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+IB BiologySBI3U7
BIOCHEMISTRY Topic 3
Biological Macromolecules
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1.What are the 4 main types of biological macromolecules and what is their function within cells?
2.How does the structure of each macromolecule contribute to their function within cells?
Essential Questions:
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Carbon: The Central Atom
What’s so special about ?
Virtually all chemicals of life are carbon based (exceptions – H2O, CO2) – called organic compounds. It can form four covalent bonds (H, O, N, P, S, C) C-C bonds enable carbon to form a variety of geometrical structures (e.g., straight chains, branched chains, rings)
MethaneCH4
EthaneC2H6
BenzeneC6H6
+ CH2 + C4
The diversity of life relies on carbon!!!
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Molecular Isomers: The same, yet different
What’s so special about ?
Isomer – an organic compound with the same molecular formula, but different structure
Fructose (fruit sugar)
Galactose(milk sugar)
C6H12O6
Glucose(simple sugar)
Example:
C
C C
C
C C
C
C
C
Metabolized by cells differently due to structure
Structural isomers
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Molecular Isomers: The same, yet different
What’s so special about ?
Isomer – an organic compound with the same molecular formula, but different structure
Structural isomers
Same atoms, bonded differently
Stereoisomers
Same atoms, Same bonds,
Differently arranged in space
Geometrical Optical
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Molecular Isomers: The same, yet different
What’s so special about ?
Isomer – an organic compound with the same molecular formula, but different structure
Stereoisomers
Same atoms, Same bonds,
Differently arranged in space
Geometrical Optical
Carvone
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Macromolecules
What is the relationship between atoms, bonding and macromolecules?
Atoms
Bonds
Molecules
Macromolecules
join together
that form
that form large structures called
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Macromolecules and their subunits
Monomer Monomer Monomer+ + = Polymer = Macromolecule
smaller subunits long chain of monomers
glucoseglycogen
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CarbonCompounds
include
Which are made of
which contain
Which are made of Which are made of Which are made of
which contain which contain which contain
Carbohydrates Lipids Nucleic acids(e.g., DNA/RNA) Proteins
Simple sugars(e.g., glucose)
Glycerol &3 Fatty Acids Nucleotides Amino Acids
Carbon,hydrogen,
oxygen
Carbon,hydrogen,
oxygenCarbon, hydrogenoxygen, nitrogen,
phosphorus
Carbon,hydrogen, oxygen,
nitrogen,
Macromolecules and their subunits
1 2 3 4
ENERGYSTORAGE
short-term
main function main function main function main function
ENERGYSTORAGE
long-term
CATALYSIS&
STRUCTURE/SUPPORT
ENCODINGHEREDITARY
INFORMATION
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CarbonCompounds
include
Which are made of
which contain
Which are made of Which are made of Which are made of
which contain which contain which contain
Carbohydrates Lipids Nucleic acids Proteins
Simple sugars(e.g., glucose)
Glycerol &3 Fatty Acids Nucleotides Amino Acids
Carbon,hydrogen,
oxygen
Carbon,hydrogen,
oxygenCarbon, hydrogenoxygen, nitrogen,
phosphorus
Carbon,hydrogen, oxygen,
nitrogen,
Carbohydrates
1 2 3 4
Main Function: quick and short-term energy storage
Groupings: C, H, and O atoms (1 : 2 : 1 ratio)
Two types: 1. Simple Carbohydrate 2. Complex Carbohydrates
ENERGYSTORAGE
short-term
main function
(4 cal/g)
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The simplest carbohydrate is a MONOSACCHARIDE (mono = one, saccharide = sugar)
Since they are so simple in structure, they are broken down quickly in the body to release energy
e.g. GLUCOSE – hexose (six-carbon) sugar with 7 energy-storing C-H bonds
Glucose
C6H12O6 (ring structure – when dissolved in water)
1
23
4
5
6
Primary source of energy used by all cells
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Monosaccharides:
Galactose
Fructose - plant sugar, honey
Glucose – short term energy storage
Monosaccharides
ALL ISOMERS!!
}All have the formula C6H12O6 !
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Making & Breaking Carbohydrates
Condensation (dehydration) synthesis
HydrolysisTwo important
biochemical reactions
monosaccharide monosaccharide+ disaccharide
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Disaccharides are made of 2 monosaccharides
sucrose = glucose + fructose plant transport sugar
lactose = glucose + galactose milk sugar
maltose = glucose + glucose malt sugar
Disaccharides
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Polysaccharides
Starch Granules (purple) in Potato Cells
Starch = energy storage in plants
Main Function: quick and short-term energy storage Contain many units of glucose in long chains
Examples: Starch, glycogen, cellulose, chitin
Polysaccharides are made of several monosaccharides all linked together
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Glycogen = energy storage in animals
Glycogen (red) in Hepatocytes (liver cells)
Glucose (monomer)
Glycogen (polymer)
Glycogen
livermuscle
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Cellulose
Cellulose = polysaccharide found in plant cell walls
Cellulose fibers
Macrofibril
Microfibril
Chains of cellulose
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Chitin
Chitin = polysaccharide found in fungi cell walls and exoskeletons
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Starch v. Cellulose
What is the difference between starch and cellulose?
Starch
Cellulose
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Starch Cellulose
Glucose repeat units are facing
the same direction
Each successive glucose unit is upside-down in relation to each of the glucose molecules that it is connected to
Both polymers
Same repeat base
Same monomer(glucose)
Stronger (good for building)Weaker
Enzymes to digest Cannot digest (no enzymes)
Insoluble (fiber / roughage)Soluble
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