Big data and the promise of personalized medicine
Indrek VainuHelsinki Business Hub
[email protected]: +358 44 746 3902
Hello!
What is Personalized Medicine?
Customization of healthcare – decisions, practices, products tailored to individual patients
A lot of data
• The source code of you => 3.2 billion base pairs• Sequenced => 700 MB of data
http://cdn.trendhunterstatic.com/thumbs/illumina-hiseq-2500.jpeg http://thewinnower.com/blog/rejected-pt-1/
Beating Moore’s law
http://www.genome.gov/images/content/cost_per_genome_apr.jpg
Biobanks + data centers
http://www.ebo-enterprises.com/sites/default/files/images/07-14datacenter_lg.jpg
Genomics ROI
“Every dollar we invested to map the human genome returned $140 to our economy.”
--President Barack Obama, 2013 State of the Union address, Feb. 12, 2013
http://web.ornl.gov/sci/techresources/Human_Genome/publicat/BattelleReport2011.pdf
In the news …
The promise?
http://www.condenaststore.com/-sp/Here-s-to-the-human-genome-and-its-potential-in-finding-at-long-last-a-Cartoon-Prints_i8643225_.htm
The basis for personalized medicine
Benefits
•Genetic testing to select drugs–Xalkori, non-small cell lung cancer drug–Treatment cost $10,000 / month–Works only for ALK-positive gene mutation
patients (3-5%)–Testing costs $400–24 out of 25 patients do not respond–BOTTOM LINE => testing all $10,000 vs $250,000/month
• Categorized treatment plans
• Identifying responding patients
http://abcnews.go.com/Health/CancerPreventionAndTreatment/lung-cancer-pill-crizotinib-highlights-improved-iding-treating/story?id=14414833
Finland well positioned
• Finland has:–several biobanks–unique genomic
composition–electronic medical
records–research infrastructure
• Recently:–Biobank Act to use
biobank data for research purposes
Thank you
