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STEPHEN J. PANDOL, MDCedars-Sinai Medical Center

8730 Alden Drive, Thalians, Suite E222Los Angeles, CA 90048

[email protected]

BIOGRAPHICAL DATA: Date of Birth: June 1, 1949, Bakersfield, CA

Education: University of California, Davis, CA B.S., 1971 St. Louis University School of Medicine, St. Louis, MOM.D., 1975

PROFESSIONAL EXPERIENCE AND ACADEMIC APPOINTMENTS:

Intern in Medicine, 1975-1976Wadsworth Veterans Administration Medical Center, Los Angeles, CAResident in Medicine, 1976-1978Wadsworth Veterans Administration Medical Center, Los Angeles, CAChief Resident in Medicine, 1978-1979Wadsworth Veterans Administration Medical Center, Los Angeles, CA

Fellow in Gastroenterology, 1978-1979University of California, Los Angeles/Wadsworth Veterans AdministrationClinical Associate, 1979-1982Digestive Diseases, Nat'l Institute of Diabetes, Digestive & Kidney Diseases National Institutes of Health, Bethesda, MDStaff Physician, 1982-1995Department of Veterans Affairs Medical Center, San Diego, CAAssistant Professor of Medicine, 1982-1987University of California, San Diego, CAResearch Associate, 1984-1986Department of Veterans Affairs Medical Center, San Diego, CA Associate Professor of Medicine, 1987-1992University of California, San Diego, CAClinical Investigator, 1987-1992Department of Veterans Affairs Medical Center, San Diego, CAChief, Gastroenterology, 1992-1995Department of Veterans Affairs Medical Center, San Diego, CAProfessor of Medicine, 1992-1995University of California School of Medicine, San Diego, CADirector, Research and Development, 1996-1998West Los Angeles Veterans Administration Medical Center, Los Angeles, CA

Stephen J. Pandol, M.D. Updated: 5/6/2023

Professor of Medicine, 1996-PresentUniversity of California School of Medicine, Los Angeles, CA Staff Physician, 1996-PresentDepartment of Veterans Affairs Medical Center, West Los Angeles, CACo-Director of Southern California Research Center for ALPD and Cirrhosis, 1999-PresentProfessor of Molecular Toxicology, 2004-PresentUniversity of California School of Medicine, Los Angeles, CA Guest Professor, Southern Medical University, P.R. China, 2009-Present Co-Director of UCLA Center for Excellence in Pancreatic Diseases, 2007-PresentDirector, Basic and Translational Pancreatic Research, Cedars-Sinai Medical Center, 2012-Present

HONORS:

Phi Kappa Phi Honor SocietyUniversity of California, Davis, CA, 1970Outstanding Undergraduate Accomplishment in BiochemistryDepartment Citation, University of California, Davis, CA, 1971Bachelor of Science Degree, With Highest HonorsUniversity of California, Davis, CA, 1971Alpha Omega Alpha Medical SocietySt. Louis University School of Medicine, St. Louis, MO, 1975Doctor of Medicine Degree, Cum LaudeSt. Louis University School of Medicine, St. Louis, MO, 1975Outstanding Medical InternWadsworth Veterans Administration Hospital, Los Angeles, CA, 1978Outstanding Medical Resident Wadsworth Veterans Administration Hospital, Los Angeles, CA, 1978Department of Medicine's 7th Annual Chief Residents' Teaching AwardUniversity of California School of Medicine, San Diego, CA, 1993 Department of Medicine's Eighth Annual Chief Residents' Teaching AwardUniversity of California School of Medicine, San Diego, CA, 1994 The Kaiser Permanente Award for Excellence in Teaching Honorable MentionDept. of Medicine, Univ. of CA School of Medicine, San Diego, CA, 1994.Accreditation with CommendationJCAHO SurveyReceived by Veterans Affairs Medical Center, San Diego, CA, 1995Carey AwardReceived by Veterans Affairs Medical Center, West Los Angeles, CA, 1997Accreditation with CommendationJCAHO SurveyReceived by Veterans Affairs Medical Center, West Los Angeles, CA, 1998

BOARD REQUIREMENTS ACCOMPLISHED:


National Board of Medical Examiners, 1976 The American Board of Internal Medicine, 1978

The American Board of Internal Medicine, Gastroenterology, 1982

CERTIFICATION:

State of California, Board of Medical Quality Assurance License Number G033954

MEMBERSHIPS:

American Association for the Advancement of Science American Federation of Clinical Research

American Gastroenterological AssociationCommittee Member, Gastrointestinal Teaching Project, 1993-presentCommittee Member, Gastrointestinal Research Group, 1999-presentCommittee Member, Research Committee, 2002-present

American Liver FoundationPresident, San Diego Chapter, 1991-1993Vice-President, San Diego Chapter, 1993-1995Member, Medical Advisory Committee, Los Angeles Chapter, 1999-present

American Pancreatic Association Board Member, 2009-present President, 2013-2014American Physiological Society

American Society for Clinical InvestigationCounselor, 1994-1997

San Diego Gastroenterology Society Secretary-Treasurer, 1993-1994Vice-President, 1994-1995President, 1995

Western Association of PhysiciansWestern Society for Clinical Investigation

Counselor, 1990-1993

REVIEWER FOR:

AlcoholAmerican Journal of PathologyAmerican Journal of Physiology Biochemical Pharmacology

Biochemistry Endocrinology

Gastroenterology


GutInternational Journal of PancreatologyJournal of Biological Chemistry Journal of Cell BiologyJournal of Cellular BiochemistryJournal of Clinical InvestigationJournal of Pharmacology and Experimental Therapeutics Life SciencesNew England Journal of MedicinePancreas Peptides Proceedings of the National Academy of Sciences, USARegulatory Peptides Prostaglandins

EDITORIAL BOARD:

American Journal of Physiology Gastrointestinal and Liver PhysiologyGastroenterologyResearch NewsCellular and Molecular Gastroenterology and Hepatology

CONSULTING EDITOR:

Journal of Clinical Investigation

EDITOR:

Best and Taylor's Physiological Basis of Medical PracticeSection Editor for Gastrointestinal System, 1991

American Journal of Physiology: Gastrointestinal and Liver PhysiologyAssociate Editor, 1993-1997

Frontiers in Gastrointestinal Sciences Chief Editor, 2010-present

GRANT SUPPORT:

1983-1994 NIH/NIDDK – DK33010"Pancreatic secretion and phosphatidylinositol metabolism"

1983-1987 Veterans Affairs Career Development AwardResearch Associate

1987-1992 Veterans Affairs Career Development AwardClinical Investigator

1991-1994 Veterans Affairs Merit Review


"Pancreatic physiology and pathophysiology"Principal Investigator: Stephen J. Pandol, M.D.

1994-1998 Veterans Affairs Merit Review "Mechanisms of acinar cell death in experimental models of pancreatitis"Principal Investigator: Stephen J. Pandol, M.D.

1994-1998 NIH/NIDDK – DK33010"Function and subcellular nature of Ca2+ signaling"Principal Investigator: Stephen J. Pandol, M.D.

1995-1998 NIH/NIDDK – DK51476"Mechanism of ethanol-induced pancreatitis"Principal Investigator: Stephen J. Pandol, M.D.

1998-2002 Veterans Affairs Merit Review“Molecular mechanisms of experimental pancreatitis”Principal Investigator: Stephen J. Pandol, M.D.

1999-2002 Veterans Affairs Merit Review “Extracellular Matrix and Apoptosis in Normal & Cancer Pancreatic Cells”Principal Investigator: Anna S. Gukovskaya, Ph.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

1999-2003 NIH/NIAAA – 1 P50 AA11999-01“USC-UCLA Research Center for Alcoholic Liver and Pancreatic Disease” Director: Hide Tsukamoto, D.V.M., Ph.D.Co-Director: Stephen J. Pandol, M.D.Project IV – “Ethanol and Pancreatic Injury”Principal Investigator: Stephen J. Pandol, M.D.

2000-2002 State of California – Health and Human Services AgencyCalifornia Research Program, UC Davis 00-00776V-20071“Regulation of Pancreatic Cancer Apoptosis by Polyphenols”Principal Investigator: Stephen J. Pandol, M.D.

2001-2005 NIH/NIAAA – T32 AA07578-01“Training Program in Alcoholic Liver and Pancreatic Diseases”Principal Investigator: Hide Tsukamoto, D.V.M., Ph.D.Co-Investigator: Stephen J. Pandol, M.D.

2002-2007 NIH/NIDDK – DK59508“The Inflammatory Response of the Pancreatic Acinar Cell”Principal Investigator: Stephen J. Pandol, M.D.

2002-2007 Veterans Affairs Merit Review “Phosphatidylinositol 3-kinase and the Exocrine Pancreas”

Principal Investigator: Stephen J. Pandol, M.D.2002-2005 Veterans Affairs Merit Review

“Reactive Oxygen Species: Survival Factor in Pancreatic Cancer Cells”Principal Investigator: Anna S. Gukovskaya, Ph.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

2002-2007 NIH/NIAAA – AA13847“MAT 1A Null Mouse: Model for Alcoholic Tissue Injury”Principal Investigator: Shelly Lu, M.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

2003-2007 NIH/NIDDK – DK59936


"Apoptosis and Necrosis in Pancreatitis"Principal Investigator: Anna S. Gukovskaya, Ph.D.Co-Investigator: Stephen J. Pandol, M.D.

2003-2007 NIH/NIAAA – 1 U56 AA0114643“Role of Alcohol In Pancreatic Acinar Cell Death”Principal Investigator: Duane Smoot, M.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

2005-2009 NIH/NIAAA – T32 AA07578-02“Training Program in Alcoholic Liver and Pancreatic Diseases”Principal Investigator: Hide Tsukamoto, D.V.M., Ph.D.Co-Investigator: Stephen J. Pandol, M.D.

2004-2008 NIH/NIAAA – 1 P60 AA11999-01“USC-UCLA Research Center for Alcoholic Liver and Pancreatic Injury-Administrative Core” Director: Hide Tsukamoto, D.V.M., Ph.D.Associate Director: Stephen J. Pandol, M.D.

2004-2005 PHS/NCI – 5 P01 CA42710 Center PI: HeberUCLA CNRU Pilot Feasibility Grant“Plant-Derived Polyphenols Reverse Pancreatic Cancer Metabolic Phenotype”Project Principal Investigator: Stephen J. Pandol, M.D.

2005-2008 NIH/NIAAA – 1 P60 AA11999-01Center PI: Tsukamoto“USC-UCLA Research Center for Alcoholic Liver and Pancreatic Disease” Director: Hide Tsukamoto, D.V.M., Ph.D.Co-Director: Stephen J. Pandol, M.D.Project IV – “Protein Kinase C and Alcoholic Pancreatitis”Project Principal Investigator: Stephen J. Pandol, M.D.

2005-2007 Private Donation: Hirshberg Foundation“Pancreatic Cancer Metabolic Phenotype is Regulated by NADPH Oxidase”Principal Investigator: Stephen J. Pandol, M.D.

2006-2009 NIH/NIAAA – 5 R21 AA016010-02“Alcohol and the Exocrine Pancreas ER Stress”Principal Investigator: Stephen J. Pandol, M.D.

2006-2008 NIH/NIAAA – 1 R21 AA015781-01“Plasminogen System and Alcoholic pancreatitis”Principal Investigator: Aurelia Lugea, Ph.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

2006-2010 Veterans Affairs Merit Review“NOX4, Protein Tyrosine Phosphatases, and Pancreatic Cancer Cell Survival”Principal Investigator: Anna S. Gukovskaya, Ph.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

2006-2010 NIH/NCI – 1 R01 CA119025-01“NADPH Oxidase and pancreatic Cancer Cell Survival”


https://commons.era.nih.gov/commons/genericStatus.do?actionRole=nonPI&applID=7027819

Principal Investigator: Anna S. Gukovskaya, Ph.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

2006-2008 NIH/NIAAA – 1 R03 AA016008-01A1“Urokinase-type Plasminogen Activator System and Pancreatic Stellate Cells”Principal Investigator: Aurelia Lugea, Ph.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

2006-2011 NIH T32 DK07180-33“Gastroenterology”Director/PI: Dennis M. Jensen, M.D.Co-Directors: Peter Anton, M.D., Stephen Pandol, M.D.

2007-2009 NIH/NIAAA – R03 AA016336“The Effect of Alcohol on NADPH Oxidase Structure in Pancreatic Stellate Cells”Principal Investigator: Kym F. Faull, Ph.D.Co-Principal Investigator: Stephen J. Pandol, M.D.

2007-2010 American Gastroenterological Association Foundation“Bcl-2 Proteins Regulate Death Responses of Acute Pancreatitis”Principal Investigator: Olga Mareninova, Ph.D.Sponsor: Stephen J. Pandol, M.D.

2007-2011 Veterans Affairs Merit Review “Inflammation Mediates Necrosis in Pancreatitis”

Principal Investigator: Stephen J. Pandol, M.D.2007-2011 NIH – 1 P01 AT0003960-01

“UCLA Center for Excellence in Pancreatic Diseases – Project 1: Phytonutrients and Metabolism in Pancreatic Diseases”Project Principal Investigator: Stephen J. Pandol, M.D.

2007-2011 NIH – 1 P01 AT0003960-01“UCLA Center for Excellence in Pancreatic Diseases”Director: Vay Liang W. Go, M.D.Co-Director: Stephen J. Pandol, M.D.

2008-2011 NIH/NIAAA – 1 R21 AA017276-01 “Alcoholic Pancreatitis Results from Dysregulated Immune Response”Project Principal Investigator: Ilya Gukovsky, Ph.D.Co-Project Principal Investigator: Stephen J. Pandol, M.D.

2009-2014 NIH – P50 AA011999-11“Southern California Research Center for Alcoholic Liver & Pancreatic Diseases and Cirrhosis”Director: Hide Tsukamoto, D.V.M., Ph.D.Project Principal Investigators: Stephen J. Pandol, M.D., Anna Gukovskaya, Ph.D.

2011-2016 NIH – K01 AA019996-01 “Smoking, Alcohol Abuse and Pancreatic Disease”

Principal Investigator: Mouad Edderkaoui, Ph.D.Mentors: Anna Gukovskaya, Ph.D., Stephen J. Pandol, M.D.

2011-2016 NIH/NIAAA – R01 AA019730-01A1 “Lysosomal Damage, Impaired Autophagy and Alcoholic Pancreatitis”

Principal Investigators: Olga Mareninova, Ph.D., Ilya Gukovsky, Ph.D.


Co-Principal Investigator: Stephen J. Pandol, M.D.2011-2016 NIH – R01 AA019954

“Alcohol Abuse and Endoplasmic Reticulum Dysfunction in Exocrine Pancreas” Principal Investigator: Aurelia Lugea, Ph.D.

Co-Principal Investigator: Stephen J. Pandol, M.D.2011-2016 NIH T32 DK07180-33

“Gastroenterology”Director/PI: Dennis M. Jensen, M.D.Co-Directors: Peter Anton, M.D., Stephen Pandol, M.D.

2012-2016 Veterans Affairs Merit Review “Smoking, Alcohol Abuse and Pancreatic Disease”

Principal Investigator: Stephen J. Pandol, M.D.2012-2017 NIH/NCI – P01 CA163200-01A1

“Targeting Diet-Induced Promotion of Kras-initiated Pancreatic Adenocarcinoma-Project IV: Alcohol Abuse, Metabolic Syndrome and Desmoplasia.”Program Director: Guido Eibl, M.D.

Project IV Principal Investigator: Stephen J. Pandol, M.D.2014-2015 CalciMedica

“Development of Orai-1 inhibitors for the treatment of acute pancreatitis”Principal Investigator: Stephen J. Pandol, M.D

2014-2019 NIH/NIAAA – P50 AA011999-16“Southern California Research Center for ALPD and Cirrhosis – Project IV: Mitochondrial alcohol metabolism mediates alcoholic pancreatitis”Director: Hide Tsukamoto, D.V.M., Ph.D.Project Principal Investigators: Stephen J. Pandol, M.D., Anna Gukovskaya Ph.D.

2014-2019 NIH/NIDDK – P01 DK098108-01A1“Organelle Disorders in Pancreatitis”Director: Anna Gukovskaya, Ph.D.Project Principal Investigators: Stephen J. Pandol, M.D.

UNIVERSITY AND LOCAL COMMITTEES:

Organ Physiology Course Taught 1st year physiology to medical studentsUCSD School of Medicine, 1986-1995Standing and PromotionsUCSD School of Medicine, 1987-1992 Chairman, 1990-1992Core CurriculumUCSD School of Medicine, 1988-1991Housestaff EvaluationDepartment of Medicine, UCSD School of Medicine, San Diego, 1987-1995Quality Assurance Council


Veterans Administration Medical Center, San DiegoChairman, 1988-1995

Total Quality Improvement Steering Committee Veterans Administration Medical Center, San Diego, 1991-1995Research EquipmentVeterans Administration Medical Center, San Diego, 1986-1995 Medical Education and Research Foundation (Board member)Department of Medicine, UCSD School of Medicine, San Diego, 1989-presentPharmacy and TherapeuticsVeterans Administration Medical Center, San Diego 1983-1988Research and DevelopmentVeterans Administration Medical Center, San Diego, CA, 1986-1989Chairman, 1988-1989

Representative to the Academic Senate Department of Medicine, UCSD School of Medicine, San Diego, 1994-1995Annual Postgraduate CourseTopics and Advances in Internal Medicine

Department of Medicine, UCSD School of Medicine Course Co-Director, 1990-1995Department of Medicine Committee on Advancement and PromotionDepartment of Medicine, UCSD School of Medicine, 1994-1995Research and DevelopmentVeterans Affairs Medical Center, West Los Angeles, 1995-1998Quality CouncilVeterans Affairs Medical Center, West Los Angeles, Co-Chairman, 1996-1999.Strategic Planning CommitteeVeterans Affairs Medical Center, West Los Angeles, 1996-1998Dean’s CommitteeVeterans Affairs Medical Center, West Los Angeles, 1996-1998Medical Advisory BoardVeterans Affairs Medical Center, West Los Angeles, 1996-1998Executive CommitteeResearch Center for Alcoholic Liver and Pancreatic Disease, Los Angeles, 1999-presentOutreach CommitteeResearch Center for Alcoholic Liver and Pancreatic Disease, Los Angeles, 1999-presentIntroduction to Pathology Lecture Series Taught medical, PhD, and MS students in basic pathologic basis of diseasesUSC School of Medicine, 2002-presentPathophysiologyTaught 2nd year medical students on basic pancreatic diseasesUCLA School of Medicine, 2004-present

NATIONAL COMMITTEES:


Veterans Administration Gastroenterology Merit Review Board, 1989-1992 Chairman 1991-1992American Society for Clinical Investigation, Council Member, 1993-1996Undergraduate Teaching Project of the American Gastroenterological Association, 1995-2002Gastroenterology and Hepatic Disorders Research Review GroupDepartment of Veterans Affairs, Chairman, 1996Research Council for Southern California and Nevada VA Medical CentersChairman, 1996-1998 High School Science Teachers Project, American Society for Clinical Investigation, 1994-1997Publications Committee, American Gastroenterological Association, 1996-1997Flying Samaritans, 2000-2003Gastroenterology Teaching Project of the American Gastroenterological Association, 2002-2005Research Committee, American Gastroenterological Association, 2002-2005Legacy Society of the American Gastroenterological Association, 2007-presentCounselor, American Pancreatic Association, 2010-present

PATENTS ISSUED:

1. Compositions Comprising Plant-Derived Polyphenolic Compounds and Inhibitors of Reactive Oxygen Species and Methods of Using Thereof. Continuation-in-Part of U.S. Patent NO.: US 6,953,786, B2 Date of Patent: October 11, 2005

2. Methods for Treating Pancreatitis with Curcumin Compounds and Inhibitors of Reactive Oxygen. U.S. Patent NO.: US 7,060,733, Date of Patent: June 13, 2006

3. Methods and Systems for Modulating hormones and related methods, agents and compositions. US Patent Application 20120058965 Date Issued: March 8, 2012


BIBLIOGRAPHY

PEER-REVIEWED – PUBLISHED:

1. Pandol SJ, Korman LY, McCarthy DM, Gardner JD. Beneficial effect of oral lithium carbonate in the treatment of pancreatic cholera syndrome. N Engl J Med 302:1403-1404, 1980.

2. Richter JE, Pandol SJ, Castell DO, McCarthy DM. Gastroesophageal reflux disease in the Zollinger-Ellison syndrome. Ann Internal Med 95:37-43, 1981.

3. Pandol SJ, Jensen RT, Gardner JD. Mechanism of (Tyr4) bombesin-induced desensitization in dispersed acini from guinea pig pancreas. J Biol Chem 257:12024-12029, 1982.

4. Jensen RT, Gardner JD, Raufman JP, Pandol SJ, Doppman JL, Collen MJ. Zollinger-Ellison syndrome-current concepts and management. Ann Internal Med 98:59-75, 1983.

5. Raufman JP, Collins SM, Pandol SJ, Korman LY, Collen MJ, Cornelius MJ, Feld MK, McCarthy DM, Gardner JD, Jensen RT. Reliability of symptoms in assessing control of gastric acid secretion in patients with Zollinger-Ellison syndrome. Gastroenterology 84:108-113, 1983.

6. Jensen RT, Collen MJ, Pandol SJ, Allende HD, Raufman JP, Bissonnette BM, Duncan WC, Durgin PL, Gillin JC, Gardner JD. Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory states. N Engl J Med 308:883-887, 1983.

7. Pandol SJ, Sutliff VE, Jones SW, Charlton CG, O'Donohue TL, Gardner JD, Jensen RT. Action of natural glucagon on pancreatic acini: Due to contamination by previously undescribed secretagogues. Gastrointest Liver Physiol 245:G703-G710, 1983.

8. Jensen RT, Pandol SJ, Collen MJ, Raufman JP, Gardner JD. Diagnosis and Management of the Zollinger-Ellison syndrome. J Clin Gastro 5 (Suppl. 1): 123-131, 1983.

9. Pandol SJ, Seifert H, Thomas MW, Rivier J, Vale W. Growth hormone-releasing factor stimulates pancreatic enzyme secretion. Science 225:326-328, 1984.


10. Pandol SJ, Thomas MW, Schoeffield MS, Sachs G, Muallem S. Role of calcium in cholecystokinin-stimulated phosphoinositide breakdown in exocrine pancreas. Gastrointest Liver Physiol 248: G551-G560, 1985.

11. Seifert H, Sawchenko P, Chesnut J, Rivier J, Vale W, Pandol SJ. Receptor for calcitonin gene-related peptide: binding to exocrine pancreas mediates biological actions. Gastrointest Liver Physiol 249:G147-G151, 1985.

12. Muallem S, Schoeffield M, Pandol SJ, Sachs G. Inositol trisphosphate modification of ion transport in rough endoplasmic reticulum. Proc Natl Acad Sci USA 82:4433-4437, 1985.

13. Pandol SJ, Schoeffield MS, Sachs G, Muallem S. Role of free cytosolic calcium in secretagogue-stimulated amylase release from dispersed acini from guinea pig pancreas. J Biol Chem 260:10081-10086, 1985.

14. Dharmsathaphorn K, Pandol SJ. Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell line. J Clin Invest 77:348-54, 1986.

15. Pandol SJ, Dharmsathaphorn, K., Schoeffield MS, Vale W, Rivier J. Vasoactive intestinal peptide receptor antagonist [4Cl D-Phe6, Leu17] VIP. Gastrointest Liver Physiol 250:G553-G557, 1986.

16. Pandol SJ, Schoeffield MS. 1,2 diacylglycerol, protein kinase C, and pancreatic enzyme secretion. J Biol Chem 261:4438-4444, 1986.

17. Muallem S, Fimmel CJ, Pandol SJ, Sachs G. Regulation of free cytosolic Ca2+ in the peptic and parietal cells of the rabbit gastric gland. J Biol Chem 261:2660-2667, 1986.

18. Pandol SJ, Schoeffield MS, Fimmel CJ, Muallem S. The agonist-sensitive calcium pool in the pancreatic acinar cell. Activation of plasma membrane Ca2+ influx mechanism. J Biol Chem 262:16963-16968, 1987.

19. Krims PE, Pandol SJ. Free cytosolic calcium and secretagogue-stimulated initial pancreatic exocrine secretion. Pancreas 3:383-390, 1988.

20. Muallem S, Schoeffield MS, Fimmel CJ. Pandol SJ. Agonist-sensitive calcium pool in the pancreatic acinar cell. I. Permeability properties. Gastrointest Liver Physiol 255:G221-228, 1988.

21. Muallem S, Schoeffield MS, Fimmel CJ, Pandol SJ. Agonist sensitive calcium pool in the pancreatic acinar cell. II. Characterization of reloading. Gastrointest Liver Physiol 255:G229-G235, 1988.

22. Muallem S, Beeker T, Pandol SJ. Role of Na+/ Ca2+ exchange and the plasma membrane Ca2+ pump in hormone-mediated Ca2+ efflux from pancreatic acini. J Mem Biol 102:153-162, 1988.


23. Kelleher D, Pandol SJ, Kagnoff MF. Phorbol myristate acetate induces IL-2 secretion by HUT 78 cells by a mechanism independent of protein kinase C translocation. Immunology 65:351-355, 1988.

24. Muallem S, Pandol SJ, Beeker TG. Calcium mobilizing hormones activate the plasma membrane Ca2+ pump of pancreatic acinar cells. J Mem Biol 106:57-69, 1988.

25. Muallem S, Pandol SJ, Beeker TG. Two components of hormone-evoked calcium release from intracellular stores of pancreatic acinar cells. Biochem J 255:301-307, 1988.

26. Muallem S, Pandol SJ, Beeker TG. Hormone-evoked calcium release from intracellular stores is a quantal process. J Biol Chem 264:205-212, 1989.

27. Algazi MC, Chen H-S, Koss MA, Hogan DL, Steinbach J, Pandol SJ, Isenberg JI. Effect of VIP antagonist on VIP-PGE2-, and acid-stimulated duodenal bicarbonate secretion. Gastrointest Liver Physiol 256:G833-G836, 1989.

28. Pandol SJ, Rodriguez G, Muallem S, Mendius K. Characteristics of intracellular calcium changes required for augmentation of phorbol ester-stimulated pancreatic enzyme secretion. Cell Calcium 10:255-262, 1989.

29. Dharmsathaphorn K, Huott PA, Vongkovit P, Beuerlein G, Pandol SJ, Ammon HU. Cl- secretion induced by bile salts. A study of the mechanism of action based on cultured colonic epithelial cell line. J Clin Invest 84:945-953, 1989.

30. Muallem S, Pandol SJ, Beeker TG. Modulation of agonist-activated calcium influx by extracellular pH in rat pancreatic acini. Gastrointest Liver Physiol 257:G917-G924, 1989.

31. Schmidt DN, Pandol SJ. Differing effects of ethanol on in vitro stimulated pancreatic enzyme secretion in ethanol fed and control rats. Pancreas 5:27-36, 1990.

32. Pandol SJ, Schoeffield-Payne MS. Cyclic GMP mediates the agonist-stimulated increase in plasma membrane calcium entry into the pancreatic acinar cells. J Biol Chem 265:12846-12853, 1990.

33. Pandol SJ, Shoeffield-Payne MS. Cyclic GMP regulates free cytosolic calcium in the pancreatic acinar cell. Cell Calcium 11:477-486, 1990.

34. O'Konski MS, Pandol SJ. Effects of caerulein on the apical cytoskeleton of the pancreatic acinar cell." J Clin Invest 86:1649-1657, 1990.

35. Pandol SJ, Hsu Y, Kondratenki NF, Shoeffield-Payne MS, Steinbach JH. Dual pathways for agonist-stimulated arachidonic acid release in pancreatic acini: roles in secretion. Gastrointest Liver Physiol 260:G423-G433, 1991.


36. Brandt DW, Pandol SJ, Deftos LJ. Calcium-stimulated parathyroid hormone-like protein secretion: potentation through a protein kinase C pathway. Endocrinology 128:2999-3004, 1991.

37. Perkins PS, Bahrami LH, Lenhard LW, Pandol SJ. Intracellular mechanisms involved in short-term regulation of net protein synthesis in pancreatic acini. Biochem Biophys Acta 1092:145-152, 1991.

38. Cohen ME, Wesolek J, McGullen J, Rys-Sikora K, Pandol SJ, Rood RP, Sharp GWG, Donowitz M. Carbachol- and elevated Ca2+ -induced translocation of functionally active protein kinase C to the brush border of rabbit ileal Na+ absorbing cells. J Clin Invest 88:855-863, 1991.

39. Perkins PS, Pandol SJ. Cholecystokinin-induced changes in polysome structure regulate protein synthesis in pancreas. Biochem Biophys Acta 1136:265-271, 1992.

40. O'Konski MS, Pandol SJ. Cholecystokinin JMV-180 and caerulein effects on the pancreatic acinar cell cytoskeleton. Pancreas 8:638-646, 1993.

41. Bahnson TD, Pandol SJ, Dionne VE. Cyclic GMP modulates depletion-activated Ca2+

entry in pancreatic acinar cells. J Biol Chem 268:10808-10812, 1993.

42. Gukovskaya AS, Pandol SJ. Nitric oxide production regulates cGMP formation and calcium influx in pancreatic acinar cells. Gastrointest Liver Physiol 266:G350-G356, 1994.

43. Rutherford RE, Schoeffield-Payne MS, Pandol SJ. Cellular mechanisms and physiological implications of quantal Ca2+ release in pancreatic acinar cells. Gastrointest Liver Physiol 267: G1058-G1066, 1994.

44. Pandol SJ, Schoeffield-Payne MS, Gukovskaya AS, Rutherford RE. Sphingosine regulates Ca2+-ATPase and reloading of intracellular Ca2+ stores in the pancreatic acinar cell. Biochem Biophys Acta 1195:45-50, 1994.

45. Perkins PS, Rutherford RE, Pandol SJ. Effect of chronic ethanol feeding on digestive enzyme synthesis and mRNA content in rat pancreas. Pancreas 10: 14-21, 1995.

46. Gukovskaya AS, Pandol SJ. Dual regulation of cGMP formation by calcium in pancreatic acinar cells. Gastrointest Liver Physiol 286: G900-G907, 1995.

47. Pandol SJ, Fitzsimmons TJ, Schoeffield-Payne MS, Carlile GW, Evans WJ. Isolation of subcellular agonist-sensitive calcium stores from the pancreatic acinar cell. Cell Calcium 18: 364-376, 1995.

48. Vajanaphanich M, Schultz C, Tsien R, Traynor-Kaplan AE, Pandol SJ, Barrett KE. Cross-talk between calcium and cAMP-dependent intracellular signalling pathways:


Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells. J Clin Invest 96:386-393, 1995.

49. Abdeen O, Pandol SJ, Burton DW, Deftos LJ. Parathyroid hormone-related protein expression in human gastric adenocarcinomas not associated with hypercalcemia. Am J Gastroenterol 90:1864-186, 1995.

50. Gukovskaya AS, Perkins P, Zaninovic V, Sandoval D, Rutherford R, Fitzsimmons TJ, Pandol SJ, Poucell-Hatton S. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology 110:875-884, 1996.

51. Sandoval D, Gukovskaya AS, Reavey P, Gukovsky S, Sisk A, Braquet P, Pandol SJ, Poucell-Hatton S. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology 111:1081-1091, 1996.

52. Poucell-Hatton S, Perkins PS, Deerink TK, Ellisman MH, Hardison WGM, Pandol SJ. Myosin I is associated with zymogen granule membranes in the rat pancreatic acinar cell. Gastroenterology 113:649-658, 1997.

53. Perkins PS, Pandol SJ. The role of calcium in the regulation of protein synthesis in the exocrine pancreas. Pancreas 14:133-141, 1997.

54. Xu X, Weizhong Z, Diaz J, Gukovskaya AS, Kim L, Brown RJ, Pandol SJ, Muallem S. nNOS and Ca2+ influx in rat pancreatic acinar and submandibular salivary gland cells. Cell Calcium 22:217-228, 1997.

55. Gukovskaya AS, Zaninovic V, Gukovsky I, Song M, Sandoval D, Gukovsky S, Pandol SJ. Pancreatic acinar cells produce, release and respond to tumor necrosis factor-: Role in regulating cell death and pancreatitis. J Clin Invest 100:1853-1862, 1997.

56. Fitzsimmons TJ, McRoberts JA, Tachiki K, Pandol SJ. Acyl-coenzyme A causes Ca2+ release in pancreatic acinar cell. J Biol Chem 272:31435-31440, 1997.

57. Zhou K, Pandol SJ, Bokoch G, Traynor-Kaplan AE. Disruption of Dictyostelium PI3K genes reduces (32P) phosphatidylinositol 3,4 bisphosphate and 32P-phosphatidylinositol trisphosphate levels, alters F-actin distribution and impairs pinocytosis. J Cell Sci 111:283-294, 1998.

58. Gukovsky I, Gukovskaya AS, Blinman T, Zaninovic V, Pandol SJ. Early NF-B activation is associated with hormone-induced pancreatitis. Gastrointest Liver Physiol 275:G1402-G1414, 1998.

59. Song M, Zaninovic V, Kim D, Gukovsky I, Gukovskaya AS, Kang K, Pandol SJ. Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor. Pancreas 18:231-239, 1999.


60. Pandol SJ, Periskic S, Gukovsky I, Zaninovic V, Jung Y, Zong Y, Solomon TE, Gukovskaya AS, Tsukamoto H. Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide. Gastroenterology 117:706-716, 1999.

61. Gukovskaya AS, Gukovsky S, Pandol SJ. Endoplasmic reticulum Ca2+ ATPase inhibitors stimulate membrane guanylate cyclase in pancreatic acinar cells. Cell Physiol 278:C363-C371, 2000.

62. Zaninovic V, Gukovskaya AS, Gukovsky I, Pandol SJ. Cerulein upregulates ICAM-1 in pancreatic acinar cells which mediates neutrophil adhesion to these cells. Gastrointest Liver Physiol 279: G666-G676, 2000.

63. Fitzsimmons TJ, Gukovsky I, McRoberts JA, Rodriguez E, Lai FA, Pandol SJ. Multiple isoforms of the ryanodine receptor are expressed in rat pancreatic acinar cells. Biochem J 351: 265-271, 2000.

64. Blinman T, Gukovsky I, Mouria M, Zaninovic V, Livingston E, Pandol SJ, Gukovskaya AS. Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase. Cell Physiol 279: C1993-C2003, 2000.

65. Vaquero E, Gukovsky I, Zaninovic V, Gukovskaya AS, Pandol SJ. Localized pancreatic NF-kappaB activation and inflammatory response in taurocholate-induced pancreatitis. Gastrointest Liver Physiol. 280:G1197-G1208, 2001.

66. Beil M, Leser J, Lutz MP, Gukovskaya A, Seufferlein T, Lynch G, Pandol SJ, Adler G. Caspase 8-mediated cleavage of plectin precedes F-actin breakdown in acinar cells during pancreatitis. Gastrointest Liver Physiol. 282:G450-G460, 2002.

67. Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ. Food-Derived Polyphenols Inhibit Pancreatic Cancer Growth Through Mitochondrial Cytochrome C Release and Apoptosis. International Journal of Cancer. 98:761-769, 2002.

68. Gukovskaya AS, Vaquero E, Zaninovic V, Gorelick FS, Lusis AJ, Brennan ML, Holland S, Pandol SJ. Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis. Gastroenterology. 122:974-984, 2002.

69. Tang SJ, Tran T, Memmesheimer C, Pandol S, Aranda R, Pisegna JR, Jensen DM. Paraesophageal hernia repair and deep vein thrombosis. J Clin Gastroenterol 34:187-188, 2002.

70. Gukovskaya AS, Jung Y, Mouria M, Gukovsky I, Pandol SJ. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells: Roles in cell injury processes of pancreatitis. J Biol Chem 277: 22595-22604, 2002.


71. Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Faller LD, Pandol SJ. Ethanol metabolism and transcription factor activation in pancreatic acinar cells in rats. Gastroenterology. 122:106-118, 2002.

72. Savard CE, Blinman TA, Choi HS, Lee SK, Pandol SJ, Lee SP. Expression of cytokine and chemokine mRNA and secretion of tumor necrosis factor-alpha by gallbladder epithelial cells: response to bacterial lipopolysaccharides. BMC Gastroenterol 2:23. 2002.

73. Lu S, Gukovsky I, Lugea A, Reyes CN, Huang ZZ, Chen L, Mato JM, Bottiglieri T, Pandol SJ. Role of S-adenosylmethionine in two experimental models of pancreatitis. FASEB J 17:56-8, 2002.

74. Gukovsky I, Reyes CN, Vaquero EC, Gukovskaya AS, Pandol SJ. Curcumin ameliorates ethanol and non-ethanol experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol 28:G85-95. 2003

75. Büechler P, Gukovskaya AS, Mouria M, Buchler MC, Buchler MW, Friess H, Pandol SJ, Reber HA, Hines OJ. Prevention of metastatic pancreatic cancer growth in vivo by induction of apoptosis with genistein, a naturally occurring isoflavonoid. Pancreas 26:264-273, 2003.

76. Vaquero EC, Edderkaoui M, Nam KJ, Gukovsky I, Pandol SJ, Gukovskaya AS. Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways. Gastroenterology 125:1188-202, 2003.

77. Lugea A, Gukovsky I, Gukovskaya AS, Pandol SJ. Nonoxidative ethanol metabolites alter extracellular matrix protein content in rat pancreas. Gastroenterology 125:1845-1859, 2003.

78. Gukovskaya AS, Hosseini S, Satoh A, Cheng JH, Nam KJ, Gukovsky I, Pandol SJ. Ethanol differentially regulates NF-B activation in pancreatic acinar cells through calcium and protein kinase c pathways. Am J Physiol Gastrointest Liver Physiol, 286:G204-G213, 2004. PMID: 15550766, PMCID: Pending.

79. Gukovsky I, Cheng JH, Nam KJ, Lee OT, Lugea A, Fischer L, Penninger JM, Pandol SJ, Gukovskaya AS. Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells. Gastroenterology, 126:554-566, 2004. PMID: 14762792, PMCID: Pending.

80. Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem, 279: 34643-34654, 2004.

81. Satoh A, Gukovskaya AS, Nieto JM, Cheng JH, Gukovsky I, Reeve JR, Jr., Shimosegawa T, Pandol SJ. Protein kinase C delta and epsilon regulate NF-B activation induced by cholecystokinin and TNF- in pancreatic acinar cells. Am J


Physiol Gastrointest Liver Physiol, 287:G582-G591, 2004. PMID: 15117677, PMCID: Pending

82. Fischer L, Gukovskaya AS, Young SH, Gukovsky I, Lugea A, Buechler P, Penninger JM, Friess H, Pandol SJ. Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco-endoplasmic reticulum Ca2+-ATPase (SERCA). Am J Physiol Gastrointest Liver Physiol, 287:G1200-12, 2004. PMID: 15271649, PMCID: Pending.

83. Satoh A, Gukovskaya AS, Edderkaoui M, Daghighian MS, Reeve JR, Jr., Shimosegawa T, Pandol SJ. TNFα mediates pancreatitis responses in pancreatic acinar cells via protein kinase C and proline-rich tyrosine kinase 2. Gastroenterology, 129: 639-651, 2005. PMID: 16083718, PMCID: Pending.

84. Edderkaoui M, Hong P, Vaquero EC, Fischer L, Friess H, Buchler MW, Lerch MM, Pandol SJ, Gukovskaya AS. Extracellular matrix proteins stimulate reactive oxygen species production and increase pancreatic cancer cells survival through NADPH oxidase and 5-lipoxygenase. Am J Physiol Gastrointest Liver Physiol, 289: G1137-47, 2005.

85. Mareninova OA, Sung KF, Hong P, Lugea A, Pandol SJ, Gukovsky I, Gukovskaya AS. Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J Biol Chem, 281:3370-81, 2006. PMID: 16339139, PMCID: Pending.

86. Wang YL, Hu R, Lugea A, Gukovsky I, Smoot D, Gukovskaya AS, Pandol SJ. Ethanol feeding alters death signaling in pancreas. Pancreas, 32:351-359, 2006.

87. Satoh A, Gukovskaya AS, Reeve JR, Jr., Shimosegawa T, Pandol SJ. Ethanol sensitizes NF-B activation in pancreatic acinar cells through effects on protein kinase C epsilon. Am J Physiol Gastrointest Liver Physiol, 291: G432-8, 2006. PMID: 16574982, PMCID: Pending

88. Kubisch CH, Gukovsky I, Lugea A, Pandol SJ, Kuick R, Misek DE, Hanash SM, Logsdon CD. Long-term ethanol consumption alters pancreatic gene expression in rats: a possible connection to pancreatic injury. Pancreas, 33:68-76, 2006.

89. Lugea A, Nan L, French SW, Bezerra JA, Gukovskaya AS, Pandol SJ. Pancreas tissue repair after cerulein-induced pancreatitis is impaired in plasminogen-deficient mice. Gastroenterology, 131:885-99, 2006. PMID: 16958657, PMCID: Pending.

90. Ito Y, Lugea A, Pandol SJ, McCuskey RS. Substance P mediates cerulean-induced pancreatic micocirculatory dysfunction in mice. Pancreas, 34:138-43, 2007.

91. Fischer L, Gukovskaya AS, Penninger JM, Friess H, Gukovsky I, Pandol SJ. Phosphatidylinositol 3-kinase facilitates bile acid-induced calcium responses in pancreatic acinar cells. AJP, 292:G875-86, 2007. PMID: 17158252, PMCID: Pending.


92. Hu R, Wang YL, Edderkaoui M, Lugea A, Apte MV, Pandol SJ. Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells. Pancreatology, 7:332-340, 2007.

93. Cosen-Binker LI, Lam PP, Binker MG, Reeve J, Pandol S, Gaisano HY. Alcohol cholecystokinin evoked pancreatic acinar basolateral exocytosis is mediated by PKCalpha phosphorylation of Munc18c. J Biol Chem, 282:13047-58, 2007. PMID: 17324928, PMCID: Pending.

94. Lam PP, Cosen Binker LI, Lugea A, Pandol SJ, Gaisano HY. Alcohol redirects CCK-mediated apical exocytosis to the acinar basolateral membrane in alcoholic pancreatitis. Traffic 8:605-17, 2007. PMID: 17451559, PMCID: Pending.

95. Edderkaoui M, Hong PP, Pandol SJ, Gukovskaya AS. Insulin-like growth factor-I receptor mediates the pro-survival effect of fibronectin. J Biol Chem 282:26646-55, 2007.

96. Lee JK, Edderkaoui M, Truong P,Hong PP, Ohno I,Jang KT, Berti A, Pandol SJ, Gukovskaya AS. NADPH Oxidase Promotes Pancreatic Cancer Cell Survival via Inhibiting JAK2 Dephosphorylation by Tyrosine Phosphatases. Gastroenterology, 133:1637-48, 2007. PMID: 17983808, PMCID: Pending.

97. Gukovsky I, Lugea A, Shahsahebi M, Cheng JH, Hong PP, Jung YJ, Deng QG, French BA, Lungo W, French SW, Tsukamoto H, Pandol SJ. A rat model reproducing key pathologic responses of alcoholic chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol, 294: G68-79, 2008. PMID: 17884979, PMCID: Pending.

98. Edderkaoui M, Odinokova I, Ohno I, Gukovsky I, Go VLW, Pandol SJ, Gukovskaya AS. Ellagic acid induces apoptosis through inhibition of NF-B in pancreatic cancer cells. World Journal of Gastroenterology, 2008 Jun 21; 14(23):3672-80.

99. Rakonczay Z Jr, Hegyi P, Dósa S, Iványi B, Jármay K, Biczó G, Hracskó Z, Varga IS, Karg E, Kaszaki J, Varró A, Lonovics J, Boros I, Gukovsky I, Gukovskaya AS, Pandol SJ, Takács T. A new severe acute necrotizing pancreatitis model induced by L-ornithine in rats. Crit Care Med, 2008 Jul;36(7):2117-27. PMID: 18594222, PMCID: Pending.

102. Thrower EC, Osgood S, Shugrue CA, Kolodecik TR, Chaudhuri AM, Reeve JR Jr, Pandol SJ, Gorelick FS. The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells.Am J Physiol Gastrointest Liver Physiol. 294: G1344-53. 2008. PMCID: PMC2975015

103. Yuan J, Lugea A, Zheng L, Gukovsky I, Edderkaoui M, Rozengurt E, Pandol SJ. Protein kinase D1 mediates NF-kappaB activation induced by cholecystokinin and cholinergic signaling in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 295:G1190-201. 2008. PMCID: PMC2604803


http://www.ncbi.nlm.nih.gov/pubmed/18845574?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum




http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17451559&query_hl=1&itool=pubmed_DocSum

104. Chung C, Shugrue C, Nagar A, Doll JA, Cornwell M, Gattu A, Kolodecik T, Pandol SJ, Gorelick F. Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator. Gastroenterology. 136:331-340. 2009. PMCID: PMC2833423

105. Boros LG, Deng Q, Pandol SJ, Tsukamoto H, Go VL, Lee WN. Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer. Pancreas. 38(2) 2009. PMID: 19248221, PMCID: Pending.

106. Sung KF, Odinokova IV, Mareninova OA, Rakonczay Z, Jr., Hegyi P, Pandol SJ, Gukovsky I, Gukovskaya AS. Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in pancreatitis. Exp Cell Res. Jul 1;315(11):1975-89 2009. PMID: 19331832, PMCID: Pending.

107. Nakamura Y, Do JH, Yuan J, Odinokova I, Mareninova O, Gukovskaya A, Pandol SJ. Inflammatory cells regulate p53 and caspases in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2009 Oct 22. PMCID: PMC2806100

108. Mareninova OA, Hermann K, French SW, O'Konski MS, Pandol SJ, Webster P, Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskaya A. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest. 2009 Nov; 119(11):3340-55. PMCID: PMC2769194

109. Thrower EC, Wang J, Cheriyan S, Lugea A, Kolodecik TR, Yuan J, Reeve JR Jr, Gorelick FS, Pandol SJ. Protein Kinase C delta-Mediated Processes in Cholecystokinin-8-Stimulated Pancreatic Acini. Pancreas. 2009 Nov; 38(8):930-5. PMCID: PMC2767410

110. Lugea A, Tischler D, Gong J, Nguyen J, French SW, Pandol SJ. Cholinergic Mediation of Alcohol-Induced Experimental Pancreatitis. Alcohol Clin Exp Res. 2010 Oct; 34(10):1768-81. PMID: 20626730

111. JV Gerasimenko, P Ferdek, L Fischer, AS Gukovskaya, SJ Pandol. (2010) Inhibitors of Bcl-2 family proteins deplete ER Ca(2+) stores in pancreatic acinar cells. Pflugers Arch. 2010 Oct; 460(5):891-900. PMCID: PMC2937140

112. Ohno I, Eibl G, Odinokova I, Edderkaoui M, Damoiseaux RD, Yazbec M, Abrol R, Goddard, III WA, Pandol SJ. Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions between proteins of the Bcl-2 family. Am J Physiol Gastrointest Liver Physiol. 2010 Jan; 298(1):G63-73. PMCID: PMC2806098

113. Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovskaya AS. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent upregulation of p22phox. J.Biol Chem. 2010 Nov 30. PMID: 21118808


http://preview.ncbi.nlm.nih.gov/pubmed/19752773?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3

http://preview.ncbi.nlm.nih.gov/pubmed/19752773?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3









114. Ye R, Mareninova OA, Barron E, Wang M, Hinton DR, Pandol SJ, Lee AS. Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis.. Am J Pathol. Dec; 177(6):2827-36.2010.

115. Lugea A, Tischler, Nguyen J, Gong J, French SW, Gukovsky I, Gorelick FS, Pandol SJ. XBP1 attenuates alcohol-induced chronic endoplasmic reticulum stress in mouse pancreas. Gastroenterology. 2011 Mar; 140(3):987-97.

116. Thrower EC, Yuan J, Usmani A, Liu Y, Jones C, Minervini SN, Alexandre M, Pandol SJ, Guha S. A novel protein kinase D inhibitor attenuates early events of experimental pancreatitis in isolated rat acini. Am J Physiol Gastrointest Liver Physiol. 2011 Jan; 300(1):G120-9. PMCID: PMC3025506

117. Yuan J, Liu Y, Tan T, Guha S, Gukovsky I, Gukovskaya A, Pandol SJ. Protein kinase d regulates cell death pathways in experimental pancreatitis. Front Physiol. 2012; 3:60.

118. Pham H, Chen M, Takahashi H, King J, Reber HA, Hines OJ, Pandol S, Eibl G. Apigenin Inhibits NNK-Induced Focal Adhesion Kinase Activation in Pancreatic Cancer Cells..Pancreas. 2012 Nov; 41(8):1306-15.

119. Abrol R, Edderkaoui M, Goddard WA 3rd, Pandol SJ. Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells. Biochem Biophys Res Commun. 2012 Jun 15; 422(4):596-601.

120. Lê KA, Li Y, Xu X, Yang W, Liu T, Zhao X, Tang YG, Cai D, Go VL, Pandol S, Hui H. Alterations in fecal Lactobacillus and Bifidobacterium species in type 2 diabetic patients in Southern China population. Front Physiol. 2012; 3:496.

121. Shalbueva N, Mareninova OA, Gerloff A, Yuan J, Waldron RT, Pandol SJ, Gukovskaya AS. Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis. Gastroenterology 2013; 144:437-446.e436.

122. Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS. NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox. J Biol Chem 2013; 288:19648.

123. Mareninova OA, Hermann K, French SW, O'Konski MS, Pandol SJ, Webster P, Erickson AH, Katunuma N, Gorelick FS, Gukovsky I, Gukovskaya AS. Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. J Clin Invest 2013; 123:1844.

124. Park CH, Lee IS, Grippo P, Pandol SJ, Gukovskaya AS, Edderkaoui M. Akt kinase mediates the prosurvival effect of smoking compounds in pancreatic ductal cells. Pancreas 2013; 42:655-662.


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http://www.ncbi.nlm.nih.gov/pubmed?term=%22Guha%20S%22%5BAuthor%5D

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http://www.ncbi.nlm.nih.gov/pubmed?term=%22Pandol%20SJ%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Alexandre%20M%22%5BAuthor%5D

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http://www.ncbi.nlm.nih.gov/pubmed?term=%22Jones%20C%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Liu%20Y%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Usmani%20A%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Yuan%20J%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Thrower%20EC%22%5BAuthor%5D

125. Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl GE. High Fat, High Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model. Cancer Prev Res (Phila) Cancer Prev Res (Phila). 2013 Oct;6(10):1064-1073.

126. Edderkaoui M, Lugea A, Hui H, Eibl G, Lu QY, Moro A, Lu X, Li G, Go VL, Pandol SJ. Ellagic Acid and embelin affect key cellular components of pancreatic adenocarcinoma, cancer, and stellate cells. Nutr Cancer. 2013;65(8):1232-44.

127. Lu QY, Zhang L, Lugea A, Moro A, Edderkaoui M, Eibl G, Pandol SJ, Go VL.Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method. J Chromatogr Sep Tech 2013; 4.

128. Liu Y, Yuan J, Tan T, Jia W, Lugea A, Mareninova OA, Waldron RT, Pandol SJ.Genetic inhibition of protein kinase Cε attenuates necrosis in experimentalpancreatitis. Am J Physiol Gastrointest Liver Physiol 2014.

129. Wu BU, Pandol SJ, Amy Liu IL. Simvastatin is associated with reduced risk ofacute pancreatitis: findings from a regional integrated healthcare system. Gut2014.

PEER-REVIEWED – SUBMITTED:

1. Fischer L, Lugea A, Shahsahebi M, Penninger JM, Vanhaesebroeck B, Gukovskaya AS, Pandol SJ, Gukovsky I. Class I PI3K isoforms gamma and delta regulate key pathologic responses of cerulein-induced pancreatitis. Submitted.

2. Lugea A., Wu X, Dasari S, French SW, Pandol SJ. Plasminogen Activator Inhibitor

(PAI)-1 regulates fibrogenesis during experimental pancreatitis. Submitting.

INVITED ARTICLES, BOOK CHAPTERS, ETC.

1. Jensen RT, Collins SM, Pandol SJ, Gardner JD. "Lessons from studies of secretagogue receptors on pancreatic acinar cells." In: Gut Hormones. Edited by SR Bloom and JM Polak. Churchill, Livingston, second edition, 133-136, 1981.

2. Jensen RT, Gardner JD, Raufman JP, Pandol SJ, Doppman JL, Collen MJ. Zollinger-Ellison syndrome: current concepts and management. Ann Intern Med. 98:59-75. 1983

3. Jensen RT, Pandol SJ, Collen MJ, Raufman JP, Gardner JD. "Diagnosis and Management of the Zollinger-Ellison syndrome." In: Receptors and the Upper GI Tract. Edited by BI Hirschowitz and JG Spenney Advanced Therapeutics Communications, Inc., New York, 279-291, 1983.


4. Muallem S, Beeker TG, Fimmel CJ, Pandol SJ. "Inositol phosphate levels during Ca2+ reloading of internal Ca2+ stores in the exocrine pancreas." Progress in Clinical and Biological Research. 252: 183-189, 1988.

5. Pandol, S.J. "Structural abnormalities of the stomach and duodenum." In: Principles and Practices of Gastroenterology and Hepatology. Edited by G. Gitnick. Elsevier, New York, 101-115, 1988 .

6. Muallem S, Beeker TG, Pandol SJ, Fimmel CJ. "Evidence for activation of the ER-Ca2+ pump in intact and permeabilized cells by Ca2+ mobilizing hormones. Progress in Clinical and Biological Research. 273:349-354, 1988.

7. Pandol SJ, Mendius KE. "Calcium metabolism and bombesin - stimulated pancreatic enzyme secretion." Annuals of the New York Academy of Sciences. 547:268-276, 1988.

8. Pandol SJ, Krims PE, Schoeffield-Payne MS, Hsu Y, Muallem S. "Cellular calcium and phospholipid metabolism mediate pancreatic enzyme secretion." In: Gastrointestinal Endocrinology: Receptors and Post-Receptor Mechanisms. Edited by James C. Thompson. Academic Press, 59-72, 1990.

9. Pandol SJ. "Introduction to the function and control of the gastrointestinal system." In: Best and Taylor's Physiological Basis of Medical Practice. 12th edition. Edited by John B. West. Williams and Wilkins, Baltimore, 606-613, 1991.

10. Pandol SJ, Isenberg JI. "Salivary, gastric, duodenal and pancreatic secretion." In: Best and Taylor's Physiological Basis of Medical Practice. 12th edition. Edited by John B. West. Williams and Wilkins, Baltimore, 645-674, 1991.

11. Pandol SJ, Rutherford RE. "Quantal calcium release and calcium entry in the pancreatic acinar cell." Yale Journal of Biology and Medicine. 65:399-405, 1992.

12. Pandol SJ. "Pancreatic Physiology" In: Gastrointestinal Disease. Pathophysiology, Diagnosis, Management. Fifth Edition. Edited by Marvin Sleisenger, John Fordtran, Bruce Scharschmidt and Mark Feldman. W.B. Sanders, Philadelphia, 1585-1600, 1993.

13. Pandol SJ, Gukovskaya AS, Bahnson TD, Dionne VE. "Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell." Annals of the New York Academy of Sciences. 713:41-48, 1994.

14. Pandol SJ. "Pancreatic acinar cell signaling mechanisms." Current Opinion in Gastroenterology. 10: 485-490, 1994.

15. Pandol SJ. "Structural abnormalities of the stomach and duodenum." In: Principals and Practice of Gastroenterology and Hepatology, Second Edition. Edited by Gary


Gitnick, Daniel Hollander, I. Michael Samloft, Leslie J. Schoenfield, and John M. Vierling. Appleton and Lange, Norwalk, Connecticut, 87-98,1994.

16. Pandol SJ, Gukovskaya AS, Bahnson TD. "Nitric oxide and cyclic GMP mediate agonist-stimulated calcium influx in pancreatic acinar cell." Regulatory Peptide Letter 6: 39-42, 1995.

17. Pandol SJ, Pandol KA, Raybould H. "Integrated response to a meal". Undergraduate Teaching Project, American Gastroenterological Association, Milner-Fenwick, Timonium, Maryland, 1995 (slides).

18. Raybould H, Pandol KA, Pandol SJ. "Gastrointestinal movements and their functions." Undergraduate Teaching Project, American Gastroenterological Association. Milner-Fenwick, Timonium, Maryland, 1995 (20 minute video).

19. Pandol SJ. "Pancreatic Physiology and Secretory Testing." In: Gastrointestinal and Liver Disease. Pathophysiology, Diagnosis, Management. Sixth Edition. Edited by Marvin Sleisenger, Bruce Scharschmidt and Mark Feldman, W.B. Sanders, Philadelphia, 771-782, 1997.

20. Pandol SJ. “Anoikis: Assisted cellular suicide.” Trendletters: News in Physiological Sciences. Twelfth Edition, pg 96, 1997.

21. Raybould HE, Pandol SJ. “The integrated response of the gastrointestinal tract to a meal.” In: Textbook of Gastroenterology. Third Edition. Edited by Tadataka Yamada. Lippincott-Raven, Philadelphia, 2-10, 1999.

22. Pandol SJ. “Congressional testimony before a joint hearing on suspension of medical research at West Los Angeles and Sepulveda VA Medical Facilities and informed consent and patient safety in VA medical research.” http://www.house.gov/va/schedule106/apr99/4-21-99J/pandol.htm

23. Pandol SJ. “Goals for Research on Mechanisms of Alcohol-related Pancreatic Disease.” National Institute on Alcohol Abuse and Alcoholism, 2000.

24. Pandol SJ. “Pancreatic Physiology and Secretory Testing.” In: Gastrointestinal and Liver Disease. Pathophysiology, Diagnosis, Management. Seventh Edition. Edited by Marvin Sleisenger, Lawrence S. Friedman and Mark Feldman, W.B. Sanders, Philadelphia, 871-880, 2002

25. Tang SJ, Tran T, Memmesheimer C, Pandol S, Aranda R, Pisegna JR, Jensen DM. Letters to the Editor: Paraesophageal Hernia Repair and Deep Vein Thrombosis. J Clin Gastroenterol, 34:187-188, 2002.

26. Pandol SJ. “Pancreatic Physiology and Secretory Testing.” In: Gastrointestinal and Liver Disease. Pathophysiology, Diagnosis, Management. Seventh Edition. Edited by Mark Feldman, Lawrence S. Friedman and Marvin Sleisenger, W.B. Sanders, Philadelphia, 871-880, 2002.


http://www.house.gov/va/schedule106/apr99/4-21-99J/pandol.htm

27. Pandol SJ. “Practical guidelines for diagnosis and treatment of gastrointestinal, liver and pancreatic disorders.” Greater Los Angeles, Health Care System, Intranet 2000-Present.

28. Raybould HE, Pandol SJ, Yee H. “The integrated responses of the gastrointestinal tract and liver to a meal.” In: Textbook of Gastroenterology. Fourth Edition. Edited by Tadataka Yamada. Lippincott-Raven, Philadelphia, 2-10, 2003.

29. Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS. “Animal Models of Alcoholic Pancreatitis: Role of Cholecystokinin.” Pancreas, 27:297-300, 2003.

30. Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS. “Emerging concepts for the mechanism of alcoholic pancreatitis from experimental models.” Journal of Gastroenterology, 38:623-628, 2003.

31. Gorelick F, Pandol SJ, Topazian M. “Pancreatic physiology, pathophysiology, acute and chronic pancreatitis.” Gastrointestinal Teaching Project, American Gastroenterologic Association 2003.

32. Pandol SJ. “Neurohumoral control of exocrine pancreatic secretion.” Current Opinion in Gastroenterology, 19(5):443-446, 2003.

33. Gukovskaya AS, Vaquero EC, Edderkaoui M, Pandol SJ. “Survival signals in pancreatic cancer.” 11th International Conference on Ulcer Research-ICUR, p. 345, 2003.

34. Pandol SJ, Gukovsky I, Satoh A, Fischer L, Lugea A, Gukovskaya AS. “Molecular mechanisms of pancreatitis.” 11th International Conference on Ulcer Research-ICUR, p. 349, 2003.

35. Miller A, Davis M, Pandol SJ. “The Rating Racket.” (Letter) http://govexec.com/features/1103/1103letters.htm

36. Pandol SJ, Satoh A, Fischer L, Mareninova O, Lugea A, Gukovsky I, Gukovskaya AS. “Alcoholic pancreatitis: hijacked pancreatic signals.” The Cell, 36(8):24-29, 2004.

37. Gukovskaya AS, Pandol SJ. “Cell death pathways in pancreatitis and pancreatic cancer.” Pancreatology, 4:567-86, 2004.

38. Pandol SJ. “Neurohumoral control of exocrine pancreatic secretion.” Current Opinion in Gastroenterology, 20(5):435-438, 2004.

39. Gorelick F, Pandol SJ, Topazian M, Robles-Diaz G. Pancreatitis (Version in Spanish). Gastrointestinal Teaching Project, American Gastroenterologic Association 2004.


http://govexec.com/features/1103/1103letters.htm

40. Sawicki M, Pandol SJ, McGee JB. The Genetic and Molecular Basis of Gastrointestinal and Liver Disease. Gastrointestinal Teaching Project, American Gastroenterologic Association 2004.

41. Pandol SJ. “Are we studying the correct state of the stellate cell to elucidate mechanisms of chronic pancreatitis?” Gut 54:744-5, 2005.

42. Go VL, Gukovskaya A, Pandol SJ. “Alcohol and pancreatic cancer.” Alcohol 35:205-11, 2005.

43. Pandol SJ. “Acute Pancreatitis.” Curr Opin Gastroenterol 21:538-43, 2005.

44. Apte MV, Zima T, Dooley S, Siegmund SV, Pandol SJ. Singer MV. Singal transduction in alcohol-related diseases. Alcohol Clin Exp Res, 29:1299-1309, 2005.

45. Pandol SJ, Satoh A, Fischer L, Mareninova O, Sung KF, Lugea A, Gukovsky I, Gukovskaya AS. Alcoholic Pancreatitis: Insights from Animal Models Alcohol Clin Exp Res, Vol. 29, Nr. 7, Seite 1299-1309, 2005.

46. Pandol SJ, Edderkaoui M, Lee JK, Hu R, Lugea A, Sul J, Apte M, Vaquero E, Ohno I, Gukovsky I, Go VL, Gukovskaya AS. “Alcohol, Reactive Oxygen Species, Pancreatitis and Pancreatic Cancer.” In: Alcohol, Tobacco and Cancer. Edited by Chi Hin Cho, Vishnudutt Purohit, Karger, New York, 109-118, 2006.

47. Pandol SJ. “Pancreatic Secretion.” In: Gastrointestinal and Liver Disease. Pathophysiology, Diagnosis, Management. Eighth Edition. Edited by Mark Feldman, Lawrence S. Friedman and Lawrence J. Brandt, W.B. Sanders, Philadelphia, 1189-1201, 2006.

48. Pandol, SJ. “Acute Pancreatitis: Diagnosis and Management.” Cybergrounds Gastroenterology InterNDnet. http://www.cyberounds.com/conf/gastroenterology/ 2006.

49. Gukovskaya AS, Mareninova OA, Odinokova IV, Sung KF, Lugea A, Fischer L, Wang YL, Gukovsky I, Pandol SJ. Cell death in pancreatitis: Effects of alcohol. J Gastroenterol Hepatol. Suppl 3:S10-3, 2006.

50. Pandol SJ, Tsukamoto H. Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: White paper. J Gastroenterol Hepatol. Suppl 3:S109-10, 2006.

51. Pandol SJ. “Acute Pancreatitis.” Curr Opin Gastroenterol 22:481-486, 2006.

52. Pandol SJ, Lugea A, Gukovskaya AS, Gukovsky I. Epidemiology and Pathophysiology of Alcoholic Chronic Pancreatitis. In: The Pancreas: A Integrated Textbook of Basic Science, Medicine and Surgery. 2nd Edition. Eds.: Beger HG,


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_AbstractPlus&term=%22Mareninova+OA%22%5BAuthor%5D

http://www.cyberounds.com/conf/gastroenterology/

Büchler MW, Kozarek RA, Lerch MM, Neoptolemos JP, Shiratori K, Warshaw AL, Whitcomb DC, Blackwell Publishing, Oxford 2009, Chapter 39.

53. Pandol SJ, Raraty MG. Mechanisms of alcohol-induced pancreatitis. Pancreatology, 7:105-114, 2006.

54. Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cells: a star on the rise in pancreatic diseases. J Clin Invest 117:50-9, 2007.

55. Raybould HE, Pandol SJ, Yee H. “The integrated responses of the gastrointestinal tract and liver to a meal.” In: Textbook of Gastroenterology. Fifth Edition. Edited by Tadataka Yamada. Lippincott-Raven, Philadelphia, publication in 2007.

56. Pandol, S. Acute Pancreatitis: Diagnosis and Management. Cyberounds Overview InterMDnet. http://www.cyberounds.com/conf/gastroenterology/2006-08-07/index.html

57. Pandol S., Cohen H. Chronic Pancreatitis: Diagnosis and Management. Cyberounds Overview InterMDnet. http://www.cyberounds.com/conf/gastroenterology/2007-01-08/index.html

58. Pandol SJ, Saluja AK, Imrie CW, Banks PA. Acute pancreatitis: Bench to the bedside. Gastroenterology, 132:1127-51, 2007. PMID: 17383433

59. Mukherjee R, Criddle DN, Gukovskaya A, Pandol S, Peterson OH, Sutton R. Mitochondrial injury in pancreatitis. Cell Calcium, Jul;44(1):14-23 2008

60. Sutton R, Petersen OH, Pandol SJ. Pancreatitis and calcium signalling: report of an international workshop. Pancreas. 36:e1-14. 2008. PMID: 18437073

61. Pandol SJ. Integrated Responses to a Meal. JPEN J Parenter Enteral Nutr. 32: 564-6. 2008.

62. Gorelick F, Pandol S, Thrower E. Protein kinase C in the pancreatic acinar cell. Journal of Gastroenterology and Hepatology, 23: S37-S41, 2008. PMID: 18336661

63. Sutton R, Petersen OH, Pandol SJ. Pancreatitis and Calcium Signaling: Report of an International Workshop. Pancreas, 38:e47-52, 2009

64. Topazian M, Pandol SJ. “Acute Pancreatitis.” In: Textbook of Gastroenterology. Fifth Edition, Volume 2. Edited by Tadataka Yamada. Wiley-Blackwell Publication in 68: 1761-1810, 2009.

65. Pandol SJ, Raybould HE, Yee HF. “Integrative responses of the gastrointestinal tract and liver to a meal.” In: Textbook of Gastroenterology. Fifth Edition, Volume 1. Edited by Tadataka Yamada. Wiley-Blackwell Publication in 1: 3-14, 2009.

66. Pandol SJ. Edderkaoui M, Gukovsky I, Lugea A, Gukovskaya A. Desmoplasia of Pancreatic Ductal Adenocarcinoma. Clin Gastro Hep. 2009.




http://www.cyberounds.com/conf/gastroenterology/2007-01-08/index.html

http://www.cyberounds.com/conf/gastroenterology/2006-08-07/index.html

67. Pandol SJ. “Pancreatic Secretion”. In: Gastrointestinal and Liver Disease. Ninth Edition, Volume 1. Edited by Mark Feldman, MD Lawrence Friedman, MD, and Lawrence Brandt, MD. Saunders Elsevier. 1: 921-930, 2010.

68. Pandol SJ. “Integrating the gastrointestinal sciences”. Integrating the gastrointestinal sciences. Front. Physio. 1:19, 2010

69. Pandol SJ., Gorelick FS., Gerloff A., Lugea A. Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis. Dig Dis. 2010;28(6):776-82.

70. Pandol SJ., Gorelick FS., Lugea A. Environmental and Genetic Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function- A Hypothesis. Front Physiol. 2011 Mar 10;2:8.011

71. Pandol SJ. “The Exocrine Pancreas”. San Rafael (CA): Morgan & Claypool Life Sciences; 2010.

72. Pandol SJ. “The Future of Food”. 2011.

73. Hegyi P, Pandol S, Venglovecz V, Rakonczay Z Jr. The acinar-ductal tango in the pathogenesis of acute pancreatitis. Gut. 2011 Apr;60(4):544-52. PMID: 20876773

74. Alexandre M, Pandol SJ, Gorelick FS, Thrower EC. The emerging role of smoking in the development of pancreatitis. Pancreatology. 2011;11(5):469-74.

75. Pandol SJ, Lugea A, Mareninova OA, Smoot D, Gorelick FS, Gukovskaya AS, Gukovsky I. Investigating the pathobiology of alcoholic pancreatitis. Alcohol Clin Exp Res. 2011 May;35(5):830-7..

76. Lugea A, Waldron RT, French SW, Pandol SJ. Drinking and driving pancreatitis: links between endoplasmic reticulum stress and autophagy. Autophagy. 2011 Jul;7(7):783-5.

77. Gukovsky I, Pandol SJ, Gukovskaya AS. Organellar dysfunction in the pathogenesis of pancreatitis. Antioxid Redox Signal. 2011 Nov 15;15(10):2699-710.

78. Pandol S, Gukovskaya A, Edderkaoui M, Dawson D, Eibl G, Lugea A. Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:127-34.

79. Gukovsky I, Pandol SJ, Mareninova OA, Shalbueva N, Jia W, Gukovskaya AS. Impaired autophagy and organellar dysfunction in pancreatitis. J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:27-32.

80. Pandol SJ, Apte MV, Wilson JS, Gukovskaya AS, Edderkaoui M. The burning question: Why is smoking a risk factor for pancreatic cancer? Pancreatology. 2012 Jul;12(4):344-9.














81. Simeone DM, Pandol SJ. The pancreas: biology, diseases, and therapy. Gastroenterology 2013;144:1163-1165.

82. Apte MV, Wilson JS, Lugea A, Pandol SJ. A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology 2013;144:1210-1219.

83. Liddle RA, Freeman M, Simeone DM, Saluja AK, Castillo CF, Maitra A, Pandol SJ, Go VL. Minutes of the business meeting of the American Pancreatic Association, Friday, November 2, 2012, Miami, Florida. Pancreas. 2013: 42:1333-4.

84. Liu ST, Pham H, Pandol SJ, Ptasznik A. Src as the link between inflammationand cancer. Front Physiol 2014.

85. Tan CR, Yaffee PM, Jamil LH, Lo SK, Nissen N, Pandol SJ, Tuli R, Hendifar AE. Pancreatic cancer cachexia: a review of mechanisms and therapeutics. FrontPhysiol 2014.

86. Zhou G, Sinnett-Smith J, Liu SH, Yu J, Wu J, Sanchez R, Pandol SJ, Abrol R,Nemunaitis J, Rozengurt E, Brunicardi FC. Down-regulation of pancreatic andduodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism forinhibition of cellular proliferation and insulin secretion by somatostatin. FrontPhysiol 2014.

ABSTRACTS:

1. Pandol SJ, Korman LY, McCarthy DM, Gardner JD. Beneficial effect of oral lithium carbonate in the treatment of pancreatic cholera syndrome. Gastroenterology 78:1232, 1980.

2. Richter JE, Pandol SJ, Castell DO, McCarthy DM. Esophageal abnormalities in the Zollinger-Ellison syndrome. Gastroenterology 78:1244, 1980.

3. Pandol SJ, Jensen RT, Gardner JD. Glucagon-stimulated pancreatic enzyme secretion: a potential functional relation between endocrine and exocrine pancreas. Gastroenterology 80:1247, 1981.

4. Collins SM, Kinsella T, Korman LY, Jensen RT, Collen MJ, Pandol SJ, Barlas N, O'Dorisio T, Gardner JD. Tumor radiosensitivity in the pancreatic cholera syndrome. Gastroenterology 80:1127, 1981.

5. Pandol SJ, Jensen RT, Gardner JD. Mechanism of bombesin-induced desensitization of enzyme secretion in pancreatic acini. Gastroenterology 81:1145, 1982.


6. Collen MJ, Pandol SJ, Raufman JP, Allende HD, Bissonnette BM, Jensen RT, Gardner JD. Beneficial effects of pirenzepine, a selective anticholinergic agent, in patients with Zollinger-Ellison syndrome (ZES). Gastroenterology 82:1035, 1982.

7. Allende HD, Collen MJ, Pandol SJ, Raufman JP, Gardner JD, Jensen RT. Cimetidine induced impotence and gynecomastia: reversal with ranitidine. Gastroenterology 82:1007, 1982.

8. Allende HD, Bissonnette BM, Raufman JP, Pandol SJ, Collen MJ, McCarthy DM, Gardner JD, Jensen RT. Progressive increase in drug requirement in the long-term medical management of patients with Zollinger-Ellison syndrome (ZES). Gastroenterology 82:1007, 1982.

9. Pandol SJ, O'Donohue TL, Gardner JD, Jensen RT. Natural glucagon-stimulated pancreatic enzyme secretion: due to contamination by a previously undescribed pancreatic secretagogue. Gastroenterology 84:1269, 1983.

10. Pandol SJ, Thomas MW, Rivier J, Vale W. Growth hormone-releasing factors stimulate in vitro pancreatic enzyme secretion. Gastroenterology 86:1205, 1984.

11. Pandol SJ, Thomas MW, Schoeffield MS. Independence of cholecystokinin-induced phosphatidylinositol breakdown from extracellular calcium and mobilization of intracellular calcium in dispersed acini from guinea pig pancreas. Gastroenterology 86:1205, 1984.

12. Seifert H, Pandol SJ, Rivier J, Vale W. GRF binding to pancreatic acinar cells." Gastroenterology 86:1243, 1984.

13. Pandol SJ, Sachs G, Muallem S. Transient activation of plasma membrane Ca2+

channel and Ca2+ uptake into endoplasmic reticulum upon termination of cell stimulation. Federation Proceedings 44:1228, 1985.

14. Muallem S, Pandol SJ, Sachs, G. Ion pathways and IP3-induced Ca2+ release in hepatic rough endoplasmic reticulum. Federation Proceedings 44:1228, 1985 (1 page).

15. Pandol SJ, Schoeffield MS, Sachs G, Muallem S. Role of secretagogue-induced changes in free cytosolic calcium in pancreatic enzyme secretion. Gastroenterology 88:1528, 1985.

16. Sachs G, Pandol SJ, Muallem S. The regulation of Ca2+ stores in stimulus-secretion coupling. Gastroenterology 88:1565, 1985.

17. Dharsathaphorn K, Pandol SJ. Basis for synergism between cAMP and Ca++-mediated Cl2 secretion in a human colonic cell line. Gastroenterology 88:1364, 1985.


18. Dharsathaphorn K, Pandol SJ, McRoberts JA. Cl- secretion induced by cabachol in a human colonic epithelial cell line: studies of the mechanism of action. Gastroenterology 88:1364, 1985.

19. Pandol SJ, Kondratenko NF, Schoeffield MS. Arachidonate release and sustained pancreatic exocrine secretion. Gastroenterology 90:1577, 1986.

20. Krims PE, Pandol SJ. Free cytosolic calcium in initial and sustained pancreatic exocrine secretion. Gastroenterology 90:1503, 1986.

21. Muallem S, Schoeffield M, Pandol SJ. Hormones mobilize Ca2+ from two intracellular pools of the exocrine pancreas. Gastroenterology 90:1558, 1986.

22. Fimmel CJ, Pandol SJ, Sachs G, Muallem S. Regulation of free cytosolic Ca2+ in peptic cells. Gastroenterology 90:1415, 1986.

20. McArthur K, Pandol SJ, Rivier J. A vasoactive intestinal peptide (VIP) analog distinguishes two subtypes of high affinity VIP receptor on guinea pig pancreatic acinar cells. Gastroenterology 92:1524, 1987.

24. Muallem S, Pandol SJ. Reloading of the agonist- sensitive calcium pool in the pancreatic acinar cell. Gastroenterology 92:1543, 1987.

25. Pandol SJ, Muallem S. The control of plasma membrane calcium channel activation in the pancreatic acinar cell. Gastroenterology 92:1565, 1987.

26. Pandol SJ Rodriguez G, Mendius K. The role of intracellular calcium flux in the mechanism of secretagogue-induced sustained pancreatic enzyme secretion. Gastroenterology 92:1565, 1987.

27. Algazi MC, Pandol SJ, Rivier J, Isenberg JI. Vasoactive intestinal peptide (VIP) is a mediator of HCl-induced duodenal bicarbonate secretion (B.S.). Gastroenterology 92:1796, 1987.

28. Beuerlein G, Dharmsathaphorn K, Pandol SJ. A phorbol ester inhibits Cl-secretion stimulated by carbachol and ionomycin. Clinical Research 35:588A, 1987.

29. Kelleher D, Pandol SJ, Kagnoff MK. Dissociation of protein kinase C activation from PMA induced IL2 secretion in HUT-78 cells. Clinical Research 35:3:608A, 1987.

30. Schmidt DN, Pandol SJ. No evidence of changed receptor properties or altered stimulus-secretion coupling in dispersed pancreatic acini of ethanol-fed rats. Digestion 38(1):56, 1987.

31. Schmidt DN, Pandol SJ. Prolonged exposure of isolated rat pancreatic acini to acetaldehyde does not affect secretagogue-stimulated amylase release. Digestion 38(1):56-57, 1987.


32. Schmidt DN, Pandol SJ. Effects of ethanol feeding on pancreatic enzyme content and responses to various secretagogues. Digestive Diseases and Sciences 32:(10):1187, 1987.

33. Rivier J, Rivier C, Perrin M, Hagler A, Struthers S, Pandol SJ, Brown M, Kupryszewski G, Chadhuri M, Vale W. Competitive antagonists of peptide hormones. Regulatory Peptides 19:(1-2):135, 1987.

34. Pandol SJ. Role of calcium flux in the mechanism of action of exocrine pancreatic secretagogues. Regulatory Peptides 19(1-2):131, 1987.

35. Chen HS, Hogan DL, Rivier J, Pandol SJ, Koss MA, Isenberg JI. PGE2 stimulated duodenal mucosal bicarbonate secretion (DBS) functions independently from VIP. Clinical Research 36:129A, 1988.

36. Dharmsathaphorn K, Beuerlein G, Reinlib L, Pandol SJ, Donowitz M, Cohn J. Activation of M2 acetylcholine receptors in a colonic epithelial cell line and intracellular mediators involved in the Cl- secretory response. Gastroenterology 94:A98, 1988.

37. Mendius K, Muallem S, Pandol SJ. Agonist- stimulated calcium influx is regulated by membrane potential in the pancreatic acinar cell. Gastroenterology 94:A299, 1988.

38. Pandol SJ. Evidence that arachidonic acid is an intracellular mediator of agonist-stimulated sustained enzyme secretion from exocrine pancreas. Gastroenterology 94:A341, 1988.

39. Beuerlein G, Pandol SJ, Dharmsathaphorn K. Modulation of chloride secretory response in a colonic cell line by free cytosolic calcium. Clinical Research 36:129A, 1988.

40. Pandol SJ, Schoeffield-Payne MS. Cyclic GMP regulates plasma membrane calcium pump activity in pancreatic acinar cells. Gastroenterology 96:A382, 1989.

41. Cohen ME, Pandol SJ, Donowitz M. Elevated Ca2+ increases ileal villus cell microvillus membrane diacylglycerol content: involvement in protein kinase C (PKC) translocation. Gastroenterology 96:A92, 1989.

42. O'Konski MS, Pandol SJ. Effects of Caerulein on the Apical Cytoskeleton of the Pancreatic Acinar Cell. Gastroenterology 98:A229, 1990.

43. Perkins PS, Bahrami LS, Pandol SJ. Aspects of the mechanism of regulation of pancreatic digestive enzyme synthesis by secretagogues. Gastroenterology 98:A230, 1990.

44. Rutherford RE, Pandol SJ. Rapid desensitization of calcium release from the agonist-sensitive pool in the pancreatic acinar cell. Gastroenterology 98:A520, 1990.


45. O'Konski MS, Pandol SJ. Apical cytoskeletal changes caused by caerulein are reversed by CCK-JMV-180. Gastroenterology 100:A293, 1991.

46. Pandol SJ, Schoeffield-Payne MS, Rutherford RE. Agonist mediated increases in sphingosine regulate internal calcium stores and free cytosolic calcium. Gastroenterology 100:A293, 1991.

47. Perkins PS, Pandol SJ. Regulation of digestive enzyme synthesis by CCK-induced alterations in polysome formation. Gastroenterology 100:A294, 1991.

48. Buranawuti T, Vajanaphanich M, Barrett KE, Pandol SJ, Traynor-Kaplan AE. Inositol tetrakisphosphate may mediate phorbol ester inhibition of carbachol stimulated Cl- secretion in T84 cells. Gastroenterology 102:A203, 1992.

49. Vajanaphanich M, Schultz C, Buranawuti T, Tsien RY, Pandol SJ, Traynor-Kaplan AE, Barrett KE. Synergistic epithelial chloride secretion via cAMP and calcium pathways - a re-examination. Gastroenterology 102:A249, 1992.

50. Pandol SJ, Schoeffield-Payne M. The agonist-sensitive pool of calcium regulates cellular cyclic GMP in the pancreatic acinar cell. Gastroenterology 102:A284, 1992.

51. Perkins PS, Rutherford RE, Pandol SJ. The effect of chronic ethanol feeding on digestive enzyme synthesis in rat pancreas. Gastroenterology 102:A285, 1992.

52. Poucell-Hatton S, Perkins PS, Deerinck TJ, Ellisman M, Hardison WGM, Pandol SJ. Immunolocalization of a low molecular weight myosin in the pancreatic acinar cell. Gastroenterology 102:A286, 1992.

53. Poucell-Hatton S, Perkins PS, Deerinck TJ, Ellisman M, Hardison WGM, Pandol SJ. Differential distribution of myosin I and myosin II in pancreatic acinar cells: a possible role in the transport of exocytosis of zymogen granules. Molecular and Cellular Biology Suppl. 3, pg.158A 1992.

54. Pandol SJ, Fitzsimmons T, Schoeffield-Payne M, Carlisle GW, Evans WH. Isolation of subcellular agonist-sensitive calcium stores in the pancreatic acinar cell. Gastroenterology 104:A327, 1993.

55. Perkins PS, Pandol SJ. The role of calcium in translational regulation of protein synthesis in the exocrine pancreas. Gastroenterology 104:A327, 1993.

56. Vajanaphanich M, Schultz R, Tsien RY, Traynor-Kaplan AE, Pandol SJ, Barrett KF. Crosstalk between epithelial calcium and cAMP signaling pathways: implications for secretion. Gastroenterology 104:A286, 1993.

57. Gukovskaya AS, Pandol SJ. Nitric oxide regulates neurotransmitter induced cGMP rise and Ca2+ influx in pancreatic acinar cells. Gastroenterology 104:A306, 1993.


58. Gukovskaya AS, Poucell-Hatton S, Fitzsimmons TJ, Perkins PS, Zaninovic V, Sandoval SI, Rutherford R, Pandol, S.J. Apoptosis in experimental pancreatitis. Gastroenterology 106:A295, 1994.

59. Gukovskaya AS, Pandol SJ. Regulation of nitric oxide synthase and guanylyl cyclase by Ca2+ and Ca2+-binding proteins in dispersed pancreatic acini. Gastroenterology 106:A812, 1994.

60. Fitzsimmons TS, Evans WH, Pandol SJ. Both cADP-ribose and IP3 release calcium from compartments of the intracellular stores isolated from pancreatic acinar cells. Gastroenterology 106:A1026, 1994.

61. Gukovskaya AS, Poucell-Hatton S, Perkins PS, Zaninovic V, Sandoval DI Fitzsimmons TJ, Pandol SJ. Different mechanisms of cell death in rat and opossum after duct ligation. Gastroenterology 108:A358, 1995.

62. Sandoval D, Gukovskaya AS, Reavey P, Gukovsky S, Braquet P, Pandol SJ, Poucell-Hatton S. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology 108:A388, 1995.

63. Gukovskaya AS, Pandol SJ. Membrane guanylate cyclase in exocrine pancreas. Gastroenterology 108:A973, 1995.

64. Perkins PS, Pandol SJ. Intracellular calcium distribution regulates protein synthesis at translational initiation or elongation in the exocrine pancreas. Gastroenterology 108:A998, 1995.

65. Gukovskaya AS, Pandol SJ. Ca2+ -ATPase inhibitors stimulate membrane guanylate cyclase in pancreatic acini. Gastroenterology 110:A1076, 1996.

66. Gukovskaya AS, Sandoval D, Zaninovic V, Pandol SJ. Tumor necrosis factor regulates cell death in caerulein-induced pancreatitis. Gastroenterology 110:A394, 1996.

67. Fitzsimmons TJ, Pandol SJ. Regulation of cyclic ADP ribose levels by Ca2+ in the pancreatic acinar cell. Gastroenterology 110:A388, 1996.

68. Gukovsky IY, Feng L, Gukovskaya AS, Pandol SJ. The calcium-binding protein neurocalcin is expressed in pancreas. Gastroenterology 110:A1076, 1996.

69. Blinman TA, Gukovsky IY, Gukovskaya AS, Livingston E, Pandol SJ. Pancreatic acinar cells express a variety of cytokines that are regulated in experimental pancreatitis. Gastroenterology 112:A429, 1997.

70. Song MK, Zaninovic V, Kim DR, Gukovskaya AS, Pandol SJ, Kang KW. Peptide guamerin-D modulated development of cerulein-induced acute pancreatitis in the rat. Gastroenterology 112:A483, 1997.


71. Periskic S, Zaninovic V, Gukovsky I, Gukovskaya AS, Solomon T, Tsukamoto H, Pandol SJ. Ethanol feeding increases the sensitivity of the rats to cholecystokinin (CCK) induced pancreatitis. Gastroenterology 112:A472, 1997.

72. Gukovskaya AS, Gukovsky I, Periskic S, Blinman T, Zaninovic V, Pandol SJ. Loss of extracellular matrix contacts leads to NF-B activation, cytokine expression, and production and apoptosis in pancreatic acinar cell. Gastroenterology 112:A446, 1997.

73. Gukovsky I, Gukovskaya AS, Zaninovic V, Periskic S, Tsukamoto H, Pandol SJ. NF-B activation is an early marker of pancreatic acinar cell injury in rat cerulein pancreatitis. Gastroenterology 112:A446, 1997.

74. Zaninovic V, Gukovskaya AS, Blinman T, Gukovsky I, Pandol SJ. ICAM-1 upregulation in experimental pancreatitis induced by supramaximal doses of cerulein. Gastroenterology 112:A495, 1997.

75. Fitzsimmons T, McRoberts J, Tachiki K, Pandol SJ. The role of fatty acid-CoA esters in Ca2+ signaling in the pancreatic acinar cell. Gastroenterology 112:A439, 1997.

76. Blinman T, Gukovskaya AS, Gukovsky I, Zaninovic V, Livingston E, Pandol SJ. Pancreatic acinar cells express IL-6, KC, MCP-1, and MIP-2: Evidence from RT-PCR analysis of microscopically isolated acinar cells. Gastroenterology 114:A443, 1998.

77. Blinman T, Gukovsky I, Gukovskaya A, Zaninovic V, Pandol SJ, Livingston E. Intrapancreatic expression of cytokines IL-6 and KC is increased in cerulein pancreatitis: regulation by NF-B. Gastroenterology 114:A443, 1998.

78. McRoberts JA, Gukovsky I, Rodriguez E, Lai FA, Pandol SJ. Ryanodine receptor is present in rat pancreatic acinar cells. Gastroenterology 114:A457, 1998.

79. Gukovskaya AS, Gukovsky I, Kira DT, Lam J, Gukovsky S, Pandol SJ. Ethanol and fatty acid ethyl esters induce activation of transcription factors NF-B and AP-1 in pancreatic acinar cells. Gastroenterology 114:A464, 1998.

80. Gukovskaya AS, Gukovsky I, Zaninovic V, Kira DT, Pandol SJ. Metalloproteinases regulate signal transduction pathways triggered by extracellular matrix proteins. Gastroenterology 114:A464, 1998.

81. Gukovsky I, Gukovskaya AS, Pandol SJ. Cerulein activates NF-B and AP-1 in isolated pancreatic acinar cells. Gastroenterology 114:A465, 1998.

82. Gukovsky I, Blinman TA, Zaninovic V, Jung Y, Gukovskaya AS, Pandol SJ. Role of transcription factor NF-B in mediating hormone-induced pancreatitis. Gastroenterology 114:A465, 1998.


83. Zaninovic V, Gukovskaya AS, Gukovsky I, Kim S, Pandol SJ. Adhesion molecule ICAM-1 is present and functions in rat pancreatic acinar cells. Gastroenterology 114:A512, 1998.

84. Savard CE, Blinman TA, Pandol SJ, Lee SP. Lipopolysaccharide stimulates cytokine production by mouse gallbladder epithelial cells. Gastroenterology 114:A1077, 1998.

85. Gukovskaya AS, Gukovsky I, Mouria M, Pandol SJ. Regulation of pancreatic cancer apoptosis by polyphenols. International Conference on Diet and Prevention of Cancer, Finland, 1999.

86. Gukovskaya AS, Gukovsky I, Mouria M, Pandol SJ. Cerulein stimulates apoptosis in pancreatic acinar cells. Gastroenterology 116:A1128, 1999.

87. Gukovskaya AS, Zaninovic V, Lam H, Mouria M, Neil L, Pandol SJ. Neutrophils regulate trypsin activation in cerulein pancreatitis. Gastroenterology 116:A1128-A1129, 1999.

88. Gukovsky I, Jung Y, Periskic S, Zaninovic V, Kim S, Gukovskaya AS, Tsukamoto H, Pandol SJ. Ethanol diet sensitizes pancreas to CCK-8 induced activation of NF-B and cytokine mRNA expression. Gastroenterology 116:A1129, 1999.

89. Gukovsky I, Gukovskaya AS, Mouria M, Pandol SJ. Detachment from extracellular matrix stimulates NF-B activation and apoptosis in pancreatic cancer cells. Gastroenterology 116:A416, 1999.

90. Mouria M, Gukovskaya AS, Gukovsky I, Pandol SJ. Effects of polyphenols on apoptosis and NF-B activation in pancreatic cancer cells. Gastroenterology 116:A470, 1999.

91. Zaninovic V, Gukovskaya AS, Bostandzhyan E, Eysselein VE, Pandol SJ. Effect of overexpression of transforming growth factor on necrotizing cerulein pancreatitis in mice. Gastroenterology 116:A1179, 1999.

92. Leser J, Beil M, Gukovskaya AS, Pandol SJ, Adler G, Lutz MP. Caspase-8 mediated cleavage of plectin regulates CCK-induced F-actin breakdown in pancreatic acinar cells. Gastroenterology 118:A194, 2000.

93. Buechler P, Hines OJ, Gukovskaya AS, Mouria M, Pandol SJ, Reber HA. The isoflavonoid genistein induces apoptosis by activation of caspase-3 and inhibits metastatitic tumor growth in vivo. Gastroenterology 118:A1143, 2000.

94. Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Pandol SJ. Acetaldehyde production from ethanol regulates activation of transcription factors NF-B and AP-1 in pancreatic acinar cells. Gastroenterology 118:A1146, 2000.


95. Vaquero E, Gukovsky I, Zaninovic V, Gukovskaya AS, Pandol SJ. Upregulation of transcription factors and cytokine MRNA expression in taurocholate-induced pancreatitis. Gastroenterology 118:A653, 2000.

96. Mouria M, Gukovskaya AS, Pandol SJ. Mechanisms of the effects of food polyphenolic compounds on apoptosis in pancreatic cancer cells. Gastroenterology 118:A538, 2000.

97. Vaquero E, Gukovskaya AS, Brennan ML, Lusis AJ, Holland SM, Pandol SJ. Leukocyte NADPH oxidase but not myeloperoxidase regulates pancreatic trypsin activation in cerulein induced pancreatitis. Gastroenterology 118:A170, 2000.

98. Gukovskaya AS, Mouria M, Jung Y, Zaninovic V, Pandol SJ. Intracellular mechanisms of CCK-induced apoptosis in pancreatic acinar cells. Gastroenterology 118:A156, 2000.

99. Gukovsky I, Blinman TA, Mouria M, Zaninovic V, Livingston E, Pandol SJ, Gukovskaya AS. p38 MAP kinase is a key regulator of cytokine and chemokine expression in pancreatic acinar cells. Gastroenterology 118:A157, 2000.

100. Gukovsky I, Reyes C, Zaninovic V, Wong F, Gukovskaya AS, Pandol SJ. Improvement of experimental pancreatitis with pharmacologic inhibitors of NF-κB and AP-1 activation. Pancreas, 21 vol. 4:446, 2000.

101. Lugea A, Gukovskaya AS, Zaninovic V, Reyes C, Pandol SJ. Ethanol metabolites, fatty acid ethyl esters and acetaldehyde, stimulate extracellular matrix protein production by dispersed pancreatic acini. Pancreas, 21 vol. 4:458, 2000.

102. Mouria M, Gukovskaya AS, Buechler P, Hines OJ, Reber HA, Pandol SJ. Polyphenolic compounds in food inhibit metastatic pancreatic cancer growth by causing mitochondrial cytochrome c release and apoptosis. Pancreas, 21 vol. 4:464, 2000.

103. Vaquero E, Mouria M, Pandol SJ, Gukovskaya AS. Extracellular matrix proteins protect pancreatic carcinoma cells from apoptosis. Pancreas, 21 vol. 4:487, 2000.

104. Mouria M, Gukovskaya AS, Jung Y, Buechler P, Hines OJ, Reber HA, Pandol SJ. Polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis. Pancrease 21:464, 2000.

105. Gukovskaya AS, Mouria M, Gukovsky I, Reyes CN, Kasho VN, Faller LD, Pandol SJ. Ethanol metabolism and transcription factor activation in pancreatic acinar cells. Pancreas 21:458, 2000.

106. Gukovsky I, Reyes CN, Vaquero EC, Baycher A, Gukovskaya AS, Pandol SJ. Curcumin, a natural phytochemical, inhibits pancreatic NF-kB and AP-1 activation and ameliorates pancreatitis in two experimental models. Gastroenterology 120, A537.


2001.

107. Gukovsky I, Reyes CN, Cheng JH, Jung Y, Pandol SJ, Gukovskaya AS. PI 3-kinase mediates CCK-induced activation of both trypsin and NF-kB in pancreatic acinar cells. Gastroenterology 120, A132. 2001.

108. Lu SC, Gukovsky I, Reyes CN, Huang ZZ, Chen L, Mato JM, Pandol SJ. The role of S-adenosylmethionine in the choline-deficient, ethionine supplemented diet model of pancreatitis. Gastroenterology 120, A537. 2001.

109. Lugea A, Gukovskaya AS, Gukovsky I, Cheng JH, Pandol SJ. Fatty acid ethyl esters, the non-oxidative ethanol metabolites, stimulate extracellular matrix protein production by dispersed pancreatic acini: role of TGF-beta. Gastroenterology 120, A336. 2001.

110. Vaquero EC, Jung YJ, Pandol SJ, Gukovskaya AS. Extracellular matrix proteins protect pancreatic carcinoma cells from apoptosis via inhibition of mitochondrial cytochrome C release. Gastroenterology 120, A722. 2001.

111. Gukovskaya AS, Nam KJ, Cheng J, Gukovsky I, Pandol SJ. Phosphatidylinositol 3-kinase mediates cholecystokinin induced calcium influx in pancreatic acinar cells. Gastroenterology 122, A167. 2002.

112. Gukovskaya AS, Nam KJ, Vaquero E, Pandol SJ. Polyphenols synergistically with antioxidants stimulate apoptosis in pancreatic carcinoma cells. Gastroenterology 122, A493. 2002.

113. Gukovskaya AS, Cheng J, Gukovsky I, Lugea A, Hosseini S, Pandol SJ. Ethanol and acetaldehyde decrease the activity of peroxisome proliferator-activated receptors (PPARs) in pancreatic acinar cells. Gastroenterology 122, A283. 2002.

114. Gukovsky I, Lugea A, Cheng J, French BA, Riley NE, French S, Tsukamoto H, Pandol SJ. Torrance C. Model of chronic alcoholic pancreatitis. Gastroenterology 122, A93. 2002.

115. Gukovsky I, Lugea A, Cheng JH, French BA, Riley NE, French S, Tsukamoto H, Pandol SJ. Model of chronic alcoholic pancreatitis. Alcoholism Clinical and Experimental Research 26, 140A. 2002.

116. Hosseini S, Gukovskaya AS, Cheng J, Gukovsky I, Pandol SJ, Los Angeles C. Ethanol potentiates cholecystokinin-induced but inhibits thapsigargin-induced NF-kB activation in pancreatic acinar cells. Gastroenterology 122, A282. 2002.

117. Hosseini S, Gukovskaya AS, Cheng JH, Gukovsky I, Pandol SJ. Ethanol has differential effects on pathways mediating NF-kB activation in the pancreatic acinar cell. Alcoholism Clinical and Experimental Research 26[5], 59A. 2002.


118. Lugea A, Gukovskaya AS, Pandol SJ, Los Angeles C. Ethanol metabolites alter extracellular matrix (ECM) degradation and cell death pathways in rat pancreatic acinar cells. Gastroenterology 122, A167. 2002.

119. Peng YL, Joseph RR, Gukovsky I, Pandol SJ, Wu SV, Los Angeles C. Identification and functions of somatostatin receptors in rat pancreatic acinar cells. Gastroenterology 122, A168. 2002.

120. Vaquero E, Nam KJ, Pandol SJ, Gukovskaya AS. Reactive oxygen species (ROS) as survival factor in human pancreatic cancer. Gastroenterology 122, A77. 2002.

121. Gukovskaya AS, Hosseini S, Cheng JH, Nam KJ, Gukovsky I, Pandol SJ. Ethanol regulates cholecystokinin-induced NF-B activation in pancreatic acinar cells through calcium and protein kinase C pathways. Pancreas 25:430.

122. Lugea A, Gukovskaya AS, Pandol SJ. Inhibitory effect of non-oxidative ethanol metabolites on the plasminogen system in rat pancreas. Pancreas 25:439, 2002.

123. Vaquero EC, Nam KJ, Gukovsky I, Pandol SJ, Gukovskaya AS. Intracellular sources of radical oxygen species (ROS) in human pancreatic cancer cells. Pancreas 25:455, 2002.

124. Gukovsky I, Nam KJ, Cheng JH, Pandol SJ, Gukovskaya AS. Caspases and poly(ADP-ribose) polymerase (PARP) regulate the balance between apoptosis and necrosis in experimental pancreatitis. Gastroenterology 124, DDW-2003.

125. Yazbeck MF, Nam KJ, Vaquero EC, Gukovskaya AS, Pandol SJ. The protein kinase C delta inhibitor rottlerin greatly stimulates apoptosis in pancreatic cancer cells. Gastroenterology 124:777, 2003.

126. Gukovsky I, Cheng JH, Nam KJ, Lee OT, Lugea A, Penninger JM, Pandol SJ, Gukovskaya AS. Phosphatidylinositide 3-kinase (PI3K) gamma regula-tes key pathologic responses to CCK in the pancreatic acinar cell. Gastroenterology 124, DDW-2003.

127. Vaquero EC, Nam KJ, Gukovsky I, Pandol SJ, Gukovskaya AS. Non-mitochondrial NAD(P)H oxidase mediates growth factor-induced ROS production and suppression of apoptosis in pancreatic cancer cells. Gastroenterology 124, DDW-2003.

128. Satoh A, Gukovskaya AS, Cheng JH, Nam KJ, Lee OT, Pandol SJ. Activation of individual protein kinase C isoforms and their role in CCK- and TNF- induced NF-B activation in pancreatic acinar cells. Gastroenterology 124, DDW-2003.

129. Satoh A, Gukovskaya AS, Nieto JM, Cheng JH, Reeve Jr. JR, Pandol SJ. Novel PKC isoforms, delta and epsilon, medicate NF-B activation induced by TNF and CCK-8 in pancreatic acinar cells. Pancreas 27:407, 2003.


130. Fischer L, Gukovskaya AS, Young SH, Buechler P, Beuchler MW, Friess H, Pandol SJ. Phosphatidylinositide 3-kinase regulates calcium signaling in pancreatic acinar cells. Pancreas 27: 2003.

131. Edderkaoui M, Vaquero EC, Pandol SJ, Gukovskaya AS. Extracellular matrix proteins stimulate reactive oxygen species production in human pancreatic cancer cells through non-mitochondrial NAD(P)H oxidase. Pancreas 27: 2003.

132. Lugea A, Nan L, French SW, Bezerra JA, Gukovskaya AS, Pandol SJ. Pancreas tissue repair after cerulein-induced pancreatitis is impaired in plasminogen-deficient mice. Gastroenterology 126:A-104, 2004.

133. Gukovsky I, Kubisch C, Lugea A, Tsukamoto H, Pandol SJ, Logsdon CD. Microarray Profiling of Pancreatic Gene Expression in Ethanol Fed Rats: Down-Regulation of Protective Genes May Underlie the Sensitizing Effect of Alcohol to Pancreatitis. Gastroenterology 126:A-596, 2004.

134. Fischer L, Gukovskaya AS, Young SH, Buechler P, Buechler MW, Friess H, Pandol SJ. Phosphatidylinositide 3-kinase regulates hormone-induced calcium signals in pancreatic acinar cells by inhibition of endoplasmic reticulum Ca2+-ATPase. Gastroenterology 126:A-592, 2004.

135. Satoh A, Gukovskaya AS, Daghighian MS, Reeve JR Jr, Pandol SJ. Novel protein kinase C isoforms and mediate cholecystokinin-induced activation of PYK2 and NF-B in pancreatic acinar cells by diverging pathways. Gastroenterology 126:A-530, 2004.

136. Satoh A, Daghighian MS, Reeve JR Jr, Pandol SJ, Gukovskaya AS. TNF- activated proline-rich kinase 2 (PYK2) in pancreatic acinar cells by protein kinase C dependent mechanism. Gastroenterology 126:A-529, 2004.

137. Edderkaoui M, Vaquero EC, Hong PP, Daghighian MS, Pandol SJ, Gukovskaya AS. Reactive oxygen species mediate pro-survival effects of both extracellular matrix proteins and growth factors in pancreatic cancer cells. Gastroenterology 126:A-548, 2004.

138. Edderkaoui M, Vaquero EC, Hong P, Gukovsky I, Pandol SJ, Gukovskaya AS. Growth factors and extracellular matrix proteins protect pancreatic cancer cells from death through activation of membrane NAD(P)H oxidase. Pancreatology 4:135-136, 2004.

139. Pandol SJ, Gukovsky I, Satoh A, Lugea A, Gukovskaya AS. Alcoholic pancreatitis: Insights from animal models. International Society for Biomedical Research on Alcoholism - Heidelberg 2004.


140. Lugea A, Gorelick F, Gukovskaya AS, Pandol SJ. Ethanol feeding induces a protective endoplasmic reticulum stress response: regulation by cholecystokinin. Gastroenterology 128:A-632, 2005.

141. Lugea A, Pandol SJ. Differential effects of ethanol and fatty acid ethyl esters on the plasminogen activating system in cultured pancreatic stellate cells. Gastroenterology 128:A-632, 2005.

142. Wang YL, Lugea A, Hu R, Mareninova O, Smoot D, Gukovskaya AS, Pandol SJ. Ethanol feeding switches death pathway resulting in inhibition of apoptosis and promotion of necrosis in pancreas. Gastroenterology 128:A-381, 2005.

143. Hu R, Wang YL, Hong P, Edderkaoui M, Shahsahebi M, Lugea A, Apte MV, Gukovskaya AS, Pandol SJ. Pancreatic stellate cell NADPH oxidase system and its regulation by ethanol and growth factors. Gastroenterology 128:A-631, 2005.

144. Lee JK, Edderkaoui M, Hong P, Truong P, Berti JA, Pandol SJ, Gukovskaya AS. NADPH oxidase Nox4 mediates pancreatic cancer cell survival by activating JAK2 kinase. Involvement of LMW-PTP protein tyrosine phosphatase. Pancreas 31:451-452, 2005.

145. Sung KF, Odinokova IV, Mareninova OA, Hong P, Lugea A, Hoffmann A, Gukovsky I,

Pandol SJ, Gukovskaya AS. Bcl-xL is upregulated in different models of acute pancreatitis and protects pancreas from cell death. Pancreas 31:472, 2005.

146. Hu R, Wang YL, Edderkaoui M, Lugea A, Apte M, Pandol SJ. Pancreatic stellate cell NADPH oxidase system and its role in mediating pancreatic stellate cell proliferation by platelet derived growth factor (PDGF). Pancreas 31:446, 2005.

147. Edderkaoui M, Hong P, Pandol SJ, Gukovskaya AS. IGF-R mediates the fibronectin-induced protection from apoptosis in pancreatic cancer cells. Pancreas 31:438-439, 2005.

148. Fischer L, Lugea A, Shahsahebi M, Penninger JM, Vanhaesebroeck B, Friess H, Gukovskaya AS, Pandol SJ, Gukovsky I. Class I PI3K isoforms δ and γ regulate key responses of cerulein-induced pancreatitis. PI3K δ is necessary for trypsin activation. Pancreas 31:441, 2005.

149. Mareninova OM, Sung KF, Hong P, Lugea A, Pandol SJ, Gukovsky I, Gukovskaya AS. Caspases protect from necrosis and regulate the severity of cerulein pancreatitis. Pancreas 31:454, 2005.

150. Lugea A, Nieto J, Daghighian M, Satoh A, Pandol SJ. Role of the Cholinergic ystem in Alcohol-induced Pancreatitis. Gastroenterology 130:A260, 2006.

151. Lee JK, Edderkaoui M, Hong PP, Truong P, Lambeth JD, Berti A, Pandol SJ, and Gukovskaya AS. Sustained Akt phosphorylation is required for anti-apoptotic effect of


insulin-like growth factor-I in pancreatic cancer cells: roles of phosphatases. Gastroenterology 130:A260, 2006.

152. Edderkaoui M, Ohno I, Hong P, Pandol SJ, Gukovskaya AS. Trans-activation of IGF-R by fibronectin protects from apoptosis in pancreatic cancer cells. Gastroenterology 130:A277, 2006.

153. Edderkaoui M, Ohno I, Pandol SJ, Gukovskaya AS. Embelin and resveratrol increase apoptosis and decrease proliferation in pancreatic cancer cells through regulation of IAPs. Gastroenterology 130:A278, 2006.

154. Satoh A, Gukovskaya AS, Reeve JR Jr., Gukovsky I, Pandol SJ. Ethanol sensitizes pancreatic acinar cells to NF-κB activation through activation of protein kinase C epsilon. Gastroenterology 130:A59, 2006.

155. Gukovsky I, Shahsahebi M, Hong PP, Lugea A, French SW, Pandol SJ. Suppression of IFN- and increase in IL-6 is associated with ethanol-induced chronic pancreatitis responses in the CsA model of alcoholic chronic pancreatitis. Gastroenterology 130:A560, 2006.

156. Mareninova OM, Lugea A, Odinokova IV, Tsukamoto H, Gukovsky I, Pandol SJ, and Gukovskaya AS. Ethanol stimulates Akt phosphorylation in the pancreas through PTEN oxidation: a predisposing factor in alcoholic pancreatitis? Gastroenterology 130:A384, 2006.

157. Ohno I, Edderkaoui M, Truong PB, Odinocova IV, Lee JK, Saisho H, Gukovskaya AS, Pandol SJ. Inhibition of Bcl-2/Bcl-xL proteins stimulate apoptosis and inhibit proliferation of pancreatic cancer cells. Gastroenterology 130:A279, 2006.

158. Wang JL, Satoh A, Fischer LS, Pandol SJ. Role of Protein Kinase C Delta (PKC ) in Cholecystokinin-8-Induced Amylase Secretion and Nuclear Factor Kappa-B (NF-B) Activation in Pancreatic Acini. Gastroenterology 130:A562, 2006.

159. Fischer L, Lugea A, Shahsahebi M, Vanhaesebroeck B, Penninger JM, Friess H, Gukovskaya AS, Pandol SJ, Gukovsky I. Diverse roles of class I PI3K isoforms and in cerulein-induced pancreatitis. Gastroenterology 130:A72, 2006.

160. Fischer L, Gukovskaya AS, Penninger JM, Friess H, Gukovsky I, Pandol SJ. Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca2+ responses in pancreatic acinar cells. Gastroenterology 130:A712, 2006.

161. Lugea A, Nieto J, Gukovsky I, Satoh A, Pandol SJ. Role of the Cholinergic System in Alcohol-induced Pancreatitis. Pancreas 33:479-480, 2006.

162. Lugea A, Pandol SJ. Plasminogen activating system in cultured pancreatic stellate cells: effects of ethanol. Pancreas 33:479, 2006.


163. Ohno I, Eibl G, Odinokova I, Edderkaoui M, Yazbeck M, Pandol SJ, Gukovskaya AS. Rottlerin stimulates apoptosis in pancreatic cancer throughinhibition of Bcl-xL.. Pancreas 33:487, 2006.

164. Edderkaoui M, Pandol SJ, Gukovskaya AS. Embelin regulates XIAP and survivin levels through different mechanisms and induces pancreatic cancer cell death. Pancreas 33:458, 2006.

165. Mareninova OA, Lugea A, Odinokova IV, Tsukamoto H, Gukovsky I, Pandol SJ, Gukovskaya AS. Akt activation in alcoholic pancreatitis: role of PTEN. Pancreas 33:481, 2006.

166. Gukovsky I, Lugea A, Shahsahebi M, Cheng JH, Award M, French SW, Pandol SJ. Ethanol feeding impairs recovery from acute pancreatitis. Gastroenterology 132:A722, 2007.

167. Zhao G, Reyes CN, Hermann K, Mareninova O, Sung KF, Gukovskaya AS, Hoffman A, Pandol SJ, Gukovsky I. Roles of individual NF-kB proteins in pathologic responses of experimental acute pancreatitis. Gastroenterology 132:A116, 2007.

168. Do JH, Mareninova O, Paik A, Reyes C, Lugea A, Fischer L, Gukovsky I, Gukovskaya A and Pandol SJ. The inflammatory response of acute pancreatitis promotes necrosis through effects on the PI3 kinase system. Gastroenterology 132:A250, 2007.

169. Mareninova OA, Hermann K, Pandol SJ, French SW, Gorelick FS, Gukovsky I, Gukovskaya AS. Interrelationship between autophagy and apoptosis in cerulein pancreatitis. Gastroenterology 132:A250-A251, 2007.

170. Mareninova OA, Lugea A, Odinokova IV, Gukovsky I, Pandol SJ, Gukovskaya AS. Mechanisms of pancreatic Akt activation in cerulein pancreatitis and by ethanol feeding. Role of PTEN. Gastroenterology 132:A251, 2007.

171. Osgood SE, Kolodecik TR, Reeve JR, Pandol SJ, Gorelick FS, Thrower EC. The role of protein kinase C isoforms in pancreatic zymogen activation. Gastroenterology 132:A250-A252, 2007.

172. Ohno I, Gukovskaya AS, Odinokova I, Pandol SJ. Bcl-2/Bcl-XL mediate the proapoptotic effects of ROS in pancreatic cancer cells. Gastroenterology 132:A250-A437, 2007.

173. Cosen-Binker L, Lam P, Binker M, Reeve J, Pandol S, Gaisano H. Alcohol cholecystokinin evoked pancreatic acinar basolateral exocytosis is mediated by PKC phosphorylation of Munc18c. Gastroenterology 132:A722, 2007.

174. Lugea A; Tischler DA; French SW; Gorelick FS; Pandol SJ. XBP1 plays a critical role in protecting pancreas against ethanol-induced Endoplasmic Reticulum Stress. Gastroenterology 132:723, 2007.


175. Y. Nakamura; J. H. Do; I. V. Odinokova; M. Lee; S. J. Pandol; A. S. GukovskayaNeutrophil Depletion Stimulates Apoptosis in Pancreatitis Through Upregulating p53. Pancreas 37:4;53, 2008

176. Gerasimenko J, Odinokova IV, Sung KF, Mareinova O, Lee MA, Fischer L, Pandol SJ, Gukovskaya AS. Pro-Survival BCL-2 Proteins Regulate Ca2+ Transport in Pancreatic Acinar Cells. Gastroenterolgy, A-127: 893, 2008

177. Lugea A, Wu X, Srivdya D, Pandol SJ. The Urokinase System Plays a Critical Role in Pancreatic Stellate Cell Activation. Gastroenterology, A-585: T1891, 2008

178. Lugea A, Wu X, Srivdya D, Pandol SJ. Plasminogen Activator Inhibitor-1 Mediates Fibrogenesis After Cerulein-Induced Pancreatitis. Gastroenterology, A-585: T1892, 2008

179. Yuan J, Lugea A, Zheng L, Gukovsky I, Edderkaoui M, Pandol SJ. Protein Kinase D Mediates Nf-kB Activation Induced By Cholecystokinin and Cholinergic Signaling in Pancreatic Acinar Cells. Gastroenterology, A-722: W1821, 2008.

180. Mareninova O, Odinokova IV, Lee MA, Pandol SJ, Gukovsky I, Gukovskaya AS. Role of mitochondrial permeability transition pore in pancreatitis. Gastroenterology 2009

181. Mareninova O, Lee MA, Yakubov I, Pandol SJ, French SW, Gorelick FS, Gukovsky I, Gukovskaya As. Autophagy impairment as a mechanism for acute pancreatitis: the role of cathepsins. Gastroenterology 2009

182. Lugea A, Gukovsky I, French SW, Gorelick FS, Pandol SJ. Role of XBP1 in the protective unfolded protein response to limit chronic ethanol-induced endoplasmic reticulum stress and damage in the pancreas. Gastroenterology 2009.

183. Shalbueva N., Mareninova O, Yuan J, Pandol SJ, Gukovskaya AS. Alcohol Depolarize Pancreatic Mitochondria through PTP-Dependent Mechanism. Pancreas 2009.

184. Yuan JZ, Liu Y, Pandol SJ, Gukovskaya AS, Tan T, Thrower E, Guha S. Protein Kinase D Regulates Cell Death Pathways in Acute Pancreatitis. Pancreas 2009.

185. Yuan JZ, Liu, Y, Shalbueva N, Tan T, Gukovskaya AS, Pandol SJ. Protein Kinase C Epsilon Mediates Ethanol and Carbachol-Induced Depolrization in Pancreatic Acinar Cells. Pancreas 2009.


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