dhruti avlani - bilayer tablet
TRANSCRIPT
Presented By: DHRUTI AVLANI
Roll No.: 27720316018Reg No.: 162772310024M.Pharm, 1st Year, 1st SemesterNSHM Knowledge Campus, Kolkata – Group of Institutions
GUIDE: Dr.Sutapa Biswas Majee
Novel drug delivery system suitable for sequential release of two drugs in combination Separate two incompatible substances (heterogeneous)Sustained release (homogeneous) tablet in which one layer is immediate release (IR) as initial dose and the second layer is controlled release (CR) as maintenance dose [1].
Granulation 1
Homogeneous Type: Same drug with different release
pattern
Bilayer TabletPress
COMPRESSION
Granulation 2
Heterogeneous Type: Different drugs with same or different
release pattern
Drug 1 (IR)
Drug 1 (CR)
Drug 1
Drug 2
Compaction
Sieving
Granulates of API 1/2
Preblending
Blending (API 1)
Lubrication
Blend Layer 1
Compression layer 1
Dry
gr
anul
ati
onBl
endi
ng
Tabl
etti
ng
Preblending
Lubrication
Blend Layer 2
Compression layer 2 on
layer 1
HETEROGENEOUS BILAYER TABLET
BILAYER TABLET
Simple Compaction and Ejection
Blending (API 2)
API 1/2
Multiple Compaction and Ejection
A1 B1 C1 D1 E1
A B C D E
1.DUREDAS™ TECHNOLOGY (1 Immediate Release & 1 Controlled
Release Layer)
Controlled release
hydrophilic swellable matrix
The controlled
release layer remain intact
Hydrophilic polymer start to swell up by taking water from GI fluid
After swelling up, drug release occurs in a
controlled release manner
Immediate release layer
Release of the drug from the
immediate layer by diffusion
Controlled release matrix
DUREDAS™ TECHNOLOGY (2 Controlled
Release Layers) [2]
Solvent Influx
Hydrophilic Polymer
Mixture of Hydrophilic & Hydrophobic
Polymer
Hydrophilic polymer start to
swell up by taking water from GI fluid
Rate of swelling is
different for two layers
Drug release occurs at a slower rate from the
swollen polymer mixture
Drug Molecule
2. OROS® PUSH-PULL
TECHNOLOGY
3. DUROS TECHNOLOGY
4. PRODAS TECHNOLOGY [2]
Drug Layer
1Drug Layer
2
Delivery Orifice
Push Layer
Drug Laye
r
DRUG MAIN EXCIPIENT PRESENT IN EACH LAYER
REMARKS
IMMEDIATE RELEASE LAYER
CONTROLLED RELEASE LAYER
Indomethacin (Floating tablet)
Ac-di-sol(Super disintegrant)
HPMC K-4M(Rate controlling Polymer)
Releases the drug from fast release layer within 2 hours and followed by controlled release for 24 hours. Reduce dose frequency and improve patient compliance.
Zolpidem tartarate (Matrix tablet)
Ac-di-sol(Super disintegrant)
HPMC K-100M(Rate controlling Polymer)
Optimised formulation released more than 50% of drug within the first 30 minutes and remaining drug released could be extended upto 6 hours.
TRADE NAME CHEMICAL NAME MANUFACTURERALPRAX PLUS® Sertaline, Alprazolam Torrent
Pharmaceuticals Ltd.Newcold Plus® Levocetrizine HCl,
Phenylpropanolol-amine, Paracetamol
Piramal Healthcare Ltd.
DIUCONTIN-K® 20/250
Furosemide, Potassium chloride
T.C. Healthcare Ltd.
PIOKIND®-M15 Pioglitazone, Metformin HCl
Psychotropis India Ltd.
Revelol®-Am25/5 Metoprolol succinate, Amlodipine besylate
Ipca Laboratories Ltd.
Bilayer tablet is suitable for sequential release of two drugs in combination and also for controlled release tablet in which one layer is for immediate release as initial dose and the second layer is for controlled release or maintenance dose.
Bilayer tablet is an improved beneficial technology to overcome the shortcoming of the monolayer tablet. This technology avoids frequent administration of dosage form. Now a days such technology is used for co-administration of two drugs like anti-diabetic, anti-hypertensive, anti-inflammatory to the patients.
Conventional solid oral dosage forms are a traditional approach, but bilayer tablet is a novel approach that requires new machinery for manufacturing. The technique is cost effective, safe and reproducible.
1. Reddy P, Rao D, Kumar R. 2013. Bilayer technology- an emerging trend: A review. International Journal of Research and Development in Pharmacy and Life Sciences; 2: 405.
2. Balaji G, Ghana P, Karudampala S, Venkatesh B. 2013. Bilayer tablet: A review. International Journal of Research and Reviews in Pharmacy and Applied Sciences; 3: 488-506.
3. Nilawar P, Wankhade VP, Badnag DB. 2013. An emerging trend on bilayer tablet. International Journal of Pharmacy and Pharmaceutical Science Research; 3: 15-21.