eicosanoids and other bioactive lipids in cancer ...52 inhibition of leukotriene b4 (ltb4) in human...
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EICOSANOIDS ANDOTHER BIOACTIVELIPIDS IN CANCER,INFLAVIMATION, AN DRADIATION INJURY 2Part A
Kenneth V. Honn
Santosh Nigam
Lawrence J . Marnett
PHOSPHOLIPASE S
1
Regulation of Phosphoinsitide Phospholipases by G-
3Protein sExton, J.
2
The Effects of Group II Phospholipase A2 in Ras-
9Induced MetastasisDavis, T.
3
Activation of Ca 2+-Sensitive Cytosolic Phospholipase
1 9A2 (cPLA2) in Human PlateletsKramer, R .
4
Involvement of Reactive Oxygen Species in
25Phospholipase A2 Activation : Inhibition of ProteinTyrosine Phosphatases and Activation of Protei nKinasesZor, U. and Goldman, R.
5
High Molecular Weight Phospholipase A2 : Its
3 1Occurrence and Quantification in Human Colo nCancer and Normal Mucos aTavares, LA .
BIOSYNTHETIC ENZYMES
6
(S)-Type Lipoxygenase and Cyclooxygenase Reaction
4 1Box Models Characterizing the Stereochemistry o fthe Dioxygenation ReactionLehman, W.
7
Activation of 5-Lipoxygenase in Whole
4 7Polymorphonuclear Leukocytes by Arachidoni cAcid : Evidence of Cytosolic Active EnzymeVila, L .
8
Intracellular Distribution, Activity, and Ca 2+-
5 7Dependent Translocation of 12-Lipoxygenase i nLewis Lung Tumor Cell sHagmann, W.
9
Cloning and Sequencing of Prostaglandin H
65Synthetase from Rat Tracheal Epithelial Cells :Structural Evidence that a TPA Regulated mRN ACodes for the Rat Ortholog of Murine PHS- 1Kitzler, J.
10
Non-enzymatic Rearrangement of Leukotriene A4 to
7 15-Keto-(7E, 9E, 11Z, 14Z)-eicosatetraenoic Acid i nAqueous MediaReindeau, D.
11
Bromoacetamido-Analogs of Indomethacin and
7 7Mefenamic Acid Affinity-Label Prostaglandin H 2Synthase at Two SitesTang, M.
12
Regulation of Eicosanoid Synthesis in Liver
8 5Macrophage sDieter, P.
13
Comparison of Arachidonic Acid Metabolism by
93Normal Pre-Cancerous and Neoplastic Epithelial Cel lLines of the Upper Aerodigestive TractSnyderman, C.
14
Induction of Prostaglandin Endoperoxide Synthase-1
9 9(cox-1) in a Human Promonocytic Cell Line b yTreatment with the Differentiating Agent TP ASmith, C.
15
X-ray Crystallographic Study of the Structure of
107Prostaglandin H Synthas eGaravito, M.
16
Properties of Prostacyclin Synthase
11 3Ullrich, V.
17
Regulation of Prostaglandin H Synthase-1 Gene
12 1ExpressionWu, K.
18
Mammalian Arachidonate 12-Lipoxygenases
127Yamamoto, S.
19
The Three-Dimensional Structure of Soybean
13 3Lipoxygenase-1 : An Arachidonic Acid 15 -LipoxygenaseAmzel, M.
20
Purification and Characterization of the Epidermal
1398(S)-LipoxygenaseLoschke, M.
21
The Effect of 5-Lipoxygenase-Activating Protein
145(FLAP) on Substrate Utilization by 5-LipoxygenaseVickers, P.
22
Leukotriene A4 Hydrolase: Differential Inhibition
15 3of the Catalytic Activities by Divalent Cation sHaeggstrom, J.
23
Regulation of 12(S)-HETE Production in Tumor Cells
15 9Chen, Y. Q .
24
Distribution of COX 1 and COX 2 in Normal and
16 7Inflamed TissuesSeibert, K
25
Examination of Prostaglandin H Synthase-1
17 1Topology in the Endoplasmic Reticulum Membran eKulmacz, R .
26
Coordinate Regulation of the Inducible Forms of
17 7Prostaglandin Synthase and Nitric Oxide Synthase inFibroblasts and Macrophage sHerschmann, H.
27
Molecular Cloning of Prostacyclin Synthase from
18 3Bovine Endothelial CellsTanabe, T.
28
Interaction of PGH Synthase Isozymes- 1 and -2
18 9with Nonsteroidal Anti-Inflammatory Drug sSmith, W.
RECEPTORS
29
Dual Effect of Propanonol on the Human Platelet
19 9Activation by Thrombin : Potentiation of FreeIntracellular Ca2+ Mobilization and Inhibition ofPhospholipase D ActivitySvetlov, S.
30
Molecular Diversity of Prostanoid Receptors ;
207Subtypes and Isoforms of Prostaglandin EReceptorNarumiya, S.
31
Molecular Characterization and Physiological
21 5Functions of PAF ReceptorsBito, H.
32
Identification of the FP-Receptor as a Discrete Entity
223by Radioligand Binding in Biosystems that ExhibitDifferent Functional Rank Orders of Potency i nResponse to Prostanoid sWoodward, D.
33
Celllular Activation by Thromboxane A2 and 8-EPi-PGF2a
229Fitzgerald, G.
34
Modification on Ligand Binding to TXA2/PGH2
23 5Receptors by Diethylpyrocarbonat eSchrör, K.
35
Prostaglandin Receptors Involved in Inflammatory
24 1EventsJones, R .L.
36
LTB4 Receptor Antagonists Exacerbate T
247Lymphocyte-Mediated Delayed Hypersensitivity i nGuinea PigsWong, P .
37
Isolation and Cloning of Human Peroxisome
25 3Proliferator Activated Receptor Gamma CDNAGreene, M.
38
Structure and Localization of the Rabbit
26 1Prostaglandin EP3 ReceptorBreyer, R.
39
Prostaglandin Regulation of Gene Expression and
269Growth in Normal and Malignant TissuesHughes-Fulford, M.
40
Distinct Signaling Pathways Mediate Induction of c-
27 9fos by PGE2 in Glomerular Mesangial Cell sDunn, M.
41
Cytosolic 12(S)-Hydroxy-5,8,10,14-Eicosatetraenoic
287Acid Binding Sites in Carcinoma CellsHammarström, S.
PROTEIN KINASES/PHOSPHATASE S
42
Diacylglycerol Second Messengers : Molecular
297Switches in Growth ControlBell, R .
43
Sphingolipid Second Messengers : Tumor Suppressor
305LipidsHannun, Y.
44
The Role of Protein Kinase C in Signal Transduction,
31 3Growth Control and Lipid Metabolis mWeinstein, B .
45
Tumor Responsiveness to the Metastasis-Stimulatory
32 3Effects of Prostaglandin E2 Is Restricted by ProteinPhosphatasesYoung, R.
46
Interactions between Specific Phosphorproteins
329During Modulation of Prostacyclin Secretion inCultured Bovine Aortic Endothelial CellsGrose, J.
47
The Role of Lipid Peroxidation Products in the
33 9Regulation of Protein Kinase C Activity in VitroMal'tseva, E.
48
Role of Protein Kinase C and Phosphatases in 12(S)-
34 9HETE-Induced Tumor Cell CytoskeletalReorganizationTang, D.
INHIBITORSOFBIOACTIVE LIPIDSANDSIGNALTRANSDUCTION
49
PX-52, a Novel Inhibitor of 14 kDa Cytosolic
36 5Phospholipases A2Franson, R .
50
Hepoxilin A 3 Inhibits Agonist-Evoked Rise in Free
37 5Intracellular Calcium in Human Neutrophil sPace-Asciak, C.
51
The Discovery of LY293111, A Novel, Potent and
38 1Orally Active Leukotriene B4 Receptor Antagonist ofthe Biphenylphenol ClassSofia, M.
52
Inhibition of Leukotriene B4 (LTB4) in Human
38 7Neutorphils by L-Threo-Dihydrosphingosin eDarges, J.
CARCINOGENESIS
53
Aspirin and Gastrointestinal Cancer
395Thun, M.
54
Monohydroxylated Fatty Acids in Mouse Epidermis
403Papilloma Quantification and StereochemicalCharacterizationLehmann, W.
55
Negative Growth Regulation of Oncogene-Transformed
409Mammary Epithelial Cells by Tumor Inhibitor sTelang, N.
56
Different Expression of Prostaglandin-H Synthase
41 9Isozymes and Lipoxygenase during Multistag eCarcinogenesis in Mouse Ski nFürstenberger, G.
57
Expression of Two cPLA2 Isoforms in Mouse
425Epidermis in VivoFürstenberger, G.
58
Regulation of Arachidonic Acid Release by
43 3Metabolism by Tumor PromotersFischer, S.
59
Effect of the Peroxisome Proliferators Ciprofibrate
43 9and Perfluorodecanoic Acid on Eicosanoi dConcentrations in Rat LiverGlauert, H.
CELL GROWTHI
60
A Mitogenic and Hormonal Signalling Network
449Regulate Mammalian Cell Division Commitment TimeJimenez de Asua, L.
61
Growth Inhibitory Effects of Thromboxane
455Antagonists on Breast Cancer Cell Lines : APreliminary StudyMarshall, K. and Lane, K
62
The Rise and Fall of Ceramide and 1,2-Diacylglycerol
46 1(DAG) : Modulation by Transforming Growth Factor -(31 (TGF 31) and by Epidermal Growth Factor (EGF )Goldkorn, T.
63
Antioxidant Defence Mechanisms and PGE Secretion
47 3by Different Types of Transformed and Tumor Cells :in Vivo Selective AdvantagesDeichmann, G.
64
The Relationship between Farnesylation and
47 9Carcinogenesis : The Effect of Lovastatin onFibroblast Proliferatio nBraquet, M.P.
65
Eicosanoid Production and Growth Regulation in
487Rat Intestinal Epithelial Cell sDuBois, R.
66
Role of Arachidonic Acid and Linoleic Acid Metbolism in
495Epidermal Growth Factor Initiated Proliferation o fSyrian Hamster Embryo FibroblastsEling, T.
67
Phenylacetate and Phenylbutyrate as Novel,
50 1Nontoxic Differentiation Inducers .Samid, D.
68
Structural Requirements for Enhancement of EGF-
507Dependent DNA Synthesis by Oxygenated Metabolite sof Linoleic AcidGlasgow, W.
69
Decreased DNA Synthesis in SCC-25 Cells with ETYA
51 3and SC4166 1Ondrey, F.
70
Liver Fatty Acid Binding Protein and Mitogenesis in
517Transfected Hepatoma Cell sSorof S.
71
Induction of 12-Lipoxygenase Expression by
525Epidermal Growth Factor Is Mediated by Protei nKinase C in A431 Cell sChang, W.C.
72
Prostaglandin F2 a(PGF2a) Triggers Protein Kinase C
53 1(PKC) and Tyrosine Kinase Activity in Culture dMammalian Cell sJimenez de Asua, J.
73
Mechanisms of the Selective Cytotoxic Actions of
53 9Certain Essential Fatty AcidsCantrill, R .
74
Eicosanoids, Cancer Metastasis, and Gene Regulation :
545An OverviewGao, X.
CONTENTS PART B
APOPTOSISAND DIFFERENTIATION
75
Radiation-Induced Apoptosis in Tumors : Effects of
55 9Radiation Modulating Agent sMilas, L.
76
Prostaglandin E2 Mediated Apoptosis in Subsets of
565Malignant B Lymphoma CellsPhipps, R.
77
13-HODE Dehydrogenase Activity as a Modulator of
57 1Intestinal Cell Differentiatio nBull, A .
CYTOKINESANDBIOACTIVE LIPIDSININFLAMMATIO N
78
Effect of GM-CSF on Leukotriene B4 Synthesis in
583Human Neutrophils : Facilitation of the PrimingEffect by Autologous PlasmaKrump, E.
79
Docosahexaenoic and Eicosapentaenoic Acids Inhibit
58 9in Vitro Human Endothelial Cell Production ofInterleukin- 6Khalfoun, B.
80
Regulation of 15-Lipoxygenase Expression by
599CytokinesKuhn, H.
81
Modulating Effect of co-3 Fatty Acids on the
605Proliferative Pattern of Human Colorectal Mucos aAnti, M.
82
Agonist-Induced Lipoxin A4 Generation in Vitro and
61 1in Aspirin-Sensitive Asthmatics : Detection by aNovel Lipoxin A4-ELISALevy, B.
83
Regulation of Inducible Prostaglandin G/H Synthase
61 7by Interleukin-1, Transforming Growth Factors- aand -ß, and Prostaglandins in Bone CellsPilbeam, C.
84
Potential Role of Heat Shock Transcription Factor in
625the Expression of Inflammatory Cytokine sCahill, C.
85
Transcellular Pathways and Cell Adhesion as
63 1Potential Contributors to Leukotriene and Lipoxi nBiosynthesis in Acute Glomerulonephriti sBrady, H.
86
Lipoxin Metabolism by Human Promyelocytic
64 1Leukemia (HL-60) Cell sSe than, C.
87
IL-1 Increases the Ability of Human Endothelial
647Cells to Transform Linoleic Acid into Monohydroxy-Isomers and their Incorporation into Cell LipidsCamacho, M.
CELL MOTILITY AND CYTOSKELETALALTERATION S
88
Apoptosis in Tumor Biology and Therapy
657Meyn, R.
89
Integrin Functions and Signal Transduction
669Yamada, K.
90
Regulation of Tumor Cell Motility by 12(S)-HETE
683Raz, A .
91
Inhibition of Mouse B16 Melanoma Cell Motility by
693Sphingosine- l-PhosphateIgarishi, Y.
92
Effects of Leukotrienes B4 (LTB4) and D4 (LTD4) on
699Motility of Isolated Normodense Human Eosinophil sand NeutrophilsSpada, C.
93
12(S)-HETE Increases the Motility of Prostate Tumor
70 7Cells through Selective Activation of PKCaLiu, B.
ADHESIONS MECHANISMSININFLAMMATIO NANDMETASTASI S
94
Role of Complex Gangliosides in the Integrin-
72 1Dependent Adhesion of Cells in Cultur eMugnai, G.
95
Enhancement of Metastatic Potential in a Murine
73 1Fibrosarcoma Line by Exposure to CorynebacteriumParvum-Elicited Macrophages ; Effect of Eicosanoi dBiosynthesis InhibitionRuggieri, S.
96
A Regulatory Role of Prostaglandin E2-Activated
74 1Adhesion Molecules in MyelopoiesisShibata, Y.
97
Efficacy of Cicaprost on Metastasis in Advanced
75 1Tumor DiseaseSchirner, M.
98
Post-Translational Regulation of Surface Integrin
757Expression in Tumor Cells by 12(S)-HET ETimor, J.
99
Eicosanoid 12(S)-HETE Upregulates Endothelial Cell
765av(33 Integrin Expression and Promotes Tumor Cel lAdhesion to Vascular EndotheliumHonn, K. V.
100
Dietary Fatty Acids Alter the Adhesion Properties of
775Lymphocytes to Extracellular Matrix Protein sStephen, F.
RADIOPROTECTION AND RADIOSENSITIZATIO N
101
Radioprotection by Misoprostol (PGE1 Methyl
79 1Analog) in Combination with Vitamin E ,Selenomethionine and WR-3689 794Srinivasan, V.
102
Behavioral and Radioprotective Effects of
79 9Misoprostol in Adrenalectomized Mic eLandauer, M.R.
103
Effects of Eicosanoid Radioprotectors on Rat Motor
80 5Performanc eBogo, V.
104
Protection from Radiation-Induced Oral Mucositis by
81 1a Mouth Rinse Containing the Prostaglandin E 1Analog, Misoprostol : A Placebo Controlled Doubl eBlind Clinical TrialHanson, W.R.
105
Interleukin, Radiation and Thermoregulation
819Kandasamy, S.B.
106
Tumor Radiosensitization Based on the Use of
825Inhibitors of the Mevalonate Pathway of CholesterolSynthesi sMiller, A . C.
107
Synergistic Protection of Irradiated Mice by a
83 1Combination of Iloprost and Misoprosto lKumar Sree, K.
108
Regulation of the Biosynthesis of the Sulphido-
84 1LeukotrienesFord-Hutchinson, A.W.
109
The Role of Lipid Peroxidation in Growth
849Suppression of Human Breast Carcinoma by DietaryFish OilWelsch, C.
110
Misoprostol : A Potent Cytotoxic and Oncogenic
86 1Radioprotecto rMiller, R .
111
Modification and Radiation-Induced Gastrointestinal
865and Hematopoietic Injury in Mice by Combination sof Agents : Effects of Indomethacin and CaffeineWeiss, J.
112
Anti-Inflammatory Drug Treatment of Radiation
873Injurie sMichalowski, A .S.
113
Low Dose Radiation Induces Endothelial Cell Eicosanoid
879Metabolism and Cytoskeletal RearrangementOnoda, J.M.
114
Nonlethal )(Radiation Displays Similar Cytoplasmic
88 9Rearrangements as 12(S)-HETETaylor, J.D .
DIETARY MODULATION AND PREVENTION
115
Dietary Arachidonic Acid Increases Eicosanoid
89 7Production in the Presence of Equal Amounts o fDietary Eicosapentaenoic Aci dWhelan, J.
116
Impairment in the Fatty Acid Composition of Keloids
90 5Louw, L.
117
Linoleic Acid Levels in Cutaneous Tumors with
91 1Different Growth Patterns as an Additional SensitiveDiagnostic FeatureLouw, L.
118
The Importance of Linoleic Acid in the Total Fatty
91 9Acid Compositions of Benign and MalignantNeuroglial TumorsLouw, L.
119
Dietary Fat and Energy Modulation of Biochemical
92 5Events in Tumor Promotio nBirt, D .
120
Chemoprevention of Colon Cancer by Dietary
93 1Administration of Naturally Occurring and RelatedSynthetic AgentsReddy, B .
121
Diradyglycerol Formation is Altered by n-3 Highly
937Unsaturated Fatty Acids, with Differences betweenEicosapentaenoic (EPA) and Docosahexaenoic (DHA )Acid sSebaldt, R .
CLINICAL STUDIE S
122
Arachidonic Acid Metabolites in Saliva of Patients
949with Squamous Cell Carcinoma of the Head and Nec kSnyderman, C.
123
Preparation of Two Dosage Forms Containing
955Antitumor Prostaglandin and their Antitumor Effec tin Vitro and in Vivo : Lipiodol Solution for I .A .Administration and Lipid Microspheres for I .P . orI.V. AdministrationFukushima, S.
124
Urinary Excretion of Prostanoid in Children with
963Chronic Pyelonephriti sKucherenko, A .
125
Interaction of Phospholipase C-g with Activated
97 1Growth Factor Receptor Tyrosine Kinase sCarpenter, G.
126
Prostanoid and Anti-Thrombin III Levels in
983Premature InfantsSuchkova, V.
127
Molecular Biology of Prostanoid Biosynthetic
98 9Enzymes and ReceptorsSmith, W.
128
Tumor Infiltrating Lymphocytes in Squamous Cell
1013Carcinoma of the Head and Neck : Mechanisms ofEnhancement Using Prostaglandin Synthetas eInhibitor sCross, D.
CONTRIBUTORS
1025
INDEX
1051