Supplementary Figure 2. Kunogi M et al.

A intron 5

g t c c c c c a g G T C T G C C Ctt

exon 6

g t c T G C C Ct T C GCG G T

JBR23 c.397-7_399delCCTCCAGGTC

control

deletion

1000

500400

200

300

NC PC PT

503

281

exon 7exon 5 exon 6

503 bp

281 bp

forward reverseexon 6

B control

t c t g t t t a g G T C C T G G Gtg c a c t c T

C T G G Gg c a c t c Tdeletion

G C C C C T T C T T T C C

intron 9 　 exon 10

1000bp

500400

200300 324

210

NC PC PT

c.1063-10_1065delTCTTGTTTAGGTCJBR7

324 bp

210 bp

exon 11exon 9 exon 10

exon 10

forward reverse

control

g t t t g g G T C C T G

g t t t a g G T C C T G

intron 9

G G T

G G T

c t t

c t t

exon 10

c.1063-2A>GJBR17

324 bp

210 bp

exon 11exon 9 exon 10

exon 10

forward reverse

bp1000

500400

200300 324

210

NC PC PT

C