1. (Epidermis) a. b. c. d. e. 2. (Dermis) a. (Fibroblast) b. (ECM) : 1) 2) 3) (GAGS) ****3. (Subcutis)

1. (Epidermis) TriglycerideCeramideCholesterolSqualeneNatural moisturizing factor

Triglyceride

Triglyceride

-: (1) (2) (3) (4) (5) (6)

: pHAplus

Ceramide30~40%

Ceramide

CeramideCeramide: Skin becomes dehydrated easily and is too fragile to fight against exterior stimulations, such as air pollution and UV rays. Ceramide: Ceramides help locking in hydration in the corneum, activate skin cells and protect skin surface from the exterior stimulation. Also, skin with enough Ceramides can inhibit the generation of Atopic dermatitis and Xeroderma.

Ceramide

Ceramide 136

-CMS: (1) (Ceramide) ,IIIB (2) ( Cupuacu Better) (3) (Corallina Officinalis Ext.) (4) (Hyaluronic Acid)

:

Cholesterol

Cholesterol

Squalene Squalane()

Squalene

-CMS: (1) (Phytosphingosine) (2) (Ceramides) I,II,III,IIIA,IIIB,VI (3) (Squalane) (4) (Fatty Acid) (5) (Triglycerides) (6) (Phosphatidylcholine)

:

Natural moisturizing factorA. (Amino acid)B. Na-PCAsodium pyrrolidone carboxylateC. (Lactate)D. (Urea)E. (Glucosamine)F. G.

A. (Amino acid)Amino acid-NMF

B. Na-PCAsodium pyrrolidone carboxylate sodium pyrrolidone carboxylate-NMF

C. (Lactate)

Lactate acid-NMF

D. (Urea)Urea-NMF

E. (Glucosamine)(Proteoglycan) () Glucosamine-NMF

F.

Peptide-NMF

G.-A-NMF

Glycolic acidLatic acidMalic acidTartatic acidCitric acidMandelic acid

(10%) :

(10~30%) :

(30%) :

G.-B-NMF

55-PGAGamma Polyglutamic Acid)

-(glutamic acid) () -PGA

-

-PGA4600!!!

5000

-PGA -NMF Pyrrolidone carboxyli cacid (PCA) Lactic acid()Urocanic acid () (HA) --PGA (-)

-PGA

-PGA

-PGA PH 4~6--PGA (-)

-

: (1) -PGA Hydragel - (2) -PGA (3) (4) E (5) Aloe Extract (6) Grape Extract (7) Allantoin (8) CeramideCitric AcidImidazolidinyl Urea

-

: (1) -PGA Hydragel - (2) Ceramide-||| -||| (3) Sea WeedExtract (4) Deep Sea Salt-

(W/O)(O/W)(W-O-W)()-

-

2. (Dermis) CollagenElastin (Glycosaminoglycans-GAGS)

Collagen33%

(Soluble collagen)

Elastin- NMF

(Glycosaminoglycans-GAGS)A.Hyaluronic acidB.Chondroitin sulfate

A.Hyaluronic acid15~20%16 1000c c/g

-GAGSHyaluronic acid

-: (1) 210 (2) (3) (Zine PCA)

: () ()

B.Chondroitin sulfate

Chondroitin sulfate-GAGS

Irritation Sensitization

Irritation SensitizationEyes irritation(Patch test Phototoxicity Photosensitization

-A=Hyaluronic acidCK

,,

Allantoin

-CMS: (1) (2) B5 ( Panthenol ) (3) (SOD) (4) (5) (Allantoin) (6)

:

CC

CCC

C

A C L-Ascorbic acid

-C: (1) C (Ascorbic Acid) (2) (Hyaluronic Acid) (3) (Chamomilla Recutita) (4) (Di-potassium glucyrrizinate) (5) (Enteromorpha Compressa) (6) (Squalane) (6) (NMF)

:

. Glycyrrhizicacid

-: (1) (2) 3 (3) (4) (5) E (6)

: NEO-TEC

C1 B1 B2 B3

-: (1) (Plantapon acg 30/50) (2) (Totarol) (3) (Hydrolyzed soy protein) (4) (Camelia synensis) (5) (Aloe arbadensis extract)

: PH5.5-6.0

,,

Tranexamic acid

-TA: (1) - PH5.5-6.0 (2) (Totarol)-

: (1) (2) -(plasmin)

K1

Vitamin K1

,

Ginkgo

-A

-B

-C (SPF)SPF pH3.5

-D

-E

-A

-B

-C

()

-D

-EA(Trerinoin)(Hydroquinone)(Azelaic acid )

ATRETINOIN-AAA2AAAAA

AA AA A Trentinoin

ATRETINOIN-B

ADNA

A

A7ASPF30

HYDROQUINONE-A

A

3-4

Hydroquinone

31A

1-2%4%(OCHRONOSIS)HYDROQUINONE-B

AZELAIC ACID(P.ACNE)(ROSACEA)7 Azelaic acid

AZELAIC ACID

(1) : 20%- (2) : 15%- (3) : - Azelaic acid

(Kojic acid)

Kojic acid dipalmitate

2Kojic acid

(Arbutin)

7 Arbutin

-KTC: (1) (Kojic Acid) (2) C (L-Ascorbic acid) (3) (Kalanchoe Spathulata Extract) (4) (Tranexamic acid) (5) (Cucumber Extract) (6) r-PGA

: