Our team of specialized thinkers design and execute strategic communications programs that make our clients’ technologies, products, and services known, understandable, and approachable.

www.lavoiehealthscience.com

DOMAIN EXPERTISE

• RARE DISEASE • CAR-T • GENE THERAPY AND GENETIC THERAPEUTICS • IMMUNO-ONCOLOGY • ONCOLOGY • CNS • NEURODEGENERATION • MED TECH & DEVICES

• OPHTHALMOLOGY • PRECISION MEDICINE • RNA • AUTOIMMUNE DISEASES • CELL THERAPY • CRISPR • REGENERATIVE MEDICINE • LYSOSOMAL DISEASES

We help our clients extend visibility and optimize value for their

technologies, products, and services. INTEGRATED COMMUNICATIONS • Strategy Consulting • Investor Relations & Corporate Communications • Public Relations & Marketing HIGH-TOUCH, AWARD WINNING AGENCY • Over two decades in business offering specialized expertise in health and science innovations • 360° approach to media relations, social/digital, in-person events and presentations • Building shareholder value for organizations and market value for assets • Deep Wall Street buy-side and sell-side relationships spanning over 25 years • Certified in healthcare communications compliance • Top 25 independent healthcare communications agency (O’Dwyer’s 2020) • Boston Business Journal’s The List: Largest PR Firms in Mass. • INC. 5000 Hall of Fame – Fastest Growing Private Companies • PharmaVOICE 100 most inspiring people inspiring people in the life sciences industry – Donna LaVoie • PR News’ Agency Elite 100 • 50+ awards GLOBAL REACH AND SCALE IN HEALTH Through our alliance with the DAS Group of Companies, a division of Omnicom Group, Inc. (NYSE:OMC), LaVoieHealthScience provides its clients with extended reach and global capabilities.

This alliance allows us to remain true to our innovative company client base, solving complex communications challenges, and extending the reach of our clients. We offer strategic thinking and open key markets to clients as they develop and grow their companies. STRATEGIC VALUATION ASSESSMENT Through our alliance with Bioscience Valuation BSV GmbH (“BSV”), we provide strategic valuation assessments for life science companies.

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INTEGRATED COMMUNICATIONS

Our vision is to provide the very best strategic, integrated communications to health and science clients worldwide by leveraging our strategic relationships and providing industry-tested pragmatic counsel and execution.

Proven Methodologies Through our trademarked methodologies, LHS provides its clients with a proven process for establishing its foundational positioning and messaging (The LHS Immersion®) and blueprint plan, all aligned to key stakeholders. The positioning is supported by LHS message testing and development of a strategic communications plan. Our LHS Fifteen-Slide Presentation® provides a foundational set of slides for telling your company’s story based on 15 core concepts.

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INTEGRATED COMMUNICATIONS

Strategy Consulting • LHS Immersion® positioning and messaging

(programs for established and emerging companies) • The LHS Fifteen-Slide Presentation® • The LHS Message Testing™ • Partnering and licensing representation • Market research • Crisis planning and execution Investor Relations & Corporate Communications • IPO communication planning and execution • Strategic counsel • LHS Reach™ targeting • M&A communications • IR analyst relations • Perception audit • Analyst days and KOL events • Meeting management • Investor outreach • Virtual meetings with investors and analysts • Crisis prevention and communications • Virtual roadshows and summits • Retail programs Public Relations & Marketing • Public relations strategy • Reputation management • Branding and messaging • Media relations • Speaker/media training • Executive visibility and thought leadership • Social media support • Brand communications • Advocacy relations • Health and disease awareness • Corporate materials • Video, web development, and SEO • Internal communications • Issues management and crisis preparedness • Measurement and analytics

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CASE STUDIES

Results • Increased awareness and understanding of company's value proposition • Developed new corporate communications assets including a

corporate profile video and investor presentation • Secured high profile institutional analyst coverage and created and

distributed 20 corporate and financial disclosures released within 3 months

• Coordinated more than 50 initial high-value 1-on-1 meetings with investors and potential business partners and arranged high visibility broadcast interviews with key reporters to further TFF leadership profiles

Our health science expertise uniquely positions us to help clients make their innovations known, understandable, and approachable to target audiences

through carefully executed strategies and plans.

INVESTOR RELATIONS

Challenge • Build investor relations credibility and

visibility for a recently public NASDAQ company with a novel technology for inhalant therapeutics to solve a major drug delivery challenge

LaVoieHealthScience Solution • Implemented the LHS Immersion®

and blueprint planning process to discover key messages and define visibility strategies

• Develop a “full charge” investor relations infrastructure program based on best practices to ensure disclosure, transparency, and investor confidence

• Use LHS Reach™ to aggressively extend company outreach within the institutional investment community

• Leverage LHS’ extensive capital markets access to introduce management to key analysts and bankers

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Challenges • International company on NASDAQ with broad

pipeline in neurodegenerative diseases • Impacted by recent industry trial failures in

Alzheimer’s disease • Seeking to raise visibility as a thought leader in

neurodegenerative area • Create visibility in national, business, and trade

publications in U.S. market LaVoieHealthScience Solution • Increase brand awareness throughout the U.S.,

aiming for high profile media outlets while building and cementing relationships with top journalists

• Position CEO as a major thought leader/expert in the neurodegenerative disease area

• Differentiate from competitors in the marketplace through careful, artful message crafting

PUBLIC & MEDIA RELATIONS

Results • Cohesive integrated communication

strategy plan with flawless execution • ~100 U.S. articles • Top mentions and original posts/articles in

Forbes, Reuters, PharmaVoice, Endpoints, FierceBiotech, In Vivo, BioWorld, Life Science Leader, BioSpace, Authority Magazine, and STAT

• Two thought leadership opinion/expert articles focused on the future of AD

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STRATEGIC COMMUNICATIONS & CORPORATE DEVELOPMENT

Challenge • Build awareness for a European

gene therapy viral vector technologies company targeting U.S. drug developers and investors

LaVoieHealthScience Solution • Revised messages, brand image,

and corporate materials • Created an investor presentation

based on The LHS 15-Slide Presentation® methodology

• Identified and conducted outreach to gene therapy developers

• Managed and supported SIRION Biotech roadshow and overall awareness campaign

• Drove awareness through increased news flow planning and media outreach

• Developed social media strategy, ongoing planning, and implementation

Results • Fourteen license agreements signed; LHS assisted with the first • U.S. revenue as percentage of total revenue increased from 6%

in 2012 to 67% in 2019 • Company revenue increased from approx. $648k in 2012 to

approx. $11M in 2019 • Established company as a high value partner with

differentiated value proposition • Increased social media presence with strategic planning and

content • Developed awareness and relationships with U.S. media

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PUBLIC RELATIONS

Results • Secured 13 one-on-one interviews with

leading publications • 12 original articles and 1 podcast were

written on the launch with 100% positive sentiment and on target messaging

• Press release received 6,370+ views, generated 54 syndicated articles and 172 pickups.

• Total program included 46.8M earned impressions

• Won Silver Bell Ringer Award for Media Placements Digital/Print Series

Challenges • Xontogeny and Perceptive Advisors formed a

new VC fund known as the Perceptive Xontogeny Venture (PXV) Fund

• Build recognition of the PXV Fund brand and the differentiated Xontogeny model

• Maximize impact with business and industry press LaVoieHealthScience Solution • Create positioning and messaging for the PXV

Fund that differentiated it from other traditional early-stage VCs

• Developed high impact press release and media outreach strategy including non-exclusive, embargoed access for highly desired media outlets

• Pitched fund announcement to important media targets and many “out of the box” outlets

• Included limited access interviews for key Perceptive Advisors team members

• Thought leadership series across targeting platforms

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Val Kennedy CONTENT EDITOR/ STRATEGIST

Results • On-message coverage in relevant publications including:

Medgadget, Proactive Investors, Interventional News, Drug Delivery Business, and more with 15 reporter responses to embargo and 5 interviews conducted

• Twitter ad generated 8,076 impressions and 71 engagements • 40 attendees at satellite session on TPT payment status at SIO

conference • Advertorial placed in Interventional News (12,200 subscribed

readers) and 27,000+ views on website • Placed CEO as panelist at BIO CEO & Investor Conference • Won Bronze Bell Ringer Award for Healthcare Launch Campaign

Challenges • Launch of a new drug delivery device which

received highly coveted transitional pass-through payment (TPT) status from the Centers for Medicare and Medicaid Services (CMS)

• Lack of understanding of the benefits of the TPT process among key stakeholder audiences

LaVoieHealthScience Solution • Create differentiated positioning and

messaging for the launch and promote via media outreach

• Educate key stakeholders with earned and paid approach on the unique advantages of TriNav system and its elite CMS TPT status

• Utilize medical meetings to promote awareness with media and Interventional Radiologists

• Develop Twitter ad using geotargeting around Society of Interventional Oncology (SIO) conference

• Identified additional relevant advertorial opportunities

NEW PRODUCT LAUNCH

UPDATED2/21

www.lavoiehealthscience.com

Agency Headquarters 20 Park Plaza, Suite 312 Boston, MA 02116 New York Region 646.491.7042 South Florida Region 617.865.5557

General Inquiries: info@lavoiehealthscience.com New Business Inquiries: newbusiness@lavoiehealthscience.com

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Global Alliance with OmnicomPublicRelationsGroup