dr y and dr noclue
TRANSCRIPT
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Dr NoClue,How come that with 15
animals per armWe can demonstrate drug
efficacy in Parkinson’sDisease mouse model, yet with 300 patients per arm
we can not?
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Dear Dr Y, it is not socomplicated! Just have a
lookat the disease mechanism
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Dr NoClue…So many parameters
and unknowns… where should I start?
Feeling hungry…what shall I
have for dinner?
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Dr Y, it is simple! Start with young mice, or even
young rats, and dosed them with neurotoxins. Or we can use transgenics,
we have so many wonderful models!
Didn’t we try them
already?...I want to go shopping
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I think I’ll have some pasta, and
what about dessert?
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Dr Y, it is complicated to run
a study on aged animals that are on a western
diet…this is not the way we were trained to think!
Shoes…I need new shoes
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I lost my apetite…I need to loose some weight. I am getting
old…almost irrelevant
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It might be a good idea to include the known risk factors in one
model…if you think about it there aren’t too many…just add aging,
environmental factors and western diet and you may cover 80% of
the risk factors
I need new glasses…I hate the bifocal
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125 euros a pair… 30%
discount but I like them
Dr Y, it might be worth including what we know about PD risk factors in one « dirty » model…we would be less academic
but so much more relevant!!
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I like your innovative idea, so simple and so
smart!
She likes me
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