DIABETES MELLITUS HOLISTIC NATURAL HEALTHCARE

Prof. Dr. Ananthan Krishnan Consultant Pharmacist & NaturopathDepartment of Research and StudyAK PHARMACY & NATUROPATHY CENTRE

Healing Diseases is Progressive Science

Preventing Illness is Ultimate WisdomProf. Dr. Ananthan Krishnan

Lecture presented at the Comprehensive Workshop on Diabetes ManagementOrganized by KPJ Healthcare University College28th & 29th August 2013Bayview Beach Resort, Batu Ferringhi, Penang

Holistic Natural Healthcare Model of Diabetes Mellitus Type 2

Introduction

To say that each human being yearns and prays for good health is to utter a platitude. Good health is what the people of the world want ; poor health, illness or injury is the dreaded of things , and no human being wants to be a victim of diseases.

Health is treasured and cherished by all, yet it is most often taken for granted . Only when health is lost, the desperation to heal oneself starts.To understand human health and how to remain healthy must be the pre-eminent duty of each human being.

One must learn to the best of his or her ability, every knowledge of what health is, how to maintain good health and prevent the early onset of illness in life.To know human health well , one has to understand the nature of the human being.

The Natural Healthcare and Healing Approach

BIO - ENERGENOMICS MODEL OF DIABETES MELLITUS

THE COSMIC PERPECTIVE

Philosophy, Concepts and Principles of Disease Existence : Diabetes Mellitus

Its Nature and Reality

Among the health disorders that abound in human society, resulting from the twin causes of genetic weakness

and improper management of human life process is Diabetes Mellitus Type 2.

First principle of Disease Existence is the cosmic fact that diseases and injury are natural realities, and their

existence is a natural phenomenon because the genomic imprint created at each new birth is unique and may have the

genetic weakness to cause diseases.

Second principle is that the quality of living one’s life has the potential to cause illness or injury. Diabetes Mellitus

arises largely from this twin causes.

If Diabetes Type 2 is a natural reality, how do we handle it.

It cannot be eliminated because we cannot simply change or replace defective genes.

At best we can prevent the early occurrence of the disease,reduce the morbidity and mortality associated

with the expression of the disorder.

Live the life that does not aggravate the geneticallyoriginated physiological and metabolic dysfunction.

Diabetes Mellitus is a genetic and life style driven complex metabolic disorders which is caused by

insufficiency of insulin production or insulin dysfunction.

Type 1 Diabetes ( insulin dependent ) is caused largely due to lack of functional beta cells in the pancreas and

they need exogenous supply of insulin.

Type 2 Diabetes Mellitus is unable to respond well to Iinsulin and can be treated with dietary changes,

exercise, stress management and medicinal remedies.

One of natural healing postulations of the pathogenesis of Diabetes Mellitus especially Type 2 is that a person with

deficient carbohydrate, lipid or protein metabolism has weak ability to repair free radical oxidative damage of cellular molecules, DNA, proteins and lipids leading to

altered cellular functions. In other words these people do not have the full antioxidant

power ability to destroy free radicals which are created in larger amounts in those whose blood glucose levels are

post prandially relatively high. The gravity of oxidative damage in such people is more severe

and there is every likelihood that many vital bio-chemicals including hormones such as insulin is damaged and rendered

not effective in reducing blood glucose and other related metabolic disorders.

The prolonged subtle oxidative damage in a compromised metabolic process leads to physiological complications.

Diabetic complications arise from the abnormalities produced in lipids and proteins from this free radical oxidative damage and

glycation.The targets of these free radical driven oxidative damage

include elastin, laminin, collagen and even insulin.These proteins are converted glycoproteins due to

hyperglycemia. The changes of these proteins in tissues such as lens, vascular walls, and basement membranes

are associated with the physiological and structuralcomplications of diabetes such as cataracts,

microangiopathy, atherosceloris , neuropathy, cardiomyopathynephropathy etc.

Advanced glycation end products are formed and accumulates in long lived molecules and generate abnormalities in cellular

and tissue functions. Iincreased vascular permeability in micro and macrovascular structures results in endothelial

dysfunction. AGE’s are also formed in nucleic acids and histones and may cause

mutations and altered gene expression.

FREE RADICALS – OXIDATIVE DAMAGE – GLYCATION

THE BIOMEDICAL ( ALLOPATHY ) MODEL

REPLACEMENT OF GENETICALLY ENGINEERED HUMAN INSULIN FOR THOSE WHO CANNOT PRODUCE ENOUGH INSULIN OR THOSE WHOSE CELLS DO NOT

RESPOND WELL TO INSULIN

INHIBIT / REDUCE THE ABSORBTION OF CARBOHYDRATE AT THE GIT LEVEL

EG : ARCABOSE

ENHANCE GLUCOSE UPTAKE USING BIGUANIDES EG : METFORMIN

STIMULATE BETA CELLS TO PRODUCE MORE INSULIN

GLIBENCLAMIDE

SENSITISE INSULIN RECEPTORS AVANDIA

HOW EFFECTIVE IS THE BIOMEDICAL MODEL THE MALAYSIAN OUTCOME SCENARIO

IN MALAYSIA, CURRENT STATISTICS ON THE OUTCOME OF THE ALLOPATHY BIO-MEDICAL MODEL OF TREATMENT

OF DIABETES MELLITUS TYPE 2

WITH MORE THAN 50,000 ALLOPATHY DOCTORS 335 HOSPITALS

30 MEDICAL COLLEGES WITH AN OPERATING BUDGET OF ABOUT RM 3 BILLION THE NUMBER OF DIABETICS IS STAGGERING ALMOST 3 MILLION PEOPLE IN A POPULATION OF 29 MILLION.

ONLY 15% OF THE 3 MILLION PEOPLE HAVE HBAIC READINGS BELOW 6.5

THIS ISSUE IS NOT APPROPRIATELY ADDRESSED BY THE MOH.

AT LEAST THERE SHOULD BE ABOUT 50% SUCCESS FOR A GOOD MEDICAL MODEL TO BE ACCEPTED.

WHY THIS FAILURE AND WHY NO PROPER ANSWER

THE EPISTEMOLOGY USED IN THE BIO-MEDICAL MODEL IS BASICALLY PHYSICAL AND DOES NOT COVER ALL ASPECTS AND

FACTORS THAT CREATES OR AGGRAVATES THE DISEASE.

THE NATURE OF THE HUMAN BEING HAS THREE INTER-RELATED ASPECTS OR COMPONENTS ANIMATING ENERGY, MIND ( ONTOLOGICAL)

AND BODY ( PHYSICAL )

BY IGNORING THE ONTOLOGICAL AND HOLISTIC ASPECTS THE CLINICAL POSITIVE OUTCOME WILL BE COMPROMISED

AND ONLY PARTIAL SOLUTION IS ACHIEVED.THE IATROGENIC PROBLEMS ASSOCIATED WITH

CHEMICAL THERAPY IS NOT ADDRESSED SUFFICIENTLY.

THE HOLISTIC NATURAL HEALTHCARE MODEL TAKES INTO CONSIDERATION THE ENERGY, MIND AND BODY ASPECTS.

THE ENERGY-MIND COMPONENTS HAS TO BE TRAINED AND CONDITIONED TO REGULATE THE EIGHT CRITICAL FACTORS

THAT AFFECT HEALTH AND THE GLYCEMIC STATE OF THE PERSON.

THE EIGHT MAJOR CRITCAL FACTORS THAT AFFECT HEALTH AND BLOOD GLUCOSE LEVELS :

GENOMIC STATUS DIET AND NUTRITION

PHYSICAL ACTIVITY AND EXECRCISE PHYSICAL, MENTAL AND EMOTIONAL STRESS

LIFE STYLE ENVIRONMENT ( BOTH PHYSICAL AND NON-PHYSICAL)

AGE DRUG TOXICITY / OXIDATIVE DAMAGE

THE NATURAL HOLISTIC MODEL FOR DIABETES MELLITUS TYPE2

REGULATION AND CONDITIONING OF THE MIND WITH A PROACTIVE FORECARING CONTINUOUS APPROACH WITH

MODERN MEDITATION AND YOGIC EXERCISE.

ASSUMPTION THAT EVERYONE HAS THE POTENTIAL TO DEVELOP DIABETES MELLITUS AND FORECARING PROACTIVE

SUSTAINING KNOWLEDGE EMPOWERMENT ARE INSTILLED INTO ALL PEOPLE FOR WELLNESS AND ILLNESS.

ENSURE THAT THE BODY IS OPTIMALLY NOURISHED WITH FULL SPECTRUM, BOTH MACRO AND MICRO – NUTRITION

WHICH WILL COVER THE CONTINUOUS NEED TO OPTIMISE THE VITAL BIOCHEMICAL BALANCE IN THE BODY TO ENSURE

THAT THE BODY IS PROETCTED FROM THE OXIDATIVE AND OTHER DAMAGE.

TO ENSURE THAT THE BODY, DESPITE GENETIC PREDISPOSITION TO DIABETES AND OTHER DISEASES

ARE GIVEN NUTRITIONAL PRODUCTS WHICH HAS THE FULL SPECTRUM OF NUTRITION AND VITAL BIO-ACTIVE

SUBSTANCES.

THE BODY HAS THOUSANDS OF BIO-CHEMICALS WORKING IN A COMPOSITE MANNER, IN UNISON WITH EACH OTHER

TO MAINTAIN GOOD PHYSIOLOGY AND METABOLISM.

BASED ON THIS POSTULATE, PRODUCTS FOR PREVENTION OF EARLY APPEARANCE OF THE DISEASE MUST CONTAIN THE FULL

SPECTRUM OF NUTRIENTS WITH AS MUCH ANTIOXIDANTS AS POSSIBLE AND ALL BIO-ACTIVE SUBSTANCES TO OPTIMSE

SUSTAINABLE HIGH EFFICIENT PHYSIOLOGY.

RANGE AND CATEGORIES OF MEDICINAL PRODUCTS AND THEIR SAFETY AND EFFICACY STATUS

NUTRITIONAL PRODUCTS

MINIMAL SAFETY

MODERATE SAFETY HERBAL PRODUCTS

CHEMICAL DRUGS

MAXIMUM SAFETY

HIGH IATROGENICITY

MINIMAL IATROGENICITY

HARDLY ANY IATROGENICITY

LIST OF COMMON INDIAN HERBAL PRODUCTS USED FOR DIABETES

1.ACACIA ARABICA ( BABHUL)ACTS AS A SECRETAGOUGE TO RELEASE INSULIN

2. AEGLE MARMELOS ( BENGAL QUINCE)EXHIBITS HYPOGLYCEMIC ACTIVITY AND PREVENTS PEAK

RISE IN BLOOD SUGAR IN GTT.3. ALOE VERA AND ALOE BARBADENISIS

STIMULATION OF SYNTHESIS AND RELEASE OF INSULIN FROM PANCREATIC BETA CELLS 4.AZADIRACHTA INDICA ( NEEM )

INCREASE OF GLUCOSE UPTAKE AND GLYCOGEN DEPOSITION

5 CASALPINA BONDUCELLAREDUCES BLOOD SUGAR THROUGH GLUCONEOGENSIS

6. CAPPARIS DECIDA REDUCES OXIDATIVE STRESS AND REDUCES DIABETIC

COMPLICATIONS

7 . COCCINIA INDICA REDUCES ENZYMATIC DAMAGE DUE TO DIABETES

8. EUGENIA JAMBOLANA ( INDIAN GOOSEBERRY)INHIBITS INSULINASE ACTIVITY

9. MANGIFERA INDICA INTESTINAL REDUCTION OF THE ABSORPTION

OF GLUCOSE10. OCIMUM SANCTUM (HOLY BASIL)

SIGNIIFICANT REDUCTION IN BLOOD SUGAR LEVELIN BOTH NORMAL AND ALLOXAN INDUCED DIABETIC RATS

11. PHYLLANTHUSS AMARUS REDUCED BLOOD SUGAR IN ALLOXANIZED DIABETIC RATS

12. PTEROCARPUS MARSUPIUMBETA CELL REGRANULATION, INSULINOGENIC AND COVERSION

OF PRO – INSULIN TO INSULIN IN VITRO STUDIES.

14. TINOSPORA CORDIFOLIA ANTI-HYPERGLYCEMIC IN ANIMAL MODELS

USED IN THE TREATMENT OF DIABETES IN AYURVEDIC MEDICINE

HERBAL DRUG FORMULATIONS 1. DIABECON

REPORTED TO INCREASE PERIPHERAL UTILIZATION OF GLUCOSE AND REDUCES OXIDATIVE STRESS

2. EPIINSULIN INCREASES INSULIN RELEASE, REDUCES DIABETIC

COMPLICATIONS 3.DIACARE BY ADMARK HERBALS

USED IN THE TREATMENT OF DIABETES 1 & 24. DIABETES DAILY CARE BY NATURES HEALTH SUPPLY

IMPROVES SUGAR METABOLISM 5. DIABETA BY AYURVEDIC CURE

ANTIDIABETIC FORTIFIED WITH IMMUNEMODULATORS

IN MALAYSIA LOCAL HERBAL PRODUCTS HAVE HARDLY

ANY CLINICALLY STUDIES IN REAL LIFE SITUATION.

HOWEVER HIGHLY ACTIVE MICRO-NUTRIENT FORMULATIONS USING COMPOSITE EDIBLE SEEDS HAVE BEEN DEVELOPED AT THE DEPARTMENT OF RESEARCH AND STUDY

AK PHARMACY AND NATUROPATHY CENTRE SINCE 2000.

SPECIFICALLY TWO COMPOSITE PRODUCTS ( NOT EXTRACTS )HAVE BEEN DEVELOPED

ONE IS BRANDED AS MANNA PLUS WHICH CONTAINS 373 SUBSTANCES WITH ANTI-OXIDANT PROPERTIES AND THE OTHER IS MAS PAHIT

WHICH IS USED IN COMBINATION WITH MANNA PLUS TO REDUCE HYPERGLYCEMIA.

MORE THAN 5000 PATIENTS HAVE USED THIS TWIN FORMULA AND THEIR ANTI-HYPERGLYCEMIC EFFECTS HAVE BEEN RECORDED.

THE PROTECTIVE EFFECT FROM OXIDATIVE DAMAGE HAS BEEN WELL DOCUMENTED USING

REALTIME OUTCOME- DRIVEN STUDIES.

REFER TO www amriasia.org

FOR CASE STUDY REPORTS

Mas Ayu Pahit

Number Of Known Bioactive Chemical s : 891 Number Of Reported Nutritional And Medicinal Activities : 1879

Mas Ayu Manna Plus

Number Of Known Bioactive Chemical : 14000 Number Of Reported Nutritional And Medicinal Activities : 3870

The Ultimate Biochemical Balance

BIOACTIVE PRINCIPLES

GARLIC

ONION SHALLOT

GINGER

CLOVE CUMIN

BLACK CUMIN

DILL COFFEA ARABICA SEMEN

TOTAL

ANTIOXIDANTS 78 22 59 30 25 23 22 114 373

AMINO ACIDS 6 1 4 2 NIL 3 4 1 (L-asparagin

21

MINERALS 10 5 8 4 2 4 4 NIL 37

VITAMINS 11 2 6 3 3 2 4 6 37

HORMONES 2 1 2 1 1 1 NIL 6 14

ENZYMES 3 2 1 2 NIL NIL 1 4 13

COFACTOR 24 NIL 1 1 2 1 3 3 35

                 

The Actual Number of BioActive Principles In Manna Plus

( Without Overlaps )

Posology of Highly Active Micro-Nutrient Formulae for Diabetes Prevention and Management

Prevention of Diabetes starts with conception of Life

Healthy diet for mother and fetus Minimal Physical and Mental Stress

Full Spectrum Diet Rest and Recreation

Healthy Life Style

Products are taken which can ensure minimal oxidative damage throughout life.

Manna Plus 101Pahit 101

For Diabetes Mana Plus 111 or 222

Pahit 111 or 222 or even 333For glycemic control and prevention of diabetic complication

and aggravation of the disease .

Observed Real-Time Outcome using Highly Active Micro-Nutrients alone or integrated

with allopathic drugs with more than 3000 patients

With mild or moderate hyperglycemia Highly Active Micro-Nutrients alone with proper Diet and Life

Style can control Diabetes and reduce morbidity. Case Studies available at www amriasi.org

With severe Diabetes Mellitus Highly Active Micro-Nutrient Formula

synergises and potentiates hypoglycemic activity and keep blood sugar under control.

HBAIC below 7.0In cases of insulin resistance , where insulin is rendered

inactive, through oxidative damage blood glucose improves through high antioxiddant and bio-chemical effects provided healthy life style

is practiced. Ref: www amriasia.org.

Sun

Plant

Solar Energy

Photosynthesis

CO2 & H20 & Cholorophyll

Glucose

(Energy Molecule)

Carbohydrates e.g. Rice, Wheat,

Tubers etc

Eaten & Digested to

Glucose in the Gastro

Intestinal System

Glucose transported by blood to the cells

1. Cellular uptake and intracellular breakdown of glucose to CO2, H20 & energy (ATP to ADP & energy) which is used to power reactions in the cells. E.g The production of the glucose regulating hormones insulin and glucagon in the cells of the pancreas. Oversupply or undersupply of energy will disrupt the energy balance and disturb the optimum production of insulin and glucagon.

2. Excessive glucose is converted to adipose fats.

3. Glucose is also converted to glycogen and stored in the liver.

DIABETES MELLITUS

1. Disruption of the energy balance, oversupply or undersupply of energy to the cells beyond its ability to cope.

2. Glycation and Oxidative damage to proteins and other vital bio-active chemicals in the body , causes physiological and metabolic dysfunction.

Disruption of Energy Balance & Build Up of Glucose in the Body

93 million miles away

sun

OVER CONCENTRATION OF GLUCOSE IN THE BLOOD

CELL

WHY- HOW –WHEN ???

CELLULAR UPTAKE OF GLUCOSE DEPENDS ON THE INTENSITY OF INTRACELLULAR ACTIVITY

NUMBER OF ACTIVE CELLS ESPECIALLY MUSCULAR

CELLS MUSCLE MASS REDUCES

WITH AGE AND LACK OF PHYSICALACTIVITY OXIDATIVE DAMAGE

TO DNA AND ORGANS DUE TO FREE RADICALS.

OVER EATING POOR QUALITY NUTRITION

MENTAL AND PHYSICALSTRESS

GENETIC PREDISPOSITION

MAJOR CAUSES OF DIABETES

CREATING OUR OWN SUGAR ON A LARGE COMMERCIAL SCALE

CREATING DRINKS WITH HIGH CONCENTRATION OF SUGAR AND CHEMICALS.CANNED DRINKS COCA-COLA, PEPSI ETC.SWEETENED TEA AND COFFEE SYRUPS AND ARTIFICIAL FRUIT JUICES

OVEREATING HIGH GLYCEMIC FOOD, OVER BURDENING THE SYSTEM

MENTAL AND PHYSICAL STRESS AND OXIDATIVE STRESS

BIOENERGENOMICS

THE NATURAL HEALTHCARE MODEL OF GLUCOSE IMBALANCE IN THE HUMAN LIFE FORM

INCORPORATING THE PROCESS NATURE OF THE HUMAN BEINGBASED ON THE COSMIC QUANTUM THEORY AND THE

THEORY OF RELATIVITY

THE COSMICECOLOGICAL

INTER-RELATEDNESS

THE PROCESS THEORY OF

NATURAL HEALING

CRITICAL FATORS OF

THE ENERGY –BALANCE

UNDERSTANDING THE COSMIC NATURE OF THE HUMAN BEINGAND DISEASES.

THE CONTINUUM OF HUMAN EVOLUTION THE ACUMULATED HUMAN INTELLIGENCE NATURE’S ADAPTATION THROUGH RANDOM

GENETIC MIXING , SELECTION AND ELIMINATIONNATURES PRESERVES THE STRONG AND

ELIMINATES THE WEAK.

THE HUMAN BEING

THE EVOLUTIONARY PROCESS

HIGHER AND HIGHER

LEVEL OF ACCUMULATED HUMAN INTELLIGENCE

IN THE EVOLUTIONARY PROCESS BOTH

BODILY AND INFECIVE DISEASES INDICATES A WEAK

OR DAMAGED LIFE FORM .

THEY ARE ELIMINATED THROUGH

DISEASES OR DESTRUCTION

ENERGY

MIND

BODY

THE NATURE OF THE HUMAN BODY

HUMAN BEING IS A PROCESS

IT IS ALWAYS CHANGING

LIKE THE WATERFALL

WE ARE A FUNCTION OF NATURE’S PROGRESSIVE CREATIVE WORK

OUR CREATED STATUS IS NATURE’S RANDOM EXPERIMENT

NEW CREATION NEW CREATION

BETTER CREATION

WORSE CREATION

DEFECTIVE CREATION

WEAKER CREATION

SUPER CREATION DO WE KNOW WHERE WE STAND ?

WE MUST FIRST UNDERSTAND THE NATURE OF HUMAN LIFE IN ORDER TO DEVELOP THE

TRUE SCIENCE OF HEALTH ANDMEDICINE .

THE HUMAN LIFE FORM IS AN INTEGRAL PART OF THE COSMOSAND IT IS A INTERACTIVE PROCESSWHICH INVOLVES ENERGY, MIND AND BODY

THE HUMAN LIFE FORM IS A PROGRESSIVE EXPANDING PHENOMENON WHICH IMPELLED BY THE CREATIVE FORCES OF COSMIC INTELLIGENCE.

CHANGING ALL THE TIME

COSMIC ECOLOGICAL INTER-RELATEDNESS

1. LARGELY CONFINED TO PHYSICAL BODY PARADGIM IGNORING THE ROLE

OF MIND AND ENERGY IN HUMAN HEALTH

SUN

EARTH

SOLAR /COSMIC ENERGY

93 MILLION MILES

LIFE FORMS INCLUDING HUMAN LIFE FORM

ENERGY MIND BODY

INVISIBLE & NON PHYSICAL

BODY

PHYSICAL /VISIBLE

EPISTOMOLGY BASED ON CARTESIAN-NEWTONIANMECHANISTIC -PHYSICALWRLDVIEW.

PHYSICAL SCIENTIFIC METHOD AS THE BASIS OF INQUIRY

DEPENDENT LARGELY ON PHYSICAL , QUANTIFIABLE ,MEASURABLE PARAMETERS FOR STUDY, RESEARCH AND UNDERSTANIDING

BODY IS TREATED LARGELYAS A MACHINE

REDUCTIONIST APPROACHAND MOLECULAR THEORY OF DISEASE CAUSATION.

THE COSMICECOLOGICAL

INTERRELATEDNESS

PRESERVATION OF HEALTHPREVENTION OF DISEASES

TRUE HEALTHCARE AND MEDICINE MUST COVER ALL THREE AREAS OF HUMAN LIFE

HUMAN LIFE FORM

TREATMENT (MEDICINE AND SURGERY)

HEALTHCARE

Earth

MAJOR CRITICAL FACTORS THAT AFFECT THE LEVEL OF GLUCOSE IN BLOOD

GENETTIC HEREDITARY FACTOR

DIET AND NUTRITION

PHYSICAL ACTIVITY AND EXERCISE AND REST

LIFE STYLE AND HABITS

MENTAL AND PHYSICAL STRESS

CONSUME WHAT YOU NEED

MAINTAIN YOUR EFFICIENCY

DO NO HARM TO YOUR BODY

DO NOT BURDEN YOUR BODY AND LIFE

LIVE WITHIN YOUR LIMITS

Sesame Seeds

Barley Seeds

Garlic

TurmericGinger

WORLD OF SPICES, SEEDS & CEREALS

All Kind of Seeds

Wheat Seeds

CuminFennel

Coffee Seed

Neem Leaves

All Kind of Seeds

Cinnamon

Onions

Black Cumin

A tree in a seed