pathology of endocarditis peter b. baker, m.d. clinical professor, pathology
TRANSCRIPT
Pathology of Endocarditis
Peter B. Baker, M.D.
Clinical Professor, Pathology
Cardiopulmonary Block Objective
Describe the pathologic features of bacterial and nonbacterial endocarditis
Objectives
List the features of acute and subacute infectious
endocarditis
Identify predisposing
factors for infectious
endocarditis
Describe the pathologic
features and list the morphologic complications of
infectious endocarditis.
Be able to identify 4 conditions
associated with sterile vegetations on cardiac valves
Infectious EndocarditisHandout X.B.1.a
Acute endocarditis
Short duration
Virulent organism
Large vegetations
Prominent tissue destruction
Previously normal valve
Subacute endocarditis
Longer duration
Low virulence organism
Small vegetations
Less tissue destruction
Previously abnormal valve
Infectious EndocarditisHandout X.B.1.b-c
Predisposing factors intracardiac shunts IV drug abuse valvular disease immunosuppression prosthetic valves
Pathogenesis endothelial damage
fibrin thrombi
organisms in the blood
Acute Bacterial EndocarditisAcute Bacterial Endocarditis
Bacterial Endocarditis
Vegetation
Valve
Bacterial Endocarditis
Valve
Vegetation
Infectious EndocarditisHandout X.B.1.d
Complications
rupture of chordae tendineae
contiguous spread
thromboembolism
septic emboli with abscesses
valvular regurgitation
Floppy Mitral Valve with Bacterial EndocarditisFloppy mitral valve with bacterial endocarditis
Aortic Valve with Bacterial endocarditisAortic Valve with Leaflet Perforation
Mitral Valve with Bacterial EndocarditisMitral Valve with Ruptured Chordae
Mitral Valve with Perivalvular Abscess
Abscess
Septic Embolus in Coronary ArterySeptic Embolus in Coronary Artery
Sterile Endocardial VegetationsHandout XII.B
Etiologies
1. Nonbacterial thrombotic endocarditis (marantic endocarditis)
2. Systemic lupus (Libman-Sacks endocarditis)
3. Acute rheumatic fever
4. Intra-cardiac devices (leads, catheters)
Nonbacterial Thrombotic EndocarditisNonbacterial Thrombotic Endocarditis
Histology of Nonbacterial Thrombotic EndocarditisNonbacterial Thrombotic Endocarditis
Valve Leaflet
Vegetation
Pathology of Endocarditis Quiz
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