Download - Jay mitkari. pharmaceutical packaging
Presented ByMr. Mitkari Jayshankar V.
M. Pharm. ( Pharmaceutics Department )
Under the guidance Of
Mrs. Bidkar S. J.
Sharadchandra Pawar college of Pharmacy, Otur, Pune.
Pharmaceutical Packaging Materials
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INTRODUCTION Packaging is the science, art and technology of enclosing
or protecting products for distribution, storage, sale, and use.
Pharmaceutical packaging can be defined as the economical means of providing presentation, protection, identification , information, convenience ,compliance , integrity and stability of the product .
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FUNCTIONS OF PACKAGING
• Product Identification• Product Protection• Facilitating the use of product• Product Promotion
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TYPES OF PACKAGING
Primary packaging- Is the material that first envelops the product and hold it.
Ex. Aerosol spray can, blister packs, bottle
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Secondary packaging -Is outside the primary packaging Ex. Boxes, cartons
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Tertiary packaging- Is used to bulk handling and shipping.
Ex. Barrel, container, edge protector
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SOLID DOSAGE FORM (TABLETS, CAPSULES, POWDERS)Glass Bottles• type III glass and NP glass is used.• Transparent and Amber coloured glass bottle Plastic Bottle :• Bottles made from polyethylene, Polypropylene , Polystyrene.• It is light weighted and non breakable.
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Blister packaging: Forming cavity or pocket Polyvinyl chloride (PVC). Backing membrane seal of aluminum foil
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Strip Packaging Strip packs for a unit dosage. Made from cellulose, paper, plastic, foil or
combination of these
The use of high barrier material like aluminum foil or saran-coated film with excellent seal formation for moisture-sensitive products.
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Pouches
Plastic Pouches : With a re-sealable strip at the top,
easy to open and close It have Waterproof, tide proof, air
proof and non-poisonous property .
Aluminum pouches :1. It have tear strip facility2. It offers excellent barrier properties
to the moisture, gas and light
Plastic Pouches
Aluminium pouches
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Solids-Rectal (Suppository) :
1) Aluminum Foil Offers the highest possible protection
against moisture, oxygen, and light,. The aluminum suppository package takes the
shape of individual doses .
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2) Laminates for suppositories :
• It is made of Polyolefine, Aluminum, P.E. .
• It gives protection from moisture, gas ,vapors, light
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Solids (Inhalation) Dry-Powder Inhaler :• It is made of plastics such as polyethylene (HDPE), Polypropylene ,
polystyrene .
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LIQUID DOSAGE FORM- Glass Or Plastic Bottle - Bottle With Spray PumpCapacity: 50ml
Material: Bottle-polyethylene terephthalate; Sprayer-polypropylene
Spray output: 0.05ml-0.20ml
Used for body spray, oral spray, anti-bacterial spray.
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Bottle With Dropper Assembly:
• Dropper assemblies can be supplied with
coloured caps
• glass type II is used
• Dropper glass is of Sodalime glass(type III) and Neutral glass(type I).
• Bottle capacity is from 2 to 100ml
• pipettes are up to 120mm in length
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Aerosol spray :Container: To withstand pressure 140-180 psi 1) Tin plate container- it is sheet of steel plates electroplated on both side with tin
2) Aluminum container- it has seamless nature and greater resistance to corrosion
3)Stainless steel container –used inhalation aerosol 4)Glass container – type I glass is used
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STERILE PRODUCTS Glass Ampoules :• Type I (borosilicate glass is used)• Up to 3 colour can be placed for identification purpose.• PVC mono films used for 20 packaging.
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Vial With Stopper :
• Vials are mainly used for multiple dose parenteral preparation and are provided with the closure followed by aluminum seal to ensure the perfect air tight packing
Closure:
• Made from Butyl rubber ,Nitrile rubbers ,Neoprene, Silicon rubbers.
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- Pre-Filled Syringe:
• It is used for small volume parenteral preparation.
• Reduction of medication errors like drug overfill.
• It gives Increased assurance of sterility
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Sterile plastic devices :
Irrigation solution container :
• It is made of Polyolefin , polypropylenes
• It is light in weight, transparent, impermeable to
water
• Material have high boiling point so that it is sterilizable .
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OPHTHALMIC DOSAGE FORM
1) Plastic bottles:• Material used for plastic bottle is low density polyethylene,
• for caps are harder plastic materials such HighdensityP.E. or Polypropelene is used.
2) Collapsible Tube
3) blow-Fill-Seal Plastic Bottle
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Pouching Materials
There are three main layers in the composite materials used for pouches:
1) Internal plastic heat sealable layer, - material used -polyethylene, surlyn
2) Aluminium foil layer – Its important role in protecting the product from light and oxygen.
3) External printable layer. It is used to achieve a better 'finishing' and printing quality material- Paper or polyester film is used
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Opti-nose device :
• In this , air is blown out of the container and sealing nozzle is used its direct flow of air in nose
• It gives bi-directional flow so that it prevents deposition of drug in lungs.
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Direct-haler device :
for turbulent dispersion of dose
for moisture protection
Transparency of
divice for drug
visibility
REFERENCE Lachman, Libarman; “The theory and practice of industrial
pharmacy”, third edition, varghese publishing house
Jain U.K., Nayak S.; “Pharmaceutical packaging technology” PharmaMed Press
Dean D.A., Hall I.H.; “Pharmaceutical packaging technology” Taylor and Francis
Hanlon F. J., “Handbook of package engineering”, second edition, Technomic Publishing CO. ING
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“ THANK –YOU”All