Chapter 6Gene Prediction: Finding Genes
in the Human Genome
Figure 6.1: Map of the human X-chromosome
Figure 6.2: Schematic view of a typical prokaryotic gene and the mRNA transcribed from the gene
Figure 6.3: Transcriptional units in prokaryotes (A) can contain multiple open reading frames; eukaryotic transcriptional units (B) can have only one
ORF each
Figure 6.4: The eukaryotic promoter, defined by an assemblage of interacting protein transcription factors bound to DNA
Figure 6.5: A eukaryotic mRNA is processed by splicing after transcription to remove introns and join exons into a continuous coding sequence
Figure 6.6: Consensus promoter sequences based on a few strong E. coli promoters
Figure 6.7: The six possible reading frames within a short piece of double-stranded DNA
Figure 6.8: Output from NCBI’s ORF Finder program
Courtesy of ORF/National Center for Biotechnology Information
Figure 6.T1: Promoter sequences recognized by some E. coli sigma factors
Figure 6.T2: One-letter code for ambiguous nucleotides
Figure 6.9: The splicing process and consensus sequences at the exon-intron boundaries and branch site
Figure 6.T3: Codon usage table for human genes