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Interesting Cases Dr. Sara Edward FRCPath, Dip Dermpath Consultant Dermatopathologist St. James’s University Hospital, Leeds,UK

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Interesting Cases. Dr. Sara Edward FRCPath, Dip Dermpath Consultant Dermatopathologist St. James’s University Hospital, Leeds,UK. Case 1. F-56,Lump on elbow O/E Firm Lump. IHC Results. Positive for S100,CD68 Negative for MNF116,AE1/AE3, CD34,CD31,Desmin,SMA, HMB45, MelanA and INI1. - PowerPoint PPT Presentation

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Page 1: Interesting Cases

Interesting Cases

Dr. Sara Edward FRCPath, Dip Dermpath

Consultant Dermatopathologist

St. James’s University Hospital, Leeds,UK

Page 2: Interesting Cases

Case 1

F-56,Lump on elbow O/E Firm Lump

Page 3: Interesting Cases
Page 4: Interesting Cases
Page 5: Interesting Cases
Page 6: Interesting Cases
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Page 8: Interesting Cases

IHC Results

Positive for S100,CD68

Negative for MNF116,AE1/AE3, CD34,CD31,Desmin,SMA,

HMB45, MelanA and INI1

Page 9: Interesting Cases

Molecular Analysis

Negative for EWSR1- seen in 50% of myoepithelial tumours

Page 10: Interesting Cases

Malignant Epithelioid Schwannoma

Page 11: Interesting Cases

Malignant Epithelioid Schwannoma

Tumour in a superficial location Clinically and radiologically no association with

nerve trunks

Page 12: Interesting Cases

Differential Diagnosis

Epithelioid MPNST Deeper location Association with a nerve Membranous staining with Collagen IV

Page 13: Interesting Cases

Malignant Epithelioid Schwannoma

Half the numbers of cases reported have developed distant metastasis


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