HSV1 HSV2 Varicella Zoster EBV CMV HHV6 HHV7 HHV8

Epidem <5yo

90% adults

Ab

Female,

Sexual

By 10yo

90% adults

10-20% V

50-60yo

Immc/sup

15-24yo Worldwide

<6yo, y adults,

newbown,

immcomp

<3yo 3-5yo Subsaharan,

Mediterranean,

USA, Jap; Kaposi

Transmis Oral Contact Sexual High contag Saliva Fluid Saliva Sex + non

Clinical Orofacial I

Recurrent

Encephalitis

Genital &

Neonatal

Infections

Maculopapular

rash

Pruritic rash

Postherpetic

neuralgia

Infectious

Mononucleosis

Infectious

Mononucleosis

Syndrome

Congenital I

IC Critical

Exanthem Subitum

Adult : infectious

mononucleosis

IC : encephalitis,

pneumonitis

Asympto OR

Kaposi Sarcoma

Clinical

Comp Bacterial I

Viral Pneumo.

Hrhag V, Reyes

CG & Neo V

Hodgkin’s &

Burkitt’s

Lymphoma,

Hairy

leukoplakia

Dx Tzanck/PAP : giant

multinucleated w/ inclusion

body; Culture : CPE

PCR, Serology

Clinical, Tzanck,

Culture, PCR

FBC

Clinical

Serology

Monospot Test

Histo & PCR

ImmF

Serology (IgM-

CMV)

Serology

Immf

PCR

Clinical, biopsy,

PCR

Rx Anti-herpes : disrupt

replication / block DNA pol

Live attenuated

Vacc (Oka)

VZIG, Antiviral

Contraindicated

amoxycillin

Immcomp :

ganciclovir

Antivirals

ineffective if

latency – loc +

sys