Lymph Node• Clearance via lymph node drainage is a part of

normal lymph node physiology• Not adverse unless severe and associated with

necrosis

Although there is a dose response and increased severity, this changemay be non-adverse. A recovery study would help resolve this issue.

Adrenal

• Adrenal cortical necrosis is adverse• The 2/10 incidence at the medium

exposure is a severe response• The NOAEL is the low exposure