drug check sydney - perth - brisbane · 2018-07-11 · k2/spice test forensic use only for the...

2
Sydney - Perth - Brisbane Disposable single use K2/Spice onsite drug tests are now available! Commonly called Kronic, K2, Spice or fake weed, Synthetic Cannabis contains illicit chemical compounds that offer users similar effects to smoking cannabis. Made in the USA, the DrugCheck K2-Spice test strip: Can detect more compounds than any other commercially available onsite test. Is more sensitive than any other test on the market including many lab-based tests. Is available in the DrugCheck Onsite Urine Drug Cups or as a Single Dip-test. Name Compounds Detected by DrugCheck K2 Test JWH-018 5-pentanoic acid metabolite JWH-018 N-4-hydroxypentyl JWH-073 4-butanoic acid metabolite JWH-019 6-hydroxyhexyl JWH-019 5-hydroxyhexyl JWH-210 N-(5-carboxyopentyl) metabolite C 26 H 25 NO 3 JWH-398 N-pentanoic acid metabolite MAM2201 N-pentanoic acid metabolite RCS-4 N-(5-carboxyopentyl) metabolite C 21 H 21 NO 4 Please refer to the rear of this brochure for the complete data on these test performances. PURCHASE OPTIONS: Single Dip Test DrugCheck NxStep OnSite adaption The existing cup test for the main six illicit drugs (THC, COC, AMP,MET,BZO,OPI) is simply adapted to also include this test for K2/Spice. Drug Check Sales & Service Australia Wide Call 1300 999 200 Synthetic Cannabinoid Urine Test PRICES Single Dip Test (fig. 1) ......................... $375 One box of 25 tests (fluid receptacle not incl.) Min. order 1 box ($15 per unit) DrugCheck NxStep OnSite Adaptation (fig. 2) ................... $625 One box of 25 tests Min. order 1 box ($25 per unit) All prices are per unit and exclusive of GST, postage & handling. Prices are subject to change without notice. www.breathalyser.com.au Figure 2 Figure 1 Australian AS3547 Standard To Buy On-line Scan this Code Sydney - Head Office 128 O’Riordan Street Mascot NSW 2020 PO BOX 7089 Alexandria NSW 2015 Phone: 02 8338 1555 Fax: 02 8338 1688 Email: [email protected] Brisbane Unit 11, 17-19 University Drive Meadowbrook QLD 4131 PO BOX 6189, Logan Central QLD 4114 Phone: 07 3200 4944 Fax: 07 3200 4955 Email: [email protected] Perth 486 Great Eastern Hwy Ascot WA 6104 Phone: 08 9479 3866 Fax: 08 6267 8168 Email: [email protected]

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Page 1: Drug Check Sydney - Perth - Brisbane · 2018-07-11 · K2/Spice Test FORENSIC USE ONLY FOR THE QUALITATIVE ASSESSMENT OF SYNTHETIC CANNABIS (K2) IN HUMAN URINE INTENDED USE The DrugCheck

Sydney - Perth - Brisbane

Disposable single use K2/Spice onsite drug tests are now available!

Commonly called Kronic, K2, Spice or fake weed, Synthetic Cannabis contains illicit chemical compounds that o�er users similar e�ects to smoking cannabis.

Made in the USA, the DrugCheck K2-Spice test strip:• Can detect more compounds than any other commercially

available onsite test.• Is more sensitive than any other test on the market

including many lab-based tests.• Is available in the DrugCheck Onsite Urine Drug Cups or

as a Single Dip-test.

Name Compounds Detected by DrugCheck K2 TestJWH-018 5-pentanoic acid metaboliteJWH-018 N-4-hydroxypentylJWH-073 4-butanoic acid metaboliteJWH-019 6-hydroxyhexylJWH-019 5-hydroxyhexylJWH-210 N-(5-carboxyopentyl) metabolite C 26 H25 NO 3

JWH-398 N-pentanoic acid metaboliteMAM2201 N-pentanoic acid metaboliteRCS-4 N-(5-carboxyopentyl) metabolite C 21 H21 NO 4

Please refer to the rear of this brochure for the complete data on these test performances.

PURCHASE OPTIONS: • Single Dip Test• DrugCheck NxStep OnSite adaption

The existing cup test for the main six illicit drugs (THC, COC, AMP,MET,BZO,OPI) is simply adapted to also include this test for K2/Spice.

Drug Check

Sales & Service Australia Wide Call 1300 999 200

Synthetic Cannabinoid Urine Test

PRICES

Single Dip Test (fig. 1) ......................... $375One box of 25 tests (fluid receptacle not incl.) Min. order 1 box ($15 per unit)

DrugCheck NxStep OnSite Adaptation (fig. 2) ................... $625 One box of 25 tests Min. order 1 box ($25 per unit)

All prices are per unit and exclusive of GST, postage & handling. Prices are subject to change without notice.

www.breathalyser.com.au

Figure 2

Figure 1

AustralianAS3547

Standard

To Buy On-line Scan this CodeSydney - Head Office

128 O’Riordan StreetMascot NSW 2020PO BOX 7089 Alexandria NSW 2015Phone: 02 8338 1555 Fax: 02 8338 1688Email: [email protected]

Brisbane

Unit 11, 17-19 University DriveMeadowbrook QLD 4131PO BOX 6189, Logan Central QLD 4114Phone: 07 3200 4944 Fax: 07 3200 4955Email: [email protected]

Perth

486 Great Eastern Hwy Ascot WA 6104 Phone: 08 9479 3866 Fax: 08 6267 8168Email: [email protected]

Page 2: Drug Check Sydney - Perth - Brisbane · 2018-07-11 · K2/Spice Test FORENSIC USE ONLY FOR THE QUALITATIVE ASSESSMENT OF SYNTHETIC CANNABIS (K2) IN HUMAN URINE INTENDED USE The DrugCheck

K2/S

pice

Test

FORE

NSIC

USE

ONL

YFO

R TH

E QU

ALITA

TIVE

ASS

ESSM

ENT

OF S

YNTH

ETIC

CAN

NABI

S (K

2) IN

HU

MAN

URI

NEIN

TEND

ED U

SETh

e Dr

ugCh

eck®

K2/

Spice

Test

is a

n im

mun

ochr

omat

ogra

phy-

base

d on

e st

ep in

vitro

test

. It is

des

igne

d fo

r qua

litativ

e de

term

inat

ion o

f syn

thet

ic

cann

abis

JWH-

018

and

JWH-

073’

s m

ajor m

etab

olite

s in

hum

an u

rine

spec

imen

s at

cut

-off

level

of 5

0 ng

/ml. T

his

assa

y has

not

bee

n ev

aluat

ed

in th

e po

int o

f car

e loc

ation

and

is fo

r for

ensic

use

onl

y.Th

is as

say p

rovid

es o

nly a

pre

limin

ary a

nalyt

ical t

est r

esul

t. A

mor

e sp

ecific

alte

rnat

ive c

hem

ical m

etho

d m

ust b

e us

ed in

ord

er to

obt

ain

a co

nfirm

ed a

nalyt

ical r

esul

t. Ga

s ch

rom

atog

raph

y/m

ass

spec

trom

etry

(G

C/M

S) h

as b

een

esta

blish

ed a

s th

e pr

efer

red

confi

rmat

ory m

etho

d by

th

e Su

bsta

nce

Abus

e M

enta

l Hea

lth S

ervic

es A

dmin

istra

tion

(SAM

HSA)

. Cl

inica

l con

sider

ation

and

pro

fess

ional

judg

men

t sho

uld

be a

pplie

d to

any

dr

ug o

f abu

se te

st re

sult,

parti

cular

ly w

hen

preli

min

ary p

ositiv

e re

sults

are

in

dica

ted.

SUM

MAR

Y AN

D EX

PLAN

ATIO

NSy

nthe

tic c

anna

bis

is a

psyc

hoac

tive

herb

al an

d ch

emica

l pro

duct

that

, w

hen

cons

umed

, mim

ics th

e ef

fect

s of

can

nabi

s. It

is be

st k

now

n by

the

bran

d na

me

K2 a

nd S

pice

, bot

h of

whi

ch h

ave

large

ly be

com

e ge

neric

ized

trade

mar

ks u

sed

for r

efer

to a

ny s

ysth

etic

cann

abis

prod

uct.

The

stu

dies

su

gges

t tha

t syn

thet

ic ca

nnab

inoid

into

xicat

ion is

ass

ociat

ed w

ith a

cute

ps

ycho

sis, w

orse

ning

of p

revio

usly

stab

le ps

ycho

tic d

isord

ers,

and

also

may

hav

e th

e ab

ility t

o tri

gger

a c

hron

ic (lo

ng-te

rm) p

sych

otic

diso

rder

am

ong

vuln

erab

le in

divid

uals

such

as

thos

e w

ith a

fam

ily h

istor

y of m

enta

l illn

ess.

A lar

ge a

nd c

ompl

ex va

riety

of s

ynth

etic

cann

abin

oids,

mos

t ofte

r ca

nnab

icyclo

hexa

nol, J

WH-

018,

JW

H-07

3, o

r HU-

210,

are

use

d. A

s of

M

arch

1, 2

011,

five

can

nabi

noid

s, JW

H-01

8, J

WH-

073,

CP-

47, J

WH-

200

and

cann

abicy

clohe

xano

l are

illeg

al in

US

beca

use

thes

e su

bsta

nces

hav

e th

e po

tent

ial to

be

extre

mely

har

mfu

l and

, the

refo

re, p

ose

an im

min

ent

haza

rd to

the

publ

ic sa

fety.

TEST

PRI

NCIP

LETh

e K2

/Spi

ce Te

st is

bas

ed o

n th

e pr

incip

le of

spe

cific

imm

unoc

hem

ical

reac

tion

betw

een

antib

odies

and

ant

igen

s to

ana

lyze

parti

cular

com

poun

ds

in h

uman

urin

e sp

ecim

en. T

he a

ssay

relie

s on

the

com

petit

ion fo

r bin

ding

an

tibod

y bet

wee

n dr

ug c

onju

gate

and

free

dru

g w

hich

may

be

pres

ent

in th

e ur

ine

spec

imen

bein

g te

sted

. Whe

n dr

ug is

pre

sent

in th

e ur

ine

spec

imen

, it c

ompe

tes

with

dru

g co

njug

ate

for t

he lim

ited

amou

nt o

f an

tibod

y-dy

e co

njug

ate.

Whe

n th

e am

ount

of d

rug

is eq

ual o

r mor

e th

an

the

cut-o

ff it

will

prev

ent t

he b

indi

ng o

f dru

g co

njug

ate

to th

e an

tibod

y. Th

eref

ore,

a p

ositiv

e ur

ine

spec

imen

will

not s

how

a c

olore

d ba

nd o

n th

e te

st lin

e zo

ne, in

dica

ting

a po

sitive

resu

lt, w

hile

the

pres

ence

of a

colo

red

band

indi

cate

s a

nega

tive

resu

lt.A

cont

rol li

ne is

pre

sent

in th

e te

st w

indo

w to

wor

k as

pro

cedu

ral c

ontro

l. Th

is co

lored

ban

d sh

ould

alw

ays

appe

ar o

n th

e co

ntro

l line

zone

if th

e te

st

devic

e is

stor

ed in

goo

d co

nditio

n an

d th

e te

st is

per

form

ed a

ppro

priat

ely.

MAT

ERIA

LS P

ROVI

DED

1.

Inst

ruct

ions

for u

se.

2.

K2/S

pice

Test

: The

am

ount

of e

ach

coat

ed a

ntig

en a

nd/o

r ant

ibod

y on

the

strip

is le

ss th

an 1

.0 m

g fo

r ant

igen

con

juga

te a

nd is

less

than

1.0

mg

for g

oat a

nti-r

abbi

t IgG

ant

ibod

y.Te

st zo

ne: c

onta

ins

K2 p

rote

in a

ntig

en c

onju

gate

s.Co

ntro

l zon

e: c

onta

ins

goat

ant

i-rab

bit I

gG a

ntib

ody.

3.

Conj

ugat

e pa

d: c

onta

ins

mou

se a

nti-K

2 m

onoc

lonal

antib

ody.

MAT

ERIA

LS R

EQUI

RED

BUT

NOT

PROV

IDED

1.

Urin

e co

llect

ion c

onta

iner

.2.

Tim

er o

r cloc

k.ST

ORAG

E AN

D ST

ABILI

TYTh

e te

st d

evice

sho

uld

be s

tore

d at

4 to

30º

C an

d w

ill be

effe

ctive

unt

il the

ex

pira

tion

date

sta

ted

on th

e pa

ckag

e. T

he p

rodu

ct is

hum

idity

-sen

sitive

an

d sh

ould

be

used

imm

ediat

ely a

fter b

eing

open

. Any

impr

oper

ly se

aled

prod

uct s

houl

d be

disc

arde

d.

PREC

AUTI

ONS

1.

For f

oren

sic u

se o

nly.

2.

Do n

ot u

se th

e pr

oduc

t bey

ond

the

expi

ratio

n da

te.

3.

Hand

le all

spe

cimen

s as

pot

entia

lly in

fect

ious.

4.

Hum

idity

sen

sitive

pro

duct

, do

not o

pen

foil p

ouch

unt

il it i

s re

ady t

o be

te

sted

.5.

Us

e a

new

urin

e sp

ecim

en c

up fo

r eac

h sa

mpl

e to

avo

id c

ross

co

ntam

inat

ion.

SPEC

IMEN

COL

LECT

ION

AND

PREP

ARAT

ION

It is

requ

ired

that

app

roxim

ately

120

-150

ml o

f sam

ple

for e

ach

test

. Fr

esh

urin

e sp

ecim

ens

do n

ot n

eed

any s

pecia

l han

dlin

g or

trea

tmen

t. Sp

ecim

ens

shou

ld b

e co

llect

ed in

a c

lean,

dry,

plas

tic o

r glas

s co

ntain

er.

If th

e as

say i

s no

t per

form

ed im

med

iately

, urin

e sp

ecim

en m

ay b

e re

frige

rate

d at

2-8

ºC o

r fro

zen

up to

7 d

ays.

Spec

imen

s sh

ould

be

thaw

ed a

nd b

roug

ht to

room

tem

pera

ture

bef

ore

test

ing.

Urin

e sp

ecim

ens

exhi

bitin

g a

large

am

ount

of p

recip

itate

or t

urbi

dity

shou

ld b

e ce

ntrif

uged

or

allow

ed to

set

tle b

efor

e te

stin

g. A

void

con

tact

with

skin

by w

earin

g gl

oves

an

d pr

oper

labo

rato

ry a

ttire

.QU

ALIT

Y CO

NTRO

LGo

od L

abor

ator

y Pra

ctice

reco

mm

ends

the

daily

use

of c

ontro

l mat

erial

s to

valid

ate

the

relia

bility

of d

evice

. Con

trol m

ater

ials

shou

ld b

e as

saye

d as

cli

nica

l spe

cimen

and

cha

lleng

ing

to th

e as

say c

utof

f con

cent

ratio

n, e

.g.,

25%

abo

ve a

nd b

elow

cut

off c

once

ntra

tion.

If c

ontro

l valu

es d

o no

t fall

w

ithin

est

ablis

hed

rang

e, a

ssay

resu

lts a

re in

valid

. Con

trol m

ater

ials

whi

ch

are

not p

rovid

ed w

ith th

is te

st k

it ar

e co

mm

ercia

lly a

vaila

ble.

The

K2/S

pice

Test

pro

vides

a b

uilt-

in p

roce

ss c

ontro

l with

a d

iffer

ent

antig

en/a

ntib

ody r

eact

ion a

t the

con

trol r

egion

(C). T

his

cont

rol li

ne s

houl

d alw

ays

appe

ar re

gard

less

the

pres

ence

of d

rug

or m

etab

olite

. If th

e co

ntro

l lin

e do

es n

ot a

ppea

r, th

e te

st d

evice

sho

uld

be d

iscar

ded

and

the

obta

ined

re

sult

is in

valid

. The

pre

senc

e of

this

cont

rol b

and

in th

e co

ntro

l reg

ion

serv

e as

1) v

erific

ation

that

suf

ficien

t volu

me

is ad

ded,

2) t

hat p

rope

r flow

is

obta

ined

.PR

OCED

URE

For T

est S

trip

1.

Brin

g all

mat

erial

s an

d sp

ecim

ens

to ro

om te

mpe

ratu

re.

2.

Rem

ove

the

singl

e te

st s

trip

or d

evice

from

the

seale

d fo

il pou

ch.

3.

Dip

the

strip

into

the

urin

e sp

ecim

en w

ith th

e ar

row

poin

ting

tow

ard

the

sam

ple.

The

sam

ple

level

shou

ld n

ot b

e hi

gher

than

the

arro

w p

ointe

d m

axim

um lin

e.4.

Ho

ld th

e st

rip in

the

urin

e un

til a

redd

ish c

olor a

ppea

rs a

t the

test

are

a (a

ppro

ximat

ely 1

5 se

cond

s).5.

W

ithdr

aw th

e st

rip a

nd p

lace

it fa

ce u

p on

a c

lean,

non

-abs

orpt

ive

surfa

ce o

r lea

ve th

e st

rip in

urin

e if

the

urin

e lev

el is

not h

ighe

r tha

n ar

row

po

inte

d m

axim

um lin

e.6.

Re

ad th

e re

sults

at 5

-10

min

utes

min

utes

afte

r add

ing

the

sam

ple.

Test

resu

lts m

ay n

ot b

e ac

cura

te a

fter 1

0 m

inut

es.

INTE

RPRE

TATI

ON O

F RE

SULT

SNe

gativ

e: Tw

o co

lored

ban

ds fo

rm. T

he a

ppea

ranc

e of

two

color

ed

band

s, on

e in

test

line

zone

and

the

othe

r in

cont

rol li

ne zo

ne, in

dica

tes

nega

tive

resu

lts. T

he n

egat

ive re

sult

indi

cate

s th

at th

e m

ethy

lphe

nida

te

conc

entra

tion

in th

e sp

ecim

en is

eith

er ze

ro o

r les

s th

an c

ut-o

ff lev

el.Po

sitive

: One

colo

red

band

form

s. On

e co

lored

ban

d ap

pear

s in

con

trol li

ne

zone

. No

color

ed b

and

is fo

und

in te

st lin

e zo

ne. T

his

is an

indi

catio

n th

at

the

met

hylp

heni

date

leve

l in th

e sp

ecim

en is

abo

ve th

e cu

t-off

level.

Inva

lid: If

ther

e is

no c

olore

d ba

nd in

con

trol li

ne zo

ne, t

he te

st re

sult

is in

valid

. Ret

est t

he s

ampl

e w

ith a

new

dev

ice.

Note

: A b

orde

rline

(+/-)

in te

st lin

e zo

ne s

houl

d be

con

sider

ed n

egat

ive

resu

lt.LIM

ITATI

ON O

F PR

OCED

URE

The

assa

y is

desig

ned

for u

se w

ith h

uman

urin

e on

ly. A

pos

itive

resu

lt w

ith

any o

f the

test

s in

dica

tes

only

the

pres

ence

of a

dru

g/m

etab

olite

and

doe

s no

t ind

icate

or m

easu

re in

toxic

ation

. Th

ere

is a

poss

ibilit

y tha

t tec

hnica

l or p

roce

dura

l erro

r as

well

as

othe

r su

bsta

nces

in c

erta

in fo

ods

and

med

icine

s m

ay in

terfe

re w

ith th

e te

st

and

caus

e in

corre

ct re

sults

. Pl

ease

refe

r to

the

“SPE

CIFIC

ITY”

sec

tion

for

lists

of s

ubst

ance

s th

at w

ill pr

oduc

e eit

her p

ositiv

e re

sults

, or t

hat d

o no

t in

terfe

re w

ith te

st p

erfo

rman

ce. If

a d

rug/

met

aboli

te is

foun

d pr

esen

t in

the

urin

e sp

ecim

en, t

he a

ssay

doe

s no

t ind

icate

freq

uenc

y of d

rug

use

or

dist

ingu

ish b

etw

een

drug

of a

buse

and

cer

tain

food

s an

d m

edici

nes.

EXPE

CTED

RES

ULTS

The

K2/S

pice

Test

test

is a

qua

litativ

e as

say.

It id

entifi

es J

WH-

018

pent

anoic

acid

or J

WH-

073

buta

noic

acid

in h

uman

urin

e at

a

conc

entra

tion

of 5

0 ng

/mL

or h

ighe

r. The

con

cent

ratio

n of

the

synt

hetic

ca

nnab

is ca

nnot

be

dete

rmin

ed b

y thi

s as

say.

The

test

is in

tend

ed to

di

stin

guish

a n

egat

ive re

sult

from

a p

resu

mpt

ive p

ositiv

e re

sult.

All p

ositiv

e re

sults

mus

t be

confi

rmed

usin

g an

alte

rnat

e m

etho

d, p

refe

rabl

y GC/

MS.

PERF

ORM

ANCE

CHA

RACT

ERIS

TICS

A. S

ensit

ivity

The

cut-o

ff co

ncen

tratio

n (se

nsitiv

ity le

vel)

of K

2/Sp

ice Te

st is

det

erm

ined

to

be

50 n

g/m

L of

JW

H-01

8 5-

pent

anoic

acid

met

aboli

te a

nd 5

0 ng

/mL

of

JWH-

073

4-bu

tano

ic ac

id m

etab

olite

resp

ectiv

ely.

B. A

ccur

acy

1. T

he a

ccur

acy o

f the

K2/

Spice

Test

was

eva

luat

ed in

K2

spike

d ur

ine

spec

imen

s. Fo

rty (4

0) K

2 ur

ine

spec

imen

s w

ere

spike

d w

ith J

WH-

018

pent

anoic

acid

or J

WH-

73 b

utan

oic a

cid fr

om 1

0 to

150

ng/

mL;

30

sam

ples

with

JW

H-01

8 pe

ntan

oic a

cid o

r JW

H-07

3 bu

tano

ic ac

id

conc

entra

tion

betw

een

50 a

nd 1

50 n

g/m

L w

ere

all fo

und

posit

ive (1

00%

ag

reem

ent )

; 10

sam

ples

with

JW

H-01

8 pe

ntan

oic a

cid o

r JW

H-07

3 bu

tano

ic ac

id c

once

ntra

tion

betw

een

10 a

nd 3

7.5

ng/m

L w

ere

foun

d ne

gativ

e.2.

A s

econ

d st

udy w

as c

ondu

cted

by a

third

-par

ty lab

orat

ory u

sing

know

n po

sitive

urin

e fro

m s

ix (6

) don

ors.

Each

spe

cimen

was

scr

eene

d w

ith th

e K2

/Spi

ce Te

st. T

he la

bora

tory

then

pro

cess

ed a

nd te

sted

eac

h sp

ecim

en

follo

win

g fo

rens

ic gu

ideli

nes.

JWH-

018

Pent

anoic

Acid

JWH-

073

Buta

noic

Acid

Dono

rK2

/Spi

ce

Test

Lab

confi

r-m

ation

Resu

lt (n

g/m

l)K2

/Spi

ce

Test

Lab

confi

r-m

ation

Resu

lt (n

g/m

l)1

Posit

ivePo

sitive

1.5

Nega

tive

--

2Po

sitive

Posit

ive65

.2Po

sitive

Posit

ive2.

33

Posit

ivePo

sitive

107.

1Po

sitive

Posit

ive7.

04

Posit

ivePo

sitive

116.

4Po

sitive

Posit

ive3.

35

Posit

ivePo

sitive

269.

8Po

sitive

Posit

ive6.

86

Posit

ivePo

sitive

396.

4Po

sitive

Posit

ive20

.4

C. P

recis

ionTh

e pr

ecisi

on s

tudy

was

per

form

ed b

y thr

ee in

divid

uals

obse

rvin

g th

e te

st re

sult

to d

eter

min

e th

e ra

ndom

erro

r of v

isual

inte

rpre

tatio

n. T

he te

st

resu

lts w

ere

foun

d to

hav

e no

sig

nific

ant d

iffer

ence

s be

twee

n th

e th

ree

obse

rver

s.

Devic

eCo

ntro

l Co

n.

ng/m

l

No. o

f Te

sted

No. o

f pos

itive

1

2

3

No. o

f bo

rder

line

1

2

3No

. of n

egat

ive1

2

3

JWH-

018

and

JWH-

073

042

4242

4225

4242

4242

7542

4041

402

12

D. S

pecifi

city

The

spec

ificity

for K

2/Sp

ice Te

st te

st w

as te

sted

by a

ddin

g va

rious

dru

gs,

drug

met

aboli

tes,

and

othe

r com

poun

ds th

at a

re lik

ely to

be

pres

ent i

n ur

ine.

All c

ompo

unds

wer

e pr

epar

ed in

dru

g-fre

e no

rmal

hum

an u

rine.

1.

Inte

rfere

nce

test

ing

The

K2/S

pice

Test

per

form

ance

at c

ut-o

ff lev

el is

not a

ffect

ed w

hen

pH

and

Spec

ific G

ravit

y ran

ges

of u

rine

spec

imen

are

at 5

.0 to

8.0

and

1.0

05

to 1

.035

.Th

e fo

llow

ing

subs

tanc

es w

ere

test

ed a

nd c

onfir

med

not

to in

terfe

re w

ith

K2/S

pice

Test

at t

he lis

ted

conc

entra

tions

.Gl

ucos

e 20

00 m

g/dL

Hum

an a

lbum

in

2000

mg/

dL

Hum

an h

emog

lobin

10

mg/

dL

Urea

4000

mg/

dL

Uric

acid

10

mg/

dL

2.

Spec

ificity

K2/S

pice

Test

is s

pecifi

c w

ith J

WH-

018

pent

anoic

acid

and

JW

H-07

3 bu

tano

ic ac

id.

Com

poun

ds

Conc

entra

tion

Cros

s re

activ

ityJW

H-01

8 pe

ntan

oic a

cid

50 n

g/m

l

100%

JW

H-07

3 bu

tano

ic ac

id

50 n

g/m

l

100%

Each

liste

d su

bsta

nce

that

may

be

foun

d in

the

urin

e w

as e

valu

ated

and

in

dica

ted

nega

tive

resu

lt at

con

cent

ratio

n of

100

μg/

ml o

r hig

her u

nles

s it

is sp

ecifie

d.

Acet

amin

ophe

n 4-

Acet

amid

ophe

nol

Acet

ylsali

cylic

acid

Am

ikacin

Am

itrip

tylin

e Am

obar

bita

l Am

phet

amin

e Ar

tere

nol

Aspa

rtam

e As

corb

ic ac

id

At

enolo

l At

enon

al

Atro

phin

e Be

nzoy

olecg

onin

e

Bupr

enor

phin

e Bu

p-3-b-

gluc

uron

ide

Buta

barb

ital

Buta

lbita

l Ca

ffein

e Ca

mph

or

Cann

abid

iol

Cann

abin

al Ce

tirizi

ne

Chlor

oqui

ne

Corti

sone

Ch

lorph

enira

min

e Co

cain

e Co

dein

e Co

tinin

e De

spira

min

e De

xtrom

etho

rpha

n De

oxye

phed

rine

Digi

toxin

Di

goxin

Di

phen

hydr

amin

e Di

phen

hydr

amin

e Do

xylam

ine

Ecgo

nine

Ec

goni

ne m

ethy

l est

er

EDDP

Ephe

drin

e Ep

inep

hrin

e Fe

ntan

yl Flu

oxet

ine

Gent

isic

acid

Gu

aiaco

l glyc

er e

ster

He

rtoin

e Hi

stam

ine

Hom

atro

phin

e Hy

droc

hlor

othi

azid

e Hy

drox

yzin

e Ib

upro

fen

Imip

ram

ine

Isopr

oter

enol

Keta

min

e Lid

ocain

e M

DA

M

DMA

M

eper

idin

e M

ethy

lphe

nida

te

Met

ham

phet

amin

e

Met

hado

l M

etha

done

M

etha

qualo

ne

Mor

phin

e Na

lbup

hine

Na

lophi

ne

Nalxo

ne

Natre

xone

Ne

omyc

in

Niac

inam

ide

Ni

cotin

e No

iger

talin

e No

rtrip

tylin

e Or

phen

adin

e Ox

carb

azep

ine

Oxyc

odon

e Ox

ymor

phon

e

Perp

hena

zine

Peni

cillin

G

Pent

obar

bita

l Ph

ency

clidi

ne (P

CP)

Phen

obar

bita

l Ph

enyle

thyla

min

e-a

Phen

ylpro

pano

lamin

e

Prom

etha

zine

Prop

rano

lol

Prop

oxyp

hene

Pr

otrip

tylin

e Qu

etiap

ine

fum

arat

e Qu

inin

e an

tidin

e

Ra

nitid

ine

Salic

ylic

acid

Se

coba

rbita

l Se

rtral

Se

rtrali

ne

Tetra

cycli

ne

Tetra

hydr

ozoli

ne

Theo

phyli

ne

Thior

idaz

ine

Triflu

oper

azin

e Tr

ihex

yphe

nidy

l Tr

imip

ram

ine

Tryp

toph

en

Tyra

min

e Ve

nlaf

axin

e Ve

rapa

mil

11-n

or-D

8 –TH

C-9-

COOH

(10

μg/m

l)*11

-nor

-D9 –

THC-

9-CO

OH (1

0 μg

/ml)

*

*The

hig

hest

leve

l to

be

test

ed is

as

indi

cate

d.

REFE

RENC

ES1.

Ur

ine

test

ing

for d

rugs

of a

buse

, NID

A Re

sear

ch M

onog

raph

73

(198

6).

2.

Info

Fact

s-Cl

ub d

rugs

, NID

A , M

ay 2

006,

http

://w

ww.

nida

.nih

.gov

/in

fofa

cts/

clubd

rugs

.htm

l.3.

Dr

ug F

act S

heet

, DEA

, Jan

uary

201

2, h

ttp://

ww

w.de

a.go

v.4.

K2

/Spi

ce Te

st s

cree

ning

and

con

firm

ation

stu

dy, C

linica

l Ref

eren

ce

Labo

rato

ry, F

ebru

ary 2

012,

pp.

2-7

.

Expr

ess

Diag

nost

ics

Int’l

, Inc

. CE

Partn

er4U

15

50 In

dust

rial D

rive

Es

door

nlaa

n 13

Bl

ue E

arth

, MN

5601

3 US

A

3951

DB

Maa

rn

The

Neth

erla

nds

DC23

6A-F

UO

Febr

uary

201

2