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Contents

Environmental Analysis ....................................3

General Analysis................................................5

Medicinal and Bioanalysis ..............................12

Separation Techniques ....................................19

Spectroscopy ..................................................26

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2 Page 28

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3

Environmental Analysis

For more information and complete contents, visit www.crcpress.com

EnvironmentalChemometricsPrinciples andModern Applications

Grady HanrahanCalifornia Lutheran University,Los Angeles, USA

A delineation of modern environmental analy-sis and methods for effectively solving limita-tions through multivariate approaches, thisbook begins with an overview of chemometricsin relation to quantitative environmental analy-sis and a review of descriptive statistical con-cepts. It examines environmental samplingconsiderations, experimental design, optimiza-tion techniques, and multivariate analysis ofenvironmental and chemical data sets.

The book also covers quality assurance andmethod validation. The author’s presentationof the basic principles of these methods togeth-er with real applications in the field of environ-mental chemistry simplifies comprehension ofcomplex environmental problems and chemi-cally related concepts. The coverage of envi-ronmental analysis, backed by studies fromexperts in the field, elucidates the rapidly devel-oping world of chemometric methods in envi-ronmental analysis.

Features

• Provides a modern introduction and practical guide to chemometrics methodswritten by a practicing expert

• Covers classical and modern methods toimprove the effectiveness and efficiency ofenvironmental sampling and monitoringprograms

• Introduces modern chemometric methods,the basic theory behind them, and theirincorporation into current environmentalinvestigations

• Presents basic principles of chemometricmethods together with real applicationsin the field of environmental chemistry

Catalog no. 67966, 2009, 310 pp., Soft Cover,ISBN: 978-1-4200-6796-5, $89.95 / £49.99

New!

AnalyticalMeasurementsin AquaticEnvironmentsEdited by

Jacek Namiesnik andPiotr SzeferGdansk University of Technology, Poland

Covering the composition and underlyingproperties of freshwater and marine systems,this work provides a basis for understandingboth. The contributors employ a range ofexamples to explain the behavior of traceconstituents in aquatic environments. Theydiscuss collection and preparation, modernextraction techniques, conservation, and stor-age. They also elucidate the use of passivedosimetry, mineralization techniques, specia-tion analytics, green analytical chemistry, andchemometric techniques. Extensive details onquality control and quality assurance providea complete perspective on the difficulties ofsample preparation in aquatic environments.

Features

• Provides a critical evaluation of a widespectrum of extraction of organic andinorganic constituents from environmentalsamples

• Includes coverage of preservation techniques of samples used in environmental studies

• Explores the possibility of application ofbiotests as part of an integrated approachin evaluating the level of pollution ofaquatic ecosystems

• Presents green aspects of analytical protocols used in environmental studies

• Describes the application of the Life CycleAssessment (LCA) technique for evaluatingthe environmental impact of different analytical aspiration and processes

• Contains a range of examples thatdemonstrate the behavior of trace constituents in aquatic environments

Catalog no. 8268X, January 2010, 503 pp.,ISBN: 978-1-4200-8268-5, $129.95 / £82.00




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Environmental Analysis

ChromatographicAnalysis of theEnvironmentThird EditionEdited by

Leo M.L. NolletUniversity College Ghent, AppliedEngineering Sciences, Belgium

“This totally renewed edi-tion … is a detailed handbook on differentchromatographic analytical techniques andchromatographic data for compounds foundin air, water, soil, and sludge. The book dis-cusses the parameters of each environmentalcompartment in a consistent format thathighlights sample-preparation techniques,chromatographic separation methods, anddetection modes. Most of the data are com-piled in tables and illustrated with figures.These are well updated and are most usefulfor an easy access to the relevant literature. …This unique resource of chromatographictechniques, data, and references will be anattractive read for analytical chemists, chro-matographic analysts, scientists, technolo-gists, and engineers involved in the analysis ofenvironmental compounds and in qualityassurance and control.” —J. Albaigés, International Journal of Environmental

Analytical Chemistry, Vol. 86, 2006

Features

• Provides discussions of parameters of the different compartments of the environment in the same format

• Covers the specific aspects of sampling inthe environment and the different samplepreparation methods

• Discusses the importance of data processing • Presents data tables that make valuableinformation easy to find

• Reviews analytical methods for nitrogen andsulfur compounds, organic andorganometallic compounds, and VOCs,such as benzene, toluene, ethylbenzene,and xylene (BTEX)

• Includes information and data relevant toinsecticides and herbicides, oil and petroleum products, and surfactants

Catalog no. DK3095, 2006, 1320 pp.ISBN: 978-0-8247-2629-4, $269.95 / £172.00

Analysis ofPesticides inFood andEnvironmentalSamplesEdited by

Jose L. TadeoNational Institute for Agriculturaland Food Research andTechnology (INIA), Madrid, Spain

“A nine page index (approximately 700entries), copious references (1,072) to pertinentscientific literature and useful websites, and anabundance of tables, graphs, mathematicaland chemical formulae, structures, schematics,diagrams, and photographs enable this bookto impart a wealth of factual knowledge, pro-tocols and analytical know-how. If your remit isto measure and evaluate pesticide levels andresidues in environmental materials or foods,then this book is indispensible.”—Steve Mitchell, Imperial College, ISSX Newsletter,

Summer 2009, Vol. 29, No. 2

Features

• Provides a concise review of pesticide classes and their physicochemical properties

• Describes specific analytical methods andinstrumentation for measuring pesticidesin food, soil, water, and air samples

• Highlights effective new technologies formonitoring chemical contaminants

• Covers trends in sample preparation, pesticide analysis, and quality assurance

• Details extraction and determination techniques for analyzing real-world samples

• Addresses regulatory aspects of pesticidesin the environment

• Includes extensive reference data on thelevels of pesticides found in actual foodsand environmental samples

• Enables scientists to measure and predictthe behavior and toxicity of pesticideswith a higher degree of accuracy

Catalog no. 7552, 2008, 384 pp.ISBN: 978-0-8493-7552-1, $159.95 / £99.00




5

General Analysis


New!

Electroanalytical ChemistryA Series of Advances: Volume 23Edited by

Allen J. BardUniversity of Texas, Austin, USA

Cynthia ZoskiNew Mexico State University, Las Cruces, USA

Praise for Previous Volumes

“Highly recommended.”—Journal of the American Chemical Society

“Essential … [This is] a series which, from its very beginning, proved to be one of the most suc-cessful and most frequently cited … . The series has shaped the electrochemists of the last thirtyyears and, even more remarkably, each volume has turned out to be of lasting significance andinfluence.”

—Journal of Solid State Electrochemistry

For more than three decades, this unique series has delivered the most in-depth and criticalresearch related to issues in electrochemistry, offering state-of-the-art material to both specialistsand non-specialists. While this volume provides a background and a starting point for graduatestudents looking for a place to focus their research, it also presents valuable findings and newmethods for analytical and industrial chemists seeking to develop new products and applica-tions, including new approaches to electroplating and corrosion resistance and fuel cell develop-ment.

The book covers electroanalytical techniques being currently used in such diverse areas as elec-tro-organic synthesis, fuel cell studies, and radical ion formation. These techniques are alsoemployed to solve problems dealing with kinetics and mechanisms of electrode reactions, theeffects of electrode surface phenomena, adsorption, and the electrical double layer of electrodereactions.

Features

• Examines electrochemistry activity at the liquid-liquid interfaces, demonstrating researchthat moves the concept from an exotic curiosity into one that shows the promise of newapplication development, especially in the field of energy-related chemistry

• Explores an electrochemical approach to the reduction of platinum under superdry conditions in an effort to uncover the perfect working electrode

• Investigates the impact of metal-ligand bonding interactions on the electron-transfer chemistry of transition-metal nanoparticles

• Presents an introduction to sol-gel processing, with an emphasis on silicate formation, whilelooking at the dramatic advances in silicate science that electrochemists are technologicallyready and eager to apply

Catalog no. 84852, February 2010, c. 301 pp., ISBN: 978-1-4200-8485-6, $169.95 / £108.00




General Analysis

The Scientist orEngineer as anExpert WitnessJames G. SpeightCD & W Inc., Laramie,Wyoming, USA

“…Speight, who has testified numerous timesas an expert witness, provides guidance thatgives witnesses all the information needed totestify confidently and effectively. … Highlydetailed and exceedingly thorough in scope,the book is clear and readable.”

—SirReadaLot.org, January 2009, Issue 117

This book assists technical experts who mustclearly convey often complicated informationto a non-technical audience. It discusses thefunctions of the expert witness, describeshow attorneys find experts, and explores theprofessional résumé and other tools expertwitnesses can use to market themselves. Itprovides a primer on the rules of evidenceand examines issues that arise during deposi-tions. The book closes with a discussion ofthe trial itself and post-trial responsibilities. Acomplete glossary of terms further clarifiesthe material.

Features

• Reviews responsibilities before, during,and after trial

• Conveys legal terms in an understandablemanner for non-legal experts

• Includes coverage of significant SupremeCourt cases and rulings that determinethe use of expert witnesses, including Fryeand Daubert

• Explains the traps and attempts to dis-qualify that witnesses may encounter andprovides tips on how to counter them

• Details the courtroom layout, the processof the trial, and the use of visual aids


QualityAssurance andQuality Controlin theAnalyticalChemicalLaboratoryA Practical Approach

Piotr Konieczka and Jacek NamiesnikGdansk University of Technology, Poland

Using an approach grounded in hands-onexperience, this clearly written, well-orga-nized book provides a strong foundation inthe concepts of practical QA/QC. It beginswith the theory behind QC systems and thendiscusses examples of tools, such as valida-tion parameter measurements. The text alsoexamines the use of statistical tests, describesthe process of counting the margin of error,and discusses estimating uncertainty. Theauthors draw on their experience in traceabil-ity, statistics, proficiency tests, and methodvalidation to craft a resource that providespractical guidance for each step of the qualityassurance process.

Features

• Includes a CD-ROM with Excel datasheetsthat allow users to develop and customizetheir own models

• Highlights the increasing importance ofQA/QC in analytical and testing laboratories

• Discusses all aspects of QA and measure-ments results, rather than selectedaspects, such as method validation

• Provides an integrated view on measures,such as the use of reference materials andmethod validation

• Covers some frequently misunderstoodconcepts, including uncertainty andtraceability

• Presents discussions of radionuclides,green analytical chemistry, and chemometrics in relation to QA/QC





7

General Analysis


Introduction toMultivariateStatisticalAnalysis inChemometricsKurt Varmuza and Peter FilzmoserVienna University of Technology,Austria

Using formal descriptions, graphical illustra-tions, practical examples, and software tools,this introduction presents simple yet thor-ough explanations of the most importantmultivariate statistical methods for analyzingchemical data. Some of the statistical meth-ods discussed include principal componentanalysis, regression analysis, classificationmethods, and clustering.

Written by a chemometrician and a statisti-cian, the book applies the methods to realdata examples from chemistry. It also exam-ines results of the different methods, compar-ing traditional approaches with their robustcounterparts. The authors use the freely avail-able R package to implement methods,encouraging readers to go through theexamples and adapt the procedures to theirown problems. The book effectively imparts abasic understanding of how to apply statisti-cal methods to multivariate scientific data.

Features

• Includes important multivariate statisticalmethods, such as principal componentanalysis and support vector machines, foranalyzing scientific data

• Explains the methods using formulae,graphical illustrations, and schemes

• Demonstrates R software tools with fullyworked-out, real-world examples

• Emphasizes the use of robust statisticalmethods

• Offers practical advice on applying themethods


Second-OrderNonlinearOpticalCharacterizationTechniquesAn Introduction

Thierry Verbiest andKoen ClaysKatholieke Universiteit Leuven,Belgium

Vincent RodriguezUniversity of Bordeaux 1, Talence, France

Designed for nonspecialists, this multidiscipli-nary book focuses on the potential of second-order nonlinear optics as a powerful charac-terization tool. It stresses the reliability ofnonlinear optical processes for probing sur-faces and interfaces. Avoiding extensivemathematical details, the book does notrequire a background in advanced mathe-matics or physics. After introducing linearoptics from the perspective of polarizabilityand linear susceptibility, the authors coverincoherent second-harmonic generation.They then deal with the study of surfaces andinterfaces, exploiting the intrinsic surface sen-sitivity of second-harmonic generation andsum-frequency generation. The final chapterdiscusses second-order imaging techniques,including confocal microscopy and two-pho-ton excited fluorescence microscopy.

Features

• Provides an overview of second-ordernonlinear optical characterization tech-niques, such as second-harmonic genera-tion and sum-frequency generation, thatcan be easily implemented in any lab

• Presents an elementary description ofnonlinear optics

• Includes several practical examples thatshow how to use nonlinear optics as aversatile characterization tool

• Describes how to implement nonlinearoptical techniques for specific purposes,from the determination of surface symme-try and molecular orientation to biologicalimaging






General Analysis

Ionic Liquids inChemicalAnalysisEdited by

Mihkel KoelTallinn University of Technology,Estonia

Exploring the future in chemical analysisresearch, this volume provides a broadoverview of the applications of ionic liquids invarious areas of analytical chemistry. Itreviews the properties and structure of ionicliquids and the role of these materials in opti-cal, electrochemical, and biochemical sensortechnology.

The book examines ionic liquids in gas, liquid,and countercurrent chromatography, alongwith their use as electrolyte additives in capil-lary electrophoresis. It also discusses gas solu-bilities, liquid-liquid extraction, and the sepa-ration of metal ions. The final chapters covermolecular, Raman, nuclear magnetic reso-nance, and mass spectroscopies. By showinghow ionic liquids can improve measurementand reduce the amount of environmentalwaste, this book confirms the staying powerof these materials in the years to come.

Features

• Collects the experience and knowledge ofexperts who use and study ionic liquids ina range of analytical chemistry areas

• Discusses structure and physicochemicalproperties, activity coefficients, phaseequilibrium with other liquids, and modeling

• Presents different extraction techniques,from the separation of gases to metals

• Examines the advantages of task-specificionic liquids in analytical chemistry applications


The ChemicalComponents ofTobacco andTobacco SmokeAlan RodgmanWinston-Salem, North Carolina,USA

Thomas A. PerfettiPerfetti and Perfetti, LLC,Winston-Salem, North Carolina, USA

“I highly recommend this book as an indispen-sable reference source for tobacco and smokechemists as well as other scientists involved inthe study of tobacco and its products …Rodgman and Perfetti are commended for theforesight, hard work, and diligence requiredfor publishing The Chemical Components ofTobacco and Tobacco Smoke.”

—Charles R. Green, R.J. Reynolds TobaccoCompany, Beiträgezur Tabakforschung International,

May 2009, Vol. 23, No. 4

“…There will not be any other comprehensivework in the next 30-50 years about this topic—Rodgman/Perfetti will be the definitive book.”

—Wolf-Dieter Heller, Karlsruhe, Germany

Features

• Provides the first single-source referencepublished on the subject since 1968

• Reviews every chemical class of components found in tobacco and tobacco smoke

• Catalogs and alphabetically indexes over8400 tobacco and tobacco smoke components

• Presents more than 6000 cited referencesthat deal with many topics pertinent tothe components in question

• Lists the corresponding ChemicalAbstracts Registry Number for most cataloged components

• Examines adverse health-related problemsassigned to specific components and thesmoke components reported to negatesuch harmful effects

• Includes a CD-ROM with a searchable,300-page alphabetical component index





9

General Analysis


Handbook ofAcid-BaseIndicatorsR.W. SabnisSquire, Sanders & Dempsey LLP,San Francisco, California, USA

This handbook provides chemical informa-tion for over 200 acid-base indicators.Organized alphabetically, entries includecommon name, other names, CA indexname, CAS registry number, Merck indexnumber, chemical structure, chemical/dyeclass, molecular formula/weight, pH range,color change, pKa, physical form, solubility,UV-visible, melting/boiling points, synthesis,and toxicity data. The book also covers majorapplications, including semiconductors, dis-plays, nanotechnology, fuel cells, pharmaceu-ticals, agrochemicals, and more.


Bestseller!

Handbook forthe ChemicalAnalysis ofPlastic andPolymerAdditivesMichael Bolgar, JackHubball, and Susan MeronekAccuStandard, Inc, New Haven, Connecticut, USA

Joe GroegerMantis Associates Inc., Storrs Mansfield, Connecticut, USA

Unique in its comprehensive presentation ofchromatograms, mass spectral information,and analytical data as well as environmentaland applications perspectives, this handbookprovides a detailed reference for the analysisof the additives that are most widely used inplastics and polymers. Examining potentialenvironmental effects of these additives, itpresents a clear guide to viable isolation tech-niques and analysis methods for accuratelyassessing plastic and polymer mixtures. Thebook covers the techniques needed toextract, identify, and quantify additives in fin-ished goods using common and readily avail-able laboratory techniques. In addition toanalytical data, it includes regulations issuedby the US FDA, US EPA, EU agencies, andother groups.

Features

• Includes chromatographic and mass spectral data obtained with commonlyused analytical instruments

• Provides a comprehensive listing of widelyused additives in plastic and polymer mixtures

• Cross-references additives by trade name,chemical name, CAS number, and evenkey mass unit ions from the GC/MS run

• Explains how to analyze polymersthrough thermal desorption and the useof a GC with a mass selective detector


AppliedPyrolysisHandbookSecond EditionEdited by

Thomas P. WamplerCDS Analytical, Inc., Oxford,Pennsylvania, USA

“The Applied Pyrolysis Handbook is a prac-tical guide to the application of pyrolysistechniques to various types of materials …This book is for chemists and researchers whouse GC/MS to analyze materials and whoneed to add pyrolysis techniques to theiranalysis tools. It contains much practicalinformation that could be useful to them.”

—Electrical Insulation Magazine, May/June 2009, Vol. 25, No. 3







General Analysis

Practical Guideto ChemometricsSecond EditionEdited by

Paul GemperlineEast Carolina University,Greenville, USA

“…an accessible introduction to application-oriented multivariate methods of data analy-sis and procedures that are highly beneficialto solving a variety of problems using analyt-ical chemistry and statistics. … Numerousworked examples using MATLAB® code areoffered to illustrate how easily these tech-niques can be adapted to various experimen-tal scenarios. … This second edition has beencompletely revised…”

—J. Albaigés, CID-CSIC, Barcelona, Spain, andEditor, International Journal of Environmental



Handbook ofPhotochemistryThird EditionMarco Montalti, Alberto Credi, Luca Prodi, and M. Teresa GandolfiUniversity of Bologna, Italy

The latest edition of this handbook presentsan exhaustive collection of information,organized in easy-to-use tables, useful in typ-ical photochemical experiments. Written byleading world experts, this third editionincludes overviews on the photochemicalprocesses that occur in organic moleculesand transition metal complexes. It containssections focusing on metal complexes andorganometallic compounds, offering photo-physical and quenching data as well as reduc-tion potential values.


InstrumentalMethods inMetal IonSpeciationImran AliJamia Millia Islamia, New Delhi,India

Hassan Y. Aboul-EneinNational Research Center, Cairo, Egypt

“The book has been presented by well-knownscientists … presents very interesting material… The book as a whole will certainly be a use-ful source of information for numerous analyt-ical chemists [who] work in the timely impor-tant field of chemical analysis.”

—Adam Hulanicki, Chemical Analysis,Vol. 52, No. 157, 2007


UndergraduateInstrumentalAnalysisSixth EditionJames W. RobinsonLouisiana State University, BatonRouge, USA

Eileen M. Skelly FrameRensselaer Polytechnic Institute,Troy, New York, USA

George M. Frame IINew York State Department of Health, Albany, USA

“… Now in its sixth edition, [this book] hasdeveloped and grown in size and stature andis much improved … Each chapter comes witha useful collection of additional material suchas bibliographies, sources of spectral data-bases, experiments and problems. … [thebook effectively removes] the artificial bound-ary between the construction and function ofthe instrument and the understanding of theresults that the instrument generates. …”

—Journal of Raman Spectroscopy, 2005







11

General Analysis


Handbook ofDetergentsPart C AnalysisEdited by

Heinrich WaldhoffHenkel KGaA, Dusseldorf,Germany

Rudiger SpilkerSasol Germany GmbH, Marl

Emphasizing techniques and methods thathave proved effective and useful in daily work,the third installment of this handbook demon-strates the full spectrum of strategies, meth-ods, and techniques for the analytical defor-mulation of modern detergents developed inthe last decade. It covers typical ingredients ofmodern products, testing of detergent formu-lations, the determination of detergent ingre-dients in the environment, and the applicationof modern instrumental techniques.


DetectionTechnologies forChemicalWarfare Agentsand Toxic VaporsYin SunAdvanced AnalyticalTechnologies Group LLC,Bridgewater, New Jersey, USA

Kwok Y. OngRetired, Joppa, Maryland, USA

“…this book not only features a comprehen-sive resource for technical and emergencyresponse personnel, but also reviews detectionrequirements and protocols considered by theUS government, discusses specific devices fordetection, and describes laboratory techniquesand analyses. … The book is well written, per-fectly organized, and accessible to both tech-nical and non-technical audiences. …”

—A. Buekens, Free University of Brussels,International Journal of Environment and Pollution,

Vol. 27, Nos. 1-3, 2006

Catalog no. L1668, 2005, 288 pp.ISBN: 978-1-56670-668-1, $154.95 / £98.00

AnalyticalInstrumentationHandbookThird EditionEdited by

Jack CazesLady Lake, Florida, USA

“This is a practical reference handbook …[that] provides excellent descriptions aboutspecific instrumental techniques and refer-ences dealing with more in-depth theory andmethods. … The information is well-illustrat-ed, and each of the chapters gives the readera good basic understanding of how the tech-nique works, various measurement methodsand a list of applications and practical con-siderations … a must-have reference book.”

—IEEE Electrical Insulation Magazine,Vol. 22, No. 4, August 2006


ElectrogeneratedChemilumines-cenceEdited by

Allen J. BardUniversity of Texas, Austin, USA

The first resource on this expanding analyticalscience, this reference explores advances inthe instrumentation, design, and applicationof techniques with electrogenerated chemilu-minescence (ECL). It examines the use andimpact of ECL-based assays in clinical diag-nostics, life science research, environmentaltesting, food and water evaluation, and thedetection of biowarfare agents. Compiled bythe pioneer of this highly innovative technol-ogy, this volume provides contributions from16 leading authorities.








Medicinal and Bioanalysis

New!

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysisand Discovery Paul C.H. LiSimon Fraser University, Burnaby, British Columbia, Canada

This comprehensive text presents the fundamentals of microfluidic lab-on-a-chip systems andprovides an overview of the available technology, its limitations, and its breakthroughs. Itemphasizes analytical applications of microfluidic technology and provides in-depth coverage ofmicromachining, nucleic acids, and mass spectrometry. The book also covers more recentadvances in microdrops and nanoparticles. Ideal for students, the text includes historical back-ground, expanded problem sets in each chapter, a comprehensive glossary, a complete index,and extensive references.

Features

• Reviews basic principles of micromachining and fluid flow and control for lab-on-a-chiptechnology

• Adapts traditional principles of operation for the size of a chip, optimizing the miniaturization advantage and favorable scaling down

• Presents problem sets in each chapter • Includes a glossary, complete index, and extensive references

ContentsIntroduction. Micromachining Methods. Micromachining of Silicon. Micromachining of Glass.Micromachining of Fused Quartz (or Fused Silica). Micromachining of Polymeric Chips. MetalPatterning. World-to-Chip Interface. Microfluidic Flow. Liquid Pumping Methods. MicrofluidicFlow Control. Sample Introduction. Electrokinetic Injection. Hydrodynamic Injection. OtherSample Injection Methods. Sample Preconcentration. Sample Stacking. Extraction. PorousMembrane. Other Preconcentration Methods. Separation.Gas Chromatography. CapillaryElectrophoresis. Chromatographic Separations. Coupled Separations.Detection Methods. OpticalDetection Methods. Electrochemical Detection. Mass Spectrometry. Other Detection Methods.Applications to Cellular/Particle Analysis. Retention of Cells and Particles. Studies of Cells in aFlow. Other Cell Operations. Applications to Nucleic Acids Analysis. Nucleic Acids Extraction andPurification. Nucleic Acids Amplification. DNA Hybridization. Other Nucleic Acid Applications.Applications to Protein Analysis. Immunoassay. Protein Separation. Enzymatic Assays.

Catalog no. K10977, February 2010, c. 352 pp., Soft Cover, ISBN: 978-1-4398-1855-8, $99.95 / £38.99



13



New!

Mass Spectrometry of Nucleosides and Nucleic AcidsEdited by

Joseph H. BanoubFisheries and Oceans Canada, Science Branch and Memorial University ofNewfoundland, Canada

Patrick A. LimbachUniversity of Cincinnati, Ohio, USA

Assembling the work of an international panel of researchers, this volume summarizes the latestdevelopments in the field and provides a window on the next generation of analysis. It shouldinspire new findings and avenues of research.

The book describes studies performed on deoxyinosine and its analogues and provides an intro-duction to tandem mass spectrometry. It then examines mass spectrometric application in thestudy of cyclic nucleotides in biochemical signal transduction. The contributors analyze urinarymodified nucleosides and explore DNA adducts. They also discuss isotope labeling of DNA-massspectrometry and examine various uses of electrospray ionization mass spectrometry (ESI-MS).They review recent progress in the direct MS characterization of noncovalent nucleic acid-pro-tein complexes, explore the interaction and ionization of guanidine-derived compounds withhighly acidic biomolecules, and examine quantitative identification of nucleic acids via signaturedigestion products detected using mass spectrometry.

In addition, the book describes a direct-infusion ESI-MS approach that can serve as a screeningtechnique for the presence of modified nucleosides from small RNAs. It discusses the LC-MS/MSmethod for the in vitro replication studies on damage-containing DNA substrates. The book con-cludes with an examination of the influence of metal ions on the structure and reactivity ofnucleic acids.

Features

• Reviews the progress of nucleic acid research by mass spectrometry• Highlights the most popular ionization methods• Illustrates the diverse strategies used in the characterization and sequencing of novel nucleosides and nucleotides

• Covers complex DNA, single strands and duplexes, DNA-adducts, RNA oligomers of biomedical importance, DNA-drug complexes, and post-transcriptional modifications

Catalog no. 44028, January 2010, 504 pp., ISBN: 978-1-4200-4402-7, $149.95 / £95.00





New!

Using MassSpectrometryfor DrugMetabolismStudiesSecond EditionEdited by

Walter A. KorfmacherSchering-Plough Research Institute, Kenilworth, New Jersey, USA

Praise for the First Edition

“… an invaluable reference … very well writ-ten … an informative look at the problemsand successes of the modern drug discoveryand development process.”

—Journal of Medicinal Chemistry, Vol.48, 2005

The first edition of this now classic workhelped establish mass spectrometry as thepremier tool for drug metabolism studies.Keeping pace with rapid advances, the emer-gence of new approaches, and increasingdemands by vendors, the second edition ofthis bestseller includes cutting-edge coverageof new instrumentation and software as wellas significant new information on the latestfindings regarding biomarkers andmetabolomics. In addition to exploring allmodern techniques and strategies, it offers anexcellent overview of the entire drug discov-ery process, including the latest develop-ments in molecular research.

This edition also contains new chapters onboth UPLC and DESI/DART. With more than180 illustrations and an eight-page colorinsert, this valuable reference explores multi-ple modern mass spectrometry techniquesand strategies. It includes an excellentoverview of the entire drug discovery processplus the latest developments on how massspectrometry is used to support this endeavor.

Catalog no. 92200, January 2010, 451 pp.ISBN: 978-1-4200-9220-2, $169.95 / £108.00

New!

Advances inChromatographicTechniques forTherapeutic DrugMonitoringEdited by

Amitava DasguptaUniversity of Texas Health Sciences Center at Houston, USA

“…This excellent book reviews not only thosedrugs for which chromatographic techniqueshave long been used, but also drugs for whichtherapeutic monitoring is newer (e.g., anti-retroviral agents, immunosuppressive drugs,antineoplastic compounds, antidepressantdrugs, analgesics, cardioactive drugs, andantibiotics). … Edited by a distinguishedauthority on therapeutic drug monitoring,this book should serve as both an invaluablereference for analytical toxicologists and apractical guide for laboratory physicians andscientists who are involved in the monitoringof therapeutic agents.”

—From the Foreword by David N. Bailey, Vice Chancellor for Health Affairs,

Dean of the School of Medicine, and Professor of Pathology & Laboratory Medicine,

University of California, Irvine, USA

Providing practical guidelines for implement-ing chromatographic methods, this volumedescribes the theory and application of ther-apeutic drug monitoring in clinical laborato-ries. It presents the theoretical frameworkand addresses preanalytical variables, the pit-falls of immunoassays, tandem mass spec-trometry, issues related to pain management,and drug monitoring for a range of medica-tions. The book also examines the interactionof herbal supplements with drugs beingmonitored.





15



Quantitationand MassSpectrometricData of Drugsand IsotopicallyLabeledAnalogsRay H. LiuBirmingham, Alabama, USA

Dennis V. CanfieldFederal Aviation Administration, Oklahoma City,Oklahoma USA

Sheng-Meng WangCentral Police University, Taoyuan Hsien, Taiwan

“Forensic toxicologists would benefit from thisbook most … This book shall remain a readyreference tool for me.”

—Anil Aggrawal’s Internet Journal of ForensicMedicine and Toxicology, Vol. 11, No. 1

The availability and the selection of qualityion-pairs designating the analytes and theirisotopically labeled analogs are importantconsiderations in achieving the accuracy ofquantitation results. With more than 1,500full-scan mass spectra and quick access datatables, this text provides a valuable referencefor labs involved in the analysis of abused andtherapeutic drugs. The first part illustratesapproaches, mechanisms, and challengespertaining to the use of isotopic analogs asinternal standards for drug quantitation.

The second section compiles mass spectra,including drugs and their analogs, as parentcompounds and as derivatives resulting fromvarious chemical derivatization approachescommonly encountered in today’s labs. Thethird part provides corresponding tables ofion-pairs that can potentially be adapted todesignate the drugs and their analogs in theanalytical processes. The unparalleled scopeof this compilation makes it a critical one-stop reference for those involved in druganalyses of biological specimens and inter-pretation of results.

Catalog no. 94971, January 2010, 510 pp. ISBN: 978-1-4200-9497-8, $189.95 / £121.00

BiochemicalApplications ofNonlinearOpticalSpectroscopyEdited by

Vladislav YakovlevUniversity of Wisconsin,Milwaukee, USA

This volume presents the most significantadvances and future directions within thisimportant field. It provides an understandingof the nonlinear optical response of complexmolecules and reviews developments in ultra-fast technology. In addition, the editorincludes a theoretical analysis of nonlinearoptical spectroscopies. Novel experimentalapproaches, such as spatial and temporalpulse shaping, are addressed as well as vari-ous nonlinear optical spectroscopic tools,including harmonics generation and Ramanspectroscopy. The book also provides insightinto the extension of nonlinear optical spec-troscopy to the nanoscale through the use ofplasmonic tip-enhanced arrangement. Thebook’s balanced coverage from a wide rangeof international contributors not only eluci-dates important achievements, but also out-lines future directions in this dynamic andpromising field.

Features

• Reflects the latest technological advancement in the biomedical, biochemical, and biophotonics industry

• Focuses on practical applications, such asphoto echo, nonlinear optics, two-dimensional IR, and stimulated Ramanspectroscopy

• Balances coverage of optical science,engineering, biology, chemistry, andphysics

• Includes contributions from an internationalpanel drawing on experts from Japan,Germany, Israel, and the Netherlands







Biomolecular EPRSpectroscopyWilfred Raymond HagenDelft University of Technology,The Netherlands

“EPR is being increasingly used to investigatebiological systems, but there is currently notext that biologists, biochemists, and bioinor-ganic chemists can use to understand theexperimental and theoretical aspects of thistechnique without being experts in quantummechanics … [this book] provides a valuableintroductory text that can be recommended… The author is a prolific writer with a clearand concise writing style.”

—Michael K. Johnson, University of Georgia,Athens, USA


Methods ofAnalysis forFunctionalFoods andNutraceuticalsSecond EditionEdited by

W. Jeffrey HurstHershey Foods Technical Center, Pennsylvania, USA

Providing an invaluable source of informationfor laboratories involved in the food, dietarysupplement, and pharmaceutical industry,the second edition of this highly successfultext reflects dramatic advances in the field offunctional foods and nutraceuticals. It offersnew techniques for the analysis ofcarotenoids, phytoestrogens, flavonoids, vita-mins, and carbohydrates. This edition alsoincludes three new chapters on polyphenolanalysis along with 85 percent new or revisedinformation.


High-ThroughputAnalysis in thePharmaceuticalIndustryEdited by

Perry G. WangTeleflex, Wyomissing,Pennsylvania, USA

“This book provides excellent up-to-datereviews on the newest developments of high-throughput analysis in drug discovery anddevelopment … has a good balance of boththeoretical and practical information thatshould appeal to a broad base of readers … aquick and valuable resource for readers, rang-ing from professionals to academics, to gainknowledge about recent developments ofhigh-throughput analysis in the pharmaceuti-cal industry.”

—Keyang Xu, Genentech, Inc., 2009

Catalog no. 5953X, 2009, 432 pp.ISBN: 978-1-4200-5953-3, $159.95 / £99.00

Principles andPractice ofBioanalysisSecond EditionEdited by

Richard F. VennPfizer Central Research, Kent, UK

“The book consists of 15 chapters written byinternationally distinguished experts frombiotech and pharmacological companies …This book is quite valuable theoretically andmethodologically for specialists of variousfields of analytical chemistry and biochem-istry, molecular biology, and biotechnology.… an important desk book for researchersworking with bioanalysis of various drugsand metabolites.”

—G. Ya. Wiederschain, Biochemistry,2008, Vol. 73, No. 12







17



SpectralTechniques inProteomicsEdited by

Daniel S. SemMarquette University,Milwaukee, Wisconsin, USA

Providing insight into future directions in theapplication of spectral techniques in pro-teomics, this book presents the techniquesused to analyze proteomes. It begins with anoverview of structural proteomics and chem-ical proteomics and continues with an in-depth exploration of widely used methods,such as ESI, MALDI, SELDI, ICAT, tandem MS,and shotgun proteomics. The book alsoexamines spectroscopic tools, including SPR,EPR, NIR fluorescence, x-ray crystallography,and NMR.


ThermalAnalysis ofPharmaceuticalsEdited by

Duncan Q.M. Craig andMike ReadingUniversity of East Anglia,Norwich, UK

“The editors did a really good job in creating afine balance between topics of commonly used,well-established methods, and of techniquesthat are the focus of recent research efforts …Due to the high scientific value, timely industri-al relevance, and didactic approach, this bookis an invaluable information resource for read-ers both in academia and industry … . I warm-ly recommend this book … .”

—Ádám Demeter, Gedeon Richter Plc,ChemMedChem, 2008, No. 3


VanadiumChemistry,Biochemistry,Pharmacology andPracticalApplicationsAlan S. TraceySimon Fraser University, Burnaby,British Columbia, Canada (retired)

Gail R. Willsky andEsther S. TakeuchiUniversity at Buffalo, New York, USA

“The first comprehensive resource on thechemistry of vanadium, this book has evolvedfrom over a quarter century of research thatconcentrated on delineating the aqueouscoordination reactions that characterize thevanadium oxidation state … [the book] makethis information accessible to a wide range ofreaders …”—Anticancer Research, September/October 2007,

Vol. 27, No. 5A


Immunoassayand OtherBioanalyticalTechniquesEdited by

Jeanette M. van EmonUS EPA, Las Vegas, Nevada, USA

Using an interdisciplinary approach, this vol-ume describes the strength and the versatilityof immunochemical and related bioanalyticalmethods for a wide range of environmentaland biological measurement applications. Itexplores the wide base of immunoassay meth-ods and discusses the evolution of the tech-nology. It presents both standard and innova-tive applications of immunochemical andrelated methods as well as quality assuranceguidelines. The book also offers insight intorecently developed products and procedures.









FluorescenceSensors andBiosensorsEdited by

Richard B. ThompsonUniversity of Maryland,Baltimore, USA

“… emphasizes the most recent developmentsand emerging technologies with the broadestimpacts in prominent fields such as fluores-cence-activated cell sorting, DNA sequencing,high throughput screening, and clinical diag-nostics. … an up-to-date account of fluores-cence-based sensors focused on practicalapplications in biotechnology, analyticalchemistry, and biomedicine.”

—J. Albaigés, CID-CSIC, Barcelona, Spain, and Editor, International Journal of Environmental



MicrofluidicLab-on-a-Chipfor Chemicaland BiologicalAnalysis andDiscoveryPaul C.H. LiSimon Fraser University, Burnaby, British Columbia, Canada

“…truly an awesome book … [a] well-docu-mented book with a multitude of references …a great book to learn about instrumentdesign, with numerous pictures and illustra-tions making the text much easier to under-stand. …”

—Gary S. Vardon, Salt Lake Tribune,Journal of Materials, 2007

“…an excellent book, well thought out andwritten.”—P. Myers, Chromatographia, June 2007, Vol. 65


SeparationMethods inProteomicsEdited by

Gary B. Smejkal andAlexander LazarevPressure Biosciences, Inc.,Woburn, Massachusetts, USA

“This volume provides a comprehensive exam-ination of all major separation techniques forproteomics research. Written as a compilationof hands-on methods exemplified by the workof several recognized leaders in the field, thisbook may serve as a guide for the selection ofoptimal separation strategies to solve partic-ular biological problems. …”

—Anticancer Research, Vol. 26, 2006


NMRSpectroscopy ofBiological SolidsEdited by

A. RamamoorthyUniversity of Michigan, Ann Arbor, USA

This book examines the developments,implementation, and interpretation of solid-state NMR experiments and the advantagesof applying them to biological systems. Itemphasizes how these techniques can beused to realize the structure of noncrystallinesystems of any size. The book provides a crit-ical selection of solid-state NMR methods forsolving a wide range of practical problemsthat arise in both academic and industrialresearch of biomolecules in the solid state.







19

Separation Techniques


New!

High Performance LiquidChromatography in Phytochemical AnalysisEdited by

Monika Waksmundzka-HajnosMedical University of Lublin, Poland

Joseph ShermaLafayette College, Easton, Pennsylvania, USA

Practical and valuable across a range of fields, this volume presents up-to-date methods in highperformance liquid chromatography (HPLC) applied to phytochemistry. This precise, rapid, ver-satile, and automated separations tool has broad applications in the separation, identification,and quantification of important components of medicinal plants. A team of well-respectedindustrial researchers, academicians, and regulators from around the world cover methods todetermine plant taxonomy, structure, biochemistry, physiology, ecology, and genetics. Thesemethods are essential for the standardization of plant-based drugs, identification of plant mate-rial, and creation of new herbal medicines. Applications for crop management and productionare also addressed.

Features

• Provides a comprehensive source of phytochemical analysis to determine plant taxonomy,structure, biochemistry, physiology, ecology, and genetics.

• Covers applications for crop management and production

• Offers contributions from an international roster of contributing authors spanning industry,academia, and government regulatory agencies

ContentsOverview of the Field of HPLC in Phytochemistry and Organization of the BookHerbal Drugs and the Role for Chromatographic Methods in Their AnalysisPlant Products in Nutrition and Dietary Supplements: Quality ControlRole of HPLC in Chemosystematics. Phytochemistry, Phytopharmacology, and Biological Role ofPlant Metabolites. Sample Preparation of Plant Material. Stationary Phases and Columns in Analysis of Primary andSecondary Metabolites.

Catalog no. 9260X, March 2010, c. 688 pp., ISBN: 978-1-4200-9260-8, $199.95 / £127.00





New!

Forensic Applications of High PerformanceLiquid ChromatographyShirley BayneTeesside University, Middlesbrough, UK

Michelle CarlinUniversity of Northumbria, Newcastle, UK

Chromatography has many roles in forensic science, ranging from toxicology to environmentalanalysis. In particular, high-performance liquid chromatography (HPLC) is a primary method ofanalysis in many types of laboratories. Maintaining a balance between practical solutions and thetheoretical considerations involved in HPLC analysis, Forensic Applications of HighPerformance Liquid Chromatography uses real-life examples likely to be found within a foren-sic science laboratory to explain HPLC from a forensic perspective.

Focusing chiefly on the reverse phase HPLC mode of separation, the book presents key pointsummaries and questions to enhance learning and test comprehension. It also includes a com-plete glossary of terms as well as references at the end of each chapter to facilitate further study.An invaluable guide for those in the early stages of their forensic analysis careers, this volume isalso suitable as a textbook for students studying analytical chemistry, applied chemistry, forensicchemistry, or other courses with an element of HPLC within the course curriculum.

Features

• Examines the history of HPLC and the theory behind the separation process

• Describes the requirements for successful analysis and best practice tips

• Introduces the modes of separation and detection most appropriate for forensic science applications

• Covers HPLC method development and evaluation

• Presents the quality aspects of laboratory operation

• Discusses troubleshooting HPLC systems and analyses

• Explores applications of HPLC within the field of forensic science

Catalog no. 91913, February 2010, c. 272 pp., Soft Cover, ISBN: 978-1-4200-9191-5, $59.95 / £38.99



21



New!

Advances in ChromatographyVolume 48Edited by

Eli GrushkaHebrew University of Jerusalem, Israel

Nelu GrinbergBoehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA

Praise for Previous Editions

“… the articles are of high scientific standard, up to date, very wellwritten, and interesting to read.”

—Journal of Chromatography

“… a valuable contribution to the chromatography literature—belongs in every library used bychromatographers.”

—Liquid Chromatography

“… maintains the high quality that chromatographers have come to expect from this valuable series.”—Journal of Pharmaceutical Science

For more than four decades, scientists and researchers have relied on the Advances inChromatography series for the most up-to-date information on a wide range of developments inchromatographic methods and applications. These volumes present timely, cutting-edge reviewson chromatography in the fields of bio, analytical, organic, polymer, and pharmaceutical chem-istry. Each author’s clear presentation of topics and vivid illustrations make the material inVolume 48 accessible and engaging to biochemists and analytical, organic, polymer, and phar-maceutical chemists at all levels of technical skill. Topics covered include new advances in affinityinteraction chromatography, simulated moving bed processes, retention mechanism in RP, silicahydride chemistry and applications, and UPLC.

Features

• Presents the most recent significant developments in separation science • Offers contributions from prominent international researchers • Includes chapters on issues of great timely concern, including one on leachables andextractables


Recent volumes in the series

Volume 47

Catalog no. 60368, 2009, 462 pp., ISBN: 978-1-4200-6036-2, $189.95 / £115.00

Volume 46


Volume 45

Catalog no. DK4478, 2007, 285 pp., ISBN: 978-1-57444-735-4, $189.95 / £121.00

For complete contents of these and other volumes in the series, visit www.crcpress.com








New!

ChiralSeparations byCapillaryElectrophoresisEdited by

Ann Van Eeckhaut andYvette MichotteVrije Universiteit Brussel, Belgium

With contributions from internationalexperts, this volume provides a comprehen-sive, up-to-date overview of the principles ofchiral separation by capillary electrophoresisand the different chiral selectors available. Itexplains how this technique can be used inthe separation of molecules, offering insightinto both existing and emerging applications.

The book discusses the most important aswell as several new chiral selectors used incapillary electrophoresis. It reviews recentpharmaceutical and biomedical applicationsand explores novel techniques, such as capil-lary electrophoresis coupled to mass spec-trometry and microchip technology. Thebook also examines the quantitative aspectsof capillary electrophoresis, the possibilities ofcapillary electrochromatography, and thevarious chiral columns available.

Features

• Presents a comprehensive, up-to-dateoverview of chiral separations with capil-lary electrophoresis

• Describes recent techniques, such as cap-illary electrophoresis-mass spectrometry,capillary electrochromatography, andmicrochips

• Explores new modes of chiral selectors,including microemulsion electrokineticchromatography

• Discusses the principles of separation,recent developments, and novel applica-tions of the most common chiral selectors


New!

Ion-PairChromatographyand RelatedTechniquesTeresa CecchiIstituto Tecnico IndustrialeStatale Montani, Fermo, Italy

Ion-pair chromatography (IPC) is a rapidlyevolving method for difficult analyses oforganic and inorganic ions and ionogenic,neutral, and zwitterionic compounds.Providing a thorough exploration of the mul-tiplicity of interactions involved in an IPC sys-tem, this book emphasizes the progress fromtheoretical modeling to application. Itexplores the practical potential of IPC in thelife science, medicine, pharmacology, foren-sic, food, and environmental sectors. It exam-ines the upgrade of column technology andinstrumentation to improve data quality andincrease sample throughput. The book alsocompares IPC to other instrumental methodsof analysis and discusses the rising impor-tance of the ion-pair concept in different ana-lytical techniques.

Features

• Provides basic tips, decisive skills, andpractical advice to experienced andnovice chromatographers

• Presents a theoretical description of thephysico-chemical separation principle ofIPC

• Demonstrates applications showing themultiplicity of interactions involved in anIPC system

• Describes upgrades to column technologyand instrumentation

• Reveals how to exploit the modification ofthe analyte hydrophobicity, via ion-pair-ing in different analytical techniques, toimprove their versatility

• Offers stimulating research suggestionsand investigation needs

Catalog no. K10075, January 2010, 215 pp.ISBN: 978-1-4398-0096-6, $129.95 / £82.00




23



New!

Encyclopedia of ChromatographyThird Edition Edited by


Praise for Previous Editions

“…a wealth of information.”—Journal of Planar Chromatography

“…This encyclopedia should become a first and frequently used source of information on justabout every conceivable chromatographic technique.”

—The Chemical Educator

Thoroughly revised and expanded, this third edition is an authoritative guide to specific chro-matographic techniques and theory. It provides a basic introduction to the science and technol-ogy of the method, offering key references that deal with the methodology for analyzing specificchemicals and applications in industry. With a focus on emerging technologies and uses, the textcontains tables and figures that cogently illustrate and clarify technical points in the articles.

New to the Third Edition

• Bioanalysis: Silica- and Polymer-Based Monolithic Columns • Bioluminescence: Detection in TLC • Chemical Warfare Agent Degradation Products: HPLC/MS Analysis • Chemical Warfare Agents: TLC Analysis • Cyclodextrins in GC and HPLC • Detection in Ion Chromatography • Drug Development: LC/MS • Flash Chromatography • Food Analysis: Ion Chromatography • Inorganic and Organic Cations: Ion Chromatographic Determination • Inverse GC • Multidimensional Separations • Spiral Column Assembly for HSCCC • Thin Layer Radiochromatography • Topological Indices: TLC • UV-Visible Detection Including Multiple Wavelengths

Available in print and online versions or as a combination of the two. Visit www.crcpress.com for more information.



http://www.crcpress.com/utility_search/search_results.jsf?conversationId=189134



Thin LayerChromatographyin PhytochemistryEdited by

Monika Waksmundzka-HajnosMedical University of Lublin,Poland


Teresa KowalskaUniversity of Silesia, Katowice, Poland

Worldwide TLC experts in diverse fields pres-ent the first resource to focus on TLC as itapplies to the separation, identification,quantification, and isolation of medicinalplant components. The first part of the textoffers a current overview of TLC and phyto-chemistry. The second section emphasizesreal strategies and procedures for analyzingall types of primary and secondary plantmetabolites. Organized by compound type,each chapter discusses key topics, such assample preparation, plate development, andbiodetection. From identification to commer-cial scale production and quality control, thistext is an essential bench-top companion andreference on using TLC for the study of plant-based bioactive compounds.

Features

• Underscores the advantages of using TLCfor locating and analyzing bioactive compounds from plant sources

• Explains the benefits of using TLC overmore expensive and complexchromatographic techniques

• Reviews the techniques, materials, instrumentation, and procedures specificto the analysis and isolation of each compound class

• Discusses methods for online derivatization,detection, identification, and quantification

• Includes up-to-date tables, figures, andreferences throughout the text


LiquidChromatography-MassSpectrometryThird EditionWilfried M.A. Niessenhyphen MassSpec Consultancy,Leiden, The Netherlands

“… this book covers a variety of topics thatare of interest to practitioners of LC-MS. The22 chapters cover multiple topics and includepractical tips as well as a useful list of refer-ences for the reader who wants to learn moreabout the particular topic. This book can beused as a reference book by both scientistswith years of LC-MS experience as well asthose scientists who are just beginning to uti-lize this excellent analytical tool.”

—Walter A. Korfmacher, Schering-Plough Research Institute,

American Society for Mass Spectrometry, 2007

"... well-rounded coverage of the latest tech-nological developments and applications …"

—Anticancer Research, October 2008

Featuring new chapters and extensive revi-sions throughout, this new edition explainshow to use LC-MS and interpret data for var-ious disciplines. This edition places a strongeremphasis on applications, dedicating morethan two-thirds of the text to examining newdevelopments of LC–MS in emerging appli-cation areas, including environmental, foodsafety, and clinical analysis as well as pro-teomics, pharmaceutical drug discovery, andnatural products research. Supported by themost relevant literature available, each chap-ter examines how the strategies, technolo-gies, and recent advances in LC-MS continueto shape many disciplines.





25



PreparativeLayerChromatographyEdited by

Teresa KowalskaUniversity of Silesia, Katowice,Poland


“… A valuable and important supplement tothe existing vast chromatographic literature,[this book] demonstrates the potential of pla-nar chromatography for separation and iso-lation of pure compounds, even from verycomplex mixtures.”—Journal of Liquid Chromatography, August 2006

“The book is quite well produced and has alarge number of illustrations … a worthyaddition to the PLC literature and a goodplace to start for the novice.”

—I.D. Wilson, Chromatographia,January 2008, Vol. 67, No. 1/2

Preparative Layer Chromatography (PLC)explains how this method is used for separat-ing large quantities of mixtures containing awide variety of important compounds. Itoffers a broad review of PLC applications andadaptable working procedures for microsepa-rations involving organic, inorganic, andorganometallic compounds.

The book describes procedures and strategiesfor selecting the most suitable eluents anddesigning application-specific PLC systems. Italso discusses commercially available sor-bents applicable to PLC, including bulk sor-bents and precoated chromatographic platesavailable on the international market.


SeparationMethods inMicroanalyticalSystemsEdited by

Jorg P. KutterTechnical University of Denmark,Lyngby

Yolanda Fintschenko

“This is just what I have been looking for. Tomy knowledge it’s the first time that anyonehas put together a definitive book on the sub-ject … The editors have done an excellent jobin ensuring that the authors keep to their briefand do not cover data or examples given byother authors, but [still] have allowed theauthors their individual styles … it is [of]great value, a book every researcher and stu-dent should have.”

—P. Myers, Chromatographia, 2006, Vol. 63


Handbook ofAffinityChromatographySecond EditionEdited by

David S. HageUniversity of Nebraska, Lincoln, USA


“The topics are well illustrated and range fromfields of biochemistry, molecular biology andbiotechnology to analytical chemistry, phar-maceutical and environmental science. Thishandbook can be an excellent source of infor-mation not only to the students but also to thepersons involved in research and academia.”

—Carbohydrate Polymers







Spectroscopy

New!

Linearly Polarized IR SpectroscopyTheory and Applications for Structural AnalysisBojidarka KolevaSofia University, Bulgaria

Tsonko KolevPlovdiv University, Bulgaria

Reviewing theory but focusing on practice, Linearly Polarized IR Spectroscopy: Theory andApplications for Structural Analysis introduces linearly polarized IR spectroscopy as a methodof molecular structural analysis, a technique that is useful in the study of pharmaceutical prod-ucts and biological molecules. Examples demonstrate both the advantages and limitations of thistechnique. The text explains the possible applications of this new orientation method for thestructural characterization of various chemicals. More specifically, it demonstrates how to obtainimportant information about the structure and spectral properties of oriented compounds.

Features

• Reviews the general theory of linearly polarized IR spectroscopy

• Focuses on the use of the method for molecular structural analysis

• Demonstrates the advantages and limitations of this technique through illustrative examples

• Includes practical aspects associated with the characterization of inorganic chemicals andglasses as well as various classes of organic compounds

ContentsBackground of the Orientation MethodApplication for Spectroscopic and Structural Elucidation of Suspended ChemicalsInorganic Compounds and GlassesOrganic CompoundsSubstituted PyridinesAmino Acids, Their Salts, and Ester-Amides of Squaric AcidSmall Peptides and Their SaltsArylaliphatic AminesPharmaceutical ProductsOrganic DyesBenzylsList of Acronyms

Catalog no. K11223, March 2010, c. 232 pp., ISBN: 978-1-4398-2559-4, $129.95 / £82.00



27

Spectroscopy


New!

Practical Aspects of Trapped Ion Mass SpectrometryVolume V: Applications of Ion Trapping DevicesEdited by

Raymond E. MarchTrent University, Ontario, Canada

John F.J. ToddUniversity of Kent, Canterbury, UK

Widely used in medical research, pharmaceutical and fine chem-icals industries, biological and physical sciences, and securityand environmental agencies, mass spectrometry techniques arecontinually under development. In this volume, an internationalpanel of authors presents a worldwide view of the practicalaspects of recent progress using trapped ion devices. Spanningsixteen chapters, the text examines ion/neutral and ion/ion reactions, ion spectroscopy, and thestructural characterization of proteins and peptides using quadropole ion trap mass spectrome-try, Fourier transform -ion cyclotron resonance mass spectrometry, and traveling wave ion mobil-ity mass spectrometry. It also provides practical examples of trapped-ion technology that reflectthe wide diversity of applications of trapped-ion devices.

Features

• Compiles into one volume new and established mass spectrometric techniques utilizingtrapped ions for prolonged investigation and increased sensitivity

• Explores commonalities in theories of instrument operation, proteins, flavonoids, atomicclocks, and single ion mass spectrometry

• Uses a consistent format and writing style in each chapter, explaining all terms, acronyms,procedures, and equations

• Provides complete references for each chapter


Other volumes in the set

Volume IV: Theory and Instrumentation

Catalog no. 83716, April 2010, c. 914 pp., ISBN: 978-1-4200-8371-2, $179.95 / £114.00

Volume III: Chemical, Environmental, and Biomedical Applications


Volume II: Ion Trap Instrumentation


Volume I: Fundamentals of Ion Trap Spectroscopy


For more information about these books, visit www.crcpress.com








Spectroscopy

Two-DimensionalOpticalSpectroscopyMinhaeng ChoKorea University, Seoul, South Korea

Effectively introducing a newly developedresearch field, this book provides a detailedaccount of basic theory required for an under-standing of two-dimensional vibrational andelectronic spectroscopy. It also bridges thegap between the formal development of non-linear optical spectroscopy and the applica-tion of the theory to explain experimentalresults. The author presents novel definitionsand theoretical frameworks for linear andnonlinear response spectroscopy anddescribes a range of two-dimensional spectro-scopic techniques to compare the merits anddisadvantages of each technique.

From the development of the theory to novelapplications, this book covers a gamut of top-ics in this field, including perturbation theory,coherent Raman scattering, pump-probespectroscopy, photon echo spectroscopy, IR-visible four-wave mixing, and linear and non-linear optical activity spectroscopy.

Features

• Provides the first published source ofmaterial on the principles of two-dimensional optical spectroscopy

• Presents novel definitions and theoreticalframeworks for linear and nonlinearresponse spectroscopy

• Describes a range of two-dimensionalspectroscopic techniques to compare themerits and disadvantages of each

• Includes various examples and applicationsto real molecular and electronic systems,such as chemical exchange systems, proteins, and light-harvesting complexes


Differential IonMobilitySpectrometryNonlinear IonTransport andFundamentals ofFAIMSAlexandre A. ShvartsburgPacific Northwest Laboratory,Richland, Washington, USA

This state-of-the-art book explores a novelanalytical technology that separates andcharacterizes ions by the difference betweentheir mobility in gases at high and low elec-tric fields. It also covers the novel topics ofhigher-order differential IMS and IMS withalignment of dipole direction. Incorporatingsome of his own unpublished research, theauthor integrates the fundamental physics ofhigh-field ion mobility with practical consid-erations of FAIMS implementation.


Practical Guideto ICP-MSA Tutorial forBeginners, Second EditionRobert ThomasScientific Writing Solutions,Gaithersburg, Maryland, USA

This book offers key concepts in a reader-friendly format suitable for those with limitedknowledge of the technique. Detailing thefundamental principles, analytical advan-tages, and practical capabilities of ICP-MS,this second edition features new and updatedcoverage of hyphenated techniques, user-friendly selection criteria for commercialICP-MS equipment, and a new glossary ofICP-MS terms as well as specifications andfeatures for commercial equipment.






29

Spectroscopy


Core LevelSpectroscopy of SolidsFrank de GrootDebye Institute, UtrechtUniversity, The Netherlands

Akio KotaniRIKEN/SPring-8, Hyogo, Japan

This work presents the theoretical calcula-tions, experimental data, and underlyingphysics of x-ray photoemission spectroscopy(XPS), x-ray absorption spectroscopy, x-raymagnetic circular dichroism, and resonant x-ray emission spectroscopy. It discusses hardXPS, resonant photoemission, spin polariza-tion, electron energy loss spectroscopy, andresonant inelastic x-ray scattering. Theauthors also use the charge transfer multiplettheory to interpret core level spectroscopy fortransition metal and rare earth metal systems.


Practical Guideto InterpretiveNear-InfraredSpectroscopyJerry WorkmanLuminous Medical, Inc.,Calrlsbad, California, USA

Lois WeyerLandenberg, Pennsylvania, USA

With an emphasis on structure correlation andinterpretation of spectra, Practical Guide toNear Infrared Spectroscopy provides the nec-essary tools to interpret near infrared spectra.Organized by functional group type and chem-ical structure, chapters include more than 300figures representing NIR frequency ranges andstructural information for a broad range offunctional groups, organic compounds, andpolymers. Over 120 pages of tables and chartsillustrate overlapping spectra.


Handbook ofNear-InfraredAnalysisThird EditionEdited by

Donald A. BurnsNIR Resources, Los Alamos, New Mexico, USA

Emil W. CiurczakCadrai Technologies, Goldens Bridge, New York, USA

Presenting nearly 50 percent new and revisedmaterial, this edition underscores accurate aswell as time- and cost-effective current trendsin sample preparation, calibration transfer,process control, data analysis, and commercialNIR instrumentation. Drawing on the experi-ence of more than 60 experts in the field, newchapters highlight novel applications in phar-maceuticals, polymers, plastics, petrochemi-cals, textiles, foods and beverages, baked prod-ucts, agricultural products, biomedicine, neu-traceuticals, and counterfeit detection.


OpticalSpectroscopy ofLanthanidesMagnetic andHyperfine InteractionsBrian G. WybourneNicolaus Copernicus University,Torun, Poland

Lidia SmentekVanderbilt University, Nashville, Tennessee, USA

Highlighting the impact of lanthanides onmodern technology, medicine, biochemistry,and molecular biology, this book documentsthe theory of the spectroscopic properties oflanthanides in various materials and the funda-mental principles of their magnetic and hyper-fine interactions. Enhanced with numerousexamples, exercises, and sample programs, thetext also explores a range of applications,including electronic data storage, lasers, super-conductors, medicine, nuclear engineering,and nanomaterials.








Spectroscopy

CRC Handbookof FundamentalSpectroscopicCorrelationChartsThomas J. BrunoNational Institute of Standardsand Technology, Boulder,Colorado, USA

Paris D.N. SvoronosCity University of New York, Bayside, USA

Compiled from an extensive search of spec-troscopic literature, this handbook provides acollection of spectroscopic information andcorrelation charts for use in the interpretationof spectroscopic measurements. Applicableto organic and inorganic materials, it pro-vides useful analysis and assignment of spec-tra and structural elucidation of organic andorganometallic molecules. An ideal compan-ion in academic, industrial, and governmentlabs, the book offers fundamental charts thatare needed on a day-to-day basis.

Catalog no. 3250, 2006, 240 pp., Soft CoverISBN: 978-0-8493-3250-0, $99.95 / £63.99

AssigningStructures toIons in MassSpectrometryJohn L. Holmes,Christiane Aubry, andPaul M. MayerUniversity of Ottawa, Ontario,Canada

Exploring the tools currently available fordetermining gas-phase ion structures,Assigning Structures to Ions in MassSpectrometry surveys experimental methodsfor ion production and separation as well asthose designed to reveal qualitative andquantitative aspects of gas-phase ions. It alsoexamines how and when to apply computa-tional chemistry and theoretical calculations.The book contains experimental data and keyresults collected over the past four decades.


Ion MobilitySpectrometrySecond EditionG.A. EicemanNew Mexico State University, Las Cruces, USA

Z. KarpasNuclear Research Center, Beer-Sheva, Israel

“…The second edition of this book provides atimely update to the fundamental theory,advancements in instrumentation, and thedevelopment of new applications of IMS …The CD [is] a useful and practical addition tothis book … a well-balanced combination oftheory and application … I highly recom-mend it to anyone interested in IMS.”

—Robert G. Ewing, New Mexico Institute ofMining and Technology, JACS, Vol. 128, 2006


VibrationalSpectroscopy ofBiological andPolymericMaterialsEdited by

Vasilis G. GregoriouAdvent Technologies SA, Athens,Greece

Mark S. BraimanSyracuse University, New York, USA

“It manages to stand out from most compiledtexts consisting of contributions from many dif-ferent authors by having instrumentation as thecohesive thread connecting the chapters. … [it]provid[es] detailed descriptions of instrumenta-tion and the specific requirements of operation… the choice of topics and contributors doesjustice to recent advances in the area … .”

—Garth J. Simpson, Journal of the AmericanChemical Society, Vol. 128, No. 36, 2006







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