Interesting Cases

Dr. Sara Edward FRCPath, Dip Dermpath

Consultant Dermatopathologist

St. James’s University Hospital, Leeds,UK

Case 1

F-56,Lump on elbow O/E Firm Lump

IHC Results

Positive for S100,CD68

Negative for MNF116,AE1/AE3, CD34,CD31,Desmin,SMA,

HMB45, MelanA and INI1

Molecular Analysis

Negative for EWSR1- seen in 50% of myoepithelial tumours

Malignant Epithelioid Schwannoma

Malignant Epithelioid Schwannoma

Tumour in a superficial location Clinically and radiologically no association with

nerve trunks

Differential Diagnosis

Epithelioid MPNST Deeper location Association with a nerve Membranous staining with Collagen IV

Malignant Epithelioid Schwannoma

Half the numbers of cases reported have developed distant metastasis