![Page 1: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/1.jpg)
Pathology of Endocarditis
Peter B. Baker, M.D.
Clinical Professor, Pathology
![Page 2: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/2.jpg)
Cardiopulmonary Block Objective
Describe the pathologic features of bacterial and nonbacterial endocarditis
![Page 3: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/3.jpg)
Objectives
List the features of acute and subacute infectious
endocarditis
Identify predisposing
factors for infectious
endocarditis
Describe the pathologic
features and list the morphologic complications of
infectious endocarditis.
Be able to identify 4 conditions
associated with sterile vegetations on cardiac valves
![Page 4: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/4.jpg)
Infectious EndocarditisHandout X.B.1.a
Acute endocarditis
Short duration
Virulent organism
Large vegetations
Prominent tissue destruction
Previously normal valve
Subacute endocarditis
Longer duration
Low virulence organism
Small vegetations
Less tissue destruction
Previously abnormal valve
![Page 5: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/5.jpg)
Infectious EndocarditisHandout X.B.1.b-c
Predisposing factors intracardiac shunts IV drug abuse valvular disease immunosuppression prosthetic valves
Pathogenesis endothelial damage
fibrin thrombi
organisms in the blood
![Page 6: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/6.jpg)
Acute Bacterial EndocarditisAcute Bacterial Endocarditis
![Page 7: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/7.jpg)
Bacterial Endocarditis
Vegetation
Valve
![Page 8: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/8.jpg)
Bacterial Endocarditis
![Page 9: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/9.jpg)
Valve
Vegetation
![Page 10: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/10.jpg)
Infectious EndocarditisHandout X.B.1.d
Complications
rupture of chordae tendineae
contiguous spread
thromboembolism
septic emboli with abscesses
valvular regurgitation
![Page 11: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/11.jpg)
Floppy Mitral Valve with Bacterial EndocarditisFloppy mitral valve with bacterial endocarditis
![Page 12: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/12.jpg)
Aortic Valve with Bacterial endocarditisAortic Valve with Leaflet Perforation
![Page 13: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/13.jpg)
Mitral Valve with Bacterial EndocarditisMitral Valve with Ruptured Chordae
![Page 14: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/14.jpg)
Mitral Valve with Perivalvular Abscess
Abscess
![Page 15: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/15.jpg)
Septic Embolus in Coronary ArterySeptic Embolus in Coronary Artery
![Page 16: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/16.jpg)
Sterile Endocardial VegetationsHandout XII.B
Etiologies
1. Nonbacterial thrombotic endocarditis (marantic endocarditis)
2. Systemic lupus (Libman-Sacks endocarditis)
3. Acute rheumatic fever
4. Intra-cardiac devices (leads, catheters)
![Page 17: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/17.jpg)
Nonbacterial Thrombotic EndocarditisNonbacterial Thrombotic Endocarditis
![Page 18: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/18.jpg)
Histology of Nonbacterial Thrombotic EndocarditisNonbacterial Thrombotic Endocarditis
Valve Leaflet
Vegetation
![Page 19: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/19.jpg)
Pathology of Endocarditis Quiz
![Page 20: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/20.jpg)
Thank you for completing this module
• I hope that I was able to teach the subject clearly.
• If you have any questions or feedback, write to me.
![Page 21: Pathology of Endocarditis Peter B. Baker, M.D. Clinical Professor, Pathology](https://reader036.vdocuments.net/reader036/viewer/2022062806/5697bf8b1a28abf838c8b03d/html5/thumbnails/21.jpg)
Survey
We would appreciate your feedback on this module. Click on the button below to complete a brief survey. Your responses and comments will be shared with the module’s author, the LSI EdTech team, and LSI curriculum leaders. We will use your feedback to improve future versions of the module.
The survey is both optional and anonymous and should take less than 5 minutes to complete.
Survey