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Lymph Node• Clearance via lymph node drainage is a part of
normal lymph node physiology• Not adverse unless severe and associated with
necrosis
Although there is a dose response and increased severity, this changemay be non-adverse. A recovery study would help resolve this issue.
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Adrenal
• Adrenal cortical necrosis is adverse• The 2/10 incidence at the medium
exposure is a severe response• The NOAEL is the low exposure