david heber, m.d., ph.d., c.n.s., f.a.c.p., f.a.c.n ...presidenthbl.com/documents/dr david heber...

Curriculum Vitae, D. Heber, M.D., Ph.D.–

November 8, 2010

David Heber, M.D., Ph.D., C.N.S., F.A.C.P., F.A.C.N

CURRICULUM VITAE OFFICE: UCLA Center for Human Nutrition Division of Clinical Nutrition David Geffen School of Medicine at UCLA 900 Veteran Ave. Rm 12-217 Los Angeles, CA 90095-1742 TELEPHONE & FAX: Tel: (310) 206-1987 Fax: (310) 206-5264 HOME: 29368 Castlehill Drive Agoura Hills, CA 91301 TELEPHONE & FAX: Tel: (818) 707-2215 Fax: (818) 991-6327 Date of Birth: April 26, 1948 Place of Birth: Celle, Germany Citizenship: Naturalized United States Citizen, 1956 Marital Status: Married, with two children. EDUCATION: 1969 B.S. (Chemistry), Magna Cum Laude, University of California, Los Angeles 1973 M.D., Harvard Medical School, Boston Massachusetts 1978 Ph.D. (Physiology), University of California, Los Angeles LICENSURE (Medical): 1974 State of California, #G28371 BOARD CERTIFICATION: 1976 Diplomate, American Board of Internal Medicine, June 14. 1977 Certified, American Board of Internal Medicine Subspecialty Board in Endocrinology and Metabolism,

October 18. 1983 Certified, Specialist in Clinical Nutrition, American Board of Nutrition, April 28. PROFESSIONAL EXPERIENCE: 10/03/96 - present Director, UCLA Center for Human Nutrition 06/01/90 – 04/30/07 Director, UCLA/NCI Clinical Nutrition Research Unit 09/30/92 – 07/01/08 Director, UCLA/NIH Nutrition Training Program


10/01/99 – 2/01/05 Director, UCLA/ODS Center for Dietary Supplement Research :Botanicals 07/01/91 - present Professor of Medicine, Department of Medicine, UCLA School of Medicine 07/01/91 - present Professor of Public Health, Department of Community Health Services, UCLA School of Public Health 07/01/83 – present Chief, Division of Clinical Nutrition, Department of Medicine, UCLA School of Medicine, Los Angeles, CA. 07/01/83 - 06/30/91 Associate Professor of Medicine, UCLA School of Medicine, Los Angeles, CA. 02/01/82 - 06/30/83 Associate Chief and Head, Metabolism and Nutrition Section, Division of Endocrinology, Metabolism and Nutrition, Harbor-UCLA Medical Center, Torrance, CA. 12/01/78 - 06/30/83 Associate Program Director, NIH General Clinical Research Center, Harbor-UCLA Medical Center, Torrance, CA. 07/01/78 - 06/30/83 Assistant Professor of Medicine, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA. 07/01/78 - 11/30/78 Clinical Associate Physician, Clinical Research Center, Division of Endocrinology and Metabolism, Harbor-UCLA Medical Center, Torrance, CA. 09/01/76 - 06/20/78 Doctoral Student, Department of Physiology, UCLA School of Medicine 07/01/75 - 06/30/77 NIH Special Fellowship, Division of Endocrinology and Metabolism, Harbor-UCLA Medical Center, Torrance, CA. 07/01/74 - 06/30/75 Residency, Internal Medicine, Harbor General Hospital, Torrance, CA. 07/01/73 - 06/30/74 Internship, Straight Medicine, Beth Israel Hospital, Boston, MA. PROFESSIONAL ACTIVITIES PROFESSIONAL NATIONAL ADVISORY COMMITTEES: 2010 Member, Clinical/Translational Council, The Obesity Society 2008 Member, Sub-Committee for Continuing Medical Education, American Society for Nutrition, Federation of

American Societies for Experimental Biology 2009 Director of the Board, Certification Board for Nutrition Specialists 2009 Member, Development Committee, American Society for Nutrition, Federation of American Societies for

Experimental Biology

2007 Organizing Committee, Medical Nutrition Conference and Education Forum, 2007 American Society for Nutrition Annual Meeting at Federation of American Societies for Experimental Biology Annual Meeting, Washington, DC

2006 Testimony to The President’s Cancer Panel, “Diet, Obesity, Fat Cells, Inflammation and Cancer”, Portland,

OR


2006 Chair, Medical Nutrition Council, American Society for Nutrition, Federation of American Societies for Experimental Biology

2005 Member, NCI, Study Section on Chemo/Dietary Prevention 2005 Chair, NIH/NIDDK Special Study Section for Clinical Nutrition Research Units 2003 NIH/NCCAM Center Director's Meeting Organizing Chair 2002 Member, NCI, Special Study Section : Gene-Nutrient Interaction Centers Review 2002 Congressional Testimony Hearing Before the Committee on Government Reform, "Diet Physical Activity,

Dietary Supplements, Lifestyle and Health", Washington DC. 2000-present Member, NIH Nutrition Center Directors’ Association 1999-2002 Member, Site Visit Committee, Cancer Prevention Studies Branch, Division of Clinical Sciences National

Cancer Institute, National Institutes of Health 1998-present Director, Centers for Obesity Research and Education, UCLA Center for Human Nutrition 1995-present Member, Patient Care Committee, American Institute for Cancer Research 1995-present Member, Physician Members’ Task Force, American Society of Clinical Nutrition 1982-present Nutritional Consultant, California State Board of Medicine. 1998-2000 Chair, Organizing Committee, Year 2000 North American Association for the Study of Obesity (NAASO) Annual Meeting, Los Angeles 1998-2000 Member, California Cancer Advisory Council, State of California.(Council for Gender-Specific Cancer Research in California) 1998-1999 Member, Nutrition Implementation Committee, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health 1997-1998 Chair, Ad Hoc Committee for Primary Care Nutrition Education, American Society of Clinical Nutrition 1997-1999 Member, Design and Analysis Subcommittee, Women’s Health Initiative 1996-1997 Member, Program Committee, American Society of Clinical Nutrition Annual Meeting, Montreal, Canada 1994-2000 Director, American Board of Nutrition 1994 Member, American Institute of Biological Sciences, Study Section on Nutrition and Breast Cancer for the Department of the Army 1994 Member, National Cancer Institute Study Section on Small Grants in Epidemiology 1990-1995 Chair, American Society for Clinical Nutrition, Medical/Dental School and Residency Nutrition Education and Subspecialty Certification Committee. 1987-1992 Member, Metabolic Pathology Study Section, National Institutes of Health.


1990-1992 American Society for Parental and Enteral Nutrition, Research Committee Member. 1987-1988 Continuing Medical Education Committee, American Society for Clinical Nutrition. 1989-1990 Co-Chair, 13th Clinical Congress, American Society for Enteral and Parental Nutrition. 1982-1985 Veterans Administration Merit Review Board in Endocrinology. 1977-1983 Invited Participant, NIH Workshops on LHRH Analogs, Contraceptive Development Branch, Center for Population Research, NICHHD. EDITORSHIPS: Books: Co-Editor: Pomegranates: Ancient Roots to Modern Medicine, Taylor and Francis, Boca Raton, 2006 Editor-in-Chief: Nutritional Oncology, second edition, Academic Press, San Diego, CA, 2006 Volume Editor: Human Nutrition and Obesity in Atlas of Endocrinology (S.G. Korenman, ed.) Current Medicine, Inc., Philadelphia, 2000 Co-Editor: Nutritional Oncology. Academic Press, San Diego, CA, 1999 Co-Editor: Dietary Fats, Lipids, Hormones and Tumorigenesis; New Horizons in Basic Research. Adv. Exp. Biol. Med., Vol. 399. Plenum Press, 1996 Journals: Associate Editor Board, Nutrition and Cancer: An International Journal. Consulting Editor and Member Editorial Board, American Journal of Clinical Nutrition, 1997– 2003 Member, Editorial Board: Obesity Research, 1995 - present Member, Editorial Board: Alternative Medicine Alert 2002-present Member, Editorial Board: Journal of Cancer Integrative Medicine 2003 Member, Editorial Board: Health Magazine, 2004 Member, Editorial Board: Nutrition and Diabetes, 2010 JOURNAL REVIEWER: American Journal of Clinical Nutrition (Editorial Board, Consulting Editor) Obesity Research (Editorial Board) Nutrition and Cancer: An International Journal (Editorial Board) Journal of the National Cancer Institute Nutrition Journal of Clinical Endocrinology and Metabolism Endocrinology Psychoneuroendocrinology Science International Journal of Obesity Annals of Internal Medicine


ACADEMIC AND INSTITUTIONAL COMMITTEES: 2008- 2010 Member, Marilyn Magaram Center Advisory Board, California State University, Northridge 2005-2006 Member, UCLA General Clinical Research Center Advisory Committee 2004 –2005 Chair, Collaborative Centers for Integrative Medicine 2003-2004 Vice Chair, Collaborative Centers for Integrative Medicine 1999-2005 Chair, UCLA Dietary Supplement Research: Botanicals, Executive Committee 1993-present Vice Chair, UCLA CHS Clinical Research Center Advisory Committee 1992-present Member, UCLA CHS Department of Medicine, Executive Committee 1990-present Chair, UCLA Clinical Nutrition Research Unit Executive Committee 1984-present UCLA Risk Factor Obesity Program, Scientific Advisory Committee. Clinical Research Center Advisory Committee - Center for the Health Sciences. Enteral and Parenteral Nutrition Support Committee - Center for the Health Sciences. 1994-1997 Member, Legislative Assembly, UCLA Academic Senate 1990-2001 Member, Nutrition Education Task Force, Department of Medicine Member, Curriculum Working Group in Nutrition, UCLA School of Medicine. 1985-1989 Chairman, Clinical Nutrition Committee, Department of Medicine, UCLA School of Medicine. 1985-1990 UCLA Clinical Nutrition Research Unit, Executive Committee, Co-Chair. 1977-1983 Chairman, Nutrition Committee, Harbor-UCLA Medical Center. Clinical Research Center Advisory Committee, Harbor-UCLA Medical Center. Clinical Research Center Administrative Committee, Harbor-UCLA Medical Center. 1982-1983 Patent Committee, Research and Education Institute, Harbor-UCLA Medical Center. 1978-1982 Internship Selection Committee, Department of Medicine, Harbor-UCLA Medical Center. PUBLIC INFORMATION ACTIVITIES: 2005-present Advisory Board, Oxygen Club of California 2003-present Scientific Advisory Board Member, Cranberry Institute 2001-present Discovery Health Channel, Medical Expert, Discovery Health "Body Challenge" 1996–present Member, Patient Care Committee, American Institute for Cancer Research


1996-present Chair, Nutrition Advisory Committee, California Avocado Commission 1988-present Member, Scientific Advisory Board, American Council for Science and Health. 2002 CBS Early Morning News Segment "What Color Is Your Diet?" 2001 NBC Nightly News "What Color Is Your Diet?" 2001 MSNBC "Obesity and Body Mass Index" 1997 PrimeTime NBC Television, “Obesity Surgery” Segment 1997 Discovery Channel Television Host and Content Specialist, “Nutritional Oncology” –

Cutting Edge Medical Report

1997 CNN Television, Larry King Live –“ Nutrition and Cancer” 1986 California Dietetic Association/California Dairy Council "Food vs. Pills" Program. 1986-1987 KCBS Television, Los Angeles, Medical Expert. 1985-1991 Visiting Professor of Nutrition, National Dairy Council 1985-1986 Chairman, Public Education Committee, American Cancer Society, Coastal Cities Unit, Los Angeles. 1984-1989 UCLA Alumni Association, Invited Speaker, Bruin Woods Family Camp. 1984-present UCLA Speakers Bureau UCLA Extension Program in Allied Health Sciences. 1984-1986 KABC Radio and ABC Radio Network, Medical Expert Talk Show Host. 1982-1984 Project Director, Neil Konheim/UCLA Know Your Body Program, Beverly Hills School District. HONORS AND SPECIAL AWARDS: 2010-2011 Best Doctors in America 2009 Roland S. Weinsier Award in Medical/Dental School Nutrition Education 2007-2008 Best Doctors in America 2007 Kosuna Distringuished Lecturer, Department of Nutrition, University of California at Davis 2000 Who’s Who in America 2000 - 2002 Best Doctors in America 1996-1997 Best Doctors in America 1994 CaPCure (Association for the Cure of Prostate Cancer) Investigator Award 1982-1987 National Institutes of Health, Research Career Development Award


1976 Endocrinology Research Award, Harbor General Hospital 1975-1977 National Institutes of Health, National Research Service Award 1988 Sigma Xi, University of California, Los Angeles 1973 Alpha Omega Alpha, Harvard Medical School 1969 Phi Beta Kappa, University of California, Los Angeles Highest Honors in Chemistry, UCLA, Department of Chemistry RESEARCH GRANTS AND FELLOWSHIPS RECEIVED: RESEARCH GRANTS CURRENTLY FUNDED: 07/01/08 - 06/30/11 National Institutes of Health/FDP Principal Investigator (Project) “Xenobiotics, oxidative stress and allergic inflammation” FDP-NIH 1U19-AI070453-01 08/17/09-07/31/10 National Institutes of Health/NHLBI Co-Investigator “Examining the Effects of High Protein Diet on Outcomes in Hearth Failure Patients” 1R01HL093466-01 RESEARCH GRANTS PREVIOUSLY FUNDED: 09/01/03-08/31/08 National Institutes of Health/ NIDDK-"Training Program in Nutrition and Obesity". Principal Investigator/Program Director T32 DK07688 04/01/02-03/31/07 National Institutes of Health - UCLA Clinical Nutrition Research UCLA Prostate Cancer SPORE: Nutrition Project Co-Investigator (Principal Inv. DeKernion) 1P50 CA92131 04/01/02-3/31/07 National Institutes of Health - UCLA Clinical Nutrition Research Chemoprevention of Superficial Bladder Cancer: Project on Green Tea Co-Investigator (Principal Inv. Belledegrun) 1U01 CA 96116 05/01/02-4/30/07 National Institutes of Health/National Cancer Institute - UCLA Clinical Nutrition Research Unit, Principal

Investigator/CNRU Director PO1 CA42710 09/30/94-04/01/05 National Institutes of Health, "Womens' Health Initiative, UCLA Clinical Center". Co-Principal Investigator for

Nutrition (Principal Inv. Dr. Howard Judd, UCLA Dept. of Obstetrics & Gynecology) N01-WH-4—2125 10/01/99-02/01/05 National Institutes of Health/Office of Dietary Supplement Research – UCLA Center for Dietary Supplement

Research in Botanicals, Principal Investigator and Director and Principal Investigator “Chinese Red Yeast Rice Comparison to Lovastatin” R01 research project within the Center.

1P50 AT 00151 04/01/96-03/30/00 National Institutes of Health/National Cancer Institute - “Estradiol Metabolism in Postmenopausal Women”.

Principal Investigator R01 CA71052


07/01/93-06/30/98 National Institutes of Health, "Longterm Outcome of Obesity Treatment in Minority Women". Principal

Investigator at UCLA. Principal Investigator at Harvard University: Dr.George Blackburn. NIH 5 R01 DK46574 07/01/90-06/30/94 National Institutes of Health ,"Megestrol Acetate Treatment for Cancer Cachexia, "Principal Investigator. 1RO1 CA51165 05/01/91-04/30/94 National Institutes of Health, Clinical Nutrition Research Unit, Principal Investigator/Program CNRU Director and

Director, Lipid-Hormone Core Lab 2 PO1 CA42710 04/01/87-03/30/92 National Institutes of Health, Cancer Control Science Program Project, "Psychological Factors in Adherence to a

Low Fat Diet for Cancer Prevention in Women". Project P.I. (Ellen Gritz, P.I. of Program Project). CA36409 09/03/85-07/31/90 National Institutes of Health, Clinical Nutrition Research Unit Lipid Hormone Core Laboratory (Core Laboratory

Director and Co-Director) (J.Kopple,P.I.) 1PO1 CA42710 12/01/84-03/31/88 National Cancer Institute, Women's Health Trial 1-UO1-CA38446 07/01/82-06/30/87 National Institutes of Health, Research Career Development Award. 1 K04 HD00442 04/01/80-12/30/86 National Institutes of Health ,"Enteral supplements and protein metabolism in cancer." 2 R01 CA 26563 04/01/83-03/31/86 National Institutes of Health, A Phase III Trial of a Low Fat Diet in Women with Stage II Breast Cancer. 1 U01 CA 37640 06/30/82-06/29/84 Principal Investigator, National Institutes of Health, "Peptide antagonists of LHRH as ovulation inhibitors". H01-HD-0-2832 10/15/80-6/29/83 Co-Principal Investigator National Institutes of Health, "Clinical pharmacology of LH/FSHRH analogs in the

male." N01-HD-0-2811 07/01/78-06/30/79 National Institutes of Health, "Protein turnover and energy expenditure in cancer." General Clinical Research

Center, Clinical Associate Physician (RR00425 supplement) 1975-1977 National Institutes of Health, National Research Service Award, "Peptides with LRH activity as cancer markers." CA05435 LECTURES AND PRESENTATIONS: Invited Speaker, “Obesity: Curbing the Epidemic”, 37th Annual UCLA Family Practice Refresher Course, Los Angeles, CA May, 2010


Invited Speaker, “The Science of Longevity”, Milken International Institute Global Conference, Beverly Hills, CA April, 2010 Invited Speaker, “Healthy Living Trends and Advances”, Milken International Institute Global Conference, Beverly Hills, CA April, 2010 Session Organizer and Speaker, “Weight Management: How Much Protein is Enough?” American Society for Nutrition Annual Meeting at Experimental Biology, Anaheim, CA April 2010 Invited Speaker, Melanoma Research Alliance 2nd Annual Scientific Retreat, “Nutrition and Cancer – Approaches for Melanoma Research”, Las Vegas, NV, February, 2010 Invited Speaker, Prostate Cancer Research Foundation Annual Meeting, Lake Tahoe, CA September, 2009 Invited Speaker, Prostate Cancer Research Institute, Los Angeles, CA September, 2009 Invited Speaker, UCLA Endocrine Grand Rounds, Los Angeles, CA June, 2009 Invited Speaker, 2nd International Symposium on Translational Research in Cancer “Pomegranate Ellagitannins in Cancer Prevention. Lonavala, Mumbai, India, December, 2007

Invited Speaker, Prostate Cancer Research Foundation Annual Meeting, Lake Tahoe, CA October, 2007 Invited Speaker, “Obesity and Chronic Disease Prevention”, Harbor-UCLA Medical Center Endocrine Grand Rounds, Torrance, CA, September, 2007 Invited Speaker, “Obesity, Inflammation and Phytochemicals – Implications for Chronic Disease Prevention”, UCLA Medical Grand Rounds, September, 2007 Invited Speaker, "Integration and Translation of Nutritional Science into Cancer Prevention Practice", Integrative Medicine Program Lecture Series, M.D. Anderson Cancer Center, Houston, TX, June, 2007 Invited Speaker, “What Color is Your Berry?”, Keynote Address, Oregon State University Berry Health Symposium, OSU, Corvallis, OR, June, 2007 Invited Speaker, “Phytochemicals Beyond Antioxidation: Pomegranate Secrets from the Garden of Eden”, Kosuna Distinguished Lecture in Nutrition, University of California, Davis, May, 2007 Invited Speaker, “Phytonutrients: Anature’s Bonus from Plant Foods” and “Nutrigenomics, Fruits and Vegetables: Implications for Prevention” 4th Annual Nutrition and Health Conference, University of Arizona Program in Integrative Medicine, San Diego, CA, May, 2007 Conference Chair and Invited Speaker, Medical Nutrition Insights: Obesity, Phytonutrients, Oxidation, Inflammation and Heart Disease, American Society for Nutrition Conference at Experimental Biology, Washington, DC, April, 2007 Chair: D. Heber and G. Jensen Invited Speaker, “Nutrition: Staying Healthy, Getting Healthy” Milken International Institute Global Conference, Beverly Hills, CA April, 2007

Invited Speaker, University of California at Los Angeles, Surgery Grand Rounds, “Malnutrition and Obesity: Two sides of the same coin”, April, 2007

Invited Speaker, “OTC and Herbals for Weight Loss” and “Cytokines, Inflammation and Metabolic Syndrome”, C.O.R.E. Annual Obesity Prevention and Treatment Conference, Las Vegas, March, 2007 Invited Speaker, “The Promise of the Cannabinoid Receptor Antagonists” Third International Summit on Cardio-Metabolic Risk, Los Angeles, CA, January, 2007


Invited Speaker, “ Diet, Obesity, Fat Cells, Inflammation, and Cancer”, President’s Cancer Panel: Promoting Lifestyles to Reduce the Risk of Cancer, Portland, OR, December, 2006 Invited Speaker, “Integrated Programs for the Management of Obesity” International Symposium on Obesity, Monterrey, Mexico, July, 2006.

Invited Speaker, “Overweight and Obesity: Eat for your Genes (Jeans)” Century City Hospital Grand Rounds, Los Angeles, CA, May, 2006. Invited Speaker, “Phytochemicals: Beyond Antioxidation” and “Nutrigenomics, Nutrigenetics and Micronutrients” 3rd Annual Nutrition and Health Conference, University of Arizona Program in Integrative Medicine, New York, NY, May, 2006 Invited Moderator, “Good Nutrition: Understanding its Complex Role in Healthy Aging” and “The Coming American Health Renaissance and the Role of Nutrition” Milken International Institute Global Conference, Beverly Hills, CA April, 2006 Invited Speaker, “Impact of Weight Reduction in Diabetes Type 2 on Inflammation and Oxidative Stress”, Oxygen Club of California annual meeting, Oxidants and Antioxidants in Biology, Santa Barbara, CA, March 2006 Invited Speaker, “Nutrigenetics, Nutrigenomics and Phytochemicals: What Color is Your Diet?” and “A New Look at Plant-Based Proteins in the Worldwide Epidemics of Obesity and Malnutrition” Brazilian Congress of Integrated Nutrition, Sao Paulo, Brazil, June, 2005

Invited Speaker, “Cures in the Cupboard”, and “Metabolize This! How to Create your Own Nutrition Portfolio” Milken International Institute Global Conference, Beverly Hills, CA April, 2005

Invited Chair, “Preventive and Therapeutic Effects of Garlic Against Cancer”, Significance of Garlic and its Constituents in Cancer and Cardiovascular Disease, Washington DC, April, 2005 Invited Speaker, “New Paradigms for Old Disease: The Future of Laboratory Investigation”, Southern California Section of the American Association for Clinical Chemistry, Long Beach, CA, March,2005

Invited Speaker, Plenary Antioxidant Panel, “Phytochemicals and Cancer, Beyond Antioxidation”, and “Future Trends in Nutrition Research” 2nd Annual Nutrition and Health Conference: State of the Science and Clinical Applications, University of Arizona Program in Integrative Medicine, Tucson, AZ, March 2005

Invited Speaker, Korea Society for the Study of Obesity, Seoul Korea, January 2005 Invited Speaker, International Life Sciences Institute, Sao Paolo, Brazil, December, 2004

Invited Speaker, “Using Meal Replacements in Your Practice” , Obesity Treatment and Prevention National Conference, Washington, DC, October 2004 Invited Speaker, UCLA Grand Rounds, “Obesity and Cancer”, Los Angeles, CA , June 2004 Invited Speaker, Cedars Sinai Medical Center Grand Rounds, “Update on Obesity: The Epidemic and its Solution”, Los Angeles, CA, May 2004 Invited Speaker, Milken Institute Annual Global Conference, "Nutrition: Good for People, Good for Business, Good for the Economy", Beverly Hills, CA, April 2004 Invited Speaker, “Protective Phytochemicals” and “Complexity of Food: Fundamentals in Action”, University of Arizona Program in Integrative Medicine Annual Food and Nutrition Conference, Tucson, AZ, March 2004

Invited Speaker, “Food Nutrition and Health in the Genomic Era”, UCLA Center for the Society, the Individual and Genetics


Symposium, Nurturing our Nature, Los Angeles, CA, February 2004

Invited Speaker, “Metabolic Syndrome and Diabesity: Alternative Medicine?” UCLA Collaborative Centers for Integrative Medicine Second Annual Integrative Medicine Symposium: Translating Science into Clinical Practice, Los Angeles, CA, February 2004

Invited Speaker, “Diabesity Pharmacological Interventions: Prescription and OTC” Second National Conference on Diabesity in America, Rutgers University, New Brunswick NJ, November 2003 Invited Speaker, “Supplementation of Tomato-Based Vegetable Juice in Men with Prostate Cancer: Effect on Serum Lycopene and Prostate-Specific Antigen Level CaPCURE 10th Annual Scientific Retreat, New York NY, November 2003

Invited Speaker, “Diet, Lifestyle and Cancer” International Symposium on Free Radicals and Health: Molecular Interventions and Protection of Lifestyle-Related Diseases, Sakata Japan, October 2003 Invited Speaker, “Multivitamins in Obesity and Diabetes” Multivitamins and Public Health: Exploring the Evidence. Washington DC, October 2003 Invited Speaker, “Herbal Approaches to Cancer” First International Conference, Susan Samueli Center International Conference in Complementary and Alternative Medicine, Irvine CA, September 2003 Invited Panelist, National Dialogue on Cancer Leadership Forum on Obesity and Cancer, at the invitation of President George H.W. Bush, Kennebunkport ME, September 2003 Invited Speaker, “Diet and its Effect on Prostate Cancer” Prostate Cancer Research Institute National Conference on Prostate Cancer, 2003, Burbank, CA, September 2003 Invited Speaker “Phytochemical Effects Beyond Antioxidation” Free Radicals: The Pros and Cons of Antioxidants, National Cancer Institute Division of Cancer Prevention, Bethesda MD, June 2003 Invited Speaker, “Invited Speaker, “Obesity and the Metabolic Syndrome” UCLA Family Practice Refresher Course, Beverly Hills, CA, May 2003 Invited Speaker, "Evaluation of botanicals and dietary supplement therapy in cancer patients", Diet and Optimum Health Conference, Portland, OR, May 2003 Invited Speaker, "Metabolic Syndrome and Obesity: Prevention and Treatment Options” Kaiser Permanente Harbor City Physician's Open Conference, Kaiser City, CA, May 2003

Invited Speaker, "Obesity and Endocrine Gland Dysfunction", Nutrition Week Annual Meeting, San Antonio, TX, January 2003

Invited Speaker, "Diet and the Cancer Survivor", Nutrition after Cancer Conference, Chicago, IL, May 2002 Invited Speaker, "Obesity and the Metabolic Syndrome", Primed Primary Medicine Annual Meeting, Denver, CO, November 2002 Invited Speaker, "Obesity and the Metabolic Syndrome", Primed Primary Medicine Annual Meeting, Los Angeles CA, November 2002 Invited Speaker, "Treatment of Medication-Induced Weight Gain", Pharm-Med Pharmacy Medicine Annual Meeting, Los Angeles, CA, October 2002 Invited Speaker, "Plant-Based Diets and Weight Loss" American Dietetic Association Annual Meeting, Philadelphia, PA, October 2002


Co-Chair, Organizing Committee and Invited Speaker, WM Keck Nutrition and Genomics Symposium, UCLA, October 2002 Invited Speaker, "Obesity and the Metabolic Syndrome", Primed Primary Medicine Annual Meeting, Pittsburgh, PA, September 2002 Chair of Nutrition Section and Invited Speaker, CaPCure Scientific Symposium, "Investigation of Plant-Based Diets and Caloric Restriction: Effects on Prostate Cancer" Washington DC, September 2002 Invited Speaker, "Metabolic Syndrome", Primed Primary medicine Annual Meeting, Chicago, IL, September 2002 Invited Speaker, "How Do You Define a Healthy Eating Pyramid?", Approaches to the Treatment of Obesity, Harvard Medical School, Cambridge, MA, June 2002 Invited Speaker, "Obesity Management Update", Plenary Lecture, Kaiser Family Practice Symposium, Las Vegas, NV, June 2002 Invited Speaker, Otsuka Academy Vitamin Program, "Vitamin and Mineral Supplementation: Impact on Health", Tokyo, Japan, June 2002 Invited Speaker, UCLA Family Practice Refresher Course, "Obesity Management in Primary Care", Santa Monica, May 2002 Invited Speaker, "Can Lifestyle Changes Reverse Prostate Cancer?" CaPCure Scientific Symposium, Beverly Hills, CA, April 2002 Invited Speaker, "Healthy Lifestyles in a Fast Food/TV Society", Oldways Preservation and Exchange Trust Whole Grains Summit San Diego, CA, April 2002 Invited Speaker, "Obesity Management In Primary Care", Women's Health Care Forum, Foundation for Better Health Care, Anaheim, CA, March 2002 Invited Speaker, "Developing the Science Base to Support Dietary Supplements", Consumer Health Products Association, Anaheim, CA, February 2002 Invited Speaker, "Nutrition and Botanical Supplements: Lessons from China." East West Medicine Conference, Beverly Hills, CA, November 2001 Invited Speaker, "Cancer Prevention & Control in Asian Populations." The Asian American Network for Cancer Awareness, Research & Training, Los Angeles, CA, October 2001 Invited Speaker, "The Antioxidant Initiative: Phytonutrients Complete the Good Health Puzzle", Oldways Preservation & Exchange Trust, Lake Tahoe, CA, April 2001

Invited Speaker, International Symposium on the Role of Tomato Products and Carotenoids in Disease Prevention New York, NY, April 2001

Invited Speaker, Shape Up America!'s Diabesity Conference. The Contributions of Diet and Inactivity to Diabesity in America: An Agenda for Action, Alexandria, Virginia, March 2001

Course Chair and Invited Speaker, UCLA Continuing Medical Education Program in Conjunction with NAASO 2000 Meeting, Long Beach California, October 2000 NIH, NIDDK 5oth Anniversary Celebration in conjunction with NAASO 2000 “New Approaches to the Food Supply:


Education vs. Structuring”, Long Beach, CA, October 2000 Invited Speaker, American Dietetic Association Annual Meeting, “Eat for Your Genes", Denver, October 2000

Invited Speaker, International Congress of Gynecological Endocrinology, “Phytoestrogens and Herbal Medicines for Women: Mechanisms of Action” and “Clinical Experience with Herbal Medicines for Women’s Health”. Rio de Janiero, Brazil, October 2000

Invited Speaker, Daniel Freeman Hospital Continuing Medical Education, “Tofu and Green Tea Trials”, Los Angeles, October 2000

Invited Speaker, Consumer Health Products Association and NIH Office of Dietary Supplements “Panel Discussion on Research at the UCLA Center for Dietary Supplements Research in Botanicals” October 2000

Invited Speaker, Council for Responsible Nutrition Annual Meeting, “NIH Centers for Dietary Supplement Research” Miami, Florida, September 2000

Invited Speaker, CaPCure Scientific Symposium, “Lessons from China: Gene-Nutrient Interaction in Prostate Cancer”. Lake Tahoe, September 2000

Invited Speaker, Summit Meeting on Obesity and Diabetes “Clinical Experience and a Case Presentation” Laguna Beach, California, August 2000 Invited Speaker, Otsuka Academy Vitamin Program, “Vitamin and Mineral Supplementation: Impact on Health”. Tokyo, Japan, June 2000 Invited Speaker, UCLA Family Practice Refresher Course, “Obesity Management in Primary Care”, Santa Monica, May 2000 Invited Speaker, Providence-St. Joseph’s Hospital Continuing Medical Education, “Update on Nutrition and Cancer”. Burbank, CA, April 2000

Invited Speaker, Medical Grand Rounds, UCLA Santa Monica Medical Center “ Primary Care Management of Obesity”, February 2000 Invited Speaker, World Economic Forum, “ Food and the Worldwide Epidemics of Obesity and Cancer”. Davos, Switzerland, January 2000

Invited Speaker, North American Association for the Study of Obesity, “ Use of Meal Replacements for Weight Loss in Type II Diabetics”, Charlotte, South Carolina Invited Speaker, CaPCure Scientific Symposium, “Nutrition and Prostate Cancer” Lake Tahoe, October 1999 Invited Speaker, American Institute for Cancer Research “Phytochemicals in Cancer Prevention”, Washington, D.C. August 1999 Invited Speaker, Harvard Medical School Continuing Medical Education Program, Current Clinical Issues in Primary Care Conference, “Comprehensive Management of Obesity in the Office Setting”, Boston, MA, November 1998

CaPCure Scientific Symposium, “Nutrition and Prostate Cancer”, Lake Tahoe, CA, September 1998

Visiting Professor, Pennington Biomedical Research Inst., “Nutrition, Obesity and Cancer” Louisiana State University, Baton Rouge, LA, August 1998

Invited Speaker, The Fifth International Symposium on Functional Medicine, “Functional Medicine: Applications to Disorders


of Gene Expression”, Kona, Hawaii, May 1998

Invited Speaker at National Press Club Press Conference and Congressional Briefing, “Benefits of Nutritional Supplementation”, Washington, D.C., March 1998 Invited Speaker, “Obesity: Weighing in On a National Health Problem”, Knoll MERIDIA Breakfast Briefing, Washington, D.C., March 1998

Invited Speaker, UCLA/Harvard Current Clinical Issues in Primary Care Conference, “Vertically Integrated Systems for Managing Obesity”, Long Beach, CA, February 1998 Invited Speaker, California Dietetic Association, “Soy Protein and Cancer”, Santa Monica, CA, February 1998 Invited Speaker, Therapeutic Consortium Scientific Meeting, CaPCURE, the Association for the Cure of Prostate Cancer, “Studies in Nutrition and Prostate Cancer”, Sloan-Kettering Cancer Center, New York, January 1998 Scientific Symposium Organizer and Chair, “Health Impact of Soy Protein”, Clinical Nutrition Research Unit, UCLA, Los Angeles, CA, January 1998

Invited Speaker, Steering Committee for White House Conference on Food, Nutrition and Health in May 2000. Washington, D.C., December 1997

Co-Chair and Discussant, “Nutritional Medicine in Your Clinical Practice: Preventive Approaches to Prevention and Treatment”, University of California, Los Angeles, Los Angeles, CA, November 1997

Keynote Speaker, North American Association for the Study of Obesity International Congress, “Pharmacotherapy: An

Essential Component of the Multimodal Treatment of Obesity”, Cancun, Mexico, November 1997

University of California, Los Angeles, Department of OB-GYN Grand Rounds, “Obesity in the Female Patient”, October 1997

Co-Chair and Conference Organizer, 4th International Congress on Nutrition and Cancer. New Orleans, LA, October 1997 Organized and Chaired, “Health Impact of California Cuisine”, University of California, Los Angeles, CA, September 1997

16th International Congress of Nutrition, “Natural Antioxidants, Phytochemicals and Cancer Prevention”, The American Society for Clinical Nutrition, and 16th International Congress of nutrition Meeting, Montreal, Canada, July 1997

Invited Speaker & Faculty, “The international epidemics of obesity and cancer: Hormonal, Phytochemicals, Micronutrients and physical activity factors”, International Conference on Nutrition and Cancer, Irvine, CA, July 1997

Invited Speaker, “Weight Management: The Primary Role of the OB-GYN”, Santa Monica, CA, July 1997

Invited Speaker, Beijing Medical University, Department of Pharmacology. “Nutrition in Cancer Prevention and Treatment”. May 1997

Invited Speaker, Shanghai Medical University. “The International Epidemic of Obesity and Cancer”. May 1997

Instructor, University of California, Los Angeles, Family Practice Refresher Course, “Nutrition and Heart Disease”, May 1997

Chair and Conference Moderator, Washington, D.C., National Press Club, a UCLA-CME program in Obesity (For 1000 medical students), Los Angeles, CA, April 1997


Lecturer, American College of Obstetrics and Gynecology, “Multimodal Treatment of Obesity, Las Vegas, Nevada, April 1997 University of California, Los Angeles, Department of Surgery, Surgical Grand Rounds, “Obesity”, April 1997 University of California, Los Angeles, Department of Medicine, Medical Grand Rounds, “Sarcopenic Obesity”, April 1997 Visiting Professor in Nutrition and Medical Grand Rounds, University of Wisconsin at Madison, March 1996

University of California, Los Angeles, Department of Medicine, Medical Grand Rounds, "Diagnosis, Pharmacotherapy and Surgical Therapy of Obesity, 1996", March 1996

Visiting Professor in Nutrition, University of North Carolina at Chapel Hill, " Nutrition and Cancer Prevention", November 1995 Fifth Annual Advances and Controversies in Clinical Nutrition, ASPEN and the Mayo Foundation "Nutrition and Cancer Prevention: New Directions in Research and Treatment" and "Pathophysiology and Treatment of Malnutrition in Cancer and HIV Infection", Scottsdale, AZ, April 1995

Plenary Speaker, California Dietetic Association Annual Meeting, " Diagnosis, Pharmacotherapy and Surgical Therapy of Obesity, 1995", Los Angeles, April 1995

Visiting Professor, National Cancer Centre (Rumah Sakit Kanker "Dharmais"), "Nutrition and the Cancer Patient", Jakarta, Indonesia, March 1995 Visiting Professor and Lecturer, Singapore Medical Society, " Nutrition and the Cancer Patient", Singapore, March 1995 Lecturer, Malaysian Oncological Society, "Nutrition and the Cancer Patient", Kuala Lumpur, Malaysia, March 1995 Lecturer, Royal College of Physicians of Thailand, "Nutrition and the Cancer Patient", Bangkok, Thailand, March 1995

Loma Linda University School of Medicine, Annual Conference on Preventive Medicine, "Diagnosis and Therapy of Obesity", Loma Linda, California, March 1995

University of California, Los Angeles, Department of Medicine, Medical Grand Rounds, "Diagnosis, Pharmacotherapy and Surgical Therapy of Obesity, 1995", February 1995

National Institutes of Health Technology Development Conference on Body Composition Methods, "Use of Bioelectrical Impedance in the Clinician's Office", Bethesda, Maryland, December 1994

Twenty-Fifth Anniversary, Harbor-UCLA Clinical Research Center, " Pathophysiology of Cancer and AIDS Cachexia", October 1994

New Frontiers in Prostate Cancer Research, UCLA Extension, "Nutrition and Prostate Cancer Prevention and Treatment", October 1994

University of California, Los Angeles, Center for Aging Keynote Speaker, "Nutrition and Aging", October 1994 University of Utah School of Medicine, Update in Internal Medicine, "Nutrition and Weight Control", Park City, Utah, July 1994 Fox Chase Cancer Center, "Nutrition and Cancer", Philadelphia, PA, June 1994 Endocrine Society Annual Meeting, "Protein-Calorie Malnutrition", Anaheim, CA, June 1994 University of California, Los Angeles, Family Practice Refresher Course, " Antioxidants and Heart Disease", Santa Monica, CA, June 1994


American College of Radiology, Second Annual Meeting on Breast Cancer: Plenary Talk: "Nutrition and Breast Cancer", Palm Springs, CA, May 1994

Western Association of Physicians Annual Meeting, Plenary Session, "Pathophysiology of Cancer Cachexia", Carmel, CA,

February 1994

American Society of Parenteral and Enteral Nutrition, Postgraduate Course," Nutrition and Cancer" San Antonio, TX, January 1994

Harvard University, Course on Treatment of Obesity and Eating Disorders: "Endocrinology of Obesity", Boston, Massachusetts, November 1993 University of California, Los Angeles/North American Association for the Study of Obesity: "Endocrinology of Obesity", Santa Monica, CA, March 1993

American Society of Parenteral and Enteral Nutrition, "Nutrition and Cancer", Physicians' Symposium, San Diego, CA, February 1993

University of California, Los Angeles/CNRU, "Nutritional Medicine in the Treatment and Prevention of Common Chronic Diseases" (Co-Chair), Santa Monica, California, January 1993 Harvard University Course on Treatment of Obesity and Eating Disorders: "Endocrinology of Obesity", Boston, MA, November 1992 Japanese Surgical Society Clinical Congress, "Nutrition and Cancer", Osaka, Japan, July, 1992 Harvard University Course on Nutritional Approaches to the Treatment and Prevention of Chronic Diseases: "Nutrition in the Cancer Patient", Boston, MA, May, 1992

American Society of Parenteral and Enteral Nutrition: (Co-Chair) , NIH-sponsored Research Workshop, "Nutrition and Cancer: Critical Issues in Basic and Clinical Research", Orlando, FL, January 1992

University of California, Los Angeles, Endocrine Clinical Conference - "Hyperlipidemia", July 1991

American Society of Clinical Nutrition, Plenary Symposium, "Can Nutrition Prevent Breast Cancer? What are Realistic Expectations?" - "Weight Reduction as a Strategy for Breast Cancer Prevention", Seattle, WA, May 1991

Nathan Pritikin Research Foundation - National Conference on Diet and Breast Cancer Prevention. "Hormones, Diet and Breast Cancer", April 1991

Harvard University - Current Advances in Nutritional Medicine and Disease Prevention, "Nutrition and Cancer", Boston, MA, April 1991 University of California, Davis, "Fourth Annual Conference on Clinical Nutrition: Women's Health", March 1991

UCLA Intensive Course in Geriatric Medicine, "Nutrition and Enteral Feeding in the Nursing Home", January 1991 UCLA Multicampus Division of Family Medicine Conference, "Nutrition and Heart Disease", May 1990 Harvard University, Comprehensive Treatment of Obesity: "Endocrinology of Obesity", Boston, MA, November 1990 St. Louis University, St. Louis, MO, "Cancer and Nutrition", (Visiting Professor), May 1990 University of Washington, “Current Issues in Nutrition”, Honolulu, HI, March 1988


University of Rochester, "Malnutrition in the Adult Cancer Patient", Rochester, NY, October 1988

Memorial Sloan-Kettering Cancer Center, "Dietary Fat and Calories in the Prevention of Breast Cancer”, New York, NY, (Visiting Professor), May 1988

TPN - Into the 90's, "Pathophysiology of Malnutrition in the Adult Cancer Patient", Los Angeles, CA, November, 1988 American Society for Clinical Nutrition, "Nutrition in Organ System Failure", New Orleans, LA, September, 1988

University of Texas, MD Anderson Cancer Center, "Sixth National Symposium on Nutrition and Cancer", Houston, TX, June 1988

City of Hope National Medical Center, Medical Grand Rounds, "Breast Cancer and Nutrition", May 1988 Pharmacological and Nutritional Intervention, "New Approaches to Cardiovascular Therapy”, Palm Beach, FL, March 1987 CMA State Convention, "Preventive Medicine in Clinical Practice", 1986 American Dietetic Association Annual National Meeting, "Food vs. Pills", Las Vegas, NV, October 1986 California Dairy Council, "Pills vs. Food: An Emerging Controversy”, Los Angeles, CA, January 1987 18th Annual Geiger Memorial Lecture in Nutrition, "Nutrition and Cancer", University of Southern California, Los Angeles, May 1987 American Cancer Society, Second National Symposium on Nutrition and Cancer, Houston, TX, August, 1985

Contraceptive Development Branch, Center for Population Research, NICHHD, NIH, Research Workshop on GnRH Analogs, Washington, D.C., 1978-1983

International Symposium on Male Contraception, Maui, HI, 1982 8th Training Course in Competitive Protein Binding Assay Techniques (Faculty), The Endocrine Society, Long Beach, CA, 1981 Program for Applied Research on Fertility Regulation, Workshop on Research Frontiers in Fertility Regulation, Mexico City, Mexico, 1978 BIBLIOGRAPHY: A. RESEARCH PAPERS (PEER REVIEWED) 1. Heber, D., M.E. Molitch and M.A. Sperling. Low-dose continuous insulin therapy for diabetic ketoacidosis, prospective

comparison with "conventional" therapy. Arch. Intern. Med. 1977; 137:1377-80. 2. Heber, D., W.D. Odell, H. Schedewie and A.R. Wolfsen. Improved iodination of peptides for radioimmunoassay and membrane

radioreceptor assay. Clin. Chem. 1978; 24:796-99. 3. Heber, D. and W.D. Odell. Pituitary receptor binding activity of active, inactive, superactive and inhibitory analogs of

gonadotropin-releasing hormone. Biochem. Biophys. Res. Com. 1978; 82:67-73. 4. Heber, D. Gonadotropin-releasing hormone: Membrane receptors and physiology. Doctoral thesis. University of California, Los

Angeles, 1978. 5. Heber, D., J.C. Marshall and W.D. Odell. GnRH membrane binding: Identification, specificity, and quantification in


nonpituitary tissues. Am. J. Physiol. 1978; 235:E227-30. 6. Swerdloff, R.S., M. Peterson, A. Vera, R.A.L. Batt, D. Heber and G.A. Bray. The hypothalamic-pituitary axis in genetically

obese (ob/ob) mice: response to luteinizing hormone-releasing hormone. Endocrinology. 1978; 103:542-47. 7. Heber, D. and W.D. Odell. Development of a GnRH radioimmunoassay utilizing a superactive synthetic GnRH analog: d-lys6

GnRH. Proc. Soc. Exp. Biol. Med. 1978; 158:643-46. 8. Heber, D. and W.D. Odell. Estrogen modulation of the pituitary LHRH receptor in the rat: in vivo and in vitro. Am J. Physiol.

1979; 237(2): E135-41. 9. Patritti-Laborde, N., and A.R. Wolfsen , D. Heber and W.D. Odell. Pituitary Gland: Site of short-loop feedback for luteinizing

hormone in the rabbit. J. Clin. Invest. 1979; 64:1066-69. 10. Heber, D. and R.S. Swerdloff. Male contraception: synergism of androgens and gonadotropin releasing hormone agonist in

suppression of gonadotropins. Science. 1980; 209:936-39. 11. Heber, D. and R.S. Swerdloff. Down-regulation of pituitary gonadotropin secretion in postmenopausal females by continuous

GnRH administration. J. Clin. Endo. Metab. 1981; 52:171-72. 12. Heber, D. and R.S. Swerdloff. Gonadotropin-releasing hormone analog and testosterone synergistically inhibit spermatogenesis.

Endocrinology. 1981; 108:2019-21. 13. Greenway, F.L., D. Heber and G.A. Bray. Failure of oral glycerol treatment to induce weight loss in obese humans. Current

Therapy. 1981; 29:849-52. 14. Mason, J.S. and D. Heber. Endogenous opiates modulate insulin secretion in flushing non-insulin dependent diabetics. J. Clin.

Endo. Metab. 1982; 693-97. 15. Heber, D., R. Dodson, R.S. Swerdloff, K. Channabasavaiah and J.M. Stewart. Pituitary receptor site blockade by a gonadotropin

releasing hormone antagonist in vivo: mechanism of action. Science. 1982; 216:420-21. 16. Heber, D. Dodson, C. Stoskopf, M. Peterson and R.S. Swerdloff. Pituitary desensitization and the regulation of pituitary GnRH

receptors following chronic administration of superactive GnRH analog and testosterone. Life Science. 1982; 30:2301-08. 17. Chlebowski, R.T. and D. Heber. Hypogonadism in male patients with metastatic cancer prior to chemotherapy. Cancer Res.

1982; 42:2495-97. 18. Heber, D., R.T. Chlebowski, D.E. Ishibashi, J.N. Herrold and J. Block. Abnormalities in glucose and protein metabolism in

non-cachectic lung cancer patients. Cancer Res. 1982; 42:4815-19. 19. Bhasin, S., D. Heber, M. Peterson and R.S. Swerdloff. Partial isolation and characterization of testicular GnRH-like factors.

Endocrinology. 1983; 112:1144-46. 20. Swerdloff, R.S., S. Bhasin and D. Heber. Effect of superactive GnRH analogs on testicular function in man and experimental

animals. J. Steroid. Biochem. 1983; 19:491-97. 21. Abrass, C.K., D. Heber and J. Lieberman. Circulating immune complexes in patients with diabetes mellitus. Clin. Exper.

Immunol. 1983; 52:164-72. 22. Henson, L.C. and D. Heber. Whole body protein breakdown rates and hormonal adaptation during fasting in obese subjects. J.

Clin. Endo. Metab. 1984; 57:316-19. 23. Rajfer, J., D. Heber, S. Peng and R.S. Swerdloff. Effects of chronic D-leu6-desGly10 GnRH ethylamide on male sex tissues.

Bio. Repro. 1984; 30:646-51.


24. Chlebowski, R.T., D. Heber, B. Richardson, J.B. Block. Influence of hydrazine sulfate on abnormal carbohydrate metabolism in

cancer cachexia: A randomized placebo-controlled trial. Cancer Research. 1984; 44:857-61. 25. Heber, D. R. Dodson, K. Channabasavaiah, J.M. Stewart, M. Peterson and R.S. Swerdloff. Counteractive effects of agonistic and

antagonistic GnRH analogs on spermatogenesis: Sites of action. Fertil. Steril. 1984; 41(2):309-13. 26. Bhasin, S., D. Heber, L.A. Campfield, M. Jang, B. Steiner, M. Peterson and R.S. Swerdloff. Hormonal effects of GnRH agonist

in the human male: II. Testosterone enhances gonadotropin suppression induced by GnRH agonist. Clin. Endo. 1984; 20:119-28.

27. Heber, D., S. Bhasin, B. Steiner and R.S. Swerdloff. The stimulatory and down-regulatory effects of a gonadotropin-releasing

hormone agonist in man. J. Clin. Endo. Metab. 1984; 58:1084-88. 28. Rajfer, J., R.S. Swerdloff and D.Heber. Testicular histology following chronic gonadotropin releasing hormone agonist

treatment. Fertil. Steril. 1984; 42(5):765-71. 29. Condon, T.P., D. Heber, J.M. Stewart, C.H. Sawyer and D.I. Whitmoyer. Differential gonadotropin secretion: blockade of

periovulatory LH but not FSH secretion by a potent LHRH antagonist. Neuroendocrinology. 1984; 38:357-61. 30. Heber, D., The Leuprolide Study Groups (1 of 22 authors). Leuprolide Versus Diethylstilbestrol for Metastatic Prostate Cancer.

New Eng. J. Med. 1984; 311:1281-86. 31. Heber, D., L.O. Byerley, R.T. Chlebowski. Metabolic abnormalities in the cancer patient. Cancer. 1985; 55:225. 32. Bhasin, S., D. Heber, B.S. Steiner, D.K. Handelsman and R.S. Swerdloff. Hormonal effects of GnRH agonist in the human male

III: effects of long term combined treatment with GnRH agonist and androgen. J. Clin. Endo. Metab. 1985; 60:998-2003. 33. Sokol, R.Z., M. Peterson, D. Heber, R.S. Swerdloff: Identification and partial characterization of gonadotropin-releasing

hormone-like factors in human seminal plasma. Bio. Reprod. 1985; 33:370-74. 34. Heber, D., L.O. Byerley, J. Chi, M. Grosvenor, R. Bergman , M. Coleman and R.T. Chlebowski. Pathophysiology of

malnutrition in the adult cancer patient. Cancer. 1986; 58:1867-74. 35. Chlebowski, R.T., J. Herrold, I. Ali, E. Oktay, J. Chlebowski, A. Ponce, D. Heber, J.B. Block. Influence of nandrolone

decanoate on weight loss in advanced non-small cell lung cancer. Cancer, Pub type: Clinical trial; Journal article; randomized controlled trial. 1986; 58:183-86.

36. Greenway, F.L., D. Heber, D., R.J. Ruby, R.T. Chlebowski. Improvement in glycosuria and integrated insulin responses in type

II diabetic subjects one week following a three-day fast. Journal of Obesity and Weight Regulation. 1986; 5:215-21. 37. Henson, L.C., D.C. Poole, C.P. Donahoe, D. Heber. Effects of exercise training on resting energy expenditure during caloric

restriction. Am. J. Clin. Nutr. 1987; 46:893-99. 38. Tayek, J., D. Heber, R.T. Chlebowski. Effect of hydrazine sulphate on whole-body protein breakdown measured by 14C-lysine

metabolism in lung cancer patients. Lancet, 1987; 2:241-44. 39. Nixon, D.W., M. Kutner, S.B. Heymsfield, A.T. Holtz, C. Carty, S. Seitz, K. Casper, W.K. Evans, K.N. Jeejeehboy, J.M. Daly,

D. Heber, M. Poppendiek, and F.A. Hoffman. Resting energy expenditure in lung and colon cancer. Metabolism. 1988; 27-35. 40. Carr, J.G., L.W. Stevenson, J.A. Walden, and D. Heber. Prevalence and hemodynamic correlates of malnutrition in severe

congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Amer. J. Cardiol. 1989; 63:11. 41. Tayek, J., D.Heber, and L.O.Byerley, B. Steiner, J. Rajfer, and R.S. Swerdloff. Nutritional and metabolic effects of


Gonadotropin-Releasing Hormone agonist treatment for prostate cancer. Metabolism. 1990; 39 (12): 1314-19. 42. Heber, D., J. Ashley, D.A. Leaf, J.A. Barnard. Reduction of serum estradiol in postmenopausal women given free access to a

low fat high carbohydrate diet. Nutrition. 1991; 7 (2): 137-39. 43. Tchekmedyian, N.S., M. Hickman, and D. Heber. Treatment of anorexia and weight loss with megestrol acetate in patients with

cancer or acquired immunodeficiency syndrome. Seminars in Oncology. 1991; 18 (1): 35-42. Pub type: clinical trial; journal article; randomized controlled trial.

44. Byerley, L.O., D. Heber, R.N. Bergman, M. Dubria, and J. Chi. Insulin action and metabolism in patients with head and neck

cancer. Cancer. 1991; 67 (11): 2900-06. 45. Weinsier, R.L., J.R. Boker, C.M. Brooks, R.F. Kushner, A.K. Olson, D.A. Mark, S.T. St.Jeor, V.A. Stallings, M. Winick, D.

Heber, W.J. Visek. Nutrition training in graduate medical (residency) education: a survey of selected training programs. Amer. J. Clin. Nutr. 1991; 54.

46. Heber, D., J.M. Ashley, W.J. McCarthy, C-J. Chang, R. Elashoff. Assessment of adherence to a low fat diet for breast cancer

prevention. Prev. Med. 1992; 21 (2): 218-27. 47. Heber, D., J.M. Ashley, M.E. Solares, H-J. Wang, R.B. Alfin-Slater. The effects of a palm-oil enriched diet on plasma lipids and

lipoproteins in healthy young men. Nutr. Res. 1992; 12: S53-59. 48. Heber D., C.H. Halsted, C.M. Brooks, R.W. Chesney, M. DiGirolamo, D.D. Heimburger D.C., Hensrud, D.A. Mark, M.D.

Sitrin, H.H. Tillman, and S.H. Zeisel. Biennial survey of physician clinical-nutrition training programs. Am. J. Clin. Nutr. 1993. 49. Kanders BS., Ullman-Joy P, Foreyt JP, Heymsfield SB, Heber D, Elashoff RM, Ashley JM, Reeves RS, and Blackburn, GL.

The Black American Lifestyle Intervention (BALI): A weight loss program for working class African-American women. J. Am. Diet. Assoc. 1994; 94: 310-12.

50. St Jeor ST, Brownell KD, Atkinson RL, Bouchard C, Dwyer J, Foreyt JP, Heber D, Kris-Etherton P, Stern JS, Willett W, et

al. Obesity. Workshop III. AHA Prevention Conference III. Behavior change and compliance: keys to improving cardiovascular health. 1993; 88(3): 1391-96.

51. Maxwell M.H., Heber D, Waks AU, and Tuck ML. Role of insulin and norepinephrine in the hypertension of obesity. Am. J.

Hypertension. 1994; 7 (5): 402-08. 52. Bagga D, Ashley JM, Geffrey S, Wang H-J, Barnard J, Elashoff R, and Heber D. Modulation of serum and breast ductal fluid

lipids by a very low fat, high fiber diet in Premenopausal Women. J. Nat. Cancer Inst. 1994; 86:1419-21. 53. Heber D., J.M. Ashley, H-J. Wang and R.M. Elashoff. Clinical evaluation of a minimal intervention meal replacement regimen

for weight reduction. J. Am. Coll. Nutr. 1994; 13:608-14. 54. Go VLW, Wilkerson LA, and Heber D. Implementation of a longitudinal nutrition curriculum at UCLA. Academic Medicine.

1995; 70(5):432-33. 55. Elstner E., Linker-Israeli M, Said J, Umiel T, deVos S.,Shintaku I.P, Heber D, Binderup L, Uskokovic M, and Koeffler HP. 20-

epi-vitamin D3 analogs: A novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines. Cancer Research. 1995; 55: 2822-30.

56. Bagga, D, Byerly LO, Koziol BJ, Glick Z, Ashley JM, and Heber D. Adipose tissue and the effects of fat and calories on breast

tumorigenesis in rats. Nutr. Biochem. 1995; 6:667-72. 57. Bagga D., Ashley JM, Geffrey S, Barnard RJ, Korenman S, and Heber D. Effects of a very low fat, high fiber diet on serum


hormones and menstrual function: Implications for breast cancer prevention. Cancer. 1995; 76:2491-96. 58. Greenway FL, Bray GA., and Heber D. Topical fat reduction. Obesity Research. 1995; 4:561S-68S. 59. Bagga D, Byerley LO, Kozziol BJ, Glick Z, Ashley JM, and Heber D. Adipose Tissue and the Effects of Fat and Calories on

Breast Tumorigenesis in Rats. Journal of Nutritional Biochemistry. 1995; 6:667-72. 60. Byerley L0., and Heber D. Metabolic effects of triiodothyronine replacement during fasting in obese subjects. J. Clin. Endo.

Metab. 1996; 81:968-76. 61. Kizaki M, Dawson MI, Heyman R, Elstner E, Morosetti R, Pakkala S, Chen DL, Ueno H, Chao W, Morikawa M, Ikeda Y,

Heber D, Pfahl M, and Koeffler HP. Effects of novel Retinoid X Receptor-selective ligands on myeloid leukemic differentiation and proliferation in vitro. Blood. 1996; 87:1977-84.

62. Heber D., Ingles S., Ashley J.M., Maxwell M.H., Lyons R.F., and R.M. Elashoff. Clinical detection of sarcopenic obesity by

bioelectrical impedance anlysis. Am. J. Clin. Nutrition. 1996; 64 (suppl. 3):472S-77S. 63. Zhang J, Henning SM, Heber D, Choi J, Wang YH, Swendseid ME, and Go VLW. NADPH-Cytochrome P-450 Reductase,

Cytochrome P-450 2C11 and P-450 1A1, and the aryl hydrocarbon receptor in livers of rats fed methyl-folate-deficient diets, Nutrition & Cancer. 1997; 28(2), 160-64.

64. Bagga D, Capone S, Wang H-J, Heber D, Lill M, Chap L, and Glaspy JA. Dietary Modulation of Omega-3/omega-6

polyunsaturated fatty acid ratios in patients with breast cancer. Journal of the National Cancer Institute. 1997; 89:1123-31. 65. DeVoss S, Holden S, Heber D, Elstner E, Binderup L, Uskokovic M, Rude B, Chen DL, Cho SK, and Koeffler HP. Effects of

potent vitamin D3 analogs on clonal proliferation of human prostate cancer cell lines. Prostate. 1997; 31:77-83. 66. Chamras H, Bagga D, Elstner E, Koeffler HP, Heber D. Preadipocytes Stimulate Breast Cancer Cell Growth. Nutrition and

Cancer. 1998; 32: 59-63. 67. Elstner E, Muller C, Koshizuka K, Williamson EA, Park D, Asou H, Shintaku P, Said JW, Heber D, and Koeffler HP. Ligands

for peroxisome proliferator-activated receptor gamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Nat Acad Sci. 1998; 95:8806-11.

68. Davidson M, Hauptman J, DiGirolamo M, Foreyt J, Halsted C, Heber D, Heimburger D, Lucas C, Robbins D, Chung J and

Heymsfield S. Weight control and risk factor reduction in obese subjects treated for 2 Years with orlistat. JAMA. 1999; 281:235-42.

69. Heber D, Yip I, Ashley, JM, Elashoff DA, Elashoff R, Go VLW. Cholesterol-lowering effects of a proprietary Chinese Red

Yeast Rice Dietary Supplement. AJCN. 1999; 69: 231-36. 70. Greenway, F, Heber D, Raum W and Morales, S. Double-blind, randomized, placebo-controlled clinical trials with non-

prescription medications for the treatment of obesity. Obesity Res. 1999; 7(4):370-78. 71. Flechtner-Mors, M. Dieschuneit HH., Yip, I., Alt, A., Torres-Schow RM., Membrano S., Caquin R., Tam, C., Johnson, T.,

Heber, D. Reduced epinephrine-stimulated lipolytic activity in male golden-mantled ground squirrel during hibernation : an in situ microdialysis study. Comp. Biochem and Physiology. 1999; 123:281-84.

72. Elstner E, Campbell MJ, Munker R, Binderup L, Heber D, and Koeffler HP. Novel 20-epi-vitamin D3 analog combined with 9-

cis-retinoic acid markedly inhibit clonal growth of prostate cancer cells. The Prostate. 1999; 40: 141-49. 73. Aronson WJ, Tymchuk CN, Elashoff RM, McBride WH, McLean C, Wang H, Heber D. Decreased growth of human prostate

LNCaP tumors in SCID mice fed a low-fat, soy protein diet with isoflavones. Nutr Cancer. 1999; 35(2): 130-36.


74. Henning SM, Ingles S, Mahmoud D, Go VLW, Carlton E, Caulfield M, Nelson JC and Heber D. Multivitamin and Mineral

Supplement did not alter the antioxidant capacity in Plasma of Health Young Men and Women. Nutr Res. 2000; 20(2); 167-76. 75. Hui E., Henning SM, Park N, Heber D and Go VLW. Genistein and daidzein/glycitein content in tofu. J Food Comp Anal.

2001; 14(2); 199-206. 76. Go VLW, Wong DA, Resnick MS, and Heber D. Evaluation of Botanicals and Dietary Supplements Therapy in Cancer

Patients. J. Nutr. 2001; 131: 179S-80S. 77. Heber, D. Herbs and Atherosclerosis. Current A therosclerosis Reports. 2001; 3:93-96. 78. Heber, D, Lembertas, A, Lu, Q-Y, Bowerman, S, Go, VLW. An Analysis of Nine Proprietary Chinese Red Yeast Rice Dietary

Supplments: Implications of Variability in Chemical Profile and Contents. The Journal of Alternative and Complementary Medicine. 2001; 7(2): 133-39.

79. Tymchuk CN, Barnard RJ, Heber D and Aronson WJ. Evidence of an Inhibitory Effect of Diet and Exercise on Prostate Cancer

Cell Growth. J Urol. 2001; 166:1185-89. 80. Heber, D and Bowerman, S. Applying Science to Changing Dietary Patterns. J. Nutr. 2001; 131: 3078S-81S. 81. Livingston, E.H, Sebastian, JL, Huerta, s, Yip, I and Heber, D. Biexponential Model for Predicting Weight Loss after Gastric

Surgery for Obesity. Journal of Surgical Research. 2001; 101, 216-24. 82. Ikezoe, T, Chen, SS, Heber, D, Taguchi, H, and Koeffler, HP. Baicalin Is a Major Component of PC-SPES Which Inhibits the

Proliferation of Human Cancer Cells Via Apoptosis and Cell Cycle Arrest. The Prostate. 49:285-92. 83. Bowerman, S, Bellman, M, Saltsman, P, Garvey, D, Pimstone, K, Skootsky, S, Wang, HJ, Elashoff, R, and Heber, D.

Implementation of a Primary Care Physician Network Obesity Management Program. Obesity Research. 2001; 9:321S-25S. 84. Huerta S, Heber D, Yip I, Li Zp, Alexander P, Arthur D, Livingston EH. Reduced length of stay by implementation of a Clinical

Pathway for Bariatric Surgery in an Academic Health Center. The American Surgeon. 2001; 67(12): 1128-35. 85. Yip, I, Go, VLW, DeShields, S, Saltsman, P, Bellman, M, Thames, G, Murray, S, Wang, HJ, Elashoff, R and Heber, D. Liquid

Meal Replacements and Glycemic Control in Obese Type 2 Diabetes Patients. Obesity Research. 2001; 9:341S-47S. 86. Sartippour, MR, Heber, D, Ma, J, Lu, Q, Go, VL, and Nguyen, M. Green Tea and Its Catechins Inhibit Breast Cancer

Xenografts. Nutrition and Cancer. 2001; 40(2), 149-56. 87. Sartippour, MR, Liu, C, Shao, ZM, Go, VL, Heber, D, and Nguyen. Livistona extract inhibits angiogenesis and cancer

growth. Oncology Reports. 2001; 8: 1355-57. 88. Lu Q-Y, Hung J-C, Heber D, Go VLW, Reuter VE, Cardon-Carado C, Scher HI, Marshall JR, Zhang Z-F. Inverse Associations between plasma lycopene and other carotenoids and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2001;

Jul: 10(7): 749-56. 89. Aronson WJ, Glaspy JA, Reddy ST, Reese D, Heber D, Bagga D. Modulation of Omega-3/Omega-6 Polyunsaturated Ratios

With Dietary Fish Oils In Men With Prostate Cancer. Urology 2001; 58(2): 283-88.

90. Huerta S, Irwin RW, Heber D, Go VL, Koeffler HP, Uskokovic MR, and Harris DM. 1α,25-(OH)2-D3 and Its Synthetic Analogue Decrease Tumor Load in the Apcmin Mouse. Cancer Res. 2002; 62:741-46.

91. Shao, ZM, Shen, ZZ, Liu, CH, Sartippour, MR, Go, VL, Heber, D, and Nguyen, M. Curcumin Exerts Multiple Suppressive

Effects on Human Breast Carcinoma Cells. Int. J. Cancer. 2002; 98, 234-40.


91. Huerta S, Arteaga JR, Irwin RW, Ikezoe T, Heber D, and Koeffler HP. PC-SPES Inhibits Colon Cancer Growth in Vitro and in Vivo. Cancer Res. 2002; 62:5204-09.

93. Sartippour M, Heber D, Zhang L, Beatty P, Elashoff R, Go VLW, and Brooks MN. Inhibition of fibroblast growth factors

by green tea. Int. J. Oncol. 2002; 21:487-91. 94. LeRoy A, Potter E, Woo HH, Heber D and Hirsch AM. Characterization and Identification of Alfalfa and Red Clover

Dietary Supplements Using a PCR-Based Method. J. Agriculture &.Food Chem. 2002; 50: 5063-69. 95. Huerta S, Rogers L, Li Z, Heber D, Liu C, Livingston EH. Vitamin A deficiency in a newborn due to maternal vitamin A

deficiency after biliopancreatic diversion for the treatment of morbid obesity: a case report. American Journal of Clinical Nutrition. 2002; 76:426-29.

96. Elstner E, Williamson EA, Zang C, Fritzs J, Heber D, Possinger,K, and Koeffler, HP. Novel Therapeutic Approach: Ligands

for PPARy and Retinoid Receptors Induce Apoptosis in BCL-2-Positive Human Breast Cancer Cells. Breast Cancer Research and Treatment. 2002; 74:155-65.

97. Sartippour, MR, Shao, Heber, D, Elashoff, D, Liu, C, Zhang, L, Beatty, P, Elashoff R, Go, VL, and Nguyen, M. Green Tea

Inhibits Vascular Endothelial Growth Factor (VEGF) Induction in Human Breast Cancer Cells. Nutrition and Cancer. 2002; 2307-11.

98. Livingston EH, Huerta S, Arthur D, Lee S, DeShields S, Heber D. Male Gender is a Predictor of Morbidity and Age a

Predictor of Mortality for Patients Undergoing Gastric Bypass Surgery. Ann Surg. 2002; Nov; 236 (5) 576-82. 99. Yip, I., Wang HJ, DeShields, S., Elashoff R., Go, VLW, Heber, D. Insulin- leptin- visceral fat relation during weight loss.

Pancreas. 2002; Aug; 23(2):197-203. 100. Heber D, Lu QY. Overview of Mechanisms of Action of Lycopene. Exp Biol Med (Maywood). 2002; Nov; 227(10): 920-23. 101. Huerta S, Hannestad J, Jazirehi A, Bonavida B, Harris DM, Irwin R, , Heber D, Elashoff D, and Livingston EH. Gene

Expression Profile of Metastatic Colon Cancer Cells Resistant to Cisplatin-Induced Apoptosis. Int J Oncol. 2003; Mar; 22(3): 633-70.

102. Huerta S, Irwin RW, Heber D, Go VLW, Moatamed F, Huerta S, Ou C, Harris DM. Intestinal Polyp Formation in the Apcmin

Mouse. Digestive Diseases and Sciences. 2003; May; 48 (5). 103. Henning S.M., Fajardo-Lira C., Lee H.W., Youssefian A.A., Go V.L.W., Heber D. Catechin content of 18 teas and a green

tea extract supplement correlate with the antioxidant capacity. Nutrition and Cancer. 2003; 45(2) 26-35. 104. Ngo T, Cohen P, Heber D, Barnard J, Yahya E. Effect of Isocaloric Low-Fat Diet on Human LAPC-4 Prostate Cancer

Xenografts In Severe Combined Immunodeficient Mice and the Insulin-like Growth Factor Axis. Clinical Cancer Research. 2003; Jul; 9(7): 2734-43.

105. Basa NR, Wang L, Arteaga JR, Heber D, Livingston EH, Taché Y. Bacterial lipopolysaccharide shifts fasted plasma ghrelin

to postprandial levels in rats. Neuroscience Letters. 2003; May; 29:43(1): 25-8. 106. Gan XH, Zhang L, Heber D, Bonavida B. Mechanism of activation of human peripheral blood NK cells at the single cell

level by Echinecea water soluble extracts: recruitment of lymphocyte-target conjugates and killer cells and activation of programming for lysis. International Immunopharmacology. 2003; 3: 811-24.

107. Taylor JE, Poston II WSC, Haddock CK, Blackburn GL, Heber D. Psychometric characteristics of the General Well-Being

Schedule (GWB) with African-American women. Quality of Life Research. 2003; 12:310-39. 108. Li Z, Hong K, Yip I, Huerta S, Heber D. Body weight loss with phentermine alone versus phentermine and fenfluramine


with very-low-calorie diet in an outpatient obesity management program: A retrospective study. Current Therapeutic Research. 2003; 64 (7).

109. Grau MV, Baron JA, Sandler RS, Haile RW, Beach ML, Church TR, Heber D. Vitamin D, calcium supplementation, and

colorectal adenomas: results of a randomized trial. J Natl Cancer Inst. 2003; Dec 3; 95 (23): 1765-71. 110. Ikezoe T, Yang Y, Heber D, Taguchi H, Koeffler HP. PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice

from lipopolysaccharide-induced septic shock. Mol Pharmacol. 2003; Dec; 64(6): 1521-29. 111. Frost P, Bornstein S, Ehrhart-Bornstein M, O'Kirwan F, Hutson C, Heber D, Go V, Licinio J, Wong ML. The prototypic

antidepressant drug, imipramine, but not Hypericum perforatum (St. John's Wort), reduces HPA-axis function in the rat. Horm Metab Res. 2003; Oct; 35 (10): 602-6.

112. Ikezoe T, Chen SS, Yang Y, Heber D, Taguchi H, Koeffler HP. PC-SPES: Molecular mechanism to induce apoptosis and

down-regulate expression of PSA in LNCaP human prostate cancer cells. Int J Oncol. 2003; Nov; 23 (5): 1461-70. 113. Ikezoe T, Chen S, Saito T, Asou H, Kyo T, Tanosaki S, Heber D, Taguchi H, Koeffler HP. PC-SPES decreases proliferation

and induces differentiation and apoptosis of human acute myeloid leukemia cells. Int J Oncol. 2003; Oct; 23(4): 1203-11. 114. Ikezoe T, Chen SS, Tong XJ, Heber D, Taguchi H, Koeffler HP. Oridonin induces growth inhibition and apoptosis of a

variety of human cancer cells. Int J Oncol. 2003; Oct; 23 (4): 1187-93. 115. Seeram NP, Adams LS, Hardy ML, Heber D. Total Cranberry Extract versus Its Phytochemical Constituents: Antiproliferative

and Synergistic Effects against Human Tumor Cell Lines. J. Agric. Food Chem. 2004; 52:2512-17. 116. Kim D-H, Heber D, Still DW. Genetic Diversity of Echinacea Species Based upon AFLP Markers. Genome. 2004; 47: 102-11. 117. Sartippour MR, Rao JY, Apple S, Wu D, Henning S, Wang H, Elashoff R, Rubio R, Heber D, Brooks M. A Pilot Clinical Study

of Short Term Isoflavone Supplements in Breast Cancer Patients. Nutrition and Cancer 2004; 49(1):59-65. 118. Henning SM, Niu Y, Lee NH, Thames GD, Minutti RR, Wang H, Go VL, Heber D. Bioavailability and antioxidant activity

of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. Am J Clin Nutr. 2004 Dec;80(6):1558-64.

119. Lu QY, Jin YS, Zhang Q, Zhang Z, Heber D, Go VL, Li FP, Rao JY. Ganoderma lucidum extracts inhibit growth and induce

actin polymerization in bladder cancer cells in vitro. Cancer Lett. 2004 Dec 8;216(1):9-20. 120. Marks LS, Kojima M, Demarzo A, Heber D, Bostwick DG, Qian J, Dorey FJ, Veltri RW, Mohler JL, Partin AW. Prostate

cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue. Urology. 2004 Oct;64(4):765-71.

121. Huerta S, Li Z, Li HC, Hu MS, Yu CA, Heber D. Feasibility of a partial meal replacement plan for weight loss in low-

income patients. Int J Obes Relat Metab Disord. 2004 Dec;28(12):1575-9. 122. Seeram, N.P.; Lee. R.; and Heber, D.; Bioavailability of ellagic acid in human plasma after consumption of ellagitannins

from pomegranate (Punica granatum L.) juice. Clinica Chimica Acta. 2004 Oct;348(1-2):63-8. 123. Lu QY, Sartippour MR, Brooks MN, Zhang Q, Hardy M, Go VL, Li FP, Heber D. Ganoderma lucidum spore extract inhibits

endothelial and breast cancer cells in vitro. Oncol Rep. 2004 Sep;12(3):659-62. 124. Sartippour MR, Heber D, Henning S, Elashoff D, Elashoff R, Rubio R, Zhang L, Norris A, Brooks MN. cDNA microarray

analysis of endothelial cells in response to green tea reveals a suppressive phenotype.Int J Oncol. 2004 Jul;25(1):193-202. 125. Ngo TH, Barnard RJ, Anton T, Tran C, Elashoff D, Heber D, Freedland SJ, Aronson WJ. Effect of isocaloric low-fat diet on

prostate cancer xenograft progression to androgen independence. Cancer Res. 2004 Feb 15;64(4):1252-4.


126. Krochmal R, Hardy M, Bowerman S, Lu Q-Y, Wang H-J, Elashoff R, Heber D. Phytochemical Assays of Commercial

Botanical Dietary Supplements. ECam 2004;1(3)305-313. 127. Lu QY, Arteaga JR, Zhang Q, Huerta S, Go, VLW, Heber D. Inhibition of prostate cancer cell growth by an avocado

extract: role of lipid soluble bioactive substances. J Nutr Biochem. 2005 Jan;16(1):23-30. 128. Lu QY, Jin YS, Pantuck A, Zhang ZF, Heber D, Belldegrun A, Brooks M, Figlin R, Rao J. Green tea extract modulates actin

remodeling via Rho activity in an in vitro multistep carcinogenic model. Clin Cancer Res. 2005 Feb 15;11(4):1675-83. 129. Sartippour MR, Seeram NP, Heber D, Hardy M, Norris A, Lu Q, Zhang L, Lu M, Rao JY, Brooks MN.

Rabdosia rubescens inhibits breast cancer growth and angiogenesis. Int J Oncol. 2005 Jan;26(1):121-7. 130. Wang C, Catlin DH, Starcevic B, Heber D, Ambler C, Berman N, Lucas G, Leung A, Schramm K, Lee WNP, Hull L,

Swerdloff RS. Low Fat High Fiber Diet Decreased Serum and Urine Androgens in Men. J. Clin. Endocrinol. Metab., Mar 2005; 10.1210/jc.2004-1530.

131. Baron JA, Beach M, Wallace K, Grau MV, Sandler RS, Mandel JS, Heber D, Greenberg ER. Risk of prostate cancer in a

randomized clinical trial of calcium supplementation. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):586-9. 132. Li Z, Hong K, Saltsman P, DeShields S, Bellman M, Thames G, Liu Y, Wang HJ, Elashoff R, Heber D. Long-term efficacy

of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur J Clin Nutr. 2005 Mar;59(3):411-8.

133. Mu LN, Lu QY, Yu SZ, Jiang QW, Cao W, You NC, Setiawan VW, Zhou XF, Ding BG, Wang RH, Zhao J, Cai L, Rao JY,

Heber D, Zhang ZF. Green tea drinking and multigenetic index on the risk of stomach cancer in a Chinese population. Int J Cancer. 2005 Oct 10;116(6):972-83

134. Hong K, Li Z, Wang HJ, Elashoff R, Heber D. Analysis of weight loss outcomes using VLCD in black and white overweight

and obese women with and without metabolic syndrome. Int J Obes Relat Metab Disord. 2005 Apr;29(4):436-42. 135. Chamras H, Barsky SH, Ardashian A, Navasartain D, Heber E, Glaspy JA. Novel Interactions of Vitamin E and Estrogen in

Breast Cancer. 2005 Nutr Cancer 52(1), 43-48. 136. Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, Heber D. In vitro antiproliferative, apoptotic and

antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 2005 Jun;16(6):360-7.

137. Chen L, Cheng X, Shi W, Lu Q, Go VL, Heber D, Ma L. Inhibition of growth of Streptococcus mutans, methicillin-resistant

Staphylococcus aureus, and vancomycin-resistant enterococci by kurarinone, a bioactive flavonoid isolated from Sophora flavescens. J Clin Microbiol. 2005 Jul;43(7):3574-5.

138. Henning SM, Niu Y, Liu Y, Lee NH, Hara Y, Thames GD, Minutti RR, Carpenter CL, Wang H, Heber D. Bioavailability

and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals. J Nutr Biochem. 2005 Oct;16(10):610-6.

139. Gao K, Henning SM, Niu Y, Youssefian AA, Seeram NP, Xu A, Heber D. The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells. J Nutr Biochem. 2006 Feb;17(2):89-95

140. Harris DM, Besselink E, Henning SM, Go VL, Heber D. Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells. Exp Biol Med (Maywood). 2005 Sep;230(8):558-68.

141. Hong KM, Burdick MD, Phillips RJ, Heber D, Strieter RM. Characterization of human fibrocytes as circulating adipocyte

progenitors and the formation of human adipose tissue in SCID mice. FASEB J. 2005 Dec;19(14):2029-31.


142. Lum MR, Potter E, Dang T, Heber D, Hardy M, Hirsch AM. Identification of botanicals and potential contaminants through RFLP and sequencing. Planta Med. 2005 Sep;71(9):841-6.

143. Desmond JC, Kawabata H, Mueller-Tidow C, Simamura E, Heber D, Hirai K, Koeffler HP. The synthetic

furanonaphthoquinone induces growth arrest, apoptosis and differentiation in a variety of leukaemias and multiple myeloma cells. Br J Haematol. 2005 Nov;131(4):520-9

144. Li, Z.; Seeram N.P.; Lee R.; Thames, G.; Minutti, C.; Wang, H-J.; Heber, D. Plasma clearance of Lovastatin vs. Chinese Red

Yeast Rice in healthy volunteers. Journal of Alternative and Complementary Medicine, 2005, 11, 1031-1038. 145. Gao K, Xu A, Krul C, Venema K, Liu Y, Niu Y, Lu J, Bensoussan L, Seeram NP, Heber D, Henning SM. Of the Major

Phenolic Acids Formed during Human Microbial Fermentation of Tea, Citrus, and Soy Flavonoid Supplements, Only 3,4-Dihydroxyphenylacetic Acid Has Antiproliferative Activity. J Nutr. 2006 Jan;136(1):52-57.

146. Seeram, N.P.; Lee, R.; Scheuller, H.S. and Heber, D. Identification of phenolics in strawberries by liquid chromatography

electrospray ionization mass spectroscopy. Food Chemistry, 2006, 97, 1-11. 147. Cai L, Mu L-N, Lu H, Lu Q-Y, You N-C, Yu, S-Z, Le A, Zhao J, Zhou X-F, Marshall J, Heber D, Zhang Z-f. Dietary

Selenium Intake and Genetic Polymorphisms of the GSTP1 Genes on the Risk of Esophageal Squamous Cell Carcionoma. Cancer Epidemiol Biomarkers Prev 2006; 15(2), 294-300.

148. Seeram NP, Henning SM, Niu Y, Lee R, Scheuller HS, Heber D. Catechin and Caffeine Content of Green Tea Dietary

Supplements and Correlation with Antioxidant Capacity. J Ag Food Chem 2006 149. Adams LS, Seeram NP, Hardy ML, Carpenter C, Heber D. Analysis of the interactions of botanical extract combinations

against the viability of prostate cancer cell lines. Evid Based Complement Alternat Med. 2006 Mar;3(1):117-24. 150. Howard BV, Van Horn L, Hsia J, Manson JE, Stefanick ML, Wassertheil-Smoller S, Kuller LH, LaCroix AZ, Langer RD,

Lasser NL, Lewis CE, Limacher MC, Margolis KL, Mysiw WJ, Ockene JK, Parker LM, Perri MG, Phillips L, Prentice RL, Robbins J, Rossouw JE, Sarto GE, Schatz IJ, Snetselaar LG, Stevens VJ, Tinker LF, Trevisan M, Vitolins MZ, Anderson GL, Assaf AR, Bassford T, Beresford SA, Black HR, Brunner RL, Brzyski RG, Caan B, Chlebowski RT, Gass M, Granek I, Greenland P, Hays J, Heber D, Heiss G, Hendrix SL, Hubbell FA, Johnson KC, Kotchen JM. Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006 Feb 8;295(6):655-66.

151. Beresford SA, Johnson KC, Ritenbaugh C, Lasser NL, Snetselaar LG, Black HR, Anderson GL, Assaf AR, Bassford T,

Bowen D, Brunner RL, Brzyski RG, Caan B, Chlebowski RT, Gass M, Harrigan RC, Hays J, Heber D, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Jackson RD, Kotchen JM, Kuller LH, LaCroix AZ, Lane DS, Langer RD, Lewis CE, Manson JE, Margolis KL, Mossavar-Rahmani Y, Ockene JK, Parker LM, Perri MG, Phillips L, Prentice RL, Robbins J, Rossouw JE, Sarto GE, Stefanick ML, Van Horn L, Vitolins MZ, Wactawski-Wende J, Wallace RB, Whitlock E. Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006 Feb 8;295(6):643-54.

152. Prentice RL, Caan B, Chlebowski RT, Patterson R, Kuller LH, Ockene JK, Margolis KL, Limacher MC, Manson JE, Parker

LM, Paskett E, Phillips L, Robbins J, Rossouw JE, Sarto GE, Shikany JM, Stefanick ML, Thomson CA, Van Horn L, Vitolins MZ, Wactawski-Wende J, Wallace RB, Wassertheil-Smoller S, Whitlock E, Yano K, Adams-Campbell L, Anderson GL, Assaf AR, Beresford SA, Black HR, Brunner RL, Brzyski RG, Ford L, Gass M, Hays J, Heber D, Heiss G, Hendrix SL, Hsia J, Hubbell FA, Jackson RD, Johnson KC, Kotchen JM, LaCroix AZ, Lane DS, Langer RD, Lasser NL, Henderson MM. Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006 Feb 8;295(6):629-42.

153. Henry GE, Adams LS, Rosales JC, Jacobs H, Heber D, Seeram NP. Kaurene diterpenes from Laetia thamnia inhibit the

growth of human cancer cells in vitro. Cancer Lett. 2006 Jan 28 (epub ahead of print) 154. Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and


punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem. 2006 Feb 8;54(3):980-5. 155. He J, Chen L, Heber D, Shi W, Lu QY. Antibacterial compounds from Glycyrrhiza uralensis. J Nat Prod. 2006

Jan;69(1):121-4. 156. Muller CI, Kumagai T, O'kelly J, Seeram NP, Heber D, Koeffler HP. Ganoderma lucidum causes apoptosis in leukemia,

lymphoma and multiple myeloma cells. Leuk Res. 2006 Jan 16 157. Cai L, You NC, Lu H, Mu LN, Lu QY, Yu SZ, Le AD, Marshall J, Heber D, Zhang ZF. Dietary selenium intake, aldehyde

dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma. Cancer. 2006 Apr 25;106(11):2345-2354.

158. Henning SM, Aronson W, Niu Y, Conde F, Lee NH, Seeram NP, Lee RP, Lu J, Harris DM, Moro A, Hong J, Pak-Shan L,

Barnard RJ, Ziaee HG, Csathy G, Go VL, Wang H, Heber D. Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. J Nutr. 2006 Jul;136(7):1839-43.

159. Sartippour MR, Pietras R, Marquez-Garban DC, Chen HW, Heber D, Henning SM, Sartippour G, Zhang L, Lu M, Weinberg

O, Rao JY, Brooks MN. The combination of green tea and tamoxifen is effective against breast cancer. Carcinogenesis. 2006 Jun 19; [Epub ahead of print]

160. Pantuck, A.J.; Leppert, J.T.; Zomorodian, N.; Aronson, W.; Hong, J.; Barnard, R.J.; Seeram, N.P.; Liker, H.; Wang, H-E.;

Elashoff, R.; Heber, D.; Aviram M.; Ignarro, L.; Belldegrun, A. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clinical Cancer Research, 2006. Jul 1;12(13):4018-26.

161. Hung RJ, Zhang, Z-F, Rao J-U, Pantuck A, Reuter VE, Heber D, Lu, Q-Y. Protective Effects of Plasma Carotenoids on the

Risk of Bladder Cancer. J Urology, 2006. 176: 1192-1197. 162. Kobayashi N, Barnard RJ, Henning SH, Elashoff D, Reddy ST, Cohen P, Leung P, Hong-Gonzalez J, Freedland SJ, Said J,

Gui D, Seeram NP, Popoviciu LM , Bagga D, Heber D, Glaspy JA, and Aronson WJ. Effect of Altering Dietary Omega-6: Omega-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2 and Prostaglandin E-2. Clinical Cancer Research 2006 12(15):4662-4670.

163. Ikezoe T, Yang Y, Saitoh T, Heber D, McKenna R, Taguchi H, Koeffler HP. PC-SPES down-regulates COX-2 via inhibition

of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. Int J Oncol. 2006 Aug;29(2):453-61. 164. Henry GE, Adams LS, Rosales JC, Jacobs H, Heber D, Seeram NP. Kaurene diterpenes from Laetia thamnia inhibit the

growth of human cancer cells in vitro. Cancer Lett 244:190194, 2006. 165. Seeram, N.P.; Lee, R.; Hardy, M.L.; Heber, D. Rapid large-scale purification of ellagitannins from pomegranate husk, a by-

product of the commercial juice industry. Sep. Purific. Tech. 41:49-55, 2005. 166. Wang L, Basa NR, Shaikh A, Luckey A, Heber D, St-Pierre DH, Tache Y. LPS inhibits fasted plasma ghrelin levels in rats:

role of IL-1 and PGs and functional implications. Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G611-20. 167. Seeram NP, Zhang Y, Henning SM, Lee R, Niu Y, Lin G, Heber D. Pistachio skin phenolics are destroyed by bleaching

resulting in reduced antioxidative capacities. J Agric Food Chem. 2006 Sep 20;54(19):7036-40. 168. Seeram NP, Henning SM, Zhang Y, Suchard M, Li Z, Heber D. Pomegranate juice ellagitannin metabolites are present in

human plasma and some persist in urine for up to 48 hours. J Nutr. 2006 Oct;136(10):2481-5. 169. Henry GE, Raithore S, Zhang Y, Jayaprakasam B, Nair MG, Heber D, Seeram NP. Acylphloroglucinol derivatives from

Hypericum prolificum. J. Nat Prod. 2006 Nov;69(11):1645-8. 170. Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D. Blackberry, black raspberry, blueberry, cranberry,


red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem. 2006 Dec 13;54(25):9329-39.

171. Lu QY, Jin YS, Zhang ZF, Le AD, Heber D, Li FP, Dubinett SM, Rao JY. Green tea induces annexin-I expression in human

lung adenocarcinoma A549 cells: involvement of annexin-I in actin remodeling. Lab Invest. 2007 Mar 12 172. Kumagai T, Muller CI, Desmond JC, Imai Y, Heber D, Koeffler HP. Scutellaria baicalensis, a herbal medicine: anti-

proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk Res. 2007 Apr;31(4):523-30.

173. Li Z, Hong K, Wong E, Maxwell M, Heber D. Weight cycling in a very low-calorie diet programme has no effect on

weight loss velocity, blood pressure and serum lipid profile. Diabetes Obes Metab. 2007 May;9(3):379-85. 174. Seeram, N.P.; Aronson, W.J.; Zhang, Y.; Henning, S.M.; Moro, A.; Lee, R.; Sartippour, M.; Harris, D.M.; Rettig, M.B.;

Suchard, M.A.; Pantuck, A.J.; Belldegrun, A.; Heber, D. Pomegranate ellagitannin derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem. 2007, 55:7752-7737

175. Heber D, Seeram NP, Wyatt H, Henning SM, Zhang Y, Ogden LG, Dreher M, Hill JO. Safety and antioxidant

activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size. J Agric Food Chem. 2007, 55(24):10050-4.

176. Early JL, Apovian CM, Aronne LJ, Fernstrom MH, Frank A, Greenway FL, Heber D, Kushner RF, Cwik KM, Walch JK, Hewkin AC, Blakesley V. Sibutramine plus meal replacement therapy for body weight loss and maintenance in obese patients. Obesity (Silver Spring). 2007 Jun;15(6):1464-72.

177. Venkatachalam M, Kshirsagar HH, Seeram NP, Heber D, Thompson TE, Roux KH, Sathe SK. Biochemical composition and immunological comparison of select pecan [Carya illinoinensis (Wangenh.) K. Koch] cultivars. J Agric Food Chem. 2007 Nov 28;55(24):9899-907.

178. Sartippour MR, Seeram NP, Rao JY, Moro A, Harris DM, Henning SM, Firouzi A, Rettig MB, Aronson WJ, Pantuck AJ, Heber D. Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo. Int J Oncol 2008, 32(2): 475-480

179. Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, Dreher M, Heber D. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem. 2008, 56(4): 1415-22.

180. Zhang Y, Seeram NP, Lee R, Feng L, Heber D. Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties. J Agric Food Chem. 2008 Feb 13;56(3):670-5.

181. Yan E, Chen S, Hong K, Kim WS, Bajpai A, Treyzon L, Gratton L, Elashoff R, Wang HJ, Li Z, Heber D. Insulin, hs-CRP, leptin, and adiponectin. An analysis of their relationship to the metabolic syndrome in an obese population with an elevated waist circumference. Metab Syndr Relat Disord. 2008 Spring;6(1):64-73.

182. Li, Z., Aronson, W.J., Arteaga, J.R., Hong, K., Thames, G., Henning, S.M., Liu, W., Elashoff, R., Ashley, J.M., Heber D. Feasibility of a LowFat/High Fiber Diet Intervention with Soy Supplementation in Prostate Cancer Patients after Prostatectomy. Eur J Clin Nutr.2008 Apr;62(4):526-36.

183. Seeram NP, Zhang Y, McKeever R, Henning SM, Lee RP, Suchard MA, Li Z, Chen S, Thames G, Zerlin A, Nguyen M, Wang D, Dreher M, Heber D. Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food. 2008 Jun;11(2):390-394.

184. Tinker LF, Bonds DE, Margolis KL, Manson JE, Howard BV, Larson J, Perri MG, Beresford SA, Robinson JG, Rodríguez B, Safford MM, Wenger NK, Stevens VJ, Parker LM; Women's Health Initiative. Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial. Arch Intern Med. 2008 Jul 28;168(14):1500-11.


185. Hong MY, Seeram NP, Zhang Y, Heber D. Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells. J Nutr Biochem. 2008 Jul;19(7):448-58.

186. Henning SM, Choo JJ, Heber D. Nongallated compared with gallated flavan-3-ols in green and black tea are more bioavailable. J Nutr. 2008 Aug;138(8):1529S-1534S.

187. Rettig MB, Heber D, An J, Seeram NP, Rao JY, Liu H, Klatte T, Belldegrun A, Moro A, Henning SM, Mo D, Aronson WJ, Pantuck A. Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappa dependent mechanism. Mol Cancer Ther. 2008 Sep;7(9):2662-71.

188. Brunner RL, Cochrane B, Jackson RD, Larson J, Lewis C, Limacher M, Rosal M, Shumaker S, Wallace R; Women's Health Initiative Investigators. Calcium, vitamin D supplementation, and physical function in the Women's Health Initiative. J Am Diet Assoc. 2008 Sep;108(9):1472-9.

189. Sathe SK, Seeram NP, Kshirsagar HH, Heber D, Lapsley KA. Fatty acid composition of California grown almonds. J Food Sci. 2008 Nov;73(9):C607-14.

190. Hong MY, Seeram NP, Heber D. Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor. J Nutr Biochem. 2008 Dec;19(12):848-55.

191. Hong MY, Seeram NP, Zhang Y, Heber D. Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression. J Med Food. 2008 Dec;11(4):657-66.

192. Lu QY, Jin YS, Zhang ZF, Le AD, Heber D, Li FP, Dubinett SM, Rao JY. Lu QY, Yang Y, Jin YS, Zhang ZF, Heber D, Li FP, Dubinett SM, Sondej MA, Loo JA, Rao JY. Effects of green tea extract on lung cancer A549 cells: proteomic identification of proteins associated with cell migration. Proteomics. 2009 Feb;9(3):757-67.

193. Zhang Y, Krueger D, Durst R, Lee R, Wang D, Seeram N, Heber D. International multidimensional authenticity specification (IMAS) algorithm for detection of commercial pomegranate juice adulteration. J Agric Food Chem. 2009 Mar 25;57(6):2550-7.

194. Evangelista LS, Heber D, Li Z, Bowerman S, Hamilton MA, Fonarow GC. Reduced body weight and adiposity with a high-protein diet improves functional status, lipid profiles, glycemic control, and quality of life in patients with heart failure: a feasibility study. J Cardiovasc Nurs. 2009 May-Jun;24(3):207-15.

195. Lu QY, Zhang Y, Wang Y, Wang D, Lee RP, Gao K, Byrns R, Heber D. California Hass Avocado: Profiling of Carotenoids, Tocopherol, Fatty Acid, and Fat Content during Maturation and from Different Growing Areas. J Agric Food Chem. 2009 Oct 8.

196. Koyama S, Cobb LJ, Mehta HH, Seeram NP, Heber D, Pantuck AJ, Cohen P. Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Horm IGF Res. 2010 Feb;20(1):55-62.

197. Aronson WJ, Barnard RJ, Freedland SJ, Henning S, Elashoff D, Jardack PM, Cohen P, Heber D, Kobayashi N. Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer. J Urol. 2010 Jan;183(1):345-50.

198. Heber D. An Integrative View of Obesity. Am J Clin Nutr. 2010 Jan;91(1):280S-283S.

199. Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila Pa). 2010 Jan;3(1):108-13.

200. Henning SM, Seeram NP, Zhang Y, Li L, Gao K, Lee RP, Wang DC, Zerlin A, Karp H, Thames G, Kotlerman J, Li Z, Heber D. Strawberry consumption is associated with increased antioxidant capacity in serum. J Med Food. 2010 Feb;13(1):116-22.

201. Li Z, Henning SM, Zhang Y, Zerlin A, Li L, Gao K, Lee RP, Karp H, Thames G, Bowerman S, Heber D. Antioxidant-rich spice added to hamburger meat during cooking results in reduced meat, plasma, and urine malondialdehyde concentrations.


Am J Clin Nutr. 2010 May;91(5):1180-4.

202. Zhang Y, Wang D, Lee RP, Henning SM, Heber D. Absence of pomegranate ellagitannins in the majority of commercial pomegranate extracts: implications for standardization and quality control. J Agric Food Chem. 2009 Aug 26;57(16):7395-400.

203. Wang P, Henning SM, Heber D. Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols. PLoS One. 2010 Apr 16;5(4):e10202.

204. Wang P, Aronson WJ, Huang M, Zhang Y, Lee RP, Heber D, Henning SM. Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer prevention. Cancer Prev Res (Phila Pa). 2010 Aug;3(8):985-93.

205. Konijeti R, Henning S, Moro A, Sheikh A, Elashoff D, Shapiro A, Ku M, Said JW, Heber D, Cohen P, Aronson WJ. Chemoprevention of prostate cancer with lycopene in the TRAMP model. Prostate. 2010 May 26.

206. Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient: An Endocrine Society Clinical Practice Guideline.

RESEARCH PAPERS IN PRESS RESEARCH PAPERS SUBMITTED Henning S, Zhang Y, Seeram NP, Lee R-P, Wang P, Bowerman S, Heber D. Antioxidant Capacity and Phytochemical Content of Herbs and Spices in Dry, Fresh and Blended Herb Paste Form. J Food Sci RESEARCH PAPERS NON-PEER REVIEWED: NONE III. BOOKS AND BOOK CHAPTERS: BOOKS 1. Heber D, and Kritchevsky D (eds.) Dietary Fats, Lipids, Hormones, and Tumorigenesis: New Horizons in Basic Research. Plenum

Press, Philadelphia, 1996. 2. Heber D. Natural Remedies for a Healthy Heart, Avery Publishing Group, New York, N.Y., 1998. 3. Heber D, and Blackburn GL (eds). Nutritional Oncology. Academic Press, San Diego, CA 1999. 4. Heber, D. The Resolution Diet, Avery Publishing Group, New York, N.Y., 1999.

5. Heber D. (volume editor) Human Nutrition and Obesity: in Atlas of Clinical Endocrinology (SG Korenman, ed.) Current Medicine, Inc. Philadelphia, PA, 2000. 6. Heber D. and Bowerman S. What Color is Your Diet? Regan Books, New York, NY, 2001. 7. Heber D. and Bowerman S. The L. A. Shape Diet, Regan Books, New York, NY, 2004. 8. Heber D., Blackburn G. , Go VLW, Milner J (eds). Nutritional Oncology 2nd Edition, Academic Press, San Diego, CA 2006 BOOK CHAPTERS 1. Odell, W.D. and D. Heber. Radioiodination of peptides and proteins for radioimmunoassays. In: Manual of Clinical Immunology,

2nd ed., (N.R. Ros and H. Friedman, eds.), American Society for Microbiology, Washington, D.C., 1980. 2. Heber, D. and G.A. Bray. Energy requirements in the aged. In: Metabolic and Nutritional Disorders in the Elderly. (A.N.


Exton-Smith and F.I. Caird, eds.) John Wright and Sons, Ltd., Bristol, England, pp. 1-12, 1980. 3. Heber, D. and R.S. Swerdloff. Brain peptides and fertility control in the male. In: Research Frontiers In: Fertility Regulation. (G.I.

Zatuchni, M.H. Labbok, J.I. Sciarra, eds.) Harper and Row, Bethesda, MD, pp.178-86, 1980. 4. Heber, D. and R.S. Swerdloff. Endocrine control of testicular function from birth to puberty. In: The Testis. (H.G. Burger and D.M.

DeKretser, eds.) Raven Press, New York, pp. 107-26, 1982. 5. Swerdloff, R.S. and D. Heber. Effects of aging on male reproductive functions. In: Endocrine Aspects of Aging. (S. Korenman, ed.)

Elsevier North Holland, New York, pp. 119-35, 1982. 6. Chlebowski, R.T., D. Heber and J.B. Block. Lung Cancer Cachexia. In: Lung Cancer II (F.A. Greco, ed.) Marinus Najhoff

Publishers, The Hague, Netherlands, 1982. 7. Swerdloff, R.S. and D. Heber. Superactive GnRH agonists. In: Annual Review of Medicine: Selected Topics in the Clinical

Sciences. (W.P. Creger, ed.) Annual Reviews, Inc. Palo Alto, CA, pp. 491-500, 1982. 8. Swerdloff, R.S. and D. Heber. Modern management of male hypogonadism. In: Endocrinology for the Practicing Internist. (H.

Carlson, ed.), 1982. 9. Swerdloff, R.S. and D. Heber. Effects of combined GnRH agonists and testosterone on testicular function in man and experimental

animals. Proceedings of Recent Advances in Male Reproductive Symposium, Catania-Taormina, Italy, June 1982, Raven Press, pp. 227-38, 1983.

10. Swerdloff, R.S., S. Bhasin and D. Heber. A new approach to male contraception using combined androgen and GnRH analog

treatment. Scherring, A.G., Symposia, 1983. 11. Heber D. and R.S. Swerdloff. GnRH antagonists potential as male contraceptives - studies in the rat. In: LHRH and Its Analogs - A

New Class of Contraceptives and Therapeutic Agents. (B. Vickery and J. Nestor, eds.) MTP Press, Ltd., Lancaster, England. pp.153-60, 1984.

12. Heber, D. R.S. Swerdloff and M. Henzl. Effects of nafarelin acetate in men. In: LHRH and Its Analogs - A New Class of

Contraceptive and Therapeutic Agents. (B. Vickery and J. Nestor, eds.) MTP Press, Ltd., Lancaster, England. pp. 257-69, 1984. 13. Heber, D. Endocrinology. In: Current Medicine. Vol. 2 (G. Gitnick, ed.) John Wiley and Sons, Inc., Chicago, IL pp. 385-407, 1984. 14. Chlebowski, R.T. and D. Heber. Nutritional Factors in the patient with cancer. In: Cancer Treatment. (C.M. Haskell, ed.) W.B.

Saunders, Philadelphia, PA pp. 889-96, 1984. 15. Heber, D. Endocrinology. In: Current Medicine. vol. 3 (G. Gitnick, ed.) John Wiley and Sons, Inc. Chicago, IL pp. 305-28, 1986. 16. Heber, D. Aging: Urologic Endocrinology. (J. Rajfer, ed.) W.B. Saunders, Philadelphia, PA pp. 346-56, 1986. 17. Heber, D. and L.O. Byerley. Effects of localized and disseminated cancers on metabolism and nutrition in man. In: Progressive

Stages of Malignant Neoplastic Growth. Vol.2 (Kaiser HE, ed.) Martinus Nijhoff Publishers, The Netherlands, pp. 53-58, 1986. 18. Heber, D. Nutritional therapy. In: Practical Gynecologic Oncology. (Berek J.S. and Hacker, N., eds.) Williams and Wilkins,

Baltimore, MD, pp. 611-30, 1989. 19. Heber, D. Cancer and Malnutrition. In: Geriatric Nutrition: A Comprehensive Review. (J.S. Morley, Z. Glick, L.Z. Rubinstein,

eds.) Raven Press, New York, pp. 307-15, 1990. 20. Maxwell, M. and Heber, D. Nutritional treatment of hyperlipidemia and obesity. In: Preventive Aspects of Coronary Heart Disease.

(E.D. Frohlich, ed.) F.A. Davis Company, pp. 20(3): 149-56, 1990.


21. Heber, D. and N.S. Tchekmedyian. Hormonal Regulation of body weight: mechanisms of action and clinical applications. In: Aktuelle Oncologie (English Version) 58:20-25, 1990.

22. Heber, D. Endocrinology of Obesity. In: Obesity: Pathophysiology, Psychology, and Treatment. (G. Blackburn and B.S. Kanders,

eds.). Andover Medical Publishers, 1994, pp.98-109. 23. Heber D. Endocrine Responses to Starvation, Malnutrition and Illness. In: Endocrinology (3rd edition), De Groot LJ, Besser M,

Burger HG, Jameson LJ, Loriaux DL, Marshall JC, Odell WD, Potts JT, and Rubenstein AH (eds). W.B. Saunders, Philadelphia, PA, 1994, pp.2663-78.

24. Heber, D. Nutritional Therapy. In: Practical Gynecologic Oncology. Berek JS and Hacker N (eds). Williams and Wilkins, Baltimore,

MD, 1993. 25. Heber D, Tchekmedyian NS, Galvin MS, and Meguid M. Pathophysiology of malnutrition in the HIV-infected patient. In: Surgical

Nutrition, Torosian E (ed), 1995. 26. Yip I, Aronson W, Heber D. Nutritional Approaches To The Prevention of Prostate Cancer Progression.Dietary Fats, Lipids,

Hormones, and Tumorigenesis.Plenum press, New York, 1996. 27. Heber D, Breast Disease. In: Current Practice of Medicine. Bone CR (ed). Current Medicine, Philadelphia, PA, 1996.

28. Heber D. Assessing Endocrine Effects of Cancer and Ectopic Hormone Syndromes. In: Nutritional Oncology. Heber D, Blackburn

GL, Go VLW (eds). Academic Press, San Diego, CA, 1999. 29. Heber D, and Tchekmedyian NS. Cancer Cachexia and Anorexia. In: Nutritional Oncology. Heber D, Blackburn GL, Go VLW (eds).

Academic Press, San Diego, CA, 1999. 30. Heber D, and Go VLW. Gene-Nutrient Interaction and the Xenobiotic Hypothesis of Cancer. In: Nutritional Oncology. Heber D,

Blackburn GL, Go VLW (eds). Academic Press, San Diego, CA, 1999. 31. Tchekmedyian NS, Cella D, and Heber D. Nutritional Support and Quality of Life. In: Nutritional Oncology. Heber D, Blackburn

GL, Go VLW (eds). Academic Press, San Diego, CA., 1999. 32. Heber D. Starvation and Nutrition Therapy. In: Endocrinology (4th edition), De Groot LJ, Besser M, Burger HG, J Jameson LJ,

Loriaux DL, Marshall JC, Odell WD, Potts JT, and Rubenstein AH (eds). W.B. Saunders, Philadelphia, PA, 1999 in press. 33. Heber, D. Nutritional Therapy. In: Practical Gynecologic Oncology. Berek JS and Hacker N (eds). Williams and Wilkins, Baltimore,

MD, 1999. 34. Heber, D. and Bowerman, S. Fundamentals of Human Nutrition. In: Atlas of Clinical Endocrinology, Volume 5: Human Nutrition

and Obesity. Korenman S (ed). Current Medicine, Inc., Philadelphia, PA, 2000. 35. Heber, D. and Maxwell, M. Causes and Metabolic Consequences of Obesity. In: Atlas of Clinical Endocrinology, Volume 5:

Human Nutrition and Obesity. Korenman S (ed). Current Medicine, Inc., Philadelphia, PA, 2000. 36. Heber, D. and Stangl S. Botanical Dietary Supplements. In: Atlas of Clinical Endocrinology, Volume 5: Human Nutrition and

Obesity. Korenman S (ed). Current Medicine, Inc., Philadelphia, PA, 2000. 37. Heber, D. Diagnosis and Vertically Integrated Management of Obesity. In: Atlas of Clinical Endocrinology, Volume 5: Human

Nutrition and Obesity. Korenman S (ed). Current Medicine, Inc., Philadelphia, PA, 2000. 38. Heber, D. Nutrition for Cancer and Aging. In: Atlas of Clinical Endocrinology, Volume 5: Human Nutrition and Obesity.

Korenman S (ed). Current Medicine, Inc., Philadelphia, PA, 2000. 39. Heber, D. and Bowerman, S. Nutrition and Cancer. In: Handbook of Nutrition and Food. Berdanier CD (ed). CRC Press LLC,


Boca Raton, FL, 2002. 40. Heber, D. Meal Replacements in the Treatment of Obesity. In: Eating Disorders and Obesity: A Comprehensive Handbook (Second

Edition). Fairburn CG and Brownell KD (eds). The Guilford Press, New York, NY, 2002. 41. Heber, D. and Bowerman, S. Body Composition Analysis. In: Evaluation of Management & Obesity. Bessesen, DH and Kushner,

R (eds). Hanley & Belfus, Inc., Philadelphia, PA, 2002. 42. Heber, D. Non-Prescription Weight-loss Products. In: Evaluation of Management & Obesity. Bessesen, DH and Kushner, R (eds).

Hanley & Belfus, Inc., Philadelphia, PA, 2002. 43. Heber, D. Herbal preparations for obesity: Are they useful? Primary Care: Clinics in Office Practice. 30: 441-63, 2003. 44. Li Z, Bowerman S, Heber D. Health Ramifications of the Obesity Epidemic. Surg Clin N Amer 85(4): 681-702, 2005. 45. Heber D. and Bowerman S. Fundamentals of Human Nutrition. In: Nutritional Oncology, 2nd edition. Heber D, Blackburn G,

Milner J and Go VLW, eds. Academic Press, San Diego, CA 2006 46. Heber D. and Cohen P. Endocrine and Paracrine Factors in Carcinogenesis. In: Nutritional Oncology, 2nd edition. Heber D,

Blackburn G, Milner J and Go VLW, eds. Academic Press, San Diego, CA 2006 47. Davis P, Heber D, Packer L. Oxidation and Antioxidation in Cancer. In: Nutritional Oncology, 2nd edition. Heber D, Blackburn

G, Milner J and Go VLW, eds. Academic Press, San Diego, CA 2006 48. Blackburn G, Heber D. Breast Cancer. In: Nutritional Oncology, 2nd edition. Heber D, Blackburn G, Milner J and Go VLW, eds.

Academic Press, San Diego, CA 2006 49. Treyzon L, Ohning G, Heber D. Colon Cancer. In: Nutritional Oncology, 2nd edition. Heber D, Blackburn G, Milner J and Go

VLW, eds. Academic Press, San Diego, CA 2006. 50. Heber D. and Tchekmeydian NS. Cancer Anorexia and Cachexia. In: Nutritional Oncology, 2nd edition. Heber D, Blackburn G,

Milner J and Go VLW, eds. Academic Press, San Diego, CA 2006. 51. Heber D. Assessing Endocrine Effects of Cancer and Ectopic Hormone Syndromes. In: Nutritional Oncology, 2nd edition. Heber

D, Blackburn G, Milner J and Go VLW, eds. Academic Press, San Diego, CA 2006. 52. Tchekmeydian NS, Cella D, Heber D. Nutritional Support and Quality of Life. In: Nutritional Oncology, 2nd edition. Heber D,

Blackburn G, Milner J and Go VLW, eds. Academic Press, San Diego, CA 2005 (2006). 53. Heber D, Blackburn G, Go VLW, Milner J. The Future of Nutritional Oncology. In: Nutritional Oncology, 2nd edition. Heber D,

Blackburn G, Milner J and Go VLW, eds. Academic Press, San Diego, CA 2006. 54. Heber, D. and Bowerman, S. Nutrition and Cancer. In: Handbook of Nutrition and Food, 2nd edition. Berdanier CD (ed). CRC

Press LLC, Boca Raton, FL, 2006. 55. Heber D. Plant Foods and Phytochemicals in Human Health. In: Handbook of Nutrition and Food, 2nd edition. Berdanier CD (ed).

CRC Press LLC, Boca Raton, FL, 2006. 56. Heber D. Foreword. In: Pomegranates: Ancient Roots to Modern Medicine. Heber D and Seeram N, eds. CRC Press, Boca Raton,

FL, 2006. 57. Seeram NP, Zhang Y, Heber D. Commercialization of Pomegranates: Fresh Fruit, Beverages and Botanical Extracts. In:

Pomegranates: Ancient Roots to Modern Medicine. Seeram N, Heber D and Schulman R, CRC Press, Taylor and Francis Group, Medicinal & Aromatic Plant Series; 2006, Chapter 12,187-196.


58. Seeram, N.P. Heber, D. Impact of berry phytochemicals on human health: Effects beyond antioxidation. In: Lipid Oxidation and

Antioxidants: Chemistry, Methodologies and Health Effects; ACS Symposium Series; Eds: Ho, C.T; Shahidi, F.S. Oxford University Press, 2006, in press.

59. Lum, M.R., Baycher, A., Prigge, B.A., Hardy, M., Heber, D., Hirsch, A.M. Identification of Green Tea (Camellia sinensis L.)

and Tea Oil (Camellia oleifera Abel.) by Molecular, Biological, and Anatomical Methods. In: Authentication of Food and Wine; ACS Symposium Series; Eds: Ebeler, S.E., Takeoka, G.R., Winterhalter, P. American Chemical Societym 2007.

60. Seeram NP, Zhang Y, Bowerman S, Heber D. Phytochemicals and Health Aspects of the Pistachio. In: Tree Nut

Nutraceuticals, Phytochemicals and Health Aspects (C. Alasalvar and F. Shahidi, eds.). CRC Press, LLC 2008

61. Heber D. Meal Replacements. In: Managing Obesity: A Clinical Guide (C. Nonas and G. Foster, eds.). Chicago: The American Dietetic Association, 2009.

REVIEWS 1. Heber, D., M. Meguid, R. Chlebowski and P. McAndrew. Malnutrition and Cancer: Mechanisms and therapy. Nutrition Int., part I.

1986; 2:184-87. 2. Heber, D., M. Meguid, R. Chlebowski and P. McAndrew. Malnutrition and Cancer: Mechanisms and therapy. Nutrition Int., part II.

1986; 2:258-67. 3. Chlebowski, R.T. and D. Heber. Metabolic abnormalities in cancer patients: carbohydrate metabolism. Surg. Clin. N. Amer. 1986;

66:957-68. 4. Heber, D., B.J. Koziol, and L.C. Henson. Low density lipoprotein receptor regulation and the cellular basis of atherosclerosis:

implications for nutritional and pharmacologic treatment of hypercholesterolemia. Am. J. Cardiol. 1987; 60:4G-8G. 5. Heber, D. Macronutrient Nutrition in Aging, pp. 894-896. In: Morley JE, moderator. Nutrition in the elderly. Ann. Intern. Med.

1988; 109:890-904. 6. Morley JE; Mooradian AD; Silver AJ; Heber D; Alfin-Slater RB. Nutrition in the elderly [clinical conference]. Annals of Internal

Medicine. 1988, 109(11): 890-904. 7. Heber, D., Metabolic pathology of cancer malnutrition. Nutrition. 1989; 5:135-37. 8. Heber D., McCarthy WJ, Ashley J, and Byerley LO. Weight reduction for breast cancer prevention: rationale, mechanisms and

interventions. Nutrition. 1989; 5:3. 9. Heber D, and Tchekmedyian NS. Clinical aspects of nutrition in advanced cancer. Oncology. 1992; 49 Suppl 2: 3-7. 10. Heber D. The role of nutrition in cancer prevention and control. Oncology. 1992; 6 (2 Suppl) 9-14. 11. Tchekmedyian N.S., Zahyna D, Halpert C, Heber D. Assessment and maintenance of nutrition in older cancer patients. Oncology.

1992; 49: 105-11. 12. Heber D., L.O. Byerley, and N.S. Tchekmedyian. Hormonal and metabolic abnormalities in the malnourished cancer patient: Effects

on host-tumor interaction. J. Parent. Ent. Nutrition. 1992; 16: 60S-65S. 13. Tchekmedyian N.S., Halpert C, Ashley J, and Heber D. Nutrition in advanced cancer: anorexia as an outcome variable and target of

therapy. J. Parent. and Ent. Nutr. 1992; 16: 88S-92S. 14. Heber D. and Tchekmedyian NS. Pathophysiology of cancer-hormonal and metabolic abnormalities. Oncology. 1992; 49: 28-31.


15. Heber D., and Tchekmedyian NS. Nutritional assessment of the cancer patient in the office. Oncology. 1993; 7 (supplement): 71-75. 16. Heber, D. Nutrition in the Prevention and Treatment of Cancer. Current Opinion in Gastroenterology. 1994; 10. 17. Heber, D, Bagga D, Ashley JM, and Elashoff RM. Nutritional strategies for breast cancer prevention. Oncology, 1993. 18. Yip I, Heber D, Aronson W. Nutrition and Prostate Cancer. Urol Clin North Am. 1999; May; 26(2): 403-11, x. 20. Heber, D. The Jatoi/Loprinzi Article Reviewed (Cancer Management of Cancer-Associated Anorexia and Weight Loss). Oncology.

2001; 15(4); 508-09. 21. Heber, D. PC-SPES: Herbal Formulation for Prostate Cancer. Elsevier Science Inc. 2002; Urology 60 (3): 369-75. 22. Heber D, Lu QY.Overview of Mechanisms of Action of Lycopene. Exp Biol Med (Maywood). 2002; Nov; 227(10): 920-23. 23. Norman HA, Butrum RR, Feldman E, Heber D, Nixon D, Picciano MF, Rivlin R, Simopoulos A, Wargovich MJ, Weisburger

EK, Zeisel SH. The role of dietary supplements during cancer therapy. J Nutr. 2003 Nov; 133(11 Suppl 1): 3794S-99S. 24. Heber D. Herbal preparations for obesity: are they useful? Prim Care. 2003; Jun; 30(2): 441-63. Review. 25. Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 2004; 50(2):145-149. 26. Heber D. Phytochemicals beyond antioxidation. J Nutr. 2004 Nov;134(11):3175S-3176S. 27. Li Z, Bowerman S, Heber D. Health ramifications of the obesity epidemic. Surg Clin North Am. 2005 Aug;85(4):681-701

28. Heber D. Multitargeted therapy of cancer by ellagitannins. Cancer Lett. 2008 Oct 8;269(2):262-8.

29. Heber D and Bowerman S. California Pomegranates: An Ancient Fruit is New Again. Nutr Today 2009 44(4):180-184.

EDITORIALS, LETTERS TO THE EDITOR, WRITINGS FOR THE POPULAR PRESS 1. Heber D. Plasma carotenoids and the menstrual cycle [editorial; comment]. American Journal of Clinical Nutrition, 1996,

64(4): 640. 2. Heber D. The stinking rose: organosulfur compounds and cancer [editorial; comment]. American Journal of Clinical

Nutrition, 1997, 66:425-6. 3. Heber D. A review of the Department of Defense’s Program for Breast Cancer Research. Am. J. Clin. Nutr. 1998; 68:406. 4. Heber D. Colorful cancer prevention: α-carotene, lycopene, and lung cancer. Am. J. Clin. Nutr., 2000; 72:901-902. 5. Heber, D. Prostate enlargement: the canary in the coal mine? Am J Clin Nutr 2002; 75:605-6. PAPERS IN PREPARATION (RESEARCH COMPLETED) NONE ABSTRACTS 1. Heber, D., M. Abe and L.M. Sherwood. Adenyl cyclase mediation of parathyroid hormone secretion in the absence of new

hormone synthesis. Presented at Am. Soc. Clin. Invest., May 1973, Atlantic City, New Jersey; Clin. Res. 1973; 21: 627. 2. Heber, D., J.C. Marshall and W.D. Odell. Leutinizing hormone-releasing hormone receptors:identification, specifity and

quantification in nonpituitary tissues. Presented at IX World Congress in Fertility and Sterility, April 1977, Miami, Florida.


Fertil. Steril. 1977; 28:346. 3. Heber, D. and W.D. Odell. Modulation of pituitary GNRH receptors by estrogens--in vivo and in vitro studies. Clin Res

25:103A, 1977. Presented at Western Section , AFCR, Carmel, California, February 1977; and at the 59th Meeting of The Endocrine Society, Chicago, Illinois, June 1977.

4. Heber, D. and W.D. Odell. Evidence for receptor mediation of gonadotropin-releasing hormone activity: biological correlates of

binding. Progr. 60th Annual Meeting of the Endocrine Society, p. 180. Presented July 1978, Miami, Florida. 5. Patritti-Laborde, N., D. Heber, A.R. Wolfsen and W.D. Odell. The site of short loop feedback control for LH. Presented at

Pacific Coast Fertility Society, Scottsdale, Arizona, October 1978. 6. Heber, D. and W.D. Odell. Post-receptor superactivity: A new concept for enhanced peptide analog hormone activity.

Presented at the Western Section, AFCR, Carmel, California, Clin. Res. 1979; 27:24a. 7. Greenway, F.L., D. Heber and G.A. Bray. Failure of oral glycerol treatment to induce weight loss in obese humans. Presented

at the Western Section, AFCR, Carmel, California, Clin. Res. 1980; 16a. 8. Heber, D. and R.S. Swerdloff. Synergism between testosterone and a superactive GnRH analog in suppressing gonadotropin

secretion. Presented at the Western Section, AFCR, Carmel, California, Clin. Res. 1980; 28:24a. 9. Heber, D., F.L. Greenway, R. Ruby and R.T. Chlebowski. Decreased glucosuria in non-insulin dependent diabetics following

fasting via decreased glucose production. Presented at the Western Section, AFCR, Carmel, California, Clin. Res. 1980; 28:24a. 10. Heber, D. and R.S. Swerdloff. Superactive GnRH and testosterone: potential as combination male contraceptive agent.

Presented at the Pacific Coast Fertility Society, 28th Annual Meeting, Fertil. Steril. 1980; 34:(3)308. 11. Heber, D. and R.S. Swerdloff. Pituitary GnRH receptor down-regulation secondary to chronic superactive GnRH analog and

testosterone treatment. Presented at the Western Section, AFCR, Carmel, California; Clin. Res. 1981; 29: (1): 27a. 12. Heber, D. and R.S. Swerdloff. Synergistic inhibition of spermatogenesis with combined GnRH analog and testosterone

treatment. Presented at the Western Section, AFCR, Carmel, California; Clin. Res. 1981; 29(1): 27a. 13. Mason, J. and D. Heber. Endogenous opiates stimulate insulin secretion in flushing non-insulin dependent diabetics (NIDD).

Presented at the Western Section, AFCR, Carmel, California; Clin. Res. 1981; 29(1): 57a. 14. Chlebowski, R.T. and D. Heber. Hypogonadism in male patients with metastatic cancer prior to treatment. Presented at the

Western Section, AFCR, Carmel, California; Clin.Res. 1981; 29(1): 63a. 15. Heber, D. and R.S. Swerdloff. Synergistic inhibition of spermatogenesis with combined GnRH analog and testosterone

treatment. Presented at the National Meeting, AFCR, San Francisco, California, Clin. Res. 1981; 29(2): 293a. 16. Heber, D. and R.T. Chlebowski. Hypogonadism in male patients with metastatic cancer prior to treatment. Presented at the

National Meeting, AFCR, San Francisco, California, Clin. Res. 1981; 29(2): 293a. 17. Stewart, J.M., K. Channabasavaiah, D. Heber and Floyd W. Dunn. Recent advances in the design of gonadoliberin antagonists.

Presented at the Eighth International Congress of Pharmacology, IUPHAR, Tokyo, Japan, July 1981. Int'l. Con. Pharmacol. (8th) Abstract #654, 1981.

18. Heber, D. and R. Chlebowski, D.E. Ishibashi, J.N. Herrold and J.B. Block. Metabolic abnormalities in lung cancer patients prior

to weight loss; role in cancer malnutrition. Presented at the Western Section, AFCR, Clin. Res. 1982; 30:67a. 19. Heber, D., R. Dodson, R.S. Swerdloff, K. Channabasavaiah and J.M. Stewart. Inhibition of pituitary GnRH receptor binding

mediates acute GnRH antagonist inhibition of gonadotropin secretion. Presented at the Western Section, AFCR, Clin. Res. 1982; 30:30a.


20. Henson, L. and D. Heber. Whole-body protein turnover and hormonal changes in fasted obese subjects. Presented at the

Western Section, AFCR, Clin. Res. 1982; 30:67a. 21. Heber, D., R. Dodson, F. Nowak, R.S. Swerdloff, K. Channabasavaiah and J.M. Stewart. Actions and interactions of a potent

GnRH agonist and antagonist in the male rat. Presented at the Western Section, AFCR; Clin. Res. 1982; 30:30a. 22. Chlebowski, R.T., D. Heber and J.B. Block. Serial assessment of glucose metabolism in patients with cancer cachexia.

Presented at the Western Section, AFCR, Clin. Res. 30:69a. 23. Bhasin, S. D. Heber, B. Steiner, M. Peterson and R.S. Swerdloff. Characterization of the stimulatory and inhibitory effects of

superactive GnRH agonist in the human male. Presented at the Eastern Section, AFCR, Clin. Res. 1982; 30:88a. 24. Heber, D., R. Dodson, F. Novak, R.S. Swerdloff, K. Channabasavaiah and J.M. Stewart. Pituitary receptor site blockade

mediates prolonged GnRH antagonist action in vivo and in vitro. Presented at the Endocrine Society 64th Annual Meeting, San Francisco, California, p.207, Abstract #511, 1982.

25. Bhasin, S., D. Heber, B. Steiner, M. Peterson and R.S. Swerdloff. Enhanced inhibition of gonadotropin secretion in man by

combined GnRH agonist and testosterone. Presented at the Endocrine Society, p. 128; Abstract #193. 26. Rajfer, J., R.S. Swerdloff and D. Heber. The pituitary gland is the primary site of action of GnRH agonist (D-leu6,

desGly10-GnRH ethylamide) in the male. Presented at the Pacific Coast Fertility Society 30th Annual Meeting, Scottsdale, Arizona, October 1982.

27. Heber, D., Bhasin and R.S. Swerdloff. Extrapituitary effects of GnRH agonist and testicular GnRH-like peptide. Presented at

the International Symposium on Male Contraception Maui, Hawaii, October 1982; Arch. Androl. 9:70, 1982. 28. Heber, D., J.M. Stewart and R.S. Swerdloff. GnRH analogues in the male. Presented at the International Symposium on Male

Contraception 1982, Maui, Hawaii, October 1982; Arch. Androl. 1982; 9:71. 29. Condon, T.P., D. Heber, J.M. Stewart, C.H. Sawyer, D.I. Whitmoyer. Periovulatory FSH secretion: effects of a potent LHRH

antagonist. Presented at the American Physiology Society, 1982. 30. Heber, D., R.T. Chlebowski, L.C. Henson, C. Larsen, L. Byerley and J.B. Block. Increased protein turnover in lung cancer.

Presented at the American Society for Parenteral and Enteral Nutrition, 7th Clinical Congress, Washington, D.C., 1983. 31. Byerley, L., C.E. Larsen, B. Richardson, R. Chlebowski and D. Heber. Assessment of prescribed enteral supplement

consumption by cancer patients. Presented at the American Society for Parenteral and Enteral Nutrition, 7th Clinical Congress, Washington, D.C., 1983.

32. Larsen, C., L. Byerley, D. Heber and R. Chlebowski. Factors contributing to altered taste sensations in cancer patients.

Presented at the American Society for Parenteral and Enteral Nutrition, 7th Clinical Congress, Washington, D.C., 1983. 33. Heber, D., R.S. Swerdloff, B. Steiner and J. Rajfer. The pituitary gland: primary site of action of gonadotropin-releasing

hormone agonists in the human male. Presented at the Western Section, AFCR, Carmel, CA; Clin. Res. 1983; 30(1): 24a. 34. Heber, D., R. Dodson, D. Neiman and J.M. Stewart. Unique receptor binding characteristics of highly substituted synthetic

gonadotropin-releasing hormone (GnRH) antagonists. Presented at the Western Section, AFCR, Carmel, CA; Clin. Res. 1983; 30(1): 24a.

35. Henson, L. and D. Heber. Whole body protein breakdown rates correlate with muscle mass during fasting. Presented at the

Western Section, AFCR, Carmel, CA 1983; Clin. Res. 31(1): 24a. 36. Sokol, R.Z. M. Peterson, D. Heber, C. Madding and R.S. Swerdloff. GnRH-like material in seminal plasma. Clin. Res. 1983;

30(1): 27a.


37. Bhasin, S., D. Heber, M. Peterson and R.S. Swerdloff. Partial isolation and characterization of GnRH-like testicular factors.

Clin. Res. 1983; 30(1): 83a. 38. Nowak, F.V., D. Heber and R.S. Swerdloff. Stimulation of GnRH release by norepinephrine (NE) utilizing a dynamic in vitro

system. Clin. Res. 1983; 30(1): 85a. 39. Heber, D., L.O. Byerley and R.T. Chlebowski. Plasma amino acids and carbohydrate metabolism in malnourished lung cancer

patients. Clin. Res. 1984; 32.(1):057a. 40. Byerley, L.O., D. Heber, M. Grosvenor, K. Kaplan, and L.C. Henson. Lack of effect of physiologic T3 replacement on protein

breakdown in fasted obese subjects. Presented in Washington, D.C.; Clin. Res. 1985; 33(2): 270A and 104A. 41. Byerley, L.O., J. Chi, M. Grosvenor, R.N. Bergman, R.T. Chlebowski and D. Heber. Insulin resistance and failure of anabolism

in patients with localized cancer. Fed. Proc. 1986; 45(4): 1078. 42. Henson, L.C., B. Koziol, J. Schoessow, Heber D. Hyperlipidemia and obesity in school children. Clin. Res. 1986; 34(1): 72a. 43. Byerley, L.O., J. Chi, P. Moley, M. Grosvenor, D. Alvey, M. Dubria, R.N. Bergman and D.Heber. Resistance to insulin action

in malnourished patients with localized cancer. Clin. Res. 1986; 34(2): 388a. 44. Henson, L.C., D.P. Poole, C.P. Donahue, D. Heber. Exercise training and resting energy expenditure in dieting exercising

subjects. Clin. Res. 1986; 34:388A. 45. Koziol, B.K., A. Shoshani, S.Y. Su, J. Colburn, R. Rosser and D. Heber. Identification and characterization of aromatase

activity in cultured human breast stroma. Fed. Amer. Soc. Exper. Biol. 1986. 46. Henson, L.C., D.C. Poole, C.P. Donahue and D. Heber. Effects of exercise training on resting energy expenditure during caloric

restriction. Clin. Res. 1987; 35:165a. 47. Malik, I., Koziol, B.J., Heber, D., and Terpenning M. Effect of dietary supplementation with fish oils on serum cholesterol and

HDL levels in normocholesterolemic subjects. Clin. Res. 1987; 35:301a. 48. Heber, D., Koziol, B.J., Shoshani A., Su, S.Y., Colburn, J., Rosser, R.J., Waisman, J., and Silvertsein. Regulation of breast

tissue estrogen production by tumor-associated rat and human stromal fibroblasts: cell culture studies. Abst. #960, 261, 1987. Presented 69th Annual Meeting of the Endocrine Society, 1987.

49. Koziol, B.J., Shoshani, A., Su, S.Y., Chao, Y., and Heber, D. Regulation of estrogen biosynthesis in human breast adipose

stromal cells: implications for the role of dietary fat. FASEB Journal. 1988; 2: A859. 50. Byerley, L.O., Jones, M., and Heber, D. Abnormalities in lipid and glucose metabolism in tumor-bearing rats prior to eight loss.

FASEB Journal. 1988; 2: A859. 51. Byerley, L.O., Jones, M., and Heber, D. Increased insulin clearance in malnourished patients with head and neck cancer. Clin.

Res. 1988; 36:354A. 52. Heber, D., Ashley, J.M., Leaf, D.A., Solares, M., McCarthy, W.J., and Elashoff, R. Markers of adherence to a low fat diet for

breast cancer prevention. I: Changes in cholesterol and body weight. Clin. Res. 1990; 38(2): 258A. 53. Heber, D., Barnard, J., Ashley, J., and Kumar, A. Decreases in serum estradiol following 4 weeks of low fat high fiber diet in

postmenopausal women. Clin. Res. 1990. 54. Heber, D., Ashley J.M., Alfin-Slater, R.B., Leaf, D.A., Solares, M. Effects of feeding palm, coconut, and hydrogenated soy oil

on plasma cholesterol and lipoproteins in healthy male volunteers. Clin. Res. 1991; 39(2): 233A.


55. Bagga, D., Ashley, J.M., and Heber, D. 7,12-Dimethyl Benz(A) anthracine induced rat breast tumor arachidonate levels are increased compared to surrounding adipose tissue. Clin. Res. 1991; 39(2): 185A.

56. Heber, D., Solares, M., Nikazy, J., Ashley, J., Leaf, D.A. Clinical evaluation of maintenance following a physician upervised

OTC meal replacement weight loss program. The 6th International Congress on Obesity - Japan. Int'l J Obesity, 1991. 57. Kaufman, R.R., Heber, D., Heymsfield, S, Blackburn G.L. Multicenter meal replacement weight-loss study. New England

Deaconess Hospital, Harvard Medical School, Boston, MA. ADA, 1991. 58. Blackburn, G. Kanders, B., Heber, D., Heymsfield S., Elashoff, B. Multicenter eveluation of obesity treatment. Comparison of a

meal replacement and fat restricted programs. Int'l J Obesity. 1991; 15(3): 18. 59. Heber, D., Ashley, J.M., Alfin-Slater, R.B., Solares, M. Effect of palm oil as compared to coconut and hydrogenated soy oil on

plasma lipids and apolipoproteins in free-living adults. FASEB. Anaheim, CA, 1992. 60. Bagga, D., Ashley, J.M., Korenman, S.G., Barnard, J.M., Geffrey, S., Elashoff, R.M.,Heber,D. Reductions in circulating

estradiol and cholesterol in non-obese premenopausal females on a high fiber, low fat diet. ASCN, Baltimore Maryland, 1992. 61. Bagga, D., Ashley, J.M., Geffrey, G. Korenman, S.G., Barnard, J.M., Heber, D. Reductions in circulating estradiol and free fatty

acids in non-obese premenopausal females on a low fat, high fiber diet. Am Fed Clin Res, 1993. 62. Z. Glick, D. Bagga, J.M. Ashley, Heber, D. Critical role of body fat depots in mediating fat and calorie promotion of breast

cancer in rats. Am Soc Clin Nut. 1993. 63. Bagga D, Ashley J, Geffrey S, Barnard J, Heber D. Breast ductal fluid linoleic acid content is decreased by a very low fat, high

fiber diet. Clin Res. 1994; 42:92A. 64. Bagga D, Ashley J, Ghani, N, Heber D 3T3L1 Preadipocyte inhibition of MCF-7 Breast Cancer Growth in Vitro". American

Society of Clinical Nutrition, 1995. 65. Zhang J, Heber D, Wang YH, and VLW Go. Aryl hydrocarbon hydroxylase is not induced by dioxin in pancreatic ductal cell

lines: Implications for smoking and pancreatic cancer. Pancreas, Vol. 12, No. 4, 1996. 66. Heber D, Ingles S, Paul C, Lee E, Kurtzman F, Rome L, Carlton E, Caldwell M, Nelson J, Lyons R, Henning S, Go VLW, and

Elashoff RM. Nutritional and metabolic determinants of plasma vitamin E and beta carotene levels. FASEB, Washington, DC, 1996.

67. Lyons RF, Thornhill-Joynes M, Fong RL, Ingles S, Heber D, Ward HJ. Microalbuminuria is highly prevalent among obese

hypertensive African-American Women. 12th Annual Meeting of American Society of Hypertension, San Francisco, CA, May 1997; Am J Hypertens. 1997; 10:183A-87A.

68. Lyons RF, Thornhill-Joynes M, Fong RL, Williams E, Heber D, and Ward HJ. Dietary Intervention Improves Blood Pressure

and Metabolic Status in Obese African-American (AA) Women. 51st Annual Fall Conference and Scientific Sessions, Council for High Blood Pressure Research, Washington, DC, 1997.

69. Maxwell MH, and Heber D. Results of Fenfluramine/Phentermine Therapy at 26 and 52 Weeks in a Large Clinic Population.

NAASO Annual Conference, Cancun, Mexico, 1997. 70. Henning SM, Ingles S, Patel S, Carlton E, Caldwell M, Nelson J, Go VLW, and Heber D. Multivitamin and Mineral Supplement

Intake for 3 Weeks Did Not Significantly Alter the Antioxidant Capacity in Plasma of Healthy Young Men and Women. 6th World Congress on Clinical Nutrition, Antioxidants & Diseases. Banff, Alberta, Canada, 1997.

71. Ashley, J., Aronson W., Yip, I., Geffrey, S., Hui, E., DeKernion J., Heber D. (1997) Acceptance of A low Fat, High Fiber

Diet with Soy Protein Supplement in Men with Prostate Cancer. 16th International Congress of Nutrition Abs. pp 271 PT


533. 72. Lyons RF, Fong RF, Heber D, and Ward HJ. Nonpharmacologic Dietary Intervention Lowers Blood Pressure, Plasma Lipids,

and Urinary Albumin Excretion Rates in Obese Hypertensive African-American Women. 51st Annual Fall Conference and Scientific Sessions of the Council for high Blood Pressure Research, Washington, D.C., 1997.

73. Lyons RF, Heber D, Thornhill-Joynes M, Fong RL, and Ward HJ. Dietary Intervention Reduces Microalbuminuria and Blood

Pressure in Obesity Hypertension, Am Soc Nephrol. 1997; 8:318A. 74. Vu H, Lyons RF, Fong RL, Heber D, Yan Y and Ward HJ. Nitric Oxide Synthesis is Decreasd in Obese Hypertensive African-

American Women. Abstract presented at the 51st Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research, Washington, D.C., September 1997.

75. Maxwell M, Elashoff RM, and Heber D. Results of Monitored Appetite Suppressant Therapy using Multimodal Intensive

Nutritional Therapy. Abstract presented at NAASO Meeting, Cancun, Mexico, November 1997. 76. Vu H, Lyons RF, Fong RL, Heber D, Yan Y, and Ward HJ. Nitric Oxide Activity is Reduced in African-American

Hypertensives. Abstract presented to 30th Annual Meeting & Scientific Exposition, The American Society of Nephrology, San Antonio, TX, November 1997. Am Soc Nephrol. 1997; 8:32A.

77. Lyons RF, Heber D, Fong RL, Morisky D, and Ward HJ. Nonpharmacologic Intervention is Effective in The Treatment of

Obesity Hypertension. Abstract presented to the 13th Annual Scientific Meeting, American Society of Hypertension, New York, N.Y., May 1998. Am J Hypertens. 1998; 11:4 (part II).

78. Henning SM, Mahmoud M, Ingles S, Heber D, Go VLW. Fruit and Vegetable Consumption and Antioxidant Capacity. FASEB

1998, Free Radicals & Antioxidant Defense in Health. 79. Lyons RF, Fong RL, Thornhill-Jones M, Heber D, and Ward HJ. Microalbuminuria in Obese Hypertensive Women. 80. Heber D, Yip I, Ashley J, Elashoff D, Elashoff RM, Go VLW: A Chinese Red Yeast Rice Dietary Supplement Significantly

Reduces Cholesterol Levels. Experimental Biology ‘98 12:4, A1201. 81. Hui E, Henning SM, Heber D, Go VLW: Genistein and Daidzein Content of Tofu. Experimental Biology ‘98 12:4, A1223. 82. Yip I, Gratton L, Ashley J, Johnson T, Elashoff R, Go VLW, Heber D: Sibutramine Reduces Visceral Fat, Leptin, and

Estradiol Levels in Obese Women. Experimental Biology ‘98 12:4, A2053. 83. Henning SM, Mahmoud M, Ingles S, Heber D, Go VLW: Fruit and Vegetable Consumption and Antioxidant Capacity.

Experimental Biology ‘98 12:4, A3237. 84. Sebastian JL, Yip L, Flechtner-Mors M, Uikema S, Heber D, Livington EH: Assessment of Body Composition in Patients

Following Gastric Bypass Surgery for Morbid Obesity. Experimental Biology ‘98 12:4, A2056. 85. Chamras H, Bagga D, Setoodeh K, and Heber D. Growth promotion of MCF-7 breast cancer cells by proliferating pre-

adipocytes. Experimental Biology ’98. 86. Yip, I, Gratton L, Ashley J, Johnson T, Elashoff RM, Go VLW, and Heber D. Leptin is reduced to a greater degree than weight

or body fat following treatment with diet and sibutramine. Experimental Biology, 1998, A353, 2053. 87. Heber D, Yip I, Ashley JM, Elashoff DA, Elashoff RM, Go VLW. A Chinese red yeast rice dietary supplement significantly

reduces cholesterol levels. Experimental Biology, 1998, A206, 1201. 88. Sebastian JL, Yip I, Flechtner-Mors M, Uikema S, Heber D, Livington EH: Assessment of Body Composition in Patients

Following Gastric Bypass Surgery for Morbid Obesity.


89. Chamras H, Ashley J, and Heber D. Modulation of MCF-7 breast cancer cell growth by fatty acids. International Congress of Obesity, Paris, France August 1998. 90. Yip I, Aronson W, Elashoff R, Go VLW, deKernion J, Heber D. UCLA Nutrition Adjuvant Study for treatment of prostate cancer. Experimental Biology ’99. Washington DC, April 1999. 91. Yip I, S DeShields, VLW Go, P Saltsman, G Thames, M Yong, R Elashoff,and D Heber. Feasibility of Using Meal

Replacements for Weight Loss in Obese Type II DM. Endocrine Society, Annual meeting, San Diego, CA. 1999. 92. Yip I, HJ Wang, R Elashoff, M Maxwell, JM Hershman, VLW Go, and D Heber. Effects of Sibutramine and Diet Therapy

on Subcutaneous and Visceral Abdominal Fat, Insulin, Glucose and Leptin in Subjects with Upper Body Obesity. European Congress of Obesity, Milan, Italy, 1999.

93. M Flechtner-Mors, HH Ditschuneit, I Yip, A. Alt, J Hogel, D Heber, G Adler. Alpha Adrenergic Receptors Modulate

Noradrenaline Activities on Lipolysis and Blood Flow- an in vivo study in Obese Human Adipose Tissue. European Congress of Obesity, Milan, Italy, 1999.

94. VLW Go, D Heber, I Yip. Insulin-Leptin Relationship During Weight Loss in Patients with Upper Body Obesity. American

Pancreatic Association Annual Meeting, Chicago, IL. 1999. 95. I Yip, S DeShields, WLV Go, P Saltsman, G Thames, M Yong, HJ Wang, R Elashoff, D Heber. Feasibility of Using Meal

Replacements for Weight Loss in Obese Type II DM. North American Association for the Study of Obesity, Annual Meeting, South Carolina, 1999.

96. Bagga D, Glaspy J, Heber D, Aronson WJ. Effect of a low fat diet supplemented with omega-3 fatty acids (fish oil tablets)

on serum and tissue levels of omega-3 and omega-6 fatty acids. AACR, Philadelphia, 1999. 97. I Yip, VLW Go, M Yong, P Saltsman, G Thames, S DeShields, M Amaba, HJ Wang, R Elashoff, D Heber. Glucose and

Insulin Response to a Meal Replacement (Slim Fasttm) versus a Standard Meal in Obese Adult Onset Type 2 Diabetes Mellitus. North American Association for the Study of Obesity, Annual Meeting, South Carolina, 1999.

98. Heber, D.; Yip, I.; Go, V.L.W.; Liu, W.; Elashoff, R.M.; Lu, Q.: Plasma Lycopene and Carotenoid Profiles in Prostate

Cancer Patients Supplemented with Mixed Vegetable Juice. 9th Annual Conference, American Institute for Cancer Research. Washington D.C., September 1999.

99. TA Don Michael, T Ishimori, A Antonescu, I Yip, E Livingston, D Heber. A Unique Approach to surgical patients with

morbid obesity. American College of Cardiology, Annual Meeting, California, 2000. 100. S Bowerman, M Bellman, P Saltsman, D Garvey, K Pimstone, S Skootsky, H-J Wang, RM Elashoof, D Heber. Implementation

of a Primary Care Physician Network Obesity Management Program. North American Association for the Study of Obesity, Annual Meeting, Long Beach, CA October, 2000.

101. M Yong, Z-P Li, Ii Yip, H-J Wang, RM Elashoff, VLW Go and D Heber. Weight Loss using Phentermine (Phen) vs.

Phentermine and Fenfluramine (Phen-Fen) in a Patient Supported Outpatient Program. North American Association for the Study of Obesity, Annual Meeting, Long Beach, CA, October, 2000.

102. M Yong, Z-P Li, I Yip, H-J Wang, RM Elashoff, VLW Go and D Heber. Weight Loss using Very Low Calorie Diets (VLCS) in a

Patient Supported Outpatient Program. North American Association for the Study of Obesity, Annual Meeting, Long Beach, CA October, 2000

103. C Allen, TA Don Michael, A Antonescu, D Heber, D Cooper. Utilization of bioelectical impedance to predict energy expenditure

in obese patients. Validation by measurement of VO2 during exercise. North American Association for the Study of Obesity, Annual Meeting, Long Beach, CA 2000.


104. Heber, D.; Yip, I.; Go, V.L.W.; Liu, W.; Elashoff, R.M.; Lu, Q.: Plasma Carotenoids Profiles in Prostate Cancer Patients after

Dietary Intervention. FASEB J, 2000, 14, A719, Experimental Biology 2000, San Diego CA. 105. Lahiji A, FC Yeung, D Heber and DM Harris. Validation of a model system to study phytoestrogen action. Western Society

for Medical Research, Caremel, CA, 2001 106. Huerta, S., Sebastian, J., Heber, D., Licinio, J. Wong, M., Hanestad, J., Livingston, E.H. Downregulation of Homeobox

Genes HOX1, HOX2 and HOX7 in Metastatic Colon Cancer. Digestive Disease Week, Atlanta, GA, 2001. 107. Huerta S, DeShields S, Kasravi B, Sebastian J, Heber D, Livingston EH. Assessment of routine elimination of postoperative

nasogastric tuve decompression following gastric bypass surgery. Journal of Investigative Medicine. 2001; 49 (1): 83A. 108. Huerta S, Ndukwe E, Lee S, Heber D, Livingston EH. Risk Factors Associated with Morbidity and Mortality in Patients

undergoing Roux-en-Y Gastric Bypass for the Treatment of Morbid Obesity. Journal of Investigative Medicine. 2001; 49 (1): 83A.

109. Huerta S, Lee S, Heber D, Livingston EH. Risk Assessment for Major Complications of Gastric Bypass Surgery.

Gastroenterology. 2001; 120: A487. 110. Huerta S, Heber D, Livingston EH. Safety and efficacy of postoperative Continuous Positive Airway Pressure (CPAP) to

prevent pulmonary complications for patients following upper gastrointestinal anastomosis. Gastroenterology. 2001; 114 (2): A613.

111. Huerta S, Hannestad J, Licinio J, Wong M, Heber D, Livingston EH. Downstream apoptosis effectors APAF-1 and CLARP are

markedly reduced in colon cancer. Gastroenterology. 2001, 114 (4): A68. 112. Huerta S, Hannestad J, Licinio J, Wong M, Heber D, Livingston EH. Large scale expression array analysis of a colon cancer

progression model reveals altered regulation of 1251 genes including the downregulation of transglutaminase. Gastroenterology. 2001; 114 (4): A902.

113. Huerta S, Hannestad J, Licinio J, Wong M, Heber D, Livingston EH. Downregulation of homeobox genes HOX1, HOX2 and

HOX7 in metastatic colon cancer. Gastroenterology. 2001; 114 (4): A310. 114. Huerta S, Irwin RW, Heber D, VLW Go, Harris DM. Intestinal Lesions are Increased by Dietary Calcium in the Apcmin

Mouse. J. Nutr. 2001; 131: 3146S. 115. Huerta S, DeShields S, Harris DM, Livingston EH, Heber D. Antiproliferative Effects of Vitamin D in Colon Cancer Cell lines:

Role of the Vitamin D Receptor. J. Nutr. 2001; 131: 3146S. 116. Huerta S, Jaziheri A, Bonavida B, Harris DM, Heber D, Livingston EH. Induction of apoptosis results in differential expression

of over 100 genes without effect on caspases 3, 8, and 9 in colon cancer. Proceedings of the Association for Academic Surgery –November 15-17, 2001.

117. Huerta S, Irwin RW, Heber D, Go VLW, Harris DM. Fecal Bile acid excretion is increased with dietary calcium

supplementation in the Apcmin mouse. Journal of Investigative Medicine. 2002; 50(1): 57A. 118. Huerta S, Wong D, DeShields S, Murray S, Dickinson S, Heber D. Effectiveness of a meal replacement plan for weight loss in

an indigent population. Journal of Investigative Medicine. 2002; 50(1): 38A. 119. Vega M, Huerta S, Jaziheri A, Bonavida B, Heber D, Livingston EH. Apoptosis protease activating factor-1 (APAF-1) is absent

in malignant colon cancer cell lines and results in resistance to apoptosis. Journal of Investigative Medicine. 2002; 50(1): 24A. 120. DeShields S, Huerta S, Gratton L, Murray S, Heber D. Body composition analysis by BIA and DEXA. Journal of Investigative

Medicine. 2002; 50(1): 72A.


121. Huerta S, Murray S, Gratton L, Li ZL, DeShields S, Heber D. Body Mass Index Underestimates Obesity in Young Women

Compared with Percent Body Fat by DEXA Scan: High Prevalence of Sarcopenic Obesity in Young Women. Journal of Investigative Medicine. 2002; 50(1): 11A.

122. Huerta S, Harris DM, Irwin RW, Moatamed F, Go VLW, Heber D, Ou C, and Livingston EH. High dietary calcium

supplementation depletes serum 25-(OH)-vitamin D and results in an increase in tumor number in the Apcmin mouse. Proceedings of the Society for University Surgeons, Honolulu, Hawaii, February 2002.

123. Sartippour, M, Shao, ZM, Liu, C, Zhang, L, Beatty, P, Ellis, L, Go, VL, Heber, D, and Nguyen, M. Green tea inhibits vascular

endithelial growth factor (VEGF) induction in human breast cancer cells. Proceedings of the AACR. 124. Huerta, S, Bowerman, S, and Heber, D. Effectiveness of an Obesity Management Program in an Indigent Population. Nutrition

Week 2002. 125. M. Fernstrom, UPMC Health System, Pittsburg, PA; R. Deaton Abbott Laboratories, Abbott Park, IL; C. Apovian, L. Aronne, J.

Early, A. Frank, F. Greenway, D. Heber, R. Kushner, SB 250 Study Group, Abbott Park, IL. Weight Loss from Combination Therapy with Sibutramine and Meal Replacement. Nutrition Week, 2002.

126. Suzanne M. Henning, Vay L. W. Go, Hyun W. Lee, Claudia Fajardo-Lira, David Heber, UCLA Center for Human Nutrition,

Los Angeles, CA. Catechin Content of Various Teas and a Green Tea Extract Supplement with Antioxidant Activity: Implications for Studies of Nutrition and Cancer Prevention. Nutrition Week, 2002.

127. Huerta S, Vega M, Jazirehi A, Heber D, Bonavida B, Livingston EH. Modification of gene products involved in resistance to cisplatin-mediated apoptosis in metastatic colon cancer: roles of Apaf-1, Bcl-xL and survivin. Accepted for a poster presentation AACR – April 2002, San Francisco, CA. 129. Henning S, Lee HW, Go VLW, Heber D. Bioavailability and Antioxidant Activity of Flavanoids From a Diet Rich in Fruits and

Vegetables. FASEB 2003, Experimental Biology, San Diego, CA. 130. Harris DM, Besselink E, Potter E, Hirsch AM, Heber D. Estrogenicity of Alfalfa and Red Clover Extracts Versus Dietary

Supplements in an. FASEB 2003, Experimental Biology, San Diego, CA. 131. Li Z, DeShields S, Saltsman P, Bellman M, Thames G, Wang H, Elashoff R, Heber D. Randomized Prospective Trial of Meal

Replacement versus Individualized Diet Plans for Weight Management in Obese Type DM Patients. FASEB 2003, Experimental Biology, San Diego, CA.

132. Lembertas A, Zambaviciute , Lu QY, Heber D. Antiproliferative Effects of Chinese Red Yeast Rice Versus Mevinolin In SW

480 and SW620 Colon Cancer Cells In Lipid-depleted Media. FASEB 2003, Experimental Biology, San Diego, CA. 133. Lu QY, Li H, Li ZP, Hong K, Yu SZ, Mu L, Zhang Z, Heber D. Differences In Dietary Intake and Nutritional Biomarkers of

Cancer Risk In Age-Matched Rural Chinese Men and Urban Caucasians In The US. FASEB 2003, Experimental Biology, San Diego, CA.

134. Ngo TH, Barnard RJ, Cohen P, Heber D, Aronson W. Effect of Isocaloric Low-Fat Diet on Human LAPC-4 Prostate

Xenografts in SCID Mice and the IGF Axis. Western University of Health Sciences, Pomona, CA; University of California, Los Angeles, Los Angeles, CA. Accepted for poster presentation AACR July 2003, Washington DC.

135. Grau MV, Baron JA, Church TR, Haile RW, Sandler RS, Beach M, Heber D. Vitamin D, Calcium Supplementation, Vitamin

D Receptor Polymorphisms and Colorectal Adenomas. Dartmouth Medical School, Lebanon, NH; University of Minnesota, Minneapolis, MN; University of Southern California, Los Angeles, CA; University of North Carolina, Chapel Hill, NC; UCLA, Los Angeles, CA. Accepted for minisymposium AACR July 2003, Washington DC.

136. Arteaga JR, Li Z, Henning SM, Heber D, Aronson WJ. Low fat/high fiber diet with soy supplementation leads to reductions


in ex vivo bioassay LNCaP cell proliferation in CaP patients following prostatectomy. UCLA, Los Angeles, CA; UCLA Department of Urology, Los Angeles, CA. Accepted for poster presentation AACR July 2003, Washington DC.

137. Rao J, Heber D, Wu D, Zhang L, Sartippour MR, Maul RS, Brooks MN. A pilot study of soy and breast cancer patients.

UCLA, Los Angeles, CA; UCLA, Los Angles, CA. Accepted for poster presentation AACR July 2003, Washington DC. 138. Chen, L; Heber, D.; Hardy, M.L.; Seeram, N.P.; Henig, S.; Leahy, M.; Wolinsky, F.; Qi, F.; Shi, W. Inhibitory effects of

cranberry on Streptococcus mutans biofilm formation. International Association for Dental Research & American Association for Dental Research, Honolulu, Hawaii, March 13, 2004.

139. Seeram, N.P.; Besselink, E.; Harris, D.M.; Hardy, M.L.; Heber, D. Evaluation of cranberry extracts for phytoestrogens by

HPLC and LC-ES/MS and their estrogenic properties in an Estrogen Response Element (ERE) assay. Annual Meeting of Federation of American Societies for Experimental Biology, Washington DC, Maryland, April 17-April 21, 2004.

140. Adams, L.S.; Seeram, N.P.; Hardy, M.L.; Heber, D. Cranberry extract and its purified phytochemicals inhibit the

proliferation of human tumor cell lines: synergistic effects. Annual Meeting of Federation of American Societies for Experimental Biology, Washington DC, Maryland, April 17-April 21, 2004.

141. Sartippour M.R.; Norris, A.; Heber D.; Hardy, M.; Seeram, N.P.; Rubio R.; Maul R.S.; Zhang, L.; Brooks, M.N. PC-SPES

components inhibit the proliferation of breast cancer cells and endothelial cells. Annual Meeting of Federation of American Societies for Experimental Biology, Washington DC, Maryland, April 17-April 21, 2004.

142. Lembertas, A.V; Seeram, N.P.; Lu, Q-Y; Lee, R.; Besselink, E.; Zambeceviciute, G.; Tedja, R.; Hardy, M.L.; Heber, D.

Chinese red yeast rice inhibits the growth of human colon cancer cells by mechanisms, which act both through and outside of the HMG-CoA reductase pathway. Annual Meeting of Federation of American Societies for Experimental Biology, Washington DC, Maryland, April 17-April 21, 2004.

143. Henning SM, Krul C, Seeram NP, Niu Y, Liu Y, Heber D. Colonic metabolism of flavonols from green and black tea

studied using an in vitro large intestinal model. Annual Meeting of Federation of American Societies for Experimental Biology, San Diego, CA, April 1-6, 2005

144. Henning SM, Gao K, Xu A, Heber D. The Citrus Flavonoid Naringenin Stimulates DNA Repair in Prostate Cancer Cells.

Annual Meeting of Federation of American Societies for Experimental Biology, San Diego, CA, April 1-6, 2005 145. Li Z, Seeram NP, Heber D. Effect of Cranberry on INR in Subjects on Warfarin for Atrial Fibrillation. Annual Meeting of

Federation of American Societies for Experimental Biology, San Diego, CA, April 1-6, 2005 146. Li Z, Lembertas A, Heber D. Plasma clearance of Lovastatin vs. Chinese Red Yeast Rice in Healthy Volunteers. Annual

Meeting of Federation of American Societies for Experimental Biology, San Diego, CA, April 1-6, 2005 147. Seeram NP Lee R, Scheuller HS, Heber, D. Identification of phenolic compounds in strawberries by liquid chromatography

electrospray ionization mass spectroscopy (LC-ESI-MS). Annual Meeting of Federation of American Societies for Experimental Biology, San Diego, CA, April 1-6, 2005

148. Adams L.S, Seeram, NP, Henning SM, Heber, D.. In Vitro effects on proliferation, apoptosis and oxidation in human tumor

cell lines by pomegranate polyphenols. Annual Meeting of Federation of American Societies for Experimental Biology, San Diego, CA, April 1-6, 2005

149. Harris DM, Arteaga J, Moro A, Seeram NP, Irwin R, Lembertas A, Raskin I, Ribnicky D, Heber D. Comparative effects of

phenethylisothiocyanate (PEITC) and an extract of upland cress (Barbarea verna) seed on intestinal tumorigenesis in vivo. American Association of Cancer Research, Anaheim, CA, April 16-20; 2005 (accepted for presentation).

150. Seeram NP, Henning SM, Heber, D. Biomarkers of bioactive dietary polyphenols in human and animal studies. 229th

National meeting of the American Chemical Society; Flavanoid Metabolism and Health; March 13- 17, 2005, San Diego, CA, USA


151. Early J, Greenway F, Heber D, Hewkin A, Frevert E. The effect of Sibutramine and Meal Replacement Combination

Therapy on Body Weight and Weight-Loss Maintenance. 87th Annual Meeting Endocrine Society; June, 2005, San Diego, CA

152. Chen S, Li, Z, Heber D. The effect of an L-arginine containing supplement on exercise performance in middle-aged and

elderly men. FASEB 2006, San Francisco, CA. 153. Hong M-Y, Seeram NP, Heber D. Chinese red yeast rice (CRYR) inhibits proliferation and stimulates apoptosis in both

COX-2 expressing and non-expressing human colon cancer cells via inhibition of cholesterolgenesis. FASEB 2006, San Francisco, CA.

154. Yan E, Bajpai A, Hong K, Li Z, Heber D. Observational Study of Weight Loss on Clinical Markers for Metabolic

Syndrome. FASEB 2006, San Francisco, CA. 155. Adams LS, Seeram NP, Hardy ML, Carpenter C, Heber D. Analysis of the Interactions of Botanical Extract Combinations

Against the Viability of Prostate Cancer Cell Lines. FASEB 2006, San Francisco, CA. 156. Seeram NP, Henning SM, Heber D. Pharmacokinetics and ex-vivo bioactivities of pomegranate polyphenols in humans.

FASEB 2006, San Francisco, CA. 157. Harris DM, Niu Y, Lu Q-Y, Berger A, Moro A, Hardy M, Henning S, Heber D, Go VLW. Uptake of baicalein into mouse

tissues after administration of Scutellaria baicalensis extract. FASEB 2006, San Francisco, CA. 158. Chen S, Darcy S, French N, Wang H-J, Li Z, Heber D. Is Body Mass Index (BMI) an Accurate Way to Assess Obesity?

NAASO 2006, Boston, MA. 159. Hong, M-Y, Seeram NP, Zhang Y, Heber D. Chinese Red Yeast Rice extract inhibits androgen-dependent and –independent

prostate cancer cell growth by by different mechanisms. FASEB 2007, Washington, DC 160. Seeram NP, Zhang Y, Sartippour M, Henning SM, Lee R, Harris DM, Moro A, Heber D. Pharmacokinetics and tissue

disposition of urolithin A, an ellagitannin-derived metabolite, in mice. FASEB 2007, Washington, DC 161. Henning SM, Reliene R, Schiestl RH, Yamamoto ML, Li L, Seeram N, Heber D. Decreased oxidative DNA damage in

Ogg1/Myh-deficient mice treated with pomegranate extract. FASEB 2007, Washington, DC 162. Henning SM, Bowerman S, Seeram NP, Heber D. Antioxidant capacity of spices and herbs in dried, fresh and blended herb

paste. FASEB 2007, Washington, DC 163. Hong M-Y, Moro M, Zhang Y, Seeram N, Heber D. Chinese red yeast rice food spice inhibits androgen-dependent and –

independent prostate tumor xenograft growth by inhibiting cholesterol biosynthesis in androgen-dependent and independent prostate cancer. FASEB, 2008, San Diego, CA.

164. Hong M-Y, Seeram N, Heber D. Pomegranate and its polyphenols downregulate gene expression of androgen synthesizing

enzymes in human prostate cancer cells overexpressing the androgen receptor. FASEB, 2008, San Diego, CA. 165. Williamson G, Sies H, Heber D, Keen CL, Macdonald IA, Actis-Goretta L, Momma TY, Ottaviani JI, Holt RR, Schroeter H,

Heiss C. Functional foods for health promotion: state-of-the-science on dietary flavonoids. Extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April 2009. Nutr Rev. 2009 Dec;67(12):736-43.

david heber, m.d., ph.d., c.n.s., f.a.c.p., f.a.c.n ...presidenthbl.com/documents/dr david heber...

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