![Page 1: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/1.jpg)
Hurserhälsoeffekterutfrånbiodrivmedel?ThomasSandström
Ins<tu<onenförfolkhälsaochkliniskmedicin,
Lungmedicin,UmeåUniversitet
![Page 2: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/2.jpg)
HälsoeffekteravluBföroreningar
ATS/ERSstatementonWhatconsitutesHealtheffectsofairpollu<on.EuropeanRespiratoryJournal2017
Lungor
Ämnesomsä-ning
Blodkärl
Hjärna
Hjärta
Hud
Fortplantning
![Page 3: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/3.jpg)
Mekanismerbakomlu;föroreningarseffekter
Brook,etal.Circula<on.2010;121:2331-78
![Page 4: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/4.jpg)
Exponeringskammare
![Page 5: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/5.jpg)
tPA
Nitric oxide
coagulation Placquerupture
Blood clot
Blood vessel dilatation
![Page 6: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/6.jpg)
Biobränslenförtransport
![Page 7: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/7.jpg)
Biodiesel
• Rapsbaseradolja-RME-RapsMetylEster• 5-7%RMEi”vanlig”diesel• Tallolja• HVO• Sojaolja• Alger• Slam• Mångaflervarianter
![Page 8: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/8.jpg)
RMEBiodieselvsPetrodiesel
• Hälsoeffekteravaabyta<llbiodiesel?
• Ingahumanstudier<digaregjordapåförnybaradrivmedel
• Fåtaldjurförsökpekarmotaaavgaserfrånbiodieselärfarligare
![Page 9: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/9.jpg)
1. RME30(30%biodiesel)vspetrodiesel– PM1300µg/m3-sammapar'kelmassa
2. RME100(100%biodiesel)vsPetrodiesel– PM1165µg/m3RME100vs300µg/m3petrodiesel–sammabelastning
ochkörningmedtvåolikabränslengavolikaemissionavpar<kelmassa
Blindadeexponeringarpåförsökspersomer-2-3vintervall
Euro3Volvomotor,EuropeanTransientCycle
1<mexponeringivilaalternerandemedergometercykel
Somgerandningsminutvolym20L/min/m2
Mätningavblodkärlseffekter2-4<meBerexponering
3. RME100(100%biodiesel)vsPetrodieselSomstudie2-menbronkoskopiförlungeffekter
TreexponeringsstudiermedbiodieselRME
![Page 10: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/10.jpg)
Par<kelkemiochfysik
NO
NO2
O3
O3
CO2
O2
PM10
PM2.5
PM1
Ultrafine
NanoPM
NucleaTonmode
![Page 11: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/11.jpg)
0,0E+00
5,0E+04
1,0E+05
1,5E+05
2,0E+05
2,5E+05
3,0E+05
3,5E+05
18
20
23
27
31
36
41
48
55
64
74
85
98
113
131
151
175
202
233
269
311
359
414
478
552
638
Par<clenu
mbe
rcon
centra<o
n(#/cm
3 )
Mobilitypar<clesize(nm)
DE RME100
ShiBtowardssmallernanopar<clesbyBiodiesel
![Page 12: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/12.jpg)
Badimonkammare
Luckingetal,EuropeanHeartJournal,2008
LuB
Diesel
![Page 13: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/13.jpg)
Bronkoskopimedprovtagningfrånlungorna
• Slemhinneprover och sköljning med koksaltlösning i luftrör (BAL)
![Page 14: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/14.jpg)
Provtagning i luftvägar
Salvietal,AmJRespirCritCareMed1999;159:702
Luft Diesel
![Page 15: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/15.jpg)
Biodieseli30%inblandningoch100%biodieselminstlikafarligtsomvanligdiesel
• Sammaeffekterpå– Blodkärl– Koagula<on– Blodtryck– LuBvägar– Inflamma<on
![Page 16: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/16.jpg)
Slutsats
• Biodieselavgaserminstlikafarligtsom”vanligadieselavgaser”
• Hälsoeffekterbörbeaktasförnyabränslen
![Page 17: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/17.jpg)
Pågåendeprojekt
• Screeningavolikabiodieselbränslenpågår• Cellförsök• Personermedlungsjukdomar• Hjärtkärleffekter
![Page 18: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/18.jpg)
Minskadexponeringförindividen
– Minskadeemissioner– Avgasfilter– Kupefilterförfordon– Filterför<lluBenihemmet– Ansiktsmasker
tPA
Nitric oxide (NO)
Coagulation Bloodclot Lucking et al. Circulation 2011
![Page 19: Hur ser hälsoeffekter ut från biodrivmedel · • Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University • Frank Kelly, Ian Mudway King’s College](https://reader033.vdocuments.net/reader033/viewer/2022041709/5e471fe5042cf65942661916/html5/thumbnails/19.jpg)
Tack till medarbetare • Christoffer Boman, Robin Nyström, Malin Nordin
Anders Blomberg, Annelie Behndig, Jenny Bosson-Damewood, Greg Rankin, Jamshid Pourazar, Ala Muala, Ragnberth Helleday, Maria Sehlstedt, Jon Unosson, Nirina Larsson, Stefan Barath, Magnus Lundbäck, Ann-Britt Lundström, Frida Holmström, Annika Johansson. Manuel Gonzales-Garcia, Stefan Söderberg Umeå universitet
• Roger Westerholm Stockholms universitet
• Jakob Löndahl, Joakim Pagels, Erik Swietlicki Lunds universitet
• Jeremy Langrish, Nicholas Mills, Andrew Lucking, David Newby. Edinburgh University
• Frank Kelly, Ian Mudway King’s College London
• Susan Wilson, Anthony J Frew, Stephen Holgate University of Southampton