Delighting irritated, dry feeling eyes

Delighting eyes everywhere

As an expert in refractive eye care, Abbott Medical Optics Inc. understands the importance of protecting the tear film from drying conditions.

• The tear film is the first refractive surface of the eye. It provides a natural defence against infection and is a highly effective lubricating device1

• Loss of moisture from the tear film can lead to reduced visual acuity as well as irritated, uncomfortable eyes2

• The blink eye drop range has a solution to suit most of your customer needs, from the lightly moisturising blink refreshing eye drops to the viscosity enhanced longer lasting blink intensive tears. For the contact lens wearer there is the specifically formulated blink contacts eye drops designed to keep eyes feeling fresh and comfortable.

blink refreshing daily eye drops

• Instantly awakens tired feeling eyes

• Designed for those occasions when your eyes natural moisture needs a boost - such as after late nights out or long periods of working at a computer

blink contacts soothing eye drops

• Specifically formulated for contact lens wearers

• The visco-elastic formulation increases tear film stability for longer, comfortable contact lens wear

blink intensive tears protective eye drops

• For longer lasting relief from irritated, dry feeling eyes

• Formulated for those experiencing more frequent feelings of irritated, dry feeling eyes

Long lasting relief from irritated, dry feeling eyes

blink intensive tears helps bring long lasting relief from irritated, dry feeling eyes through its triple action formula

1 The hypotonic formulation lowers the tear film osmolarity3 to help bring greater stability4

2 Contains a lubricating demulcent to soothe and protect

3 Viscosity enhanced for a longer lasting effect - can hold moisture in the eye for more than 60 minutes with less blurring4,5

• An increased tear film osmolarity may be linked to ocular surface damage and dry feeling eyes6,8

• blink intensive tears significantly reduced the tear film osmolarity over the 30-day study period compared to competitor drops3

1 Hypotonic blink intensive tears helps to stabilise the tear film – breaking the negative cycle of ocular irritation

Cycle of ocular irritation

Hypotonic blink intensive tears helps

maintain the tear film osmolarity

better than other eye drops3

Inflammation can result in reduced tear production so increasing tear film osmolarity and potential ocular

surface damage6

Drying environments take moisture from the eye

increasing tear film osmolarity7

Results in the release of inflammatory

agents

Day 1before drop instillation

Day 15 minutes after drop instillation

Day 30before drop instillation

Day 305 minutes after drop instillation

325

320

315

310

305

300

295

290

mO

smo

l/l

17411

mOsmol/lblink intensive tears 31211

mOsmol/lEye drop B28811

mOsmol/lEye drop A

Normal tear film 308 mOsmol/l12

Change in tear film osmolarity over a 30-day period3 (n = 20 per eye drop)

A significant fall in OSDI score for blink intensive tears users9

blink intensive tears were significantly more soothing than a competitor eye drop4

• In a recent study of VDT users after 3 weeks of using blink intensive tears, a 32% reduction in OSDI score was observed. In the same study the NIBUT was seen to increase by 5 seconds during the study period.9

69*

18

blink intensive tears A competitor* P = .021 eye drop

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Baseline After 3 weeks

40

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30

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20

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2 Demonstrated to soothe dry, irritated eyes

• After just 21 days, 48% of blink intensive users reported an improvement in vision quality10

• In a comparative study, a combined 89% of those using a competitor eye drop experienced blurring compared to only 20% with blink intensive tears.4

• In a further study, blink intensive tears users reported improved eye comfort over time with an initial average improvement of 20%10

• After using blink intensive tears a statistically significant reduction in visual aberrations was found11

Increasing comfort over time10

Start Day 7 Day 14 Day 21

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3 Demonstrated to hold moisture in the eye for over 60 minutes for lasting comfort without blurring4,5

References:1. Craig J. Structure and function of the preocular tear film. In: Korb D, et al. Tear film: structure, function and clinical examination. Butterworth-Heinemann Ltd; 2002. p18–50. 2. Reiger G. BJO 1992; 76: 157–8. 3. Albert T, Benelli U, Posarelli C. Evaluation of the change in tear osmolarity after using different eye drops. Manufacturer’s showcase presentation. BCLA Conference & Exhibition 2009. 4. Thomas Kislan MD. Randomized, Cross-Over Evaluation of PEG-400 based Artificial Tear (blink) versus HP-Guar based Artificial Tear (Systane) for Signs and Symptoms of Dry Eye. Hazleton Eye Specialists, PA. USA. Poster presented at the Annual Meeting of the American Academy of Optometry, October 22-25,2008, Anaheim, CA. 5. Wavelength-Dependent Optical Interferometry Measurements of Change in Thickness of Apical Corneal Tear Film Following Eye Drop Instillation S. Huth*, D. Tran*, C. Skotnitsky ‡, L. Lasswell‡, P. Mahmud†, T. Kim‡. *Advanced Medical Optics, Inc. (CR: E, P) ‡ Advanced Medical Optics, Inc. (CR: E) †spherion, Inc., Santa Ana, CA (CR: N). POSTER ARVO. 6. THE OCULAR SURFACE. Dews. Management and Therapy. April. 2007; 5(2): 87. 7. Santosh Khanal et al. Dry Eye Diagnosis. Ophthalmology and Visual Science. April 2008. 8. Katsuyama I, Arakawa T. A convenient rabbit model of ocular epithelium damage induced by osmotic dehydration. J Ocul Pharmacol Ther. 2003 Jun;19(3):281-9. 9. Montani G, lndrio P. Effect of blink intensive and blink contacts on the Ocular Dryness in VDT Users. University of Salento. Presentation at Assottica Meeting, Rome Nov. 2008. 10. Consumer assessment of blink intensive tears over time. A study commissioned by Abbott Medical Optics Inc. AMO data on file. 11. Robert Montés-Micó, Alejandro Cerviño, Teresa Ferrer-Blasco, Santiago García-Lázaro, Susana Ortí-Navarro. Optical Quality of the Interface Air-tear Film Following Instillation of Eye Drops in Dry Eyes. J Cataract Refract Surg June 2010. 12. Eye drop comparison. Data on File Abbott Medical Optics Inc.

OcuPure, blink and blink-n-clean are trademarks owned by or licensed to Abbott Laboratories, its subsidiaries or affiliates.

© 2010 Abbott Medical Optics Inc. 2010.10.25-CN2493 DoC:01Nov10.v6

blink refreshingdaily eye drops

blink contactssoothing eye drops

blink-n-cleaneye drops

blink intensive tearsprotective eye drops

Pack size10ml multi-dose20 x 0.5mlsingle use vials

10ml multi-dose20 x 0.35mlsingle use vials

15ml multi-dose10ml multi-dose20 x 0.4mlsingle use vials

LubricantPolyvinylalcohol1.4%

Sodiumhyaluronate0.15%

Hydroxypropyl-methylcellulose(HMPC) 0.15%

Polyethylene glycol(PEG 400)0.25%

Viscosityenhancer

- - -Sodium hyaluronate0.2%

Cleaning agent - -Tromethamine 1.2%Tyloxapol 0.025%

-

pH close tonatural tears

Yes Yes Yes Yes

Viscosity (CP) 3.612 5.5512 - 12.212

Osmolarity(mOsmol/l)

30512 26712 - 17412

Buffer Phosphate Phosphate Phosphate Borate

Preservative(multi-dose only)

Chlorite/peroxycompound (CPC)

OcuPurepreservative

Polyhexamethylenebiguanide

OcuPurepreservative

Discard10ml - 45 daysVials - Immediately after use

10ml - 45 daysVials - Immediately after use

60 days10ml - 45 daysVials - Immediately after use

blink eye drop range