Name: Abdul QaharName: Abdul Qahar

Presentation topic:diversity Presentation topic:diversity of hormone receptersof hormone recepters

Presented to:Presented to:Sir, bakhtareen khan..Sir, bakhtareen khan..

ABDUL WALI KHAN UNIVERSITY MARDAN (BUNER CAMPUS)

What is hormone?What is hormone?

What is the need of What is the need of hormone receptershormone recepters??

.

1. a protein molecule,present. on the surface of a cell, that is capable of binding to a complementary molecule, as a hormone, antibody, or antigen.

• There are two functional clasess of recepters

1. Ionotropic

2. metabotropic

ionotropicionotropic

metabotropic

Location for different types of Location for different types of hormone:hormone:

On the surface of the cell On the surface of the cell membrane e.g. membrane e.g. proteins and proteins and polypeptidespolypeptides

In the cell cytoplasm In the cell cytoplasm steroid steroid

hormoneshormones

In the cell nucleus In the cell nucleus TT33 & T & T44

Hormone

Receptor

Cell membrane

(surface/ inside)

Inside cell

(Cytoplasm/ Nucleus)

HR Complex (Change in function of cell)

Direct action 2nd Messenger System

Action on Genetic MachineryIon channels_Linked receptors

G-Proteins-Linked Receptors

Enzyme-linked receptors

Activation of genes

cAMP

Phspholipase C

Ca++-Calmodulin

Protein synthesis

Gene transcription

1

2 3

4

5

6

7

1. Ion channel linked receptors are cell membrane bound receptors. They act through synaptic signaling on electrically excitable cells. The ion channels opening and closing is controlled by neurotransmitter

2. G- Protein 2. G- Protein activationactivation

3. Activation of 3. Activation of intracellular enzymes intracellular enzymes

(Leptin receptor)(Leptin receptor)

4.Activation of genes (Steroids, thyroid 4.Activation of genes (Steroids, thyroid hormones, retinoid hormone, vitamin D3)hormones, retinoid hormone, vitamin D3)

55→

7.

→7. S

eco

nd

Seco

nd

mess

enger

mess

enger

mech

anis

mm

ech

anis

m

1.1. cAMPcAMP

(cGMP in some cases)

(cGMP in some cases)

2.2. CalmodulinCalmodulin3.3. Membrane

Membrane phospholipids

phospholipids breakdown products

breakdown products (Phospholipase C 2

(Phospholipase C 2ndnd

Messenger System)

Messenger System)