world’s No. 1 killer — and do so by targeting not mere risk factors such as high cholesterol or high blood pressure, but the actual lesions bearing direct responsibility for cardiovascular disease: atherosclerotic plaques.

“It seems that heart disease may be driven by our immune system’s inability to ‘take out the trash,’” said Nicholas Leeper, MD, associate professor of vascular surgery and of cardiovascular medicine. A study describing the researchers’ findings was published online July 20 in Nature. Leeper is the senior author.

Atherosclerosis is caused by the deposition of fatty substances along arterial walls. Over the years, these substances form plaques. It’s now known that numerous dead and dying cells accumulate in atherosclerotic plaques, which inflammation renders brittle and vulnerable to rupture, the ultimate cause of heart attack and stroke.

Contributing to the pathology is malfeasance

on the part of a class of immune cells that first arrive at the site with presumably benign intentions, said Leeper.

Many cells in the human body feature a “don’t eat me” signal on their surface: a protein called CD47. The protein tells the immune system that a cell is alive, still going strong and part of a person’s healthy tissue.

Normally, as a cell approaches death, its CD47 surface proteins start disappearing, exposing the cell to macrophages’ garbage-disposal service. But atherosclerotic plaques are filled with dead and dying cells that should have

Anti-tumor antibodies could counter atherosclerosis

Nicholas Leeper, MD

By Bruce Goldman, Science Writer Stanford Medical School Office of Communication & Public Affairs

NEW DRUG Continued on p. 9

CD47, a 'don't eat me' protein

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New Program Announcement Vascular and Vein Clinic opens its doors in Portola ValleyThe Division of Vascular Surgery announces Stanford’s first ever Vascular and Vein Clinic. It is now open for patients with venous dis-ease and is located at 3240 Alpine Road in Portola Valley. The clinic provides comprehensive vascular care for medically necessary and cosmetic procedures to treat venous disease. This common disease affects more than 30 million people in the United States and is associated with decreased quality of life due to symptoms. Treat-ments are performed by a board certified Stanford physician in a private and serene setting.

‘Metformin treatment status and abdominal aortic aneurysm disease progression’ A recent study published by Dr. Ronald Dalman’s group, Walter Clif-

ford Chidester and Elsa Rooney Chidester Profes-sor of Surgery, was featured as an Editor’s Choice publication for July in the Journal of Vascular Surgery. The research article showed the associ-ation between diabetes mellitus and metformin on abdominal aortic aneurysm (AAA) disease. The au-thors include: Naoki Fujimura, Jiang Xiong, Ellen B.

Kettler, Haojun Xuan, Keith J. Glover , Matthew W. Mell, Baohui Xu and Ronald L. Dalman.

For more visit: https://www.youtube.com/watch?v=Ot1Z3BwGA40.

Welcome to New Vascular Surgery Fellows

Left to right: Graeme McFarland, MD; Michael Sgroi, MD; Tiffany Wu, MD Andy Lee, MD

For more visit: http://vascular.stanford.edu/education/curent-fel-lows-and-residents.html

T32 Vascular Biology Training Grant RecipientNathan Itoga, MD, was selected as a new trainee for the NIH funded 'Mechanisms and Innovation in Vascular Disease' T32 training grant managed by CVI. He began his first year on the grant on July 1.His research is on "Identifying and Reducing Vari-ability of Operating Room Supplies and DiagnosticImaging in Vascular Surgery Patients".

APDVS Election of Jason Lee, MDJason T. Lee, MD, Professor of Surgery in the Division of Vascular Surgery at Stanford was elected Secretary/Treasurer of the Associ-ation of Program Directors in Vascular Surgery.

VASCULAR NEWS:

Ronald Dalman, MD

Nathan Itoga, MD

Mary Leonard, MD, MSCE, professor of pediatrics and of medicine, has been appointed chair of the Department of Pediatrics at the Stanford University School of Medicine and physician-in-chief at

Lucile Packard Children’s Hospital Stanford and Stanford Children’s Health.

Leonard has taken over from Hugh O’Bro-dovich, MD, professor of pediatrics, who is retiring after holding the position since 2007.

“This is an exceptionally exciting time for Stanford pediatrics,” Leonard said. “The

growth of our clinical and research programs and the new initia-tives in precision health are providing us with unprecedented opportunities to shape the future of pediatrics. The house staff, faculty and patients inspire me in my work every day, and it will be an honor and privilege to advocate on their behalf.”

A 1989 graduate of the School of Medicine, Leonard returned to Stanford in 2014 after spending 25 years at the Children’s Hospital

of Philadelphia and the University of Pennsylvania, first as a resi-dent and fellow and then as a faculty member.

“Dr. Leonard is an energetic, collaborative physician, research-er and mentor who cares deeply about improving the health and well-being of children everywhere,” said Lloyd Minor, MD, dean of the School of Medicine. “She is committed to Stanford Medicine’s vision of proactive and personalized health care and has been at the forefront of efforts to integrate precision health approaches and skills into our training programs.”

“Dr. Leonard invariably receives high praise from colleagues and trainees for her thoughtful leadership and inspiring vision for the future of pediatric research, education and patient care,” said Christopher Dawes, president and CEO of Lucile Packard Children’s Hospital Stanford and Stanford Children’s Health. “I’m very pleased to welcome her to the role of physician-in-chief of our hospital and network.”

At the Children’s Hospital of Philadelphia, Leonard directed the Of-

Mary Leonard appointed new chair of pediatricsBy Erin Digitale, Medical school’s Office of Communication & Public Affairs

Mary Leonard

LEONARD Continued on p. 6

c v i . s ta n fo rd .e d u | 6

A recent study titled "Enhanced electrochemical sensing with carbon nanotubes modified with bismuth and mag-netic nanoparticles in a lab-on-a-chip (Ferrochip)" was published in ChemNanoMat describing the generation of a novel material to facilitate ultrasensitive detection of Iron.

Iron plays an important role in human physiological functions and pathological impairments. The superior proper-ties of carbon nanotubes (CNTs) and its modifications with bismuth and magnetic nanoparticles developed in this work have led to an extraordinary and novel material to facilitate ultrasensitive detection in the nanomolar range.

This work was published in ChemNanoMat June 29, 2016. Authors include: Preetha Jothimuthu, Joe L. Hsu, Robert Chen, Mohammed Inayathullah, Venkata Raveendra, Pothineni, Antony Jan, Geoffrey C. Gurtner, Jayakumar Rajadas, and Mark R.Nicolls.

For more visit: http://www.ncbi.nlm.nih.gov/pubmed/27130902

Material facilitates detection of physiological iron

Jay Rajadas, PhD

New Clinical Research Center partnershipThe Stanford Center for Clincal Research (SCCR), lead by Dr. Kenneth Mahaffey, MD and AstraZeneca have en-tered into a collaboration intended to address major health care challenges.

This collaboration focuses on cardio-metabolic and respiratory diseases, oncology, mobile health (mHealth), innovations in clinical trial design and operations, and education and training initiatives. Two million dollars in funding will be provided to support innovative research projects of Stanford investigators over the next three years.

The collaboration committee has recently awarded first two research projects for funding in Year 1 (2016-2017) under this collaboration:

1. “Smartphone guided cardiac rehabilitation and medication adherence management after acute coronarysyndrome”, PI Dr. Mintu Turakhia, MD

2. “Learning Personalized Treatment Guidelines”, PI Dr. Nigam Shah, PhD

As a part of this award, the collaboration will provide a funding of $260,000 to each of these selected projects for the project duration of one year.

The collaboration is excited to announce that it will start accepting the next round of research proposal applications for Year 2 starting November, 2016. Please contact Nicole Ventre : nventre@stanford.edu for any questions about this collaboration and the proposal sub-mission process and timeline.

fice of Clinical and Translational Research and was a senior scholar in the Center for Clinical Epidemiology and Biostatistics, where she developed strong track records as a researcher and a mentor to other scientists. Her research has focused on the effects of chronic diseas-es on nutrition, physical function and bone health throughout life.

In 2015, after returning to Stanford, Leonard was appointed associate dean of maternal and child health research, a position in which she directed the transdisciplinary child and maternal health research and training initiatives of the Stanford Child Health Research Institute. She also helped build interfaces between Stanford’s pediatric and adult medical research to facilitate scientific investigations across the life span.

Leonard is a member of the American Society of Clinical Investigation and the Society for Pediatric Research.

For more visit: https://med.stanford.edu/news/all-news/2016/06/mary-leonard-appointed-chair-of-pediatrics-at-stanford-medicine.html.

LEONARD Continued from p. 5

Mintu Turakhia, MD, PhD

Nigram Shah, PhD

c v i . s ta n fo rd .e d u | 7

2016 Summer Travel Awards

Robin Wilson, PhDMyofilament Meeting; June, 2016

Beth Pruitt Lab

Haodi Wu, PhDAHA Scientific Sessions

Joseph C. Wu Lab

Mirwais Wardak, PhDNational Institute of Biomedical Imaging

and Bioengineering (NIBIB) Training

Grantees Meeting; July, 2016

Sanjiv Sam Gambhir Lab

Xulei Qin, PhDAHA BCVS Scientific Sessions, July, 2016

Joseph C. Wu Lab

Darshan Trivedi, PhDBasic Cardiovascular Sciences, July, 2016

James Spudich lab

Maureen Wanjare, PhD

NIBIB Training Grantees

Meeting; July, 2016

Ngan Huang Lab

Notable Awards

Kiran Khush, MD was promoted to Associate Professor of

Medicine, effective Oct. 1. Her research focuses heart

transplantation donor selection and post transplantation issues.

Helen Blau, PhD, School of Medicine faculty member,

was elected to the National Academy of Sciences

E. John Harris, MD, Professorof Surgery in the Division of

Vascular Surgery at Stanford,was elected President of the

San Francisco Surgical Society

September 07 KENNETH MAHAFFEY, MD"Defining the role of Immune Biomarkers in Non-ST Elevation Myocardial Infarction: analysis from TRACER trial biorepository"

October 05 EVGENIOS NEOFYTOU, PHD AND DAVID STEVENS, MD"Modeling Chronic Chagasic Cardiomyopathy Disease Mechanisms Using Human induced Pluripotent Stem Cells"

November 02 MICHAEL MCCONNELL, MD, MSEE

Topic TBD

December 07 ANITRA ROMFH AND MANISH BUTTE, MD, PHD

"T-Cell Deficiencies in Adult Congenital Heart Disease"

2016 CVI Faculty Club4:30 p.m., First Wednesday of each month, Lorry Lokey (SIM1): Room G1161

All Faculty, Junior Faculty and Instructors welcome

Euan A. Ashley, MRCP, DPhil, Associate Professor of Medicine (Cardiovascular and Genetics), received a gift from the Order of the Eastern Star to support

his research in inherited cardiovascular disease.

c v i . s ta n fo rd .e d u | 8

Michael Fischbein, MDNIH | Marfan Aortic

Embryologic Origin Influences miR-29b Regulators and Targets

Doff McElhinney, MD Children's Heart Foundation | DNA

Damage Following Radiation Exposure in Patients with Congenital Heart Disease

Undergoing Cardiac Catheterization: Exposure-Effect Variability and Factors Associated with Impaired DNA Repair

Cornelia Weyand, MDNIH | Oligoclonal T Cell

Expansion and Rheumatoid Arthritis

Phillip C. Yang, MDNIH | Patient Oriented Research in Cardiovascular Regeneration

Daria Mochly-RosenNIH | Development of a novel treatment for

hyperbilirubinemia-induced kernicterus

Russ B. Altman, MDNIH | Biomedical Data

Science Graduate Training at Stanford

Christopher D. Gardner, PhD NIH | Cardiovascular Disease Prevention Training Program

Edda SpiekerkoetterNIH | Targeting Novel BMPR2

modifiers in Pulmonary Hypertension with Repurposed Drugs

Daniel Bernstein, MDNIH | Training in Myocardial Biology at Stanford (TIMBS)

Calvin J. Kuo NIH | Modeling KRAS Dependent Synthetic

Lethality in Human Colon Organoids

PJ UtzCIRM | Stem Cell and

Regenerative Medicine- Summer Research Internship

Recently Awarded Projects

Paul Wang, MD | ARCA biopharma

GENETIC-AF - A Genotype-Directed Comparative Effectiveness Trial of Bucindolol and Toprol-XL for Prevention of Symptomatic Atrial Fibrillation/Atrial Flutter in Patients with Heart Failure

Roham T. Zamanian, MD | Eiger BioPharmaceuticals, Inc.

A Phase 2, Randomized, Double-Blind, Placebo-Con-trolled Study of UBEnimex in Patients with Pulmonary ARTerial HYpertension (WHO Group 1) (LIBERTY)

A Phase 2, Open-Label, Extension Study to Evaluate the Long-Term Safety and Efficacy of UBEnimex in Patients with Pulmonary Arterial Hypertension (WHO Group 1)

New Clinical Trials

Won Hee Lee, PhDAHA, Beginning Grant-in-Aid | Identifying Biomarkers of

Low-Dose Radiation Risk and Mechanisms of Individual

Radiation Sensitivity

c v i . s ta n fo rd .e d u | 9

JULY American Heart Association AHA Grant-In-Aid Amount of funding: $154K over two years Deadline: July, 2016 AHA Grant-In-Aid

AUGUST SEPTEMBER Stanford University Spectrum Pilot Grants Amount of funding: $15-50K for 1 year Deadline: Sept. 2016

Faculty Funding Opportunities

Postdoctoral Funding OpportunitiesJULY AHA Mentored Clinical and Population Research Amount of funding: $154,000 over 2 years Deadline: July, 2016

AHA Postdoctoral Fellowship Amount of funding: $95,450-120,800 over 2 years Deadline: July, 2016 AHA Postdoctoral

Juvenile Diabetes Research Foundation Postdoctoral Fellowships

Advanced Postdoctoral Scholar Fellowship Deadline: July, 2016

Stanford University Katherine McCormick Advanced Postdoctoral Scholar Fellowship Amount of funding: $35,000 for 1 year Deadline: July 2016 McCormick Fellowship

Walter V. and Idun Berry Postdoctoral Fellowship Program Amount of funding: $55,000 for 1 year Deadline: July 2016

Translational Research Applied Medicine (TRAM) Pilot Grant Amount of funding: $5K-30,000 for 1 year Deadline: July, 2016

AUGUST National Institute of Health Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows Deadline: August 8, 2016 PA-14-149

HOW WILL YOU MAKE YOUR MARK?

2016 CVI Seed Awards Deadline: August 1, 2016

http://tinyurl.com/cvisg2016

Stanford-Gachon 3rd Annual SessionNine faculty members and three fellows attended the annual Stan-ford-Gachon Frontiers in Cardiovascular Medicine Conference in Incheon, Korea. The conference was attended by over seventy lead-ing faculty members in Korea and 200 students and trainees. An ac-tive discussion following each session (7 total sessions) was led by the Korean experts. This format encouraged participation by all and made this conference very personal and, yet, meaningful. The final session, Young Investigator Sessions, was represented by 3 Korean and 3 Stanford fellows: Andrew Goldstone (winner!), Brian Kim, and Michelle Santoso. This effort to represent Stanford Cardiovascular Medicine globally will foster future collaboration and scholarship.

Frontiers in Cardiovascular Medicine 2016 | FIC 2016

been cleared by macrophages, yet weren’t. In fact, many of the cells piling up in these lesions are dead macrophages and other vascular cells that should have been cleared long ago.

In the new study, Leeper, Kojima and their colleagues performed genetic analyses of hundreds of human coronary and carotid artery tissue samples collected at Stanford and at Sweden’s Karolinska Institute. They found that CD47 is extremely abundant in atherosclerotic tissue compared with normal vascular tissue, and correlated with risk for adverse clinical outcomes such as stroke.

In a laboratory dish, anti-CD47 antibodies induced the clearance of

diseased, dying and dead smooth muscle cells and macrophages incubated in conditions designed to simulate the atherosclerotic environment. And in several different mouse models of atherosclerosis, blocking CD47 with anti-CD47 antibodies dramatically countered the buildup of arterial plaque and made it less vulnerable to rupture. Many mice even experienced regression of their plaques — a phenomenon rarely observed in mouse models of cardiovascular disease.

For more visit: http://med.stanford.edu/news/all-news/2016/07/anti-tumor-antibodies-could-counter-atherosclerosis.html

Also, Science magazine write-up: http://www.sciencemag.org/news/2016/07/experimental-anticancer-drug-may-tackle-heart-disease-too

NEW DRUG Continued from p. 4

c v i . s ta n fo rd .e d u | 10

National and Global Cardiovascular Conferences JULY International Academy of Cardiology – 21st World Congress on Heart Disease July 30 – Aug 1 , Boston, MA

AUGUST 9th World Cardiology Conference August 1-3, 2016, Manchester, UK

European Society of Cardiology – Congress 2016 August 27-31, 2016, Rome, Italy

SEPTEMBER Council on Hypertension 2016 Scientific Sessions September 14-17, 2016, Orlando, FL

Heart Failure Society of America Annual Scientific Meeting September 17-20, 2016, Orlando, FL

Western Vascular Society September 23-28, 2016 Colorado Springs, CO

OCTOBER Centre for Commercialization of Regenerative Medicine October 27-28, 2016, Whistler, Canada

Vascular Biology (NAVBO – North American Vascular Biology) October 30 – November 3, 2016 Boston, MA

NOVEMBER AHA Scientific Sessions November 12-16, 2016, Orleans, LA

DECEMBER World Stem Cell Summit December 6-8, 2016, West Palm Beach, FL

2016Frontiers in Cardiovascular Science

Li Ka Shing Center for Learning & Knowledge | 291 Campus Drive, Stanford, CA 94305Room LK130: Tuesdays from 12:30 - 1:30pm

SEPTEMBER 13, 2016Glenn I. Fishman, MDWilliam Goldring Professor of Medicine; Director, Leon H. Charney Division of Cardiology, NYU, School of Medicine

SEPTEMBER 20, 2016James N. Weiss, MDKawata professor of Medicine & Physiology; Chief, Division of Cardiology;Director, Cardiovascular Research Laboratory, David Geffen School of Medicine at UCLA

SEPTEMBER 27, 2016Evangelia “Litsa” Kranias, PhDHanna Professor and Director Cardiovascular Biology; Distinguished University Professor; Co-Director, Cardiovascular Center of Excellence Department of Pharmacology & Cell Biophysics, University of Cincinnati College of Medicine

OCTOBER 04, 2016Professor Thomas EschenhagenDirector, Department of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf (UKE)

OCTOBER 18, 2016Edda Spierkoetter, MD, and Vinicio de Jesus Perez, MDAssistant Professors of Medicine (Pulmonary and Critical Care Medicine) at Stanford

OCTOBER 25, 2016Sushma Reddy, MD and Francois Haddad, MDReddy: Assistant Professor of Pediatrics (Cardiology) at the Lucile Salter Packard Children's Hospital; Haddad: Clinical Associate Professor, Medicine (Cardiovascular Medicine); at Stanford

NOVEMBER 01, 2016Kirk U. Knowlton, MDDirector of Cardiovascular Research andCo-Chief of Cardiology, Intermountain Heart Institute

NOVEMBER 08, 2016Brian H. Annex, MDChief, Division of Cardiovascular Medicine; Chair, George A. Beller, M.D; Lantheus Medical Imaging Distinguished Professor of Cardiovascular Medicine ; University of Virginia Health System

NOVEMBER 22, 2016Jake Lusis, PhDProfessor of Medicine; Cardiology; and Microbiology, Immunology & Molecular Genetics; Vice-Chair of Human Genetics; David Geffen School of Medicine, UCLA

DECEMBER 06, 2016Ralph J. Damiano, MDEvarts A. Graham Professor, Surgery;Chief, Division of Cardiothoracic Surgery, Washington University School of Medicine

DECEMBER 13, 2016Jonathan M. Graff, MD, PhDProfessor, Department of Developmental Biology UT Southwestern

JANUARY 17, 2017Rui-Ping Xiao, MD, PhDProfessor at the Institute of Molecular Medicine, Peking University, Beijing, China

JANUARY 24, 2017Mark A. Creager, MD, FAHADirector, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center Professor of Medicine, Geisel School of Medicine at Dartmouth

c v i . s ta n fo rd .e d u | 11

Our MissionWe provide quantitative assessment of clinical cardiovascular phenotypes for translational research and clinical tri-als. These cardiovascular phenotypes include evaluating cardiac structure and function, measuring carotid intimal thickness and arterial stiffness, and test-ing endothelial function and cardiopul-monary exercise testing.

In collaboration with the Human Im-mune Monitoring Center at Stanford and members of the Cardiovascular Institute, we also offer central blood processing and banking capabilities. In addition, we develop new biomarker platforms and imaging modalities.

Key Initiatives1. Stanford Athletic Screening Program. The BPCL is the core laboratory responsible for the echocar-diographic studies of Stanford Athletic Screening Program and has imaged more than 500 athletes.

2. Stanford Immune Aging Longitudinal Study. The BPCL is the core providing clinical cardiovascular phenotypes for collaboration through the NIH funded projects of the Immunity Transplantation and Infection Institute led by Mark Davis, MD.

3. The Pulmonary Hypertension Wall Center Outcome and Physiology Studies. The BPCL works closely with the Vera Moulton Wall Center for Pulmonary Vascular Disease to provide quantitative echocardiographic assessment of the right heart.

4. The CCML-Stanford Collaborative Effort. Through a close collaboration with the University of Paris and the Marie-Lannelongue surgical center (CCML), the BPCL is providing quantitative analysis of experimental and clinical studies focused on right heart physiology. The CCML is a recognized worldwide center of expertise in pulmonary hypertension (Elie Fadel MD PhD and Olaf Mercier MD PhD).

Clinical Biomarker & Phenotyping Core Lab (BPCL)

Biobank

Stanford CVI Human iPSC Biobank ServiceNormal and patient-derived reprogrammed cardiomyocytes is a tremendous resource for re-searchers and physicians here at Stanford and around the country. Understanding the disease process directly at the population level and observing these cells as surrogates under a myr-iad conditions has the potential to be a game-changer for cardiovascular medical research.

To facilitate research in a dish that allows screening of new compounds or characterization of human disease phenotypes using cardiomyocytes, the Institute created a service by which de-identified PBMC samples from selected patients can be sent to Stanford CVI for reprogramming free of cost. Please contact Joseph Wu, MD, PhD ( joewu@stanford.edu) or Biobank managers, Justin Vincent ( justin81@stanford.edu), or Rinkal Chaudhary (rinkalc@stanford.edu) with any questions.

SCVI biobank is supported in part by National Heart, Lung and Blood Institute (NHLBI), the California Institute for Regenerative Medicine (CIRM), and the Stanford Cardiovascular Insti-tute (CVI). Stanford iPSC Biobank was recently mentioned in Nature Methods news: http://www.nature.com/nmeth/journal/v12/n2/full/nmeth.3263.html.

Lab Resources

Contact UsFrancois Haddad, MD (fhaddad@stanford.edu) or Ingrid Ibarra, PhD (iibarra@stanford.edu) at CVI.

3DQ Imaging LaboratoryStanford’s 3DQ Imaging Laboratory was established in 1996 at Stanford by Geof-frey Rubin, MD, and Sandy Napel, PhD, Professor of Radiology (General Radiol-ogy) and, by courtesy, Electrical Engi-neering. Today the center is co-directed by Dominik Fleischmann, MD, Profes-sor of Radiology (General Radiology) and Roland Bammer, PhD, Associate Professor (Research) of Radiology.

Currently the lab processes over 1,200 clinical cases per month. Linda Horst, Marc Sofilos, and Shannon Walters are an integral part of the 3DQ Lab manage-ment team.

For more visit: http://3dqlab.stanford.

edu/

c v i . s ta n fo rd .e d u | 12

Communication is at the heart of scientific advancement and innovation. This quarter the Stanford Cardiovascular Institute members published over 352 original manuscripts and reviews further contributing to our understanding of cardiovascular biology and disease. In the following pages, we highlight selected manuscripts by our members.

Selected Member Publications

APRIL 2016: 67 PUBLICATIONS

Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the

predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.

Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC,

Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bern-stein D, Altman RB, Wu JC. Nat Med. 2016 May;22(5):547-56.

Synthesis and characterization of polycaprolactone urethane hollow fiber

membranes as small diameter vascular grafts. Mercado-Pagán ÁE, Stahl

AM, Ramseier ML, Behn AW, Yang Y. Mater Sci Eng C Mater Biol Appl. 2016 Jul

1;64:61-73.

Pulmonary Valve Repair for Patients With Acquired Pulmonary Valve Insuffi-

ciency. Said SM, Mainwaring RD, Ma M, Tacy TA, Hanley FL. Ann Thorac Surg.

2016 Jun;101(6):2294-301.

Pediatric pulmonology: with thin phenotyping and deep genotyping, knowl-

edge is power. Cornfield DN. Curr Opin Pediatr. 2016 Jun;28(3):310-1.

Biomarkers as Predictors of Cardiac Toxicity From Targeted Cancer Therapies.

Witteles RM. J Card Fail. 2016 Jun;22(6):459-64.

Salvage Extracorporeal Membrane Oxygenation Prior to "Bridge" Transcatheter

Aortic Valve Replacement. Chiu P, Fearon WF, Raleigh LA, Burdon G, Rao V,

Boyd JH, Yeung AC, Miller DC, Fischbein MP. J Card Surg. 2016 Jun;31(6):403-

5.

Impact and pitfalls of scaling of left ventricular and atrial structure in pop-

ulation-based studies. Kuznetsova T, Haddad F, Tikhonoff V, Kloch-Badelek

M, Ryabikov A, Knez J, Malyutina S, Stolarz-Skrzypek K, Thijs L, Schnittger I, Wu JC, Casiglia E, Narkiewicz K, Kawecka-Jaszcz K, Staessen JA; European

Project On Genes in Hypertension (EPOGH) Investigators. J Hypertens. 2016

Jun;34(6):1186-94.

Challenges and opportunities in treating inflammation associated with

pulmonary hypertension. Voelkel NF, Tamosiuniene R, Nicolls MR. Expert Rev

Cardiovasc Ther. 2016 May 4:1-13.

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endotheli-

al-to-Mesenchymal Transition via HMGA1 and Its Target Slug. Hopper RK,

Moonen JR, Diebold I, Cao A, Rhodes CJ, Tojais NF, Hennigs JK, Gu M, Wang L, Rabinovitch M. Circulation. 2016 May 3;133(18):1783-94.

North American Thrombosis Forum, AF Action Initiative Consensus Document.

Ruff CT, Ansell JE, Becker RC, Benjamin EJ, Deicicchi DJ, Mark Estes NA, Eze-

kowitz MD, Fanikos J, Fareed J, Garcia D, Giugliano RP, Goldhaber SZ, Granger

C, Healey JS, Hull R, Hylek EM, Libby P, Lopes RD, Mahaffey KW, Mega J, Piazza

G, Sasahara AA, Sorond FA, Spyropoulos AC, Walenga JM, Weitz JI. Am J Med.

2016 May;129(5 Suppl):S1-S29.

Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk

Patients. Leon MB, Smith CR, Mack MJ, Makkar RR, Svensson LG, Kodali SK,

Thourani VH, Tuzcu EM, Miller DC, Herrmann HC, Doshi D, Cohen DJ, Pichard

AD, Kapadia S, Dewey T, Babaliaros V, Szeto WY, Williams MR, Kereiakes D,

Zajarias A, Greason KL, Whisenant BK, Hodson RW, Moses JW, Trento A, Brown

DL, Fearon WF, Pibarot P, Hahn RT, Jaber WA, Anderson WN, Alu MC, Webb JG;

PARTNER 2 Investigators. N Engl J Med. 2016 Apr 28;374(17):1609-20.

Emerging Research Directions in Adult Congenital Heart Disease: A Report

From an NHLBI/ACHA Working Group. Gurvitz M, Burns KM, Brindis R, Broberg

CS, Daniels CJ, Fuller SM, Honein MA, Khairy P, Kuehl KS, Landzberg MJ, Mahle

WT, Mann DL, Marelli A, Newburger JW, Pearson GD, Starling RC, Tringali GR,

Valente AM, Wu JC, Califf RM. J Am Coll Cardiol. 2016 Apr 26;67(16):1956-64.

Optimizing QT Interval Measurement for Preparticipation Screening of Young

Athletes. Pickham D, Hsu D, Soofi M, Goldberg JM, Saini D, Hadley D, Perez M, Froelicher VF. Med Sci Sports Exerc. 2016 Apr 26.

Continuum of Vasodilator Stress From Rest to Contrast Medium to Adenosine

Hyperemia for Fractional Flow Reserve Assessment. Johnson NP, Jeremias A,

Zimmermann FM, Adjedj J, Witt N, Hennigan B, Koo BK, Maehara A, Matsumura

M, Barbato E, Esposito G, Trimarco B, Rioufol G, Park SJ, Yang HM, Baptista SB,

Chrysant GS, Leone AM, Berry C, De Bruyne B, Gould KL, Kirkeeide RL, Oldroyd

KG, Pijls NH, Fearon WF. JACC Cardiovasc Interv. 2016 Apr 25;9(8):757-67.

Three-Dimensional Modeling Analysis of Visceral Arteries and Kidneys during

Respiration. Suh GY, Choi G, Herfkens RJ, Dalman RL, Cheng CP. Ann Vasc

Surg. 2016 Apr 24.

Cardiometabolic Risk in South Asian Inhabitants of California: Hypertriglycer-

idemic Waist vs Hypertriglyceridemic Body Mass Index. Abbasi F, Mathur A,

Reaven GM, Molina CR. Ethn Dis. 2016 Apr 21;26(2):191-6.

Functional Versus Anatomic Assessment of Myocardial Bridging by Intravas-

cular Ultrasound: Impact of Arterial Compression on Proximal Atherosclerotic

Plaque. Yamada R, Tremmel JA, Tanaka S, Lin S, Kobayashi Y, Hollak MB, Yock PG, Fitzgerald PJ, Schnittger I, Honda Y. J Am Heart Assoc. 2016 Apr 20;5(4).

Metformin treatment status and abdominal aortic aneurysm disease progres-

sion. Fujimura N, Xiong J, Kettler EB, Xuan H, Glover KJ, Mell MW, Xu B, Dalman RL. J Vasc Surg. 2016 Apr 19.

Simultaneous single-molecule epigenetic imaging of DNA methylation and

hydroxymethylation. Song CX, Diao J, Brunger AT, Quake SR. Proc Natl Acad Sci

U S A. 2016 Apr 19;113(16):4338-43.

The Prognostic Value of Residual Coronary Stenoses After Functionally Com-

plete Revascularization. Kobayashi Y, Nam CW, Tonino PA, Kimura T, De Bruyne

B, Pijls NH, Fearon WF. FAME Study Investigators. J Am Coll Cardiol. 2016 Apr

12;67(14):1701-11.

c v i . s ta n fo rd .e d u | 13

MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular matu-

ration. Papangeli I, Kim J, Maier I, Park S, Lee A, Kang Y, Tanaka K, Khan OF, Ju

H, Kojima Y, Red-Horse K, Anderson DG, Siekmann AF, Chun HJ. Nat Commun.

2016 Apr 12;7:11268.

Effect of Transplant Center Volume on Cost and Readmissions in Medicare Lung

Transplant Recipients. Mooney JJ, Weill D, Boyd JH, Nicolls MR, Bhattacharya

J, Dhillon GS. Ann Am Thorac Soc. 2016 Apr 11.

CT-defined phenotype of pulmonary artery stenoses in Alagille syndrome.

Rodriguez RM, Feinstein JA, Chan FP. Pediatr Radiol. 2016 Apr 4.

Intentional Fracture of Maximally Dilated Balloon-Expandable Pulmonary

Artery Stents Using Ultra-High-Pressure Balloon Angioplasty: A Preliminary

Analysis. Morray BH, McElhinney DB, Marshall AC, Porras D. Circ Cardiovasc

Interv. 2016 Apr;9(4).

Using Drosophila to discover mechanisms underlying type 2 diabetes. Alfa RW,

Kim SK. Dis Model Mech. 2016 Apr 1;9(4):365-76.

Constraints on Biological Mechanism from Disease Comorbidity Using Electron-

ic Medical Records and Database of Genetic Variants. Bagley SC, Sirota M, Chen

R, Butte AJ, Altman RB. PLoS Comput Biol. 2016 Apr 26;12(4):e1004885.

De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of

Atrioventricular Septal Heart Defects. Priest JR, Osoegawa K, Mohammed N,

Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D,

Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz

IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield

V, Quertermous T, Gelb BD, Portman M, Ashley EA. PLoS Genet. 2016 Apr

8;12(4):e1005963.

High-sensitivity cardiac troponin I and incident coronary heart disease among

asymptomatic older adults. Iribarren C, Chandra M, Rana JS, Hlatky MA, Fort-

mann SP, Quertermous T, Go AS. Heart. 2016 Mar 30.

Fibrosis of the Neonatal Mouse Heart After Cryoinjury Is Accompanied by Wnt

Signaling Activation and Epicardial-to-Mesenchymal Transition. Mizutani M, Wu JC, Nusse R. J Am Heart Assoc. 2016 Mar 15;4(3):e002457.

Association of periarterial neovascularization with progression of cardiac

allograft vasculopathy and long-term clinical outcomes in heart transplant

recipients. Kitahara H, Okada K, Tanaka S, Yang HM, Miki K, Kobayashi Y, Kimura

T, Luikart H, Yock PG, Yeung AC, Fitzgerald PJ, Khush KK, Fearon WF, Honda Y. J Heart Lung Transplant. 2016 Mar 10.

Plasmin as a complement C5 convertase. Leung LL, Morser J. EBioMedicine.

2016 Mar 11;5:20-1.

Magnetic Nanoparticles for Targeting and Imaging of Stem Cells in Myocardial

Infarction. Santoso MR, Yang PC. Stem Cells Int. 2016;2016:4198790.

MAY MAY

Inheriting the Learner's View: A Google Glass-Based Wearable Computing Plat-

form for Improving Surgical Trainee Performance. Brewer ZE, Fann HC, Ogden WD, Burdon TA, Sheikh AY. J Surg Educ. 2016 Jul-Aug;73(4):682-8.

Antibodies to myelin basic protein are associated with cognitive decline after

stroke. Becker KJ, Tanzi P, Zierath D, Buckwalter MS. J Neuroimmunol. 2016

Jun 15;295-296:9-11.

Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate De-

hydrogenase Kinase Protein-Protein Interactions: Application for Myocardial

Injury in Vivo. Qvit N, Disatnik MH, Sho E, Mochly-Rosen D. J Am Chem Soc.

2016 Jun 8.

Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel

Treatment to Prevent Kernicterus. Cunningham AD, Hwang S, Mochly-Rosen D.

Clin Perinatol. 2016 Jun;43(2):341-54.

Comparative efficacy of stellate ganglion block with bupivacaine vs pulsed

radiofrequency in a patient with refractory ventricular arrhythmias. Hayase

J, Vampola S, Ahadian F, Narayan SM, Krummen DE. J Clin Anesth. 2016

Jun;31:162-5.

An artificial niche preserves the quiescence of muscle stem cells and enhances

their therapeutic efficacy. Quarta M, Brett JO, DiMarco R, De Morree A, Boutet

SC, Chacon R, Gibbons MC, Garcia VA, Su J, Shrager JB, Heilshorn S, Rando TA.

Nat Biotechnol. 2016 May 30.

A bright cyan-excitable orange fluorescent protein facilitates dual-emission

microscopy and enhances bioluminescence imaging in vivo. Chu J, Oh Y, Sens

A, Ataie N, Dana H, Macklin JJ, Laviv T, Welf ES, Dean KM, Zhang F, Kim BB, Tang

CT, Hu M, Baird MA, Davidson MW, Kay MA, Fiolka R, Yasuda R, Kim DS, Ng HL,

Lin MZ. Nat Biotechnol. 2016 May 30.

Renal function changes after fenestrated endovascular aneurysm repair. Tran

K, Fajardo A, Ullery BW, Goltz C, Lee JT. J Vasc Surg. 2016 May 27.

Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients.

Cohen AT, Harrington RA, Goldhaber SZ, Hull RD, Wiens BL, Gold A, Hernandez

AF, Gibson CM; APEX Investigators. N Engl J Med. 2016 May 27.

Anterior Retroperitoneal Spine Exposure Following Prior Endovascular Aortic

Aneurysm Repair. Ullery BW, Thompson P, Mell MW. Ann Vasc Surg. 2016 May

26.

Knock-in editing: it functionally corrects! Porteus MH. Blood. 2016 May

26;127(21):2507-9.

Magnetic Resonance Imaging and Positron Emission Tomography Approaches

to Imaging Vascular and Cardiac Inflammation. Amsallem M, Saito T, Tada Y,

Dash R, McConnell MV. Circ J. 2016 May 25;80(6):1269-77.

Mechanisms Linking Electrical Alternans and Clinical Ventricular Arrhythmia in

Human Heart Failure. Bayer JD, Lalani GG, Vigmond EJ, Narayan SM, Trayano-

va NA. Heart Rhythm. 2016 May 20.

Dual Modality Activity Based Probes as Molecular Imaging Agents for Vascular

Inflammation. Withana NP, Saito T, Ma X, Garland M, Liu C, Kosuge H, Amsallem

M, Verdoes M, Ofori LO, Fischbein M, Arakawa M, Cheng Z, McConnell MV,

Bogyo M. J Nucl Med. 2016 May 19.

Prevalence and Anatomy of Retroesophageal Major Aortopulmonary Collateral

Arteries. Mainwaring RD, Patrick WL, Carrillo SA, Ibrahimye AN, Muralidaran A,

Hanley FL. Ann Thorac Surg. 2016 May 18.

MAY 2016: 56 PUBLICATIONS

c v i . s ta n fo rd .e d u | 14

Invasive Assessment of Coronary Physiology Predicts Late Mortality After

Heart Transplantation. Yang HM, Khush K, Luikart H, Okada K, Lim HS, Ko-

bayashi Y, Honda Y, Yeung AC, Valantine H, Fearon WF. Circulation. 2016 May

17;133(20):1945-50.

Recommendations for Genetic Testing to Reduce the Incidence of Anthra-

cycline-induced Cardiotoxicity. Aminkeng F, Ross CJ, Rassekh SR, Hwang S,

Rieder MJ, Bhavsar AP, Smith A, Sanatani S, Gelmon KA, Bernstein D, Hayden

MR, Amstutz U, Carleton BC; CPNDS Clinical Practice Recommendations Group.

Br J Clin Pharmacol. 2016 May 16.

Use of a proactive duplex ultrasound protocol for hemodialysis access. Itoga

NK, Ullery BW, Tran K, Lee GK, Aalami OO, Bech FR, Zhou W. J Vasc Surg. 2016

May 13. pii: S0741-5214(16)30026-X.

Nonrigid motion correction with 3D image-based navigators for coronary MR

angiography. Luo J, Addy NO, Ingle RR, Baron CA, Cheng JY, Hu BS, Nishimura DG. Magn Reson Med. 2016 May 13.

3D image-based navigators for coronary MR angiography. Addy NO, Ingle RR, Luo

J, Baron CA, Yang PC, Hu BS, Nishimura DG. Magn Reson Med. 2016 May 13.

Hospitalizations in patients with atrial fibrillation: an analysis from ROCKET

AF. DeVore AD, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Hacke W,

Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Singer DE, Fox KA, Patel MR,

Piccini JP; ROCKET AF Steering Committee and Investigators. Europace. 2016

May 12.

Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a

Dish to Precision Medicine. Sayed N, Liu C, Wu JC. J Am Coll Cardiol. 2016 May

10;67(18):2161-76.

Validation of BARC Bleeding Criteria in Patients With Acute Coronary Syn-

dromes: The TRACER Trial. Vranckx P, White HD, Huang Z, Mahaffey KW, Arm-

strong PW, Van de Werf F, Moliterno DJ, Wallentin L, Held C, Aylward PE, Cornel

JH, Bode C, Huber K, Nicolau JC, Ruzyllo W, Harrington RA, Tricoci P. J Am Coll

Cardiol. 2016 May 10;67(18):2135-44.

Transcatheter Aortic Valve Replacement in the Asian Population: What Did We

Learn and Not Learn? Yeung AC. JACC Cardiovasc Interv. 2016 May 9;9(9):934-6.

The entangled ER-mitochondrial axis as a potential therapeutic strategy in neu-

rodegeneration: A tangled duo unchained. Joshi AU, Kornfeld OS, Mochly-Ros-en D. Cell Calcium. 2016 May 7.

The associations of leptin, adiponectin and resistin with incident atrial fibril-

lation in women. Ermakov S, Azarbal F, Stefanick ML, LaMonte MJ, Li W, Tharp

KM, Martin LW, Nassir R, Salmoirago-Blotcher E, Albert CM, Manson JE, Assimes TL, Hlatky MA, Larson JC, Perez MV. Heart. 2016 May 4.

Clinical Characteristics, Oral Anticoagulation Patterns, and Outcomes of Med-

icaid Patients With Atrial Fibrillation: Insights From the Outcomes Registry for

Better Informed Treatment of Atrial Fibrillation (ORBIT-AF I) Registry. O'Brien

EC, Kim S, Thomas L, Fonarow GC, Kowey PR, Mahaffey KW, Gersh BJ, Piccini

JP, Peterson ED. J Am Heart Assoc. 2016 May 4;5(5).

Mitochondrial remodeling: Rearranging, recycling, and reprogramming. Gottli-

eb RA, Bernstein D. Cell Calcium. 2016 Apr 20.

Trends in the Use of Guideline-Directed Therapies Among Dialysis Patients

Hospitalized With Systolic Heart Failure: Findings From the American Heart

Association Get With The Guidelines-Heart Failure Program. Pandey A, Golwala

H, DeVore AD, Lu D, Madden G, Bhatt DL, Schulte PJ, Heidenreich PA, Yancy CW,

Hernandez AF, Fonarow GC. JACC Heart Fail. 2016 May 3.

Design and rationale for the Effects of Ticagrelor and Clopidogrel in Patients with

Peripheral Artery Disease (EUCLID) trial. Berger JS, Katona BG, Jones WS, Patel

MR, Norgren L, Baumgartner I, Blomster J, Mahaffey KW, Held P, Millegård M,

Heizer G, Reist C, Fowkes FG, Hiatt WR. Am Heart J. 2016 May;175:86-93.

Family history of atrial fibrillation is associated with earlier-onset and more

symptomatic atrial fibrillation: Results from the Outcomes Registry for Better

Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry. Gundlund A,

Fosbøl EL, Kim S, Fonarow GC, Gersh BJ, Kowey PR, Hylek E, Mahaffey KW,

Thomas L, Piccini JP, Peterson ED; ORBIT-AF Investigators. Am Heart J. 2016

May;175:28-35.

Lack of Concordance Between Local Investigators, Angiographic Core Labo-

ratory, and Clinical Event Committee in the Assessment of Stent Thrombosis:

Results From the TRACER Angiographic Substudy. Popma CJ, Sheng S, Korjian

S, Daaboul Y, Chi G, Tricoci P, Huang Z, Moliterno DJ, White HD, Van de Werf

F, Harrington RA, Wallentin L, Held C, Armstrong PW, Aylward PE, Strony J,

Mahaffey KW, Gibson CM. Circ Cardiovasc Interv. 2016 May;9(5).

Cognitive Dysfunction in Children with Heart Disease: The Role of Anesthesia

and Sedation. Char D, Ramamoorthy C, Wise-Faberowski L. Congenit Heart

Dis. 2016 May;11(3):221-9.

Adverse events in children implanted with ventricular assist devices in the

United States: Data from the Pediatric Interagency Registry for Mechanical Cir-

culatory Support (PediMACS). Rosenthal DN, Almond CS, Jaquiss RD, Peyton

CE, Auerbach SR, Morales DR, Epstein DJ, Cantor RS, Kormos RL, Naftel DC,

Butts RJ, Ghanayem NS, Kirklin JK, Blume ED. J Heart Lung Transplant. 2016

May;35(5):569-77.

Compassionate deactivation of ventricular assist devices in pediatric pa-

tients. Hollander SA, Axelrod DM, Bernstein D, Cohen HJ, Sourkes B, Reddy S, Magnus D, Rosenthal DN, Kaufman BD. J Heart Lung Transplant. 2016

May;35(5):564-7.

Major advantages and critical challenge for the proposed United States heart

allocation system. Stevenson LW, Kormos RL, Young JB, Kirklin JK, Hunt SA. J

Heart Lung Transplant. 2016 May;35(5):547-9.

Hemodynamic Effects of Phenylephrine, Vasopressin, and Epinephrine in

Children With Pulmonary Hypertension: A Pilot Study. Siehr SL, Feinstein JA,

Yang W, Peng LF, Ogawa MT, Ramamoorthy C. Pediatr Crit Care Med. 2016

May;17(5):428-37.

Surgical Repair of 115 Patients With Anomalous Aortic Origin of a Coronary

Artery From a Single Institution. Mainwaring RD, Murphy DJ, Rogers IS, Chan

FP, Petrossian E, Palmon M, Hanley FL. World J Pediatr Congenit Heart Surg.

2016 May;7(3):353-9.

Portable, one-step, and rapid GMR biosensor platform with smartphone

interface. Choi J, Gani AW, Bechstein DJ, Lee JR, Utz PJ, Wang SX. Biosens

Bioelectron. 2016 Apr 19;85:1-7.

c v i . s ta n fo rd .e d u | 15

JUNE JUNE

A prototype piecewise-linear dynamic attenuator. Hsieh SS, Peng MV, May

CA, Shunhavanich P, Fleischmann D, Pelc NJ. Phys Med Biol. 2016 Jul

7;61(13):4974-88.

The Cardiac Safety Research Consortium enters its second decade: An invi-

tation to participate. Turner JR, Kowey PR, Rodriguez I, Cabell CH, Gintant G,

Green CL, Kunz BL, Mortara J, Sager PT, Stockbridge N, Wright TJ, Finkle J, Kru-

coff MW; Cardiac Safety Research Consortium. Am Heart J. 2016 Jul;177:96-101.

NOAC monitoring, reversal agnts, and post-approval safety and effectiveness

evaluation: A cardiac safety research consortium think tank. Reiffel JA, Weitz

JI, Reilly P, Kaminskas E, Sarich T, Sager P, Seltzer J; Cardiac Safety Research

Consortium presenters and participants. Am Heart J. 2016 Jul;177:74-86.

Impact of glycoprotein IIb/IIIa inhibitors on the efficacy and safety of ticagrelor

compared with clopidogrel in patients with acute coronary syndromes: Analy-

sis from the Platelet Inhibition and Patient Outcomes (PLATO) Trial. Shimada

YJ, Bansilal S, Wiviott SD, Becker RC, Harrington RA, Himmelmann A, Neely

B, Husted S, James SK, Katus HA, Lopes RD, Steg PG, Storey RF, Wallentin L,

Cannon CP; PLATO Investigators. Am Heart J. 2016 Jul;177:1-8.

Additive Prognostic Value of Left Ventricular Systolic Dysfunction in a Popula-

tion-Based Cohort. Kuznetsova T, Cauwenberghs N, Knez J, Yang WY, Herbots

L, D'hooge J, Haddad F, Thijs L, Voigt JU, Staessen JA. Circ Cardiovasc Imaging.

2016 Jul;9(7).

Human Induced Pluripotent Stem Cells as a Platform for Personalized and

Precision Cardiovascular Medicine. Matsa E, Ahrens JH, Wu JC. Physiol Rev.

2016 Jul;96(3):1093-126.

Aspirin Instead of Oral Anticoagulant Prescription in Atrial Fibrillation

Patients at Risk for Stroke. Hsu JC, Maddox TM, Kennedy K, Katz DF, Marzec

LN, Lubitz SA, Gehi AK, Turakhia MP, Marcus GM. J Am Coll Cardiol. 2016 Jun

28;67(25):2913-23.

Finding Expandable Induced Cardiovascular Progenitor Cells. Chen IY, Wu JC.

Circ Res. 2016 Jun 24;119(1):16-20.

Multimodality Molecular Imaging of Cardiac Cell Transplantation: Part II. In Vivo

Imaging of Bone Marrow Stromal Cells in Swine with PET/CT and MR Imaging.

Parashurama N, Ahn BC, Ziv K, Ito K, Paulmurugan R, Willmann JK, Chung J,

Ikeno F, Swanson JC, Merk DR, Lyons JK, Yerushalmi D, Teramoto T, Kosuge H,

Dao CN, Ray P, Patel M, Chang YF, Mahmoudi M, Cohen JE, Goldstone AB, Habte

F, Bhaumik S, Yaghoubi S, Robbins RC, Dash R, Yang PC, Brinton TJ, Yock PG,

McConnell MV, Gambhir SS. Radiology. 2016 Jun 22:151150.

Monitoring Enzymatic Reactions in Real Time Using Venturi Easy Ambient Son-

ic-Spray Ionization Mass Spectrometry. Jansson ET, Dulay MT, Zare RN. Anal

Chem. 2016 Jun 21;88(12):6195-8.

Triglyceride Levels and Fracture Risk in Midlife Women: Study of Women's

Health Across the Nation (SWAN). Chang PY, Gold EB, Cauley JA, Johnson

WO, Karvonen-Gutierrez C, Jackson EA, Ruppert KM, Lee JS. J Clin Endocrinol

Metab. 2016 Jun 13:jc20161366.

Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Risk But Not

a Useful Target for Treatment in Patients With Stable Coronary Heart Disease.

Wallentin L, Held C, Armstrong PW, Cannon CP, Davies RY, Granger CB, Hag-

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Statin use and all-cancer survival: prospective results from the Women's Health

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Secure cloud computing for genomic data. Datta S, Bettinger K, Snyder M. Nat

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Dissecting direct reprogramming from fibroblast to neuron using single-cell

RNA-seq. Treutlein B, Lee QY, Camp JG, Mall M, Koh W, Shariati SA, Sim S, Neff

NF, Skotheim JM, Wernig M, Quake SR. Nature. 2016 Jun 8;534(7607):391-5.

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DNA damage-associated biomarkers in studying individual sensitivity to low-

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The use of machine learning for the identification of peripheral artery disease

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Giant Cell Arteritis: From Pathogenesis to Therapeutic Management. Watanabe

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c v i . s ta n fo rd .e d u | 17

Joseph C. Wu, MD, PhDDirector, Stanford Cardiovascular Institute Simon H. Stertzer, MD, Professor, Dept. of Medicine (Cardiovascular) & Radiology

Robert A. Harrington, MDArthur L. Bloomfield Professor of Medicine Chair, Dept. of Medicine

Stephen J. Roth MD, MPHProfessor of Pediatrics (Cardiology) at Lucile Salter Packard Children's HospitalChief, Division of Pediatric Cardiology James Baxter & Yvonne Craig Wood Medical Director CVICU, LPCH

Ronald L. Dalman, MDWalter C. and Elsa R. Chidester Professor of SurgeryChief, Division of Vascular Surgery

Michael Snyder, PhDStanford W. Ascherman, MD, FACS, Professor in Genetics Chair, Department of GeneticsDirector, Stanford Center for Genomics and Personalized Medicine

Dominik Fleischmann, MDProfessor, Dept. of RadiologyChief, Cardiovascular Imaging

Y. Joseph Woo, MDNorman E. Shumway Professor in Cardiothoracic SurgeryChair Department of Cardiothoracic Surgery

Kenneth Mahaffey, MDProfessor, Dept. of MedicineVice Chair of Medicine for Clinical Research

Alan Yeung, MDLi Ka Shing Professor of MedicineCo-Chief (Clinical), Division of Cardiovascular Medicine

Mark Nicolls, MDProfessor of MedicineChief, Pulmonary and Critical Care Medicine

Paul Yock, MDMartha Meier Weiland Professor of Bioengineering and MedicineProfessor, by courtesy, of Mechanical EngineeringDirector of Biodesign

Tom Quertermous, MDWilliam G. Irwin Professor of MedicineCo-Chief (Research), Division of Cardiovascular Medicine

Marlene Rabinovitch, MDDwight and Vera Dunlevie Professor in Pediatric Cardiology

Leadership

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© 2016 STANFORD CARDIOVASCULAR INSTITUTE

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