dermatopathology (skin pathology )06_24_04_pm.pdf · (latin- ulcus- “sore”)- focal loss of...
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Dermatopathology(Skin pathology )
Dr. Methaq Mueen
ميثاق معين . د
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Dermatopathology:1. Acute Inflammations:
• Urticaria,
• Acute Eczema,
2. Chronic Inflammations:
• Psoriasis,
• Lichen planus.
3. Infections
• Bacterial (Impetigo),
• Fungal(tinea) &
• Viral(warts).
•
1. Blistering Diseases
• Pemphigus,
• Pemphigoid,
• Dermatitis herpetiformis.
5. Neoplastic:
• Benign:
•Nevi,
•Malignant:
•BCC,
•SCC,
•Melanoma.
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Epidermis :Stratum corneum( keratin layer )Stratum granulosum ( granuler layer )Stratum spinosum( spinous layer )Stratum basalis ( basal layer)
Dermis
KERATINOCYTES
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• The skin composed of epidermis and dermisand subcutaneous fatty tissue (hypodermis,subcutis or pannus)
The epidermis is a stratified squamous keratinizingepithelium composed of several layers ofkeratinocytes
1-basal layer (stratum basale)of proliferative cells.2-spiny layer (stratum spinosum)Prickle cell layer
of polygonal cells3-granular cell layer(Stratum granulosum) of
flattened cells rich in dark granules(keratohyalinegranules).
4-Corneal layer: Stratum corneum (horny layer)of differentiated keratinocytes(dead cell without
nuclei, The top layer of cells loosens and falls off).
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The dermis is composed of dermal connective
tissue composed of collagen and elastic fibers.
It has two distinctive areas
1- papillary dermis rich in small nerves and
capillaries.
2-reticular dermis rich in skin appendages ( sweat
glands, pilosebaceous unit).
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Terms user in Dermatopathology
MACROSCOPIC TERMS
MICROSCOPIC TERMS
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MACROSCOPIC TERMS
Primary lesions- The original lesions
• Flat :Macule, patch
• Elevated: Papule, plaque, nodule,
• Fluid filled(blister): Vesicle , Bullae
• Wheals: pruritic edematous plaque
• pus filled: Pustule
Secondary Lesions: the primary lesions
continue to full development or may be modified by regression, trauma or other factors like scratching or rubbing
• Scales
• Crusts
• Erosions , Ulcers
• Scar-hypertrophic scars
• Keloid
• Atrophy
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Macroscopic Terms(clinical )• Macule: A flat ,circumscribed change in skin
color without elevation or depression.
• Macule := < 5 mm
• Latin: macula, “spot” بقعة
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Patch: A flat ,circumscribed change in skin color without elevation or depression> 5 mm
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Flat lesion:no elevation no depression
Macule := < 5 mm
• Flat, circumscribed area distinguished from surrounding skin by coloration
Patch > 5 mm
Clinical terms
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Papule : A solid elevated lesion usually 5 mm or less in diameter.
• Papule- (Latin Paula, “Pimple”) بثرة
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Nodule: elevated , solid lesion greater than 5 mm in diameter
(Latins: nodulus- “small knot”)-عقدة
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Elevated solid area
papule nodule
= < 5 mm > 5 mm
Clinical terms
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Plaque : elevated flat topped lesion that has a greater than 5 mm across.
• Plaques: (French- Plaque- “Plate”)
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BlisterFluid-filled raised area
Vesicle
• = < 5 mm
e.g. Herpes
Bulla
• > 5 mm
Clinical terms
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Vesicle: elevated fluid-filled lesion 5 mm or less in diameter.
(Latin “Little bladder”)
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Bulla ( blister ) elevated fluid-filled lesion more than 5mm across.
Bulloe (Latin-”Bubble”)-
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Wheals are oedematous, flat elevations of
various sizes. Associated with itching or burning sensation
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Pustule: small elevations of theskin containing pus
Latin- Pustula-Pus
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•Secondary lesions
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Scale• Dry, horny, plate-like excrescence( due to
excess dead epidermal cells produced by abnormal keratinization and shedding ).
• E.g psoriasis
Clinical terms
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Crust • A “scab” formed from dried serum , blood or
exudate on skin usually mixed with epithalial
• and bacterial debris
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Erosion
• Focal loss of epidermis not exceeding below dermo-epidermal junction heal without scar tissue formation (e.g following blister rupture
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Ulcers (Latin- Ulcus- “Sore”)- focal loss of epidermis
and dermis extending into hypodermis(e.g bedsore ).
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pathologic terms(microscopical terms)
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MICROSCOPIC TERMS
Hyperkeratosis
Parakeratosis
Acanthosis
Spongiosis
acantholysis
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Normal: Orthokeratosis: basket-weavedhorny cell layer
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HyperkeratosisHyperplasia of the stratum Corneum with
abnormal keratin.The horny cell layer becomes abnormally thick
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ParakeratosisKeratinization characterized by retention of the
nuclei.
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Hypergranulosis is a thickening of the granular cell layers to 4 or more layers from the normal (1-3 layers)
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Acanthosis• Epidermal hyperplasia preferentially involving
the stratum spinosum
pathologic terms
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Acantholysis
LOSS OF INTERCELLULAR CONNECTION RESULTING IN LOSS OF COHESION.
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SpongiosisIntracellular edema of the epidermis.
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Dermatopathology1. Acute Inflammations:
• Urticaria,
• Acute Eczema,
2. Chronic Inflammations:
• Psoriasis,
• Chronic Eczema,
• Lichen planus.
3. Infections
• Bacterial (Impetigo),
• Fungal(tinea) &
• Viral(warts).
•
1. Blistering Diseases
• Pemphigus,
• Pemphigoid,
• Dermatitis herpetiformis.
5. Neoplastic:
• Benign:
•Nevi,
•Actinic Keratosis,
•Seborrheic Keratosis.
Malignant:
•BCC, SCC, Melanoma.
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Inflammatory disorders of skin(dermatosis1. Acute inflammatory Dermatosis:
characterized by
• Duration of days to weeks
• Acute inflammatory cells infiltration rather
than neutrophils.
• Edema, vascular, epidermal, & subcutaneous
injury.
• Examples: like URTICARIA, & ECZEMA
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INFLAMMATORY disorders: Pathogenesis
Urticaria
Dermal Infl
Acute
Eczema
Epidermal Infl
Chronic
Eczema
Hyperplasia
Lichen
Sclerosis
Hyperkeratosis
Acute Inflam. Chronic Inflam.
Ep
.H
yp
erp
las
ia
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URTICARIA (Hives)• Type I hypersensitivity – Allergy
• All ages, more in 20 – 40y.
• Erythematous papules and plaques and wheals
• Individual lesions are transient, usually resolve in 24 hr, but entire episode may last for days.
• Usually on trunk and extremities.
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Urticaria (Hives)
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Urticaria :Mic:
characterized by.
1. Early normal skin biopsy.
2. Superficial perivenular infiltrate consisting of mononuclear cells, rare neutrophils.
3. Widely spaced collagen bundles than in normal skin.
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URTICARIA – Histopathology
Dermis: Perivascular inflammatory infiltrate: lymphocytes, eosinophils , rare neutrophils, .
* lack of spongiosis or other epidermal changes.
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URTICARIA (Hives)• Pathogenesis
• Type I hypersensitivity – Allergy
• Follows exposure to Ag: (pollens, foods, drugs, pressure, temperature, insect….Etc).
• Ag IgE Mast cell Degranulation Inflammation.
• perivascular inflammatory infiltrate: lymphocytes, eosinophils rare neutrophils
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Urticaria – Microscopic features
1. Superficial dermal edema (space between collagen)
2. Dilated blood vessels with perivascular inflammatory cells.
3. Normal Epidermis (no spongiosis or hyperplasia)
1
3
2
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Eczema• Origin of this word:
• The word ‘eczema’ comes from the Greek ‘boiling’ a reference to the tiny vesicles that are often seen in the early acute stages of the disorder, but less often in its later stage
غليان
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Eczema.
A number of pathogenetically different conditions, all are characterized by red, papulo-vesicular oozing & crusted lesions at early lesions( acute phase),
with time in the presence of persistent antigen stimulation these lesions become less wet (fail to ooze or form vesicles )and progressiveyscaly(hyperkeratosis) as the epidermis thickens (acanthosis) .. develop into raised, scaling plaques
( development of chronic form of dermatiotis).
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Examples: 1. Contact dermatitis (due to chemicals)
2. Atopic dermatitis(unknown cause but
family history of eczema, allergic rhinitis or asthma)
3. drug- related eczematous dermatitis
Mic:
1. epidermis: Spongiosis, which is accumulation of
edema fluid within the epidermis.
2. Dermis: Superficial perivascular, lymphocytic
infiltrate associated with papillary dermal edema &
mast cells degranulation.
3. Prominent eosinophils infiltrate.
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Eczemaclinical features
• Acute : pruritic (itchy), edematous, plaques, often containing small and large blisters (vesicles and bullae)
• oozing and crusted lesion
• Contact reaction
to poison ivy,
laundry detergent.
• Chronic: persistent antigen stimulation, lesions may become less "wet" and progressively scaly as the epidermis thickens.
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ECZEMA – histology
• Spongiosis (Intraepidermal) edema
• Superficial perivascular lymphocytic infiltrate
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ECZEMA dry - (atopic)
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ECZEMA – pathogenesis:
Hypersensitivity Reaction:
• Initial exposure to antigen:
• Antigen processed by Langerhans cells and presented to T cells in the lymph node T cell activation memory cells.
• Re-exposure to antigen:• Quick (memory T cells) response inflammation
urticaria, erythema, wet eczema
• Persistence of antigen stimulation:
• Chronic inflammation Acanthosis, hyperkeratosis– dry eczema.
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Allergic Contact Dermatitis Pathogenesis
initial exposure to an environmental contact sensitizing agent
processed by epidermal Langerhans cells
migrate to draining lymph nodes and present the antigen to T cells
Memory T cell
on re-exposure to the antigen, CD4+ T lymphocytes migrate to the affected skin
they release cytokines that recruit additional inflammatory cells
LN T cell
DELAYED TYPE HYPERSENSITIVITY
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Dermatopathology1. Acute Inflammations:
• Urticaria,
• Acute Eczema,
• Erythema Multiforme.
2. Chronic Inflammations:
• Chronic Eczema,
• Psoriasis,
• Lichen planus.
3. Infections
• Bacterial (Impetigo),
• Fungal(tinea) &
• Viral(warts).
•
1. Blistering Diseases
• Pemphigus,
• Pemphigoid,
• Dermatitis herpetiformis.
5. Neoplastic:
• Benign:
•Nevi,
•Actinic Keratosis,
•Seborrheic Keratosis.
Malignant:
•BCC, SCC, Melanoma.
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Chronic inflammatory dermatosis:
Have duration last for many months to years.
Examples (psoriasis, lichen planus).
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PSORIASIS – الصدفية• A common chronic inflammatory dermatosis affecting 2% of
people in the United States.
• Etiology : exact cause :unknown
• Multifactorial: genetic and immune and environmental
• Sensitized T cells infiltrate the skin and secrete
cytokines and growth factors
• Inflammation, Increased cell turnover
• abnormal proliferation and turnover of epidermis (reduced from a month to only 4 days for a cell to transit from basal layer to surface).
• Vascular proliferation angiogenesis
• Trauma precipitates lesions – Koebner phenomena .
• Multi system disorder:
• Arthritis, myopathy, enteropathy, Immunodefficiency.
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Clinical Features of Psoriasis• Site: skin of the elbows, knees, scalp, lumbosacral areas, and nails in 30%of
cases
• Appearance: a well-demarcated pink plaque covered by loosely adherent
silver-white scale
• Removal of scales point bleeds – Auspitz sign.Nail pittingOnycholysis
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Psoriasis
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Psoriasis Microscopically:
• Acanthosis with regular downward elongation with clubbed rete ridges.
• stratum granulosum is thinned or absent with extensive overlying parakeratotic scales,
• Thinning of suprapapillary dermis,• Blood vessels within the dermal papillae are
dilated tortuous and close to the surface. These vessels bleed easily when the scale is removed, giving rise to multiple punctate bleeding points (Auspitz sign).
• Neutrophils aggregate within superficial epidermis & the parakeratotic stratum corneum(Munro microabscess)
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epidermal thickening regular(acanthosis ) with Clubbed rete ridgesparakeratosisthinning of suprapapillary plates) The blood vessels within the papillae are dilated and tortuous and close to the surface. These vessels bleed readily when the scale is removed, giving rise to multiple punctatebleeding points (Auspitz sign). Neutrophils in stratum corneum (Munro microabscesses). • Perivascular lymphocyte in the dermis
acanthosis
parakeratosis
thinning of suprapapillary plates)
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Lichen planus الحزاز المسطح .Sites: characteristically, there are bilateral symmetrical lesions, mainly on the limbs
(about the wrists, elbows) , in 70% of cases associated with oral lesions.
Pathogenesis: the exact cause is unknown, but suppose to be a release of Ag at the level of the basal cell layer and the dermo-epidermal junction may elicit a cell mediated cytotoxic immune response.
Prognosis: is a self limited dis, resolve spontaneously 1-2 years after onset,
Often leaving zones of postinflammatory hyperpigmentation . Oral lesions may persist for years
Morphology:
Gross: 4 Ps : pruritic, purple, papules which may coalesce focally to form Plaques.
Mic:
1. Continuous infiltrate of lymphocytes along the dermoepidermal junction.
2. Dermoepidermal junction shows saw toothing appearance.
3. Civatte bodies a nucleated, necrotic basal cells incorporated into the inflamed papillary dermis.
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Lichen Planus: Pruritic, purple, papules• Pruritic, Purple, Papules and
Plaques.
• Skin , oral,
• Self limited. 1-2 years.
• Basal layer, Interface dermatitis.
• Anucleate dead epidermal cells in basal layer – Civatte bodies.
White lines: Wickham Striae
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Lichen Planusclinical
Pruritic, purple, papuleswhite lines, called Wickham's striaedisorder of skin and mucous membrane. In 70% of cases, oral lesions are present
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Lichen planus
• microscopic (histologic) description
• Hyperkeratosis and acanthosis; prominent granular cell layer, saw toothing of rete pegs, bandlike chronic inflammatory infiltrate (T cells and macrophages) that destroys the dermoepidermal junction
• Civatte bodies (apoptotic basal cells)
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Interface dermatitis, basal keratinocytes that show degenerationsawtoothing.
Morphology
Interface dermatitis, is characterized by a dense, continuous infiltrate of lymphocytes along the dermoepidermal junction basal keratinocytes show degeneration and apoptosisThis pattern of inflammation causes the dermoepidermal interface to assume an angulated contour ("sawtoothing").
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Dermatopathology1. Acute Inflammations:
• Urticaria,
• Acute Eczema,
• Erythema Multiforme.
2. Chronic Inflammations:
• Chronic Eczema,
• Psoriasis,
• Lichen planus.
3. Infections
• Bacterial (Impetigo),
• Fungal(tinea) &
• Viral(warts).
•
1. Blistering Diseases
• Pemphigus,
• Pemphigoid,
• Dermatitis herpetiformis.
5. Neoplastic:
• Benign:
•Nevi,
•Actinic Keratosis,
•Seborrheic Keratosis.
Malignant:
•BCC, SCC, Melanoma.
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Blistering (bullous)diseases.A group of disorders characterized by formation of bullae.
These bullae are either subepidermal or intraepidermal
in their location.
Cause: These bullae are due to acantholysis of epidermal
cells junctions.
Examples :
Pemphigus vulgaris, Bullous Pemphigoid, &dermatitis
herptiformis.
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BLISTERING DISEASES
• Subcornial.
• Suprabasal.
• Subepidermal.
PEMPIGUS FOLIACESOUS PEMPIGUS VULGARIS BULLOUS PEMPHIGOID
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Pemphigus
Characterized by suprabasal acantholytic blisters or bullae.
Distribution: Bullae involve skin & rare the mucous membranes.
The disease is due to type II hypersensitivity reaction.
Autoimmune disease Ig G against desmosome
By immunoflourscent technique, there is netlike pattern of intercellular IgG deposits at the sites of acantholysis
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Pemphigus vulgaris [ bulla rupture easily
and will be covered by dried serum and crust.]
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Pemphigus vulgaris [ Suparabasal bulla ]
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Acanthocytes - Acantholysis:
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Deposition of IgG and Complement along the cell
membrane, giving a Net appearance.
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Bullous Pemphigoid.Affects skin & commonly the mucous membranes (in 30%
of cases).
Characterized by subepidermal, nonacntholytic tense
blisters.
Also caused by type II hypersensitivity reaction(Ab against
hemidesmosome)
By Immunoflourscent shows linear deposits of
Immunoglobulins along the basement membrane zone.
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BULLOUS PEMPHIGOID(Tensebulla
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BULLOUS PEMPHIGOID
Eosinophils at the DE junction.
Subepidermal cleft
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BULLOUS PEMPHIGOID - histology
Subepidermal separation
Inflammation characterized by eosinophils
Intact epidermal layer.
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BULLOUS PEMPHIGOIDIgG and complement staining pattern [ Linear Deposit ]
Antibody against bullous pemphigoid
antigen in basement
membrane causing
subepidermal
separation
Type II
hypersensitivity
reaction.
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Dermatitis heptiformis
Affects male > female, at 3rd- 4th decades of life.
In 10%- 20% of cases associated with celiac disease and respond to glutean free diet
Pathogensis: IgA Anti-gluten Ab cross react with basement membrane proteins.
Clinically: bilateral symmetrical urticarial plaque and vesicles on extensor surfaces , elbows knees upper back
Vesicles are frequently grouped as are those of true herpes virus therefor called “herptiformis”
Mic.Characterized by subepidermal bullae.
By immunoflourscent, there are granular deposits of IgA in the tips of dermal papillae.
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Dermatitis Herpetiformis
• Extremely pruritic, small vesicles
• Associated with Celiac disease.
• IgA Anti-gluten Ab cross react with
basement membrane proteins.
• Gross: Intense Itchy,
small, erythematous,
papules, small blisters
in groups. (sub
epithelial)
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Site; extensor surface elbow, knees upper back.
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Dermatitis Herpetiformis Micro: supepidermal,
neutrophilic microabscesses in dermal papilla.
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The inflammatory cells within the vesicle are PMN's. Slight basophilia is seen in the partly necrotic dermal
papilla.
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Granular staining of dermal papillae with IgA in tip of dermal papillae
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Pemphigus vulgaris Pemphegoid
Younger patient affected Elderly are affected
Mucosal involvement: uncommon Is common 1/3 of cases
Ab against desmosome Ab against hemidesmosome
Intraepidermal (superficial ) blister Subspidermal (deep blister
Blisters are flaccid and rupture easily Blisters tense and firm
Acantholysis No acantholysis
IF: net like IgG Linear IgG
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Dermatopathology1. Acute Inflammations:
• Urticaria,
• Acute Eczema,
• Erythema Multiforme.
2. Chronic Inflammations:
• Chronic Eczema,
• Psoriasis,
• Lichen planus.
3. Infections
• Bacterial (Impetigo),
• Fungal(tinea) &
• Viral(warts).
•
1. Blistering Diseases
• Pemphigus,
• Pemphigoid,
• Dermatitis herpetiformis.
5. Neoplastic:
• Benign:
•Nevi,
•Malignant:
•SCC,
• BCC,
•Melanoma.
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• The most common benign skin tumor is nevus
• Microscopically It composed from:
round to oval cells that grow in nests along dermoepidermal junction (junctional nevi)
• that may grow into the underlying derms (compound nevus) &
• in older lesions only the dermal nests persist (pure dermal nevus).
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Junctional Nevus:
• Small, flat, symmetric, uniform lesions.
• Cluster of melanocytes at DE junction. (arrow)
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(compound) melanocytic nevus
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Dermal Nevus
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Malignant Tumors of Skin
Squamous Cell Carcinoma
basal cell carcinoma
Melanoma
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Malignant tumors of skin
1. Squamous cell carcinoma:
Etiology:
1. Sunlight (ultraviolet).
2. Industrial carcinogens (tar, oils)
3. Chronic ulcers.
4. Sinus of chronic osteomyelitis
5. Old burn scars
6. Arsenic compounds
7. Ionizing radiation
8. Tobacco (squamous cells carcinoma)
9. Immunocompromised patients.
10. Xeroderma pigmentosum (defect in DNA repair gene)
Gross:I. In situ carcinoma is usually sharply defined red plaques.
II. Invasive carcinoma is nodular lesion, sometimes ulcerate.
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Clinical Features of SCC
• invasive lesions are nodular, show variable scale, and may ulcerate
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Mic:
I. In situ carcinoma: atypical malignant cells are involved
the all levels of epidemis without break through the basement membrane.
II. Invasive carcinoma: malignant cells are break
through the basement membrane.
Invasive carcinomas show variable degrees of differentiation ranging from tumors well differentiated carcinoma which is formed by polygonal squamous cells arranged in orderly lobules that exhibit numerous areas of keratinization to a highly anaplastic carcinoma that is formed by rounded cells with many zones of necrosis & dyskeratosis.
.More aggressive than BCC and can metastasise if untreated. Less than 5% of squamous cells carcinoma shows metastases to regional lymph nodes
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Morphology of SCC
• Squamous cell carcinoma in situ is characterized by atypical cells at all levels of the epidermis, with nuclear crowding and disorganization.
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Invasive Squmous cell carcinoma
• When these cells break through the basement membrane, the process has become invasive
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• The neoplastic cells extend downward into the dermis forming keratin pearls.
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Tumors of Skin
Squamous Cell Carcinoma
basal cell carcinoma
Melanoma
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2. Basal cell carcinoma(BCC)The most common tumor arising on the sun exposed sites in older people
slowly growing tumors that are locally invasive but rarely metastasizing.
Has the same etiology of Squamous cell carcinoma(chronic sun exposure and in lightly pigmented people).
• Increase risk: [same as squamous cell carcinoma]
1. immunosuppressed patients as a result of chemotherapy or organ transplantation,
• 2- xeroderma pigmentosum [inherited defects in DNA repair].
Gross: Pearly papules, often containing prominent, dilated subepidermalblood vessels.
Sometime contain melanin pigment (called pigmented Basal cell carcinoma).
Advanced lesions may ulcerate & extensively invade the local bone or facial sinuses (rodent ulcer).
• Mic: tumor cells are resemble the normal basal cells of epidermis,
• with peripheral palisading,
• Clefting between tumor nest and stroma. Mucinous stroma
.
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Clinical Features of BCCPapule or nodule, often containing prominent, dilated subepidermalblood vessels (telangiectasia)
Rodent Ulcer-Ulcerated BCC
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BASAL CELL CARCINOMA
nests of basaloidcells(small cell, scant basophilic cytoplasm)
Hyperchromatic nuclei
Peripheral palisading(Peripheral
tumor cell nuclei align in the
outermost layer (palisading) with
separation from the stroma
Clefting between tumor andstroma.
Mucinous stroma
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Peripheral palisading
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Malignant Melanoma.Malignant tumor of melanocyteMelanoma is less common, but much more deadly than basal cell
carcinoma or squamous cell carcinomaSites: skin, oral cavity, anogenital areas, esophagus, meninges, &
eyes.
Etiology:
1. Sunlight, More common in fair skinned persons2. Preexisting nevus (dysplastic nevus)
3. Industrial carcinogens
4. Hereditary & familial factors
Gross & clinical features:Warning clinical signs of malignant melanoma; are
1. Enlargement of preexisting mole
2. Itching & pain in preexisting mole
3. Development of new pigmented lesion during adult life
4. Irregularity of borders of pigmented lesion
5. Variegation of color within the pigmented lesion
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Melanoma • sunlight plays an important role in the
development of melanoma
• More common in fair skinned persons
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Mic: there are two patterns of growth in malignant melanoma.1. Radial pattern of growth: represent the initial tendency of
malignant melanoma to grow horizontally within the epidermis & superficial dermal layers, for long period of time, such pattern of growth have no tendency of metastasis & angiogenesis.
2. Vertical growth: with the time melanoma now grows downward into the deeper dermal layers as an expansilemass, with high tendency of metastasis & angiogenesis.
Sites of metastasis: regional lymph nodes, liver, lung, brain, & heart.
Characteristics of melanomas cells:
1. Melanoma cells are larger than cells of nevus
2. Malignant cells have large nuclei, with irregular contour, & clumped chromatin
3. Have prominent eosinophilic nucleoli
4. Cells grow either in nests or single.
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Clinical Criteria for Dx
ABCDE CriteriaAsymmetry of moleBorder irregularityColour variegationDiameter > 6mmElevation
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Melanoma Clinical Features: note ABCD..
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• the microscopic appearance of a malignant melanoma:
• Large polygonal cells have very pleomorphic nuclei which contain prominent eosinophilic nucleoli.
• The neoplasm is making brown melanin pigment.