Circulatory Factors with effects on brain aging

Aging or deleterious factors• Eotaxin/CCL11 (Villeda et al., Nature 2011)

• Beta2-microglobulin/b2M (Smith et al., Nat Medicine 2015)

Rejuvenating or beneficial factors• Insulin-like growth factor/IGF1 (Trejo et al., JNS 2001)

• IGF2 (Stern et al. Psychoneuroimm. 2014)

• Growth hormone releasing hormone/GHRH (Baker et al., Arch

Neurol., 2012) *

• Gonadotropin releasing hormone/GnRH (Zhang, Nature 2013)

• Growth and differentiation factor 11/GDF11 (Wagers, Lee &

Rubin, Cell 2013, Science 2014)

• Colony stimulating factor 2/CSF2, Tissue inhibitor of

metalloproteinases 2/TIMP2 (Castellano, Nature 2017)

Proteins with indicated effects on healthy brain after

systemic administration in rodents or *humans

Aging, neurodegeneration and brain rejuvenation

Wyss-Coray, Nature 2016