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Research Support Information Network (RESIN)
Presented by: Office of the Vice Chancellor for Research Date: September 6, 2016
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Agenda
Updates & Timely Information from Research Support:
Office of the VCR Travel URC ORSP
IRB Research Compliance Contract Administration OSPAN IACUC Library ORRA Compliance – Export Control DLAM TRI BioVentures Core Facilities
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What Can We Do for You Now That We Couldn’t Do Last Year Brian Storrie, Ph.D. Core Director
Brian Storrie - Professor of Physiology & Biophysics, Director of Imaging Core High sensitivity confocal microscopy
GaSP detectors, more sensitivity, 2 ch, 3rd spectral AiryScan detector, even more sensitivity
Simple super res fluorescence With AiryScan confocal
1.7x improvement in X and Y resolution, 2.9x overall Fast processing, <1 min Little need to learn new things, few new steps
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High Level Super Res Imaging with Zeiss Elyra PS.1 50-100 nm Super Resolution
3 Dimensional Structured Illumination (100 nm resolution) 2-fold improvement in resolution XYZ, 8-fold overall Existing dyes, slow collection, slow calculation
Better than 50 nm resolution With dSTORM/PALM
Images in TIRF space, automated TIRF built-in New dyes, limited antibody choices, new steps to learn Very slow image capture, long calculation 9/6/2016
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What Can We Do for You Now That We Couldn’t Do Last Year Brian Storrie, Ph.D. Core Director
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Platelet Example: Wide Field, Confocal. 3D-SIM
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HeLa Cell Golgi Example: Elyra dSTORM, <50 nm
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Contact Jeff Kamykowski, Hands-on operation Room 136-2, BioMed II
Telephone: 525-7200 [email protected]
Brian Storrie, Overview and concepts Office: Room 262-2, BioMed [email protected]
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What Can We Do for You Now That We Couldn’t Do Last Year Brian Storrie, Ph.D. Core Director
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AAHRPP Update Jennifer Holland, JD, IRB Director
AAHRPP Reaccreditation Site Visit occurred on May 23-25.
The Council will meet on Monday, September 19th to review the site visit and our response.
We should be notified of the Council decision by the end of that week.
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Findings Improvement activities to assess compliance and
effectiveness of the HRPP needs to be formalized.
Serious and continuing non-compliance should be reported within policy timeframe.
IRB reviewers and chair should be provided feedback regarding their annual evaluations.
IRB discussions and decisions need to be more thoroughly documented.
AAHRPP Update Jennifer Holland, JD, IRB Director
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Researcher Access to ARresearch.org Jean McSweeney, RN, PhD, FAHA, FAAN Assoc. Dean for Research & Professor
Presented by: Jean McSweeney, RN, PhD, FAHA, FAAN Associate Dean for Research and Professor
Co-Director, PhD Program College of Nursing
University of Arkansas for Medical Sciences
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Researcher Access to ARresearch.org Jean McSweeney, RN, PhD, FAHA, FAAN
Associate Dean for Research and Professor
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Researcher Access to ARresearch.org Jean McSweeney, RN, PhD, FAHA, FAAN
Associate Dean for Research and Professor
*Unique zip codes identified in dataset as of 8/3/2016
• 62 unique Arkansas zip codes identified • In addition to Arkansas, 14 states represented within dataset, according to address provided
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Step 1 – During IRB submission process, answer ‘Yes’ to the following question in CLARA
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Researcher Access to ARresearch.org Jean McSweeney, RN, PhD, FAHA, FAAN
Associate Dean for Research and Professor
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Step 2: Fill out the PI Research Participant Request Form
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Researcher Access to ARresearch.org Jean McSweeney, RN, PhD, FAHA, FAAN
Associate Dean for Research and Professor
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Step 3: Access the report provided via secure URL by TRI
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Researcher Access to ARresearch.org Jean McSweeney, RN, PhD, FAHA, FAAN
Associate Dean for Research and Professor
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Trifecta of site visits in 2016 OLAW – January AAALAC – June USDA – July
Overall, we have a good program, but there
is room for improvement
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Points: OLAW Counting pups at the first manipulation or cage
change after birth Animal Production and Usage Policy
Timely weaning to prevent overcrowding Rodent Cage Density Policy
IACUC-approved social housing exemptions Policy on Social Housing and Environmental
Enrichment
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Points: OLAW MOUs for collaborations and subawards
involving animals Guide, p. 15
PI verification of correction of deficiencies noted during semiannual site visits, including interim status update for corrections taking longer than two weeks (ex. provide copy of a work order) Semiannual Site Visit Policy
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Points: OLAW Occupational Health for Animal Users
All animal users should have received an email from Training Tracker with a new Occupational Health Screening questionnaire attached
The completed questionnaire was due in the Student and Employee Health Services (SEHS) office by July 31
The questionnaire must be completed and submitted to SEHS annually
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Points: AAALAC Hazard Use in Animal Models
Chemical and biological hazards PI identification of hazards described in AUP PI submission of IBC protocol Hazard communication in animal facilities Adherence to approved safety protocol
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Points: AAALAC Hazard Use in Animal Models
Training consultant on campus October 7 Seminar/meeting with all animal users from noon –
1:00 pm in Walton Auditorium Mandatory attendance – at least one representative
from each animal use lab must attend This is a condition of our continued AAALAC
Accreditation
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Points: AAALAC Controlled drug storage and record keeping
UAMS Policy 16.1.13 Sterility and labeling (including expiration date)
of lab-mixed injections Policy on Preparation and Storage of Injectable
Agents
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Points: AAALAC Preparation and use of non-pharmaceutical
grade substances NIH Guidelines for the Use of Non-Pharmaceutical
Grade Compounds in Laboratory Animals Guide, p. 31
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Points: AAALAC Aseptic surgery: Surgeon PPE and instrument
sterilization Aseptic Survival Surgery on Rodents Policy
Description of humane endpoints in AUPs: Specific clinical evaluation criteria and process for intervention Guide, p. 27-28
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Key Point: USDA PI was not following the protocol as written Say what you will do, and do what you say you
will do If problems arise, contact DLAM and/or IACUC
immediately Protocol can be modified to prevent
noncompliance
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
References Policies can be found on the DLAM website:
http://intranet.uams.edu/dlam/index.htm The Guide can be found on the IACUC website:
http://inside.uams.edu/iacuc/
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Thank you for your contributions to the Animal Care and Use Program Researchers – faculty, staff and students DLAM IACUC IBC IO Compliance OHS SEHS
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Site Visit Findings Bill Gurley, Ph.D., Chair, IACUC
Mandatory Training for Animal Users
Hazard Use in Animal Models
Friday, October 7 Noon – 1:00 pm
Walton Auditorium
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OGSP Update DeAnn Hubberd, Assoc. Director, OGSP
No longer charging fees
Open to all UAMS investigators
Two new editors Kerry Evans, PhD Mary Cantrell, BS
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To learn more about OGSP services, visit our website or contact DeAnn Hubberd 686-6004 [email protected]
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OGSP Update DeAnn Hubberd, Assoc. Director, OGSP
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Showcase – Biomedical Informatics September 21, 2016 4:30 p.m. - 6:00 p.m. 10th floor Winthrop P.
Rockefeller Cancer Institute Wine & cheese research
reception and 15 poster presentations
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Showcase of Medical Discoveries - Biomedical Informatics Linda Williams, Research Liaison, Office of Research
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Next RESIN
Next RESIN – After Summer break October 4, 2016 @ 12:00 p.m. Location - Walton Auditorium, Winthrop P.
Rockefeller Cancer Institute, 10th floor All RESIN presentations archived on the UAMS
Research website http://www.uams.edu/research/RESIN_Achive.asp
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