![Page 1: Stat Club 327 Thomas February 18, 2015 Bethany C. Bray Outreach Director, The Methodology Center Research Assistant Professor, College of HHD](https://reader036.vdocuments.net/reader036/viewer/2022062423/56649e4d5503460f94b43bbc/html5/thumbnails/1.jpg)
The Cutting Edge of Design & Analysis:
Penn State’s Methodology Center
Stat Club
327 Thomas
February 18, 2015
Bethany C. Bray
Outreach Director, The Methodology Center
Research Assistant Professor, College of HHD
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What is The Methodology Center?
Our research projects
What’s in it for you?Resources from The Methodology Center
Today’s talk
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Advancing public health byimproving experimental design and data analysis◦ Substance use disorders◦ HIV◦ Prevention and treatment
Interdisciplinary, collaborative research ◦ Use best ideas from any field◦ True collaboration between methodology and application
What is The Methodology Center?
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What is The Methodology Center?
1989: Methodology
Center Founded
1994: Linda Collins named Directo
r
1996: NIDA P50 Awarded
1997: 1st
Summer Institute
2001: 1st
NIDA P50
renewal
2004: Stephanie
Lanza named
Scientific Director
2005: 2nd
NIDA P50
renewal
2005: PAMT T32 Awarded
2007: 1st 1-credit course
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What is The Methodology Center?2009: Linda Collins named
SPR President
2009: 1st
Green Team
in HHD
2010: 3rd
NIDA P50 renewal
2012: 1st
eNews
2013: Susan
Murphy named
MacArthur Fellow
2014: Bethany
Bray named
Outreach Director
2014: Susan
Murphy elected member of IOM
2014: Runze Li named “Highly Cited
Researcher”, named Willaman Professor
2014: New P50
Submitted
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22 PhD-level researchers from 13 fields◦ Communication◦ Human Development◦ Engineering◦ Epidemiology◦ Psychology◦ Statistics◦ …and more!
17 at Penn State, 5 at U of Michigan
What is The Methodology Center?
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A variety of support staff◦ Administration◦ Computer programming◦ Dissemination and outreach◦ Professional development◦ Scientific editing
What is The Methodology Center?
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Interested in the social, behavioral, and health sciences
A variety of outlets for dissemination◦ Courses◦ Publications◦ Presentations◦ Seminars◦ Software (free, user-friendly, supported)
◦ Workshops
What is The Methodology Center?
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Optimize behavioral interventions◦ Multiphase optimization strategy (MOST) is a
framework for engineering interventions in order to get the maximum impact from an intervention
Develop adaptive behavioral interventions◦ The
sequential, multiple assignment, randomized trial (SMART) helps build adaptive interventions so that treatments adapt to meet patients’ needs
What is The Methodology Center?
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Understand complex longitudinal data ◦ Intensive longitudinal data (ILD) projects provide tools
like the time-varying effect model (TVEM) for analyzing complex data, like smartphone data
Infer causality◦ Causal inference projects develop methods for
inferring causality in situations where randomization is not possible, practical, or ethical
What is The Methodology Center?
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Uncover population profiles◦ Latent class analysis (LCA) and
latent transition analysis (LTA) allow researchers to detect subgroups within a population
What is The Methodology Center?
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Optimize behavioral interventions◦ Linda Collins (Center Director, HD FS)
◦ Acknowledge real world constraints◦ Create the best possible intervention◦ Build in efficiencies
Multiphase optimization strategy (MOST)
◦ Framework for optimization◦ Uses factorial experimental designs◦ Called for specifically in NIH PAs
Our research projects
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Develop adaptive behavioral interventions◦ Susan Murphy (U of Michigan, Statistics)
◦ MacArthur Genius Grant◦ Intervention decisions: how and when to alter treatment
Sequential, multiple assignment, randomized trial (SMART)
◦ Design for building adaptive interventions◦ Test when to switch, how to switch, how to define
nonresponse◦ Called for specifically in NIH PAs
Our research projects
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Intensive longitudinal data analysis ◦ Runze Li (Statistics)
◦ New forms of data need new analyses Smart phones, Biological/physiological devices
Time-varying effect model (TVEM)
◦ Extension of linear regression◦ Regression coefficients vary over time
e.g., how do effects of craving, mood, and self-efficacy vary over time as people try to quit smoking?
Our research projects
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Infer causality◦ Donna Coffman (TMC)
◦ Sometimes, observational data is the only possible data to be collected
◦ Infer causality when randomization is broken or absent?
Propensity score-based approaches◦ e.g., HIV intervention for former prisoners targeted
risky beliefs (unprotected sex strengthens relationship) Beliefs cannot be randomized, examined if and how it worked
Our research projects
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Uncover population profiles◦ Stephanie Lanza (Scientific Director)
◦ Bethany Bray (Outreach Director)
◦ Are there subgroups in the population that can be used to understand heterogeneity?
Latent class and latent transition analysis (LCA & LTA)
Our research projects
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Some of our major LCA & LTA contributions…◦ LCA model selection and statistical power◦ Associations between covariates and classes in LCA◦ Associations between classes and outcomes in LCA◦ Casual effects of covariates in LCA◦ Causal effects of classes on outcomes in LCA◦ Changing class membership over time in LTA◦ Longitudinal patterns of change in RMLCA◦ Latent class moderators◦ Software development (SAS, Stata, R)
Our research projects
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Software◦ LCA & LTA
SAS PROC LCA & PROC LTA, macros
Stata LCA plug-in
◦ TVEM SAS macro suite
◦ SAS, Stata, R, web applets, stand-alone products
Resources
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Reading Lists FAQs Videos …and more!
Resources
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Podcasts◦ Informal intros to new research◦ Practical how-to’s
Resources
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Brown bag seminars
One-credit courses
Special Interest Groups (SIGs)
◦ complex data, causal inference, mixture modeling
Summer institute on innovative methods
Resources
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Prevention & Methodology Training (PAMT)
◦ pre- and post-doctoral fellows◦ two mentors◦ methodology.psu.edu/pamt
Taste of Methodology◦ PhD required◦ 3-hour introduction to an advanced method
Resources
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Consulting? HHD’s Methodology Consulting Group STAT Department’s Statistical Consulting Center
Resources
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Step 1. Go to: http://methodology.psu.edu and sign up for the eNews
How do I get started?
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Step 2. On the homepage, scroll down and register for the site so you can download software
How do I get started?
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Bethany C. [email protected]/people/bbray
The Methodology Center204 E. Calder Way, Suite 400State College, PA 16801methodology.psu.edu
Thank you!