September 2016
© 2016 ICAGEN - CONFIDENTIAL 22
Selectide Corp
1990s 2009
2016
Icagen Inc
2015
1992 2011
Icagen Background
2003
2013
Caldera Pharmaceuticals
© 2016 ICAGEN - CONFIDENTIAL 3
ICAGENTechnology Plus Large Pharma Experience Base
Tucson, Arizona USA
Integrated Drug Discovery Site
Benefits:
- Cost effective
- Convenient, West Coast
Capabilities:
• Compound management
• HTS & Hit identification
• In vitro & in vivo pharmacology
• Medicinal chemistry
• ADME, PK/PD
Durham, North Carolina USA
ION Channel / XR-PRO Site
Benefits:
- Cost effective
- Convenient, East Coast
Capabilities:
• Ion Channel/Transporter
HTS & Lead Optimization
Support
• Ion Channel Profiling
• Assay Development
• X-Ray Fluorescence
Platform
3
© 2016 ICAGEN - CONFIDENTIAL 4
Information Technologies
- Data modeling- Collaborative tools- Workflow solutions- HPC capabilities
Analytics- HT QC methods- Solubility- LogD- Chemical stability- Methods Development
Logistics- Workflow support - Full automation - Information control- Physical security
4
Effective and Efficient Integration- A complete solution
Biology- uHTS- Assay Creation- Patient cell models- Stem cell biology- eADMET panels- Ion Channels- SLT Transporters
Chemistry- Small molecules- Peptides - Medicinal Chemistry - Library design
Drug Design- Target assessment- Ligand design- Virtual screening- Protein dynamics- Affinity prediction
PROJECT LEVEL
INTEGRATION
© 2016 ICAGEN - CONFIDENTIAL 5
Integrated Drug Discovery
Ion ChannelsSLT Solute Transporters