Drug Delivery Australia

2019 Conference

CRS/DDA 2019 Programme

QLD

WHERE: School of Pharmacy, The University of Queensland, Brisbane, Australia WHEN: Monday November 18th and Tuesday November 19th 2019

THEME: “Emerging Materials for Drug Delivery, Diagnosis and Imaging” @CRSScience @UQPharmacy @UQHealth #DDA2019

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Time: 9 -10 am Conference Registration & Poster Set up (Foyer, Level 4)

Time: 10-10:10 am Opening Remarks – Dr. Amirali Popat (PACE Auditorium, Level 4 & 5)

10:10-11:10 am PLENARY TALK (PACE Auditorium, Level 4 & 5)

SCIENTIFIC PROGRAMME Day 1: 18th November 2019

Time: 11:10-11:30 am Morning Tea & Poster Set up (Interaction Space Level 4)

We have explored “cellular hitchhiking” which involves combining synthetic particles with circulatory cells to drastically alter the in vivo fate of the synthetic particles. I will provide an overview of the principles and capabilities of these nanoparticle drug delivery systems.

Samir Mitragotri is the Hiller Professor of Bioengineering and Wyss Professor of Biologically Inspired Engineering at Harvard University. His research has provided new insights into biological barriers of skin and gastrointestinal tract, among others. His research has also led to new methods of transdermal, oral, and targeted drug delivery systems. He is an author of over 275 publications and is a Thomson Reuters Highly Cited Researcher. Prof Mitragotri is highly active in translating his inventions to clinical and commercial products. He is an inventor on over 170 patent/patent applications. His inventions have led to several products that have been commercialized or are in advanced clinical development. He is an elected member of the National Academy of Engineering, National Academy of Medicine and National Academy of Inventors. He is a foreign member of Indian National Academy of Engineering. He is also an elected fellow of AAAS, CRS, BMES, AIMBE, and AAPS. He received BS in Chemical Engineering from the Institute of Chemical Technology, India and PhD in Chemical Engineering from the Massachusetts Institute of Technology. He is the Editor-in-Chief of AIChE’s and SBE’s journal Bioengineering and Translational Medicine.

Prof. Samir Mitragotri: Title - Hitching a Ride on Blood Cells for Targeted Delivery of Nanoparticles Nanoparticle-based drug delivery systems are widely explored to improve the biological outcome of encapsulated drugs. However, poor vascular circulation, limited targeting and the inability to negotiate many biological barriers are key hurdles in their clinical translation. Biology has provided many examples of successful “carriers” in the form of circulatory cells, which routinely overcome the hurdles faced by synthetic nanoparticle systems. Our laboratory has explored blood-cell inspired drug delivery systems that take advantage of the abilities of red blood cells and monocytes.

Time Keynote Title

11:30 am-12

pm

Prof. Bruno Sarmento Functionalized nanomedicines for the disruptive intestinal delivery of anti-diabetic peptides

12-12:30 pm Dr. Vanessa Zann Using real-time adaptive manufacturing and clinical testing to optimize Modified Release

Formulations

12:30-1 pm Prof. Nico Voelcker Engineering porous silicon nanoparticles for smart drug delivery

Time 1-1.10 pm Waters Australia Presentation (Platinum Sponsor) (PACE Auditorium, Level 4 & 5)

“Imaging for spatial distribution of drugs and their metabolites”

Session 1 (PACE Auditorium, Level 4 & 5)

Time: 1:10 – 2 pm Lunch and Poster Presentation Competition (Interaction Space Level 4)

Chairs: A/Prof. Heather Benson (President CRS Australia / DDA)

Time Speaker- title Time Speaker- title 2- 2:20 pm Invited: Prof. Steven Wise

Plasma synthesis of carbon-based nanocarriers for linker-free immobilization of bioactive cargo

2- 2:20 pm Invited: Prof. Peter Wich Polysaccharides and Proteins as Versatile Biopolymer Material for Nanoparticles

2:20-2:40 pm

Invited: Dr. Karan Gulati Customizable Nano-Engineered Titanium Dental Implants

2:20-2:40 pm

Invited: Prof. Salvatore Sortino Multicargo Polymer Nanoparticles Photoactivatable in the Therapeutic Window with Three- Color Fluorescence and Bimodal Anticancer Activity

2:40-2:50 pm

Talk 1: Alaa S Tulbah Simvastatin Nanoparticle Formulations for Pulmonary Diseases

2:40- 3 pm

Invited: Dr. Khay Fong Dynamic transformations of drug delivery systems by proteins: when equilibrium studies are not enough.

2:50- 3 pm

Talk 2: Dr. Felicity Han Development sustained release of the analgesic adjuvant drug, ketamine-loaded nanoparticles

3- 3:10 pm

Talk 1: Hayley Schultz Supersaturated Silica-Lipid Hybrids (Super-SLH) Improve In Vitro Solubilisation and Oral Bioavailability of Abiraterone Acetate

3- 3:10 pm

Talk 3: Yeakuty Jhanker Improving Diffusion of mALA Through and into the Skin by Physical Penetration Enhancement

3:10-3:20 pm

Talk 2: Ruba Almasri Supersaturated Silica-Lipid Hybrids (super-SLH) to Enhance Drug Loading Capacity and in vitro dissolution of Lipid-Based Formulations

3:10-3:20 pm

Talk 4: Dr. Meghna Talekar Liposomal antigen immunomodulator specific regulation of systemic inflammatory autoimmune disease

3:20-3:30 pm

Talk 3: Hao Song A Nanotopography Design of Silica Nanoparticles for Plasmid DNA Delivery

Chairs: Prof. Clive Prestidge and Dr. Tushar Kumeria Chairs: A/Prof. Chunxia Zhao and Dr. Peter Moyle

Session 2A: Local Drug Delivery Systems I (PACE Auditorium, Level 4 & 5)

Session 2B: Emerging Materials for Drug Delivery (Room no. 5034, Level 5)

3:20-3:30 pm

Talk 5: Hanumanth Cheruvu Development of mechanistic models to predict in vivo transdermal delivery of scopolamine from in vitro skin permeation data

3:30-3:40 pm

Talk 4: Dr. Patrick Spicer Selective shape-change response by smart droplets

3:30-3:40 pm

Talk 6: Sanjukta Duarah Biodegradable Microneedles for Inflammation: Optimisation and Ex-Vivo Evaluation in Human Skin Model

Time Speaker- title

Time Speaker- title 4- 4:30 pm

Keynote: Prof. Ranjeny Thomas Targeting Dendritic Cells for Antigen-specific Tolerising Immunotherapy in Autoimmune Disease

4- 4:20 pm

Invited: Prof. Benjamin Boyd Approaches to lipid formulation inside out or outside in?

4:30-4:50 pm

Invited: Dr. Peter Moyle Defined Semisynthetic Platforms for Producing Potent Semisynthetic Protein-Adjuvant Fusion Vaccines

4:20-4:30 pm

Talk 1: Paul Joyce Total Internal Reflection Fluorescence (TIRF) Microscopy for Oral Drug Delivery Applications

4:50- 5 pm

Talk 1: Ahmed Shalash Impact of adjuvanting moieties on critical oral delivery attributes of a B-cell epitope: Hydrophobicity, self-

4:30-4:40 pm

Talk 2: Tahlia Meola Bench-Top to Bed-Side: Evaluation of Solid Silica-Lipid Formulations in Healthy Volunteers

Session 3A: Infection and Immunity I (PACE Auditorium, Level 4 & 5)

Time: 3:40-4pm Afternoon Tea and Poster Presentation Competition (Interaction Space Level 4)

Chairs: Prof. Sanjay Garg and Dr. Sophia Gu Chairs: Prof. Istvan Toth and Dr. James Falconer

Session 3B: Oral Drug Delivery Systems I (Room no. 5034, Level 5)

assembly, strand conformation induction, and in vitro digestion

5- 5:10 pm

Talk 2: Lili Zhao Development of polysaccharide-based nanoparticles for peptide subunit vaccine against Group A Streptococcus

4:40-4:50 pm

Talk 3: Dr. Kapil Vithani Approach to Prepare Solid Self-Microemulsifying Drug Delivery System without a Solid-Phase Carrier Using 3D Printing

5:10-5:20 pm

Talk 3: Yassamin Albayaty Defeating Fungal Biofilms Using pH Sensitive Block Copolymer Micelles

4:50- 5 pm

Talk 4: Ankit Parikh Novel Curcumin Formulation for enhancement of oral bioavailability and reversal of cognitive deficits in Alzheimer's disease mice model

5:20-5:30 pm

Talk 4: Zhi Qu Oral Colonic Delivery of Prednisolone with Polymer Coated Silica Nanoparticles for Inflammatory Bowel Disease

5- 5:10 pm

Talk 5: Chun Yuen Jerry Wong Lyophilization of Polymeric-Oligonucleotide Nanoparticles for Oral Delivery of Insulin

5:10-5:20 pm

Talk 6: Arlene McDowell Cell-nanoparticle Association is Enhanced by Designing Cell-penetrating Peptide Architecture

5:20-5:30 pm

Talk 7: Silvano Paternoster Oleoyl-LPI mimetics as novel drugs targeting the enteroendocrine cell system

Venue: Kookaburra Showboat Cruises

1 Eagle Street Brisbane QLD 4000 Australia Tel: 0732211300

Email: functions@showboat.net.au Web: www.showboat.net.au

Boarding time 7 pm & Departure 7.30 pm sharp

(Nominee’s for travel bursary will be notified for their 3 minute rapid fire talk)

Please note it is the responsibility of attendees to reach there on time (7 pm)

Direction for Dinner venue

CONFERENCE DINNER

Poster Presentation : 18th November - Viewing Time : During Lunch ( 1-2 pm) and Afternoon Tea

Poster #

First Name

Last Name

Poster Title

P01 Seyed Ebrahim

Alavi Development of Alkyne-Modified Glucagon-Like Peptide-1 (GLP-1) Analogs to Evaluate Their Capacity to Rapid Conjugation to Different Carriers

P02 Waleed Hussein Self-adjuvanting liposomal polyacrylate-peptide formulation as a therapeutic vaccine candidate against cervical cancer

P03 Rachel Stephenson Carbohydrate vaccines – a sweet solution in the fight against group A Streptococcus infection P04 Amalie Møller The Effect of Liquid vs. Solid Supersaturated Lipid-Based Formulations on the Solubilisation of

the Poorly Water-Soluble Weak Base Blonanserin P05 Syaza Binte Abu

Bakar Tableting of human milk and colostrum, and their self-assembly during digestion

P06 Yunxin (Cindy)

Xiao Engineering Elongated Polymeric Nanocapsules for Prolonged Circulation and Improved Controlled Release

P07 Santhni Subramaniam Nanoantibiotics to Target Intracellular Bacteria P08 Sadia Qamar Optimization of Supercritical Fluid Equipment for Efficient Extraction of Cannabinoids from

Cannabis Flower and their Quantification by RP-HPLC P09 Sitah Alharthi Synergistic effects between sortase A inhibitors and antimicrobial peptides against antibiotic

resistant bacteria P10 Khushali Parekh Process Optimization of Nanocrystals for Improved Dermal delivery in Management of Atopic

Dermatitis P11 Shereen Yousef Skin permeation studies and MPT-FLIM imaging to assess noninvasive delivery of a cationic

anticancer agent to deeper layers of ex vivo human skin using characterized nanosystems P12 May Song A Novel Chitosan-Coated Liposome Formulation Development of Antimicrobial Compound USA

987

P13 Sajedehsadat Maghrebi PLGA-Lipid Hybrid (PLH) Microparticles Enhancing Intracellular Uptake and Anti-Bacterial Activity of Rifampicin

P14 Yuao Wu Novel nanotechnology approach for diagnosis and treatment of ROS related inflammatory diseases

P15 John Ndayishimiye Preparation and characterization of novel bicyclic nitroimidazole-cyclodextrin formulation using supercritical carbon dioxide

P16 Taskeen Janjua Facile Synthesis of Small Size Colloidal Silica Nanoparticle for Brain Drug Delivery P17 Prashamsa Koirala Development of new polymer-peptide conjugates as a delivery platform for peptide-based

vaccines against Group A Streptococcus (GAS) P18 Ummey Nahar Synthesis of C-type Lectin Receptor Targeting Vaccine Candidates Against Group A Streptococcus

(GAS) P19 Viet Tram Duong Development of novel peptide-based subunit vaccines against Tuberculosis (TB) P20 Mohammad Faruck Development an oral-delivery system for polymer-peptide conjugate based vaccine against

Group A Streptococcus P21 Harrison Madge Self Adjuvanting Cyclic Lipopeptide Vaccine Candidates Successfully Induce High Titers of

Opsonic IgG Against Multiple Group A Streptococcus Clinical Isolates

P22 Armira Azuar Bile acid-based delivery system for lipopeptide vaccine against Group A Streptococcus P23 Fahima Akther Rheological modification of carrageenan hydrogel with bovine gelatin for microfluidic drug

delivery system P24 Ruixiu Li Investigation of Marketed Products to Design Novel Canine Otitis Externa Treatment P25 Hussain Al-Sadiq Concentration stability of monolayer and bilayer lipid microbubbles – a precursor for new drug

delivery applications P26 Aun Raza Preparation and Characterization of Meropenem/Gamma-Cyclodextrin

Inclusion Complex in Liquid Carbon Dioxide

P27 Jamie Yuen Yi Lam A Metabolic Labelling Based Approach for Highly Selective Gastrointestinal Delivery P28 Jiadai Wu Fabricating acyclovir-loaded chitosan nanoparticles with high biocompatibility to corneal cells for

ocular herpes treatment

P29 Faisal Saeed M

Alsenani Development and antimicrobial screening of phytocannabinoid extracts

P30 Farzaneh Forouz Bio-evaluation of Tyrosinase Inhibitors P31 Asim Mushtaq Synthesis and in vitro validation of curcumin and siRNA loaded targeted chitosan particles for

bone metastasized breast cancer P32 Arlene McDowell Efficient Production of CPP-Functionalized Nanoparticles Using Microfluidics P33 Nhiem Tran Controlling self-assembled lipid nanoparticle mesophases using unsaturated fatty acids P34 Jayanthi Swaminathan Surface properties of electrospun nanofiber laminates P35 Mubtasim Murshed A new controlled release approach for prevention of accidental overdose with prescription

medicines P36 Farrhana Firdaus Development of Lipopeptide-based Adjuvants for Vaccine Candidates against Group A

Streptococcus (GAS) P37 Needa Alharbi Lipopeptide-anchored Liposomes as Vaccine Delivery Systems against Group A Streptococcus

Infection P38 Chee Wei Ang Nanoparticle-based Formulation for Antitubercular Bicyclic Nitroimidazoles P39 Paris Fouladian Development of a localized controlled release system for Esophageal Cancer P40 Preeti Pandey Development and Characterization of Mucoadhesive In Situ Nasal Gelling Systems P41 Maria Soliman Development of a DNA vaccine that provides protection against blood stage malaria P42 Jieru Yang Delivery of a peptide-based vaccine against Group A Streptococcus with the help of cell

penetrating peptides P43 Tom Eason Investigating the Effect of Viscosity Modifiers on the 3D-Printing Performance of Lipid-based

Formulations P44 Xin Liu Mathematical modeling of in vitro skin permeation of acyclovir creams considering penetration

enhancer effects P45 Chuankai Dai Immunological study of glyco-lipoconjugate vaccine candidates against Group A Streptococcus P46 Karla Ximen Vazquez

Prada Activatable Au@IONPs for Advanced Imaging and Diagnosis of Thrombosis

P47 Vuanghao Lim Wheat Germ Agglutinin Conjugated Disulfide Cross-Linked Sodium Alginate Nanoparticles: A Stimuli-Responsive Colon Targeted Drug Delivery System

P48 Jacinta Lam Novel nanocomposites based on iron oxide, cerium oxide and chitosan as potential theranostic agents for ROS-related inflammatory diseases

P49 Schmid Roman Synthesis and toxicological evaluation of chitosan-functionalized mesoporous silica P50 Declan Kuch Can the EPR Effect Controversy can be resolved? The view from a Science-Sociology

Collaboration P51 Yee Tat Chua

P52 Vandana Chaudhary Bioactive glass composite scaffold: a novel carrier system for oral mucosal drug delivery P53 Weizhi Xu Supercritical CO2 based Green Synthesis of Sustained Release Ketamine-PLGA

Microparticle Formulations P54 Xiaoxue

(Helen) Xu Near infrared light stimulated smart nanomedicine system for chemotherapy - drug delivery

targeting, regulating and monitoring P55 Sahra Bashiri Development of lipopeptide-based vaccine candidates against HSV-2

Time Speaker- title

Time Speaker- title 8:30- 9 am

Keynote: Prof. Maria Kavallaris Nanomedicine for drug delivery: Obstacles and Opportunities

8:30- 8:50 am

Invited: Prof. Istvan Toth Hormone-based (GnRH) immunocastration to control feral animals

9- 9:20 am

Invited: Dr. Kara Vine-Perow Dual-Drug loaded Polymer Implants for the Localized Treatment of Pancreatic Cancer

8:50- 9:10 am

Invited: Prof. Clive Prestidge Nano-carriers to Target Intracellular and Biofilm Based Pathogens and Associated Infections

9:20-9:40 am

Invited: A/Prof. Chunxia Zhao Are high drug loading nanoparticles the next step forward for cancer nanomedicine?

9:10- 9:30 am

Invited: A/Prof. Ng Shiow Fern Moringa Oleifera Standardised Leaf Extract Nanofibers Impregnated onto Hydrocolloid Film for Chronic Wound Healing

9:40-9:50 am

Talk 1: Daniel Paterson Hydrogen-sulfide responsive bicontinous nanospheres for chemotherapeutic drug delivery

9:30- 9:50 am

Invited: Dr. James Falconer Harnessing the solvent power of supercritical carbon dioxide for small and large molecules

9:50-10 am

Talk 2: Marco Falasca Testing Cannabinoids in Pancreatic Cancer Models in Combination with Current Chemotherapy Agents

9:50- 10 am

Talk 1: Minze Zhu Bioerodable Lipid Hybrid Nanoparticles Fabricated using a Microfluidics Technology for Relief of Neuropathic Pain

9:50-10 am

Talk 3: Friederike Mansfeld Teaching an old dog new tricks: Targeting Caelyx® to multiple types of cancer

Session 1A: Cancer Drug Delivery System (PACE Auditorium, Session 1B: Infection and Immunity (Room no. 5034, Level 5) Level 4 & 5)

Time: 10-10:30 am Morning Tea (Interaction Space Level 4)

Day 2: 19th November 2019

Chairs: Prof. Nicolas Voelcker and Dr. Yousuf Mohammed Chairs: A/Prof. Steven Wise and Dr. Kapil Vithani

Time Speaker- title

Time Speaker- title

10:30-11 am

Keynote: Prof. Mika Linden Mesoporous silica nanoparticles for imaging and therapy – The critical role of biodistribution

10:30-10:50 am

Invited: Prof. Sanjay Garg Challenges in developing bio-relevant dissolution methods for non-oral routes of administration

11-11:20 am

Invited: Dr. Tushar Kumeria Porous Silicon Based Nanoparticles for Bioimaging and Drug Delivery

10:50-11:10 am

Invited: Dr. Yousuf Mohammed Bioequivalence of topical products: Past, Present and Future

11:20-11:40 am

Invited: Dr. Sophia Gu Biocompatible polymer-exfoliated Clay Nanosheets for Drug Delivery and Catalytic Nanomedicine

11:10-11:20 am

Talk 1: Sarika Namjoshi Effect of “In use” Administration on Topical Product Metamorphosis and Skin Permeation of Acyclovir Creams: Implications for Bioequivalence Testing

11:40 am-12 pm

Invited: Dr. MJA Shiddiky Nanoarchitectured materials for next-generation of molecular diagnostics

11:20-11:30 am

Talk 2: Mengyang Liu Development of Glutathione Loaded Solid Lipid Nanoparticles for Topical Application

12-12:20 pm

Invited: Dr. Hang Ta Advancing the diagnosis and treatment of cardiovascular diseases with nanotechnology

11:30-11:40 am

Talk 3: Franklin Afinjuomo Novel Biodegradable Inulin Hydrogels for Colon Targeted and Controlled Release of 5-Fluorouracil

12:20-12:30 pm

Talk 1: Maggie Zhai Paclitaxel-loaded self-assembled lipid nanoparticles as targeted drug delivery systems for the treatment of aggressive ovarian cancer

11:40-11:50 am

Talk 4: Sagar Dhoble Topologically Unique Non Vesicular Lipidic System: Application in Pulmonary Drug Delivery

Session 2A: Emerging Materials for Drug Delivery/Diagnostics (PACE Auditorium, Level 4 & 5)

Session 2B: Local Drug Delivery Systems II (Room no. 5034, Level 5)

Chairs: Prof. Bruno Sarmento and Dr. Meghna Talekar Chairs: Prof. Salvatore Sortino and Dr. Kara Vine-Perow

11:50 am-12 pm

Talk 5: M. Skwarczynski The use of Polymers to Develop Peptide Nanovaccines

12-12:10 pm

Talk 6: Xiaohan Sun Magnetically Stimulated Transformation in Nanostructure of Self-assembled Lipid-based Drug Delivery Systems for Long-term Drug Administration

12:10-12:20 pm

Talk 7: Hanif Haidari Development of an Ultra small Silver Nanoparticles Formulation as the Next Generation Antimicrobial Agent

12:20-12:30

Talk 7: Maryam Dabbaghi Narrow gap rheology best describes product behavior under in-use stress: A topical semisolid product case study

Time: 1:30-2 pm Rapid Fire Talks (PACE Auditorium, Level 4 & 5) Chairs: TBC

Time: 12:30-1:30 pm Lunch and networking / CRS-DDA AGM 2019 (Interaction Space Level 4)

EXPERT PANEL MEMBERS Prof. Samir Mitragotri (https://drugdelivery.seas.harvard.edu)

Prof. Maria Kallvalaris (https://ccia.org.au/home/our-purpose/our-people/maria-kavallaris/)

Prof. Ranjeny Thomas (https://di.uq.edu.au/profile/970/ranjeny-thomas)

Prof. Michael Roberts (https://researchers.uq.edu.au/researcher/41)

Dr. Vanessa Zann (Senior Research Fellow, Scientific Consulting, Quotientsciences)

Time: 2-3 pm Round table discussion (PACE Auditorium, Level 4 & 5) Chair: Prof. Benjamin Boyd Topic: Nuts and Bolts of Translating Formulation into the Clinic

Time: 3.05-3:35 pm Closing remarks – Awards announcement (PACE Auditorium, Level 4 & 5)

Time 3-3:05 pm In Vitro Technologies Presentation (Gold Sponsor) (PACE Auditorium, Level 4)

Time 3.35 pm Afternoon Tea and networking (Interaction space, Level 4)

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