detoxing heavy metals integrative approaches in medicine
TRANSCRIPT
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Detoxing Heavy MetalsIntegrative Approaches in Medicine
Harold Ravins, DDSHarold Ravins, DDSThe Center for Holistic DentistryThe Center for Holistic Dentistry
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Advances in Holistic DentistryAdvances in Holistic Dentistry
Find hidden infections in the mouth– Not considered usual dental problems– Not the primary indicator of a health problem
How?– Good quality X-rays Bite analysis T-scan– Comprehensive exam Bio-electrical Impedance– Dental acupuncture Heavy metal fecal test– Energetic testing Other detection methods
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Determination of Hg ToxicityDetermination of Hg Toxicity
Practical experience– 200 patients tested for heavy metals – 99% showed toxic levels of Hg
Discuss harmful effects of Hg to patients Give them educational literature Recommend fecal test Patients usually decide for themselves to have
amalgams removed
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Mercury Situation in DentistryMercury Situation in Dentistry
ADA claims no scientific proof of leakage into the body
However:– FDA agrees that Hg is very toxic– Dentists are required comply with hazardous
waste remove for Hg– Test show high levels with amalgams– Amalgams banned in Europe– $2500 fine by EPA if office windows are opened
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Shouldn’t we be concerned about the established relationship between toxins, cancer, heart disease, and other chronic illnesses?... Especially now that cancer is the #1 cause of death and the #1 cause of death among our children ages 1-15!
Why are we not addressing TOXINS!
Toxins?Toxins?
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What can we do?What can we do? Inform ourselves as health care providers
what toxins are and how they damage biological systems
Develop ways to evaluate, measure and inform our patients
Develop simple, safe and effective means to do this
Let’s practice healing …Not Medicating
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In the NewsIn the News 45 States Have Issued Mercury Advisories: coal-fired
power plants– Source: News-Leader.com – Quoted from the EPA and Department of
Natural Resources
Mercury and Fish Advisories Issued for Nine More Waterways– Source: De Ridder Beauregard Daily News –Quoted from The Louisiana
Department of Health and Hospitals Environmental Quality
Dangerous Lead Levels Found in More Homes– Source: Cincinnati Enquirer – Quoted from the EPA
Lead Linked to Premature Deaths in Adults: Early Exposure = 46% Higher Mortality– Source: The Baltimore Sun – Quoted from the CDC
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In the News In the News (Cont’d)(Cont’d)
California Sues Over Heavy-Metal Fish– Source: Business Report – Quoted from the California Attorney General
Lead Poisoning Alert– Source: pediatrics.about.com – Quoted from the FDA
Mercury Air Level is Worry for Ohio– Source: Akron Beacon Journal – Quoted from the EPA
EPA Doubles Estimates of Children with Mercury in Blood
– Source: Access North Georgia – Quoted from the EPA
Mercury List Longer Each Year– Source: The News-Press – Quoted from Dept. of Environmental Protection
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In the News In the News (Cont’d)(Cont’d)
CDC Vaccine Data Leads Scientists to Shocking Discovery: Possible Autism/Neurological Link– Source: Yahoo News – Quoted from the CDC
Chromated Copper Arsenate: CCA-Treated Lumber Poses Danger from Arsenic– Toxicol Sci. 2004 Jun;79(2):287-95
EPA: Amount of Toxins in Air, Water and Land Increased at Record Rate…– Source: Axis of Logic – Quoted from the EPA
FDA Warns Pregnant Women to Limit Tuna– Richard Simmons -Los Angeles Times 3/2004
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Major Heavy Metal ToxinsMajor Heavy Metal Toxins
Mercury Lead Cadmium Aluminum Arsenic Nickel
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Metal Toxicity MechanismsMetal Toxicity Mechanisms
Neurotoxic: damage brain structures; lower IQ; down-regulates dopamine activity
Nephrotoxic Immune dysregulation Cardiovascular Bone & tissue deposits Dysbiosis; fungal mycotoxins Endocrine disruption; thyroid, adrenal, sex h Cognitive problems; ADHD, Alz, depression Metabolic dysregulation; energy decline, etc
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Health Care ProfessionalsHealth Care Professionals Education for your patients’ sake
– A plea to stay abreast of new modalities for patient care
• Be informed of what our industrialized society is doing to our patients’ health
• Be open to complementary treatments
• New diagnostic tests to assess toxicity
• Know that your patients are more informed and asking for our help for treatment and prevention of toxic pollutants
• Look toward innovation, science, research and validation of the best methods
to give your patients what they demand
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Time-Lapse Microphotography of Toxic Effects Time-Lapse Microphotography of Toxic Effects on Human Cellson Human Cells
Normal Cell GrowthNormal Cell Growth Toxic Cell Damage and DeathToxic Cell Damage and Death
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Lead-induced Hypertension: Lead-induced Hypertension: Role of Oxidative StressRole of Oxidative Stress
Chronic, low-level lead exposure causes hypertension in both animals and humans
Inactivation of endogenous nitric oxide Reactive oxygen species (ROS) lowers enzyme activity Functional deficiency in nitric oxide Increase sympathetic activity & plasma norepinephrine Lead-induced inhibition of vascular smooth muscle ACE, angiotensin II, aldosterone, thromboxane
Ref: Vaziri ND, “Lead-induced Hypertension: Role of Oxidative Stress,” Ref: Vaziri ND, “Lead-induced Hypertension: Role of Oxidative Stress,” Curr Hypertens Rep. 2004 Aug;6(4):314-20Curr Hypertens Rep. 2004 Aug;6(4):314-20
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Random Blood Sampling of Dr. Ellithorpe’s Random Blood Sampling of Dr. Ellithorpe’s Patients: Presence Excessively High Heavy MetalsPatients: Presence Excessively High Heavy Metals
Per
cent
of
Pat
ient
s
N=251100
2217
0
25
50
75
100Presence of Heavy Metals
Elevated Heavy Metals
Potentially Toxic Heavy Metals
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Sources of Toxic Metals - Sources of Toxic Metals - AluminumAluminum
Eating small amounts of aluminum in food Breathing aluminum dust in air Drinking contaminated water near:
– Waste Sites– Manufacturing plants– Areas naturally high in aluminum
Antacids Cooking utensils - minimal
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
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Sources of Toxic Metals - ArsenicSources of Toxic Metals - Arsenic
Eating food, drinking water or breathing air containing arsenic
Breathing contaminated air Breathing sawdust, burning smoke Living near hazardous waste sites Living near high levels of arsenic in rock
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
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Sources of Toxic Metals - CadmiumSources of Toxic Metals - Cadmium
Breathing contaminated air– Battery manufacturing– Metal soldering or welding
Eating foods containing cadmium:– Shellfish, Liver, Kidney meats
Breathing cigarette smoke Drinking contaminated water Breathing contaminated air
– Burning of fossil fuels, municipal waste
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
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Sources of Toxic Metals - MercurySources of Toxic Metals - Mercury
Eating fish or shellfish Breathing vapors from:
– Spills, incinerators, industry
Dental work, medical treatments Breathing contaminated air or skin
contact:– Dental, health services, chemical, other
industries using mercurySource: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
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Sources of Toxic Metals - LeadSources of Toxic Metals - Lead
Eating food, drinking water that contains lead Lead base paints Working where lead is used Health care products containing lead Hobbies which lead is used:
– Glass staining
Source: Agency for Toxic Substances & Disease RegistrySource: Agency for Toxic Substances & Disease Registry
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Global Chronic Low Level Metal ToxicityGlobal Chronic Low Level Metal Toxicity
Recognized by:– US Environmental Protection Agency (EPA)– Food & Drug Administration (FDA)– Centers for Disease Control (CDC)– State Health Departments
Treatment standards are needed– Preventative measures– Comprehensive medicine with proven results– Reduction of crisis management
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There are NO Safe Levels of There are NO Safe Levels of Heavy MetalsHeavy Metals
Low levels are becoming dangerous Low levels accumulate Low levels become stored Low levels become higher Multiple toxins compound the danger
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Death Rates of Participants with Low Death Rates of Participants with Low Pb Levels in NHANES III SurveyPb Levels in NHANES III Survey
17
39
46
68
46
0
10
20
30
40
50
60
70
80
10 20 30
All CausesCardiovascular Diseases Cancer
Per
cent
Incr
ease
in M
orta
lity
Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality. Arch Intern Med, 2002, 162: 2443-2449
Blood Lead Levels (µg/dL)
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NHANES-III Survey ResultsNHANES-III Survey Results
Estimated 29 million people (15% of adult population over age 20) had Pb levels of at least 20 µg/dL from 1976-1980.
30 µg/dL Pb is considered toxic
Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality.Arch Intern Med, 2002, 162: 2443-2449.
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Heavy MetalsHeavy Metals
Heavy metals and other toxins cause cell membrane damage through the production of free radicals and oxidative stress.
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Human Cell SchematicHuman Cell Schematic
Cell Membrane
Mitochondria
Nucleus
Cytoplasm
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The cell contains all of Life’s processes. Of particular importanceIs the mitochondria , which are the sites of energy production
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The Cell and Mitochondria Membrane
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Cell MembraneCell Membrane
Mitochondria MembraneMitochondria Membrane(Outer)
Mitochondria MembraneMitochondria Membrane(Inner)
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Oxidative DamageOxidative Damage
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Oxidative Damage to Cell Oxidative Damage to Cell MembranesMembranes
Healthy MembraneHealthy Membrane Oxidative Stress DamageOxidative Stress Damage
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Lipid layer repaired
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Chelation TherapyChelation Therapy
Modes– DMPS; IV, transdermal– DMSA; oral– Penicillinamine– EDTA
• IV• Oral• Rectal Suppositories
– Others • Oral supplements
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Recommended ModalityRecommended Modality
CaNa2 EDTA Chelation Suppositories
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DetoxaminDetoxamin®® CaNa CaNa2 2 EDTA EDTA SuppositoriesSuppositories
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Why CaNaWhy CaNa2 2 EDTA Suppositories?EDTA Suppositories?
Non-invasive Safe Broad specificity metal chelation Easy to use Low cost Less time consuming Convenient
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CaNaCaNa22 EDTA Chelation (Detoxamin) EDTA Chelation (Detoxamin)
FDA approved for lead detoxification Also chelates other metals
– Suppository form• Can be used in combination with IV, oral,
transdermal, topical or as stand alone therapy
– IV Chelation• Expensive• Time consuming – 3-5 hours• Invasive• Greater risk
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Pharmacokinetic Pre-clinical ResultsPharmacokinetic Pre-clinical Results
Over 8 hoursOver 8 hours1.5 hours1.5 hoursHalf-LifeHalf-Life
13.613.63.73.7Blood to Blood to Tissue RatioTissue Ratio
36.3 %36.3 %100%100%Absolute Absolute Bioavailability Bioavailability
Rectal Rectal (Suppositories)(Suppositories)
IntravenousIntravenous
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Specimen Collection SummarySpecimen Collection Summary
Pre-Detoxamin CaNa2-EDTA Suppositories– Comprehensive stool analysis with Fecal Metals analysis
Post-Detoxamin CaNa2-EDTA Suppositories– Comprehensive Stool Analysis with Fecal Metals analysis
after the 90th suppository
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ProtocolProtocol
Challenge for Heavy Metals– 1.5 gm CaNa2 EDTA Detoxamin suppositories
• 2 - 750 mg suppositories at night– Fecal test - send to Doctors Data, St Charles, Illinois,
(800-323-2784) Typically several heavy metals are present
– Average 6-12– Elevated 1-4
Recommend Detoxamin suppositories at bedtime– Monday through Thursday nights x 90 suppositories– Consistently used – will be finished in 6 months
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Protocol (Cont’d)Protocol (Cont’d)
Repeat the same challenge and compare results
Maintenance – 1 suppository last 5 nights of each month
Recommend Vitamin/mineral supplement– RepairACell or one of your choice
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Why Detoxamin: CaNaWhy Detoxamin: CaNa2 2 EDTA EDTA Suppositories?Suppositories?
Clinically proven Unparalleled safety EDTA - US FDA approved for Pb detox Consumer friendly Low cost Can treat large patient population, home use Less time consuming than IV chelation Broad specificity metal chelation Easy to use and convenient Effective in children, adolescents and adults
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Comparison of IV Chelation and Comparison of IV Chelation and DetoxaminDetoxamin
YesYes Clinically proven
NoYes Easy to administer
NoYes Greater risk
NoYes Expensive
NoYes Time consuming
NoYes InvasiveDetoxamin
IV Chelation
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Detoxamin SafetyDetoxamin Safety
Comprehensive Metabolic Panel– Albumin - Total Protein– Total Bilirubin - Sodium – Calcium - AST (SGOT)– Chloride - Urea Nitrogen (BUN)
– Creatinine, Serum - Bicarbonate (CO2)
– Glucose - ALT (SGPT)– Alkaline Phosphatase - C-Reactive Protein– Potassium
No statistical difference in above lab parameters between pre and post treatment with Detoxamin in all subjects
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Practical Clinical Case StudyPractical Clinical Case Study
NiPbHgCdDate
1327181.02/05
17272.61.02/04
9.543301.75/03
55 y/o 55 y/o • • W • F • 131 lbs. • School Teacher • Chronic LBP • Fatigue • HypothyroidW • F • 131 lbs. • School Teacher • Chronic LBP • Fatigue • Hypothyroid
Outcome: 7/04 – Excellent energy • Exercise 3x/day – water Outcome: 7/04 – Excellent energy • Exercise 3x/day – water aerobics • Back pain stable • Reduced need for medications.aerobics • Back pain stable • Reduced need for medications.
Patient K.MPatient K.M..
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Practical Clinical Case StudyPractical Clinical Case Study
42 y/o 42 y/o • W • W •• F • 145 lbs. • Photographer • Fibromyalgia • Chronic Fatigue F • 145 lbs. • Photographer • Fibromyalgia • Chronic Fatigue •• HypothyroidHypothyroid
Outcome: 11/04 – Energy good • Exercises daily (45 min.) with Outcome: 11/04 – Energy good • Exercises daily (45 min.) with mild to moderate pain of fibromyalgia • Increased daily activitiesmild to moderate pain of fibromyalgia • Increased daily activities
NiHgPbCdArDate
188.9123.2455/03
25157.42.14.512/02
4924202.52208/02
F.K.F.K.
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Practical Clinical Case StudyPractical Clinical Case Study
7.7163.80.75/04
1.6209.81.410/03
12121.61.012/04
3.6184.40.92/03
NiPbHgCdDate
8.4275.21.210/02
52 y/o 52 y/o • • M • 175 lbs. • Electrician • Chronic Anxiety Panic Attacks • Hypertension • LBPM • 175 lbs. • Electrician • Chronic Anxiety Panic Attacks • Hypertension • LBP
Outcome: 10/04 – Anxiety greatly improved • Reduced need for Outcome: 10/04 – Anxiety greatly improved • Reduced need for auxiolytic medication • Improved BP • Reduced anti-hypertensive auxiolytic medication • Improved BP • Reduced anti-hypertensive medication • LBP improved • Exercises daily (30 min.)medication • LBP improved • Exercises daily (30 min.)
Patient M.O.Patient M.O.
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Detoxamin Excretion of Toxic Metals in FecesDetoxamin Excretion of Toxic Metals in Feces
.1
.5
.31
.37
.15 .16
.72*
.56
.93*
.44*
0
0.2
0.4
0.6
0.8
1
Arsenic Lead Mercury Cadmium Uranium
Day 0 Cumulative Day 3 + Day 90
*Significantly different from Day 0 (p<0.05)
Mea
n V
alue
sm
g/kg
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Detoxamin Excretion of Toxic Metals in Detoxamin Excretion of Toxic Metals in FecesFeces (Cont’d)(Cont’d)
6.2
12.7*
0
2
4
6
8
10
12
14 Day 0
Cumulative Day 3 + Day 90
Mea
n V
alue
mg/
kg
*Significantly different from Day 0 (p<0.05)
NickelNickel
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Detoxamin Excretion of Toxic Metals in UrineDetoxamin Excretion of Toxic Metals in Urine
5.5
15.6
1.8 1.73.6
5.84.9
1.3.5
10.1
13.5
36.6
0
5
10
15
20
25
30
35
40
Aluminum Arsenic Lead Mercury Cadmium Nickel
Day 0
Cumulative Day 3 + Day 90
Mea
n V
alue
sµ
g/g
crea
tinin
e
*Significantly different from Day 0 (p<0.05)
*
**
* *
*
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Detoxamin SafetyDetoxamin Safety
Comprehensive Metabolic Panel– Albumin - Total Protein– Total Bilirubin - Sodium – Calcium - AST (SGOT)– Chloride - Urea Nitrogen (BUN)
– Creatinine, Serum - Bicarbonate (CO2)
– Glucose - ALT (SGPT)– Alkaline Phosphatase - C-Reactive Protein– Potassium
No statistical difference in above lab parameters No statistical difference in above lab parameters between pre and post treatment with Detoxamin between pre and post treatment with Detoxamin in all subjectsin all subjects
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Detoxamin Safety Detoxamin Safety (Cont’d)(Cont’d)
Observations within study– Dosage form is gentle– Little biological burden– In general, very well tolerated
Historical events– Over 450,000 doses administered within the past
five years• Minor complaints with first few applications
– Loose stools– Rectal gas – Headache – Lethargy– Joint pain
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Detoxamin Clinical Pilot Study SummaryDetoxamin Clinical Pilot Study Summary
Significant excretions observed– Fecal
• Ar, Pb, Cd, Ni
– Urine• Ar, Pb, Hg, Cd, Ni
Average change in pre and post DMSA– Fifty percent for Al, Ar, Pb, Hg, Ni – No difference with Cd
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NHANES-III Survey ResultsNHANES-III Survey Results
Estimated 29 million people (15% of adult population over age 20) had Pb levels of at least 20 µg/dL from 1976-1980.
30 µg/dL Pb is considered toxic
Ref: Lustberg, Mark and Silbergeld, Ellen. Blood lead levels and mortality.Arch Intern Med, 2002, 162: 2443-2449.
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Effects of Detoxamin on Elevated Effects of Detoxamin on Elevated Lead Urine Levels in ChildrenLead Urine Levels in Children
In connection with Columbia and Fordham U Purpose: To demonstrate gradual lead reduction
in blood and urine Conducted in Dominican Republic
– Residential neighborhood near battery recycling plant– 20 children identified with blood levels over 10 µg/dL– Initial mean blood determination of 66.6 µg/dL Pb– Note: Blood levels of > 10 µg/dL are of CDC concern– Treatment with 1000mg Detoxamin suppositories
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Effects of Detoxamin on Elevated Lead Effects of Detoxamin on Elevated Lead Urine Levels in ChildrenUrine Levels in Children
4.2
61.45
9
22.7
0
20
40
60
80
100
0 1 10 20 30
Pre-Treatment Baseline
After 1st Suppository 10 Days of Suppository
10 Days After Suppository 10 Days Additional Suppository
325.6
µg/
dL
Treatment Day
N=20
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Effects of Detoxamin on Elevated Lead Effects of Detoxamin on Elevated Lead Urine Levels in Children - SummaryUrine Levels in Children - Summary
Significant excretion of Pb was observed after only one initial dose of Detoxamin (325.6µg/dL or 78 times more Pb excreted above baseline of 4.2µg/dL)
Gradual Pb excretion occurred continually of a 30 day period
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Detoxamin Instructions for useDetoxamin Instructions for use
Administration– Self application rectal suppository– One per evening or one every other evening– Evacuate bowels before application– Three to six months duration
Recommendations– Eat evening meals 3-4 hours prior to Detoxtamin
• Protein rich with low sugar content– Take quality multi-vitamin/mineral supplement in AM
Maintenance– Six Detoxamin suppositories per month
For more information call 1-877-656-4553 – www.Detoxamin.com
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Effects of Detoxamin on Elevated Effects of Detoxamin on Elevated Lead Urine Levels in ChildrenLead Urine Levels in Children
In connection with Columbia and Fordham U Purpose: To demonstrate gradual lead
reduction in blood and urine Conducted in Dominican Republic
– Residential neighborhood near battery recycling plant
– 20 children identified with blood levels over 10 µg/dL– Initial mean blood determination of 66.6 µg/dL Pb– Note: Blood levels of > 10 µg/dL are of CDC
concern– Treatment with 1000mg Detoxamin suppositories
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Comparison of IV Chelation and CaNaComparison of IV Chelation and CaNa2 2 EDTA EDTA SuppositoriesSuppositories
YesYes FDA approved
YesYes Clinically proven
YesYes Broad spectrum metal removal
YesNo Increased safety
YesNo Inexpensive
YesNo Quick and easy to use
YesNo Non-Invasive
Rectal
Suppositories
IV
Chelation