dysynchiria - a possible explanation
DESCRIPTION
A possible explanation of Dysynchiria, based on some research by Acerra and Moseley, Neurology 2005;65:751–3TRANSCRIPT
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Lorimer Moseley NHMRC Senior Research Fellow Prince of Wales Medical Research Institute & School of Medical Sciences, University of New South Wales, Sydney, Australia
Team leader The GAMFI project University of Oxford, UK
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Dysynchiria Watching the mirror image of the unaffected limb elicits pain on the affected side
Acerra & Moseley 2005 Neurology 65: 751-3
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ThisisNicole.SheistouchingthegoodhandofsomeonewithCRPS,whohastheirbadhandbehindthemirror.
Acerra & Moseley 2005 Neurology 65: 751-3
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So,oneputstheirhandseithersideofamirror….
Acerra & Moseley 2005 Neurology 65: 751-3
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So,oneputstheirhandseithersideofamirror….thenmovestheirheadabitsothatitlooksliketheyareseeingbothhandswhentheyareactuallyseeingtherighthandanditsmirrorimage.
Acerra & Moseley 2005 Neurology 65: 751-3
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So,oneputstheirhandseithersideofamirror….thenmovestheirheadabitsothatitlooksliketheyareseeingbothhandswhentheyareactuallyseeingtherighthandanditsmirrorimage.
Acerra & Moseley 2005 Neurology 65: 751-3
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When you touch the good hand, nothing extraordinary happens…..
experience
normal
Acerra & Moseley 2005 Neurology 65: 751-3
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When you touch the intact hand, one feels the touch on BOTH hands
experience
“Synchiria”
Phantom/stroke
Acerra & Moseley 2005 Neurology 65: 751-3
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experience
“dysynchiria”
pain
CRPS1
When you touch the good hand, one feels that touch on that hand but it also HURTS the other hand.
Acerra & Moseley 2005 Neurology 65: 751-3
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Allodynia
Parasthaesia
Responsetolighttouch
BeforeRx ADerRx
Acerra & Moseley 2005 Neurology 65: 751-3
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Widediametersensoryneuron
Visualfieldinput
S1‘representaJve’neurons S2‘representaJve’neuronswithbimodalinput
ThisisapossibleexplanaJonforthephenomenonofdysynchiria.
Acerra & Moseley 2005 Neurology 65: 751-3
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Widediametersensoryneuron
Visualfieldinput
S1‘representaJve’neurons S2‘representaJve’neuronswithbimodalinput
Acerra & Moseley 2005 Neurology 65: 751-3
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Widediametersensoryneuron
Visualfieldinput
S1‘representaJve’neurons S2‘representaJve’neuronswithbimodalinput
Normalstate
Acerra & Moseley 2005 Neurology 65: 751-3
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Widediametersensoryneuron
Visualfieldinput
S1‘representaJve’neurons S2‘representaJve’neuronswithbimodalinput
SensiJsedstate
ThisisapossibleexplanaJonforthephenomenonofdysynchiria.InasensiJsedstate,thevisually‐evokedacJvaJonofbimodalneuronsinS2mightbeenoughto‘ignite’thenetworkofneuronsthatevokespain.
Acerra & Moseley 2005 Neurology 65: 751-3