diseases of heart
TRANSCRIPT
Diseases of
Heart
Pathology-B LabRavi A Patel
Normal Cardiac cells• Normal Interstitial space
• Normal centrally located nucleusLPOHPO
M++TB-Pericardium
Myocardial Infarction-MI
Brown Atrophy
TB-Pericardium• 1st of all we look for Granuloma, which is a classical hallmark
of TB in any organ of the body..
• Clinical presentation- Pericardial effusion– With nonspecific systemic symptoms like night sweats,Fever,fatigue
& weight loss
– Chest pain,cough and breathlessness are common
• Diagnosis- Echocardiography, pericardiocentesis
• Very common in African(sub saharan) with patients having HIV
Granuloma
LPO LPO
LPO
LPO
LPO
HPOHPO
HPO
Giant Cell within the Granuloma
HPO
HPO
LPO
LPO
LPO
Granuloma with Giant cells and inflammatory reaction
LPO
LPO
Granuloma and Giant cell
LPO
HPO
LPO
LPO
Myocardial Infarction-MI• Death of Cardiac muscle resulting from Ischemia.
• Coagulation Necrosis
• Wider than normal(edema) Interstitium
• Inflammatory cells (Neutrophils)
• Extravasation of RBC
• Karyorrhexis, Karyolysis occurs
• Clinical Manifestation:- Rapid weak pulse & often profuse sweating, Angina(chest pain) because of Necrosis
• Complication:- Contractile dysfuntion,Arrythmias,Myocardial rupture.
Wide Interstitium
LPO
LPO
LPO
LPO
Coagulation necrosis
LPO
Coagulation necrosis
LPO
LPO
LPO
Coagulation necrosis
LPO
Coagulation necrosis
LPO
LPO
Coagulation necrosis
HPOKaryorrhexis & Karyolysis
HPOKaryorrhexis & Karyolysis
HPOKaryorrhexis & Karyolysis
HPO
Karyorrhexis & Karyolysis
HPOInflammatory reactionWith numerous Neutrophils
HPO
NeutrophilsNeutrophils
HPO
Brown Atrophy
• Accumulation of Ageing/wear & tear pigment- lipofuscin near the nucleus.
• It appears to be the product of lipid peroxidation which signifies Membrane damage to mitochondria & lysosomes.
• Reduction in size of muscle cells
• Interstitium becomes wider due to reduction in size of muscle cells
LPO
•Wide Interstitium•Intact nucleus•Reduction in Muscle size
LPO
HPO
•Wide Interstitium•Intact nucleus•Reduction in Muscle size
HPO•Wide Interstitium•Intact nucleus•Reduction in Muscle size
HPO
HPO
MI Brown Atrophy
HPO
MI Brown Atrophy
HPO
MI Brown Atrophy
HPO
• Normal Heart
– Weight :- Male 300-350 gms Female-250-300 gms
– Usual thickness of the wall
» Right Ventricle—0.3-0.5 cm
» Left Ventricle– 1.3-1.5 cm
• Left ventricular hypertrophy
• Cause-Hypertension
Hypertensive Heart-Gross specimen
Thanking to the entire Universe