delirium: challenges in clinical care - steve...
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Delirium
Steve Ellen MB, BS. M.Med. MD. FRANZCP Head, Consultation, Liaison & Emergency Psychiatry, Alfred Health. Associate Professor, Monash Alfred Psychiatry Research Centre, Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University.
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Delirium
• Definitions – why is it missed so often? • Clinical features • Prevalence,Costs and Recognition etc. • Causes – systemic and neurological • Treatment
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Terminology
• Terminology varies • neurologists tend to use acute confusional syndrome (ACS) or acute brain
syndrome • definitions vary according to background of author • seen as a manifestation of widespread brain dysfunction
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Terminology
• “a change in mental state in which the most salient deficits occur in overall attentional tone” (neurologist)
• “acute change in cognitive state characterised by fluctuating consciousness and inattention” (physician)
• DSM-IV criteria list 3 categories: “disturbance of consciousness and change in cognition of rapid onset”
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Delirium: Clinical Features
• A transient organic brain syndrome – acute onset and fluctuating course – global impairment of cognitive function – altered level of consciousness – reduced attention and concentration – increased or decreased psychomotor activity – disordered sleep/wake cycle – perceptual disturbances (hallucinations, illusions)
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Delirium: Clinical Features
• Associated features: -irritability -distractibility -mood disturbance - depression /anxiety
– nocturnal exacerbation and day-time somnolence • Prodromal symptoms: -restlessness -anxiety -sleep disturbance
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Clinical features
Some focal neurological findings can also be seen e.g.: • Extensor plantar responses • Coarse tremour, myoclonus or asterixis • Asymmetric reflexes • Asymmetric power in severe cases, especially elderly and often in
hypoglycaemic states
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Subtypes
• Hyperalert/hyperactive – agitation – hyper-reactivity – aggression – hallucinations – delusions
(Olofsson et al,1995; Camus et al,2000)
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Subtypes
• Hypoalert/hypoactive – reduced reactivity – motor and speech retardation – facial inexpressiveness
• Mixed states (most common)
Camus et al 2000
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Other Clinical Presentations
• “non-compliance” and denial • anxiety and panic • “crescendo pain” • “adjustment problems” • suicidal ideation and actions • staff and family conflict
Kissane & Smith,1996; Saravay, 1987; Coyle et al,1994; Kinkel, 1997; Akechi et al,1999; Farrell & Ganzini,1995
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Incidence
Studies conflict: • 10% of all hospital in-patients • 30-50% of in-patients on geriatric wards • 40% of post-operative patients (but very wide variation – greatest in
bypass patients) • (Dyer et al 1995 meta analysis of 26 published studies – selected from
374)
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Recognition
• Recognition – generally under-diagnosed and under-treated – un-recognised in 20% – common misattributions:
> depression > anxiety > non-organic psychosis
Faisinger et al, 1991, Margolis,1994, Saravay,1987
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Risk factors
• increasing age • pre-existing cognitive impairment • drug abuse • anticholinergic medications • polypharmacy • NOT gender, race, marital status, nor education
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Pathophysiology
• poorly understood despite 2500 years of recognition (Hippocrates)and a hundred years of research
• adequate function of the CNS depends on the metabolic integrity of its constituent neurons and glia
• polysynaptic circuits appear to be especially vulnerable to toxic/metabolic insults
• believed to arise from any disruption in the “cholinergic axis” www.steveellen.com
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Costs and morbidity
• Most studies suggest that mortality at least doubles (10-65%) • Poor prognostic indicator for all surgery • Markedly lengthens inpatient stay • Excess annual health expenditure of $US2 billion (Inouye 1994)
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Causes
D-drugs E-endocrine L-Lungs I-ischaemia R-renal I-infections U-unknown M-metabolic
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Causes
Systemic vs. neurological Systemic by far commonest: • Toxic/metabolic • Hypovitaminosis • Infection • Endocrine • Hypoxia • other
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Special toxic causes
• Alcohol intoxication and withdrawal • Drug intoxication and withdrawal • Chemical toxins and poisoning • Carbon monoxide
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Neurological causes
• Multifocal brain lesions – HT, vasculitis, DIC, air and fat emboli, SAH • Infections – meningitis, encephalitis and brain abscess • Non-convulsive status epilepticus • Trauma • Neoplastic conditions
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Treatment- 4 goals
• Recognition (hardest part) • Investigation (easiest part)
a) to see if this is delirium b) to find the cause of the delirium
• Symptomatic treatment • Definitive treatment
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Investigations- for diagnosis of delirium
• History from nurses/notes- MSE on admission, fluctuation etc • History from Family- usual level of cognitive function, rate of decline • Serial MMSE • EEG- sometimes useful
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Investigations-for cause
• Careful review of drug history • Corroboration with family members regarding medications at home, diet
and pre-morbid function
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Investigations- for cause
• Toxic/metabolic screen • MSU +/- blood cultures • CXR and abdominal films • CT/MRI brain • EEG – which should show diffuse slowing to be diagnostic • LP in cases where no obvious cause apparent
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Investigations
• A common mistake is to consider the symptoms to be psychiatric if no clear cause is found.
• No clear cause is found in about 20% of cases. • Severe mental illness can lead to confusion, but this is rare, and when it is
present, it is usually associated with dementia.
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Symptomatic Treatment
– Aimed at specific indications (Carter,1995)
>aggression >safety >hallucinations >distress >capacity to cooperate with care
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Symptomatic Treatment 1. Medications
– very limited research base – antipsychotic agents
> to treat agitation and psychotic symptoms > superior to benzodiazepines
– haloperidol 1-2mg every 2-4 hours > elderly: 0.25-0.50mg every four hours > +/- short acting benzodiazepine (lorazepam in US studies),
however I prefer diazepam (valium), as available, easy to prescribe, doses rarely mucked up!!
– Olanzepine 2-5 mg O/IM
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Symptomatic Treatment 1. Medications
• Precautions – Increased sensitivity to extrapyramidal effects of DA antagonists (eg
HIV Infection) – Drug interactions (eg anticholinergic effects) – Pharmacokinetics – Polypharmacy – Sedation (eg hydration needs)
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Symptomatic Treatment 2. Environment
– environmental and supportive interventions – optimal level of environmental stimulation – familiarize environment & optimize orientation – reduce sensory impairments – address fear and demoralization – liaison roles – Watch safety: attendant Vs Special nurse Vs in
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Definitive Treatment
• Obviously depends on the cause, however, • Research findings support:
– Discontinuation of unnecessary psycho-active medication – attention to hydration – change of opioid or dose modification – use of antipsychotic drug if needed
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Prevention
– primary > identify risk groups > enhance environment > modify causative factors (eg drug treatment practices)
– secondary > early identification through cognitive monitoring > early intervention - identify key early symptoms (eg sleep
disturbance, agitation, irritability, somnolence) > Identify and address precipitants
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Prevention
• Tertiary Prevention – maintain and maximise function
> relief of distress > reduce demands > identify predisposing factors (eg dementia) > environmental factors > intervention with family and staff: goals of care > address key tasks for patient
– engaging with staff and family – participation in care at realistic level
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Screening and Diagnosis 1. Screening Instruments Confusion Rating Scale (Williams et al,1988) Clinical Assessment of Confusion (Vermeersch, 1990) 2. Diagnostic Instruments Confusion Assessment Method (Innouye et al,1990) Delirium Symptom Interview (Albert et al,1992) 3. Delirium Severity Rating Scales Delirium Rating Scale (Trzepacz,1999) Memorial Delirium Assessment Scale (Breitbart et al,1997)
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Delirium: Impact on Family
– roles and functions (esp decision-making) – demoralization and fatigue – functions needed and lost & demands on carers – impact of behavioural change – attribution for these changes – conflict: family, staff – children – ?bereavement outcome
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Issues for Staff
> confrontation with regression and fragmented mental states
> high care demands amidst poor cognitive function > therapeutic pessimism and hopelessness > blame from the family
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Issues for Staff
> overestimating decisional capacity > difficulty establishing realistic limits/safety for the
dying patient > negotiating amidst complex ethical pressures and
frameworks (eg autonomy and self determination)
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Issues for Staff
> re-establishing relationship with the patient post-delirium
> impact on team/unit function > responding to family distress and patterns of
response
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Conclusion
• Delirium – common clinical syndrome – often missed – often inappropriately attributed to psychiatric cause – significant impact on patient, family and staff – significant benefits from comprehensive treatment
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