data management in personalized medicine

© 2014 Molecular Health GmbH. All rights reserved. Confidential.

Data Management in Personalized Medicine

Christian Hachenberg | Software Development

06/10/2014

© 2014 Molecular Health GmbH. All rights reserved. Confidential. 22

PartnerWell-known, certified NGS companies and global leaders in healthcare and IT.

Management TeamMultidisciplinary team of oncologists, scientists, businesspeople, and IT experts with long-standing expertise in their fields.

VisionTo improve the quality of life of patients using the most modern information

NGS= Next Generation Sequencing | CLIA= Clinical Laboratory Improvement Amendments

MolecularHealth – a leading biomedical company

Location Headquatered in Heidelberg/Germany.In the USA, based in The Woodlands, Texas, with a CLIA-certified NGS lab.


TreatmentMAP focuses on more targeted and safer cancer treatments

● TreatmentMAP software provides decision support to the physician on:● which drugs do really work● which drugs do NOT work due to genetic

aberration leading to drug resistance● which treatments do have dangerous

side effects with the patient● if there may occur hazardous side

effects due to cancer drugs and other medication

● If there are clinical studies nearby for the patient to be able to participate in


TreatmentMAP™ – Access to currently available biomedical knowledge worldwide

Biomedical Knowledge Database

Biomedical Concepts

Analysis & Clinical Interpretation

BiomedicalDiversity

GermlineEffects

Co-medicationEffects

ContextSpecificity

Biomarker Modifiers

Genomic Data

Protein Data

Pathway Data

Medical Data

Drug Data

Literature DataClinical

DataATC Classification

Drug Safety Data

Drugs@FDA

FDA Orange Book

Guidelines

ClinicalStudy Data

Targeted Treatment

Combination Therapy

Chemotherapy

TumorHeterogenity


Personalized Medicine is also a matter of personalized information management:

– There are 200 different kinds of cancer having millions of known gene variants – in any combinations

– Experts are discovering new approaches and insights almost on a daily base

– It is actually impossible for a physician to be up to date regarding such state-of-the-art knowledge

TreatmentMAP's knowledge base contains data of more than:

– 600 indications

– 23 million references to literature

– 3.5 million publications on cancer

– 112,000 protein pathway associations

– 92,500 clinical studies

– 50,000 proteins

– 22,000 approved drugs and 15,000 experimental components

– 36,000 drug protein interactions

– 23,500 drug interactions

– 7,500 manully curated references on genetic variants and drug efficacy and safety

– 4,500 biomarkers on drug efficacy and safety

– 1,400 signal pathways

Cancer as a topic of Big Data


Source: TreatmentMAP™ Release 1.7

TreatmentMAP™ Software – Overview of identified genetic aberrations



TreatmentMAP™ Software – Summary of possible therapies


Oncoscore



TreatmentMAP™ Software: Functional interaction model



TreatmentMAP™ – Automated analysis results


Christian Hachenberg Software/ETL Developer

Molecular Health GmbH | Belfortstr. 2 | 69115 Heidelberg, GermanyT: +49.6221.43851-0F: +49.6221.43851-100E: [email protected]: www.molecularhealth.com

Thank you – your contact

mailto:[email protected]

http://www.molecularhealth.com/


www.molecularhealth.com

data management in personalized medicine

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